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Category: nutrient supplements
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 0.0003555 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-mouse LD50 4100 mg/kg Journal of the American Academy of Dermatology. Vol. 6, Pg. 652, 1982.
intravenous-mouse LD50 432 mg/kg United States Patent Document. Vol. #3878202
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | nutrient supplements |
| Recommendation for vitamin A acetate usage levels up to: | | | not for fragrance use.
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| Recommendation for vitamin A acetate flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| Carcinogenic Potency Database: | Search |
| EPA GENetic TOXicology: | Search |
| EPA Substance Registry Services (TSCA): | 127-47-9 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 638034 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 2 |
| | [(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] acetate |
| Chemidplus: | 0000127479 |
| RTECS: | VH6825000 for cas# 127-47-9 |
References:
| | [(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] acetate |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 127-47-9 |
| Pubchem (cid): | 638034 |
| Pubchem (sid): | 134974060 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | acetic acid, retinyl ester | | (2E,4E,6E,8E)-3,7- | dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-yl acetate | | (2E,4E,6E,8E)-3,7- | dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetr aenyl acetate | | [(2E,4E,6E,8E)-3,7- | dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] acetate | | all-trans- | retinol acetate | | | retinyl acetate | | all-trans- | retinyl acetate | | all-trans- | retinylacetate | | | vitamin A acetate | | all-trans- | vitamin A acetate |
Articles:
| PubMed: | Determination of vitamins A and E in infant formula and adult/pediatric nutritional formula by HPLC with UV and fluorescence detection: First Action 2012.09. |
| PubMed: | Triple-fortified rice containing vitamin A reduced marginal vitamin A deficiency and increased vitamin A liver stores in school-aged Thai children. |
| PubMed: | Simultaneous determination of 13-cis and all-trans vitamin A palmitate (retinyl palmitate), vitamin A acetate (retinyl acetate), and total vitamin E (alpha-tocopherol and DL-alpha-tocopherol acetate) in infant formula and adult nutritionals by normal phase HPLC: first action 2012.10. |
| PubMed: | [Effects of vitamin A supplementation on nutritional status of iron in healthy adults]. |
| PubMed: | β-Carotene in Golden Rice is as good as β-carotene in oil at providing vitamin A to children. |
| PubMed: | Safety evaluation of vitamin A in growing dogs. |
| PubMed: | Cloning, expression and characterization of a lipase gene from the Candida antarctica ZJB09193 and its application in biosynthesis of vitamin A esters. |
| PubMed: | The effect of food preparation on the bioavailability of carotenoids from carrots using intrinsic labelling. |
| PubMed: | UVA photoirradiation of anhydroretinol--formation of singlet oxygen and superoxide. |
| PubMed: | Vitamin A equivalence of spirulina beta-carotene in Chinese adults as assessed by using a stable-isotope reference method. |
| PubMed: | beta-Cryptoxanthin from supplements or carotenoid-enhanced maize maintains liver vitamin A in Mongolian gerbils ( Meriones unguiculatus) better than or equal to beta-carotene supplements. |
| PubMed: | [Vitamin A equivalence of spinach beta-carotene in human body]. |
| PubMed: | Use of metabolic stimulators and inhibitors for enhanced production of beta-carotene and lycopene by Blakeslea trispora NRRL 2895 and 2896. |
| PubMed: | Diets rich in polyphenols and vitamin A inhibit the development of type I autoimmune diabetes in nonobese diabetic mice. |
| PubMed: | Interactions of human serum albumin with retinoic acid, retinal and retinyl acetate. |
| PubMed: | Photodecomposition and phototoxicity of natural retinoids. |
| PubMed: | Spinach or carrots can supply significant amounts of vitamin A as assessed by feeding with intrinsically deuterated vegetables. |
| PubMed: | Photoreaction, phototoxicity, and photocarcinogenicity of retinoids. |
| PubMed: | Photodecomposition of retinyl palmitate in ethanol by UVA light-formation of photodecomposition products, reactive oxygen species, and lipid peroxides. |
| PubMed: | Use of the deuterated-retinol-dilution technique to monitor the vitamin A status of Nicaraguan schoolchildren 1 y after initiation of the Nicaraguan national program of sugar fortification with vitamin A. |
| PubMed: | Rapid determination by reversed-phase high-performance liquid chromatography of Vitamins A and E in infant formulas. |
| PubMed: | Mechanisms of TCDD-induced abnormalities and embryo lethality in white leghorn chickens. |
| PubMed: | Teratogenic effects of chronic ingestion of high levels of vitamin A in cats. |
| PubMed: | [Evaluation on intestinal and whole-body conversion of beta-carotene to vitamin A in Chinese adults using a stable isotope reference method]. |
| PubMed: | Simultaneous determination of vitamin A and beta-carotene in dietary supplements by liquid chromatography. |
| PubMed: | Determination of liposoluble vitamins in cooked meals, milk and milk products by liquid chromatography. |
| PubMed: | Alpha- and beta-carotene from a commercial puree are more bioavailable to humans than from boiled-mashed carrots, as determined using an extrinsic stable isotope reference method. |
| PubMed: | Bioavailability and antioxidant activity of some food supplements in men and women using the D-Roms test as a marker of oxidative stress. |
| PubMed: | A novel extrinsic reference method for assessing the vitamin A value of plant foods. |
| PubMed: | Influence of vitamin A status on the regulation of uridine (5'-)diphosphate-glucuronosyltransferase (UGT) 1A1 and UGT1A6 expression by L-triiodothyronine. |
| PubMed: | On-line supercritical fluid extraction/enzymatic hydrolysis of vitamin a esters: a new simplified approach for the determination of vitamins a and e in food. |
| PubMed: | A fortifier comprising protein, vitamins, and calcium-glycerophosphate for preterm human milk. |
| PubMed: | Bioavailability trials of beta-carotene from fresh and dehydrated drumstick leaves (Moringa oleifera) in a rat model. |
| PubMed: | Dietary vitamin A modulates the concentrations of RRR-alpha-tocopherol in plasma lipoproteins from calves fed milk replacer. |
| PubMed: | Estimation of the dietary vitamin A requirement of juvenile grass shrimp, Penaeus monodon. |
| PubMed: | Antimutagenic effects and possible mechanisms of action of vitamins and related compounds against genotoxic heterocyclic amines from cooked food. |
| PubMed: | Bioavailability of carotenoids in human subjects. |
| PubMed: | Effect of reduced body weight gain on the evaluation of chemopreventive agents in the methylnitrosourea-induced mammary cancer model. |
| PubMed: | Effect of vitamin A on the oxidative stability of broiler meat during storage: lack of interactions with vitamin E. |
| PubMed: | Binding of retinoids to beta-lactoglobulin isolated by bioselective adsorption. |
| PubMed: | Suppressive effects of retinoids, carotenoids and antioxidant vitamins on heterocyclic amine-induced umu C gene expression in Salmonella typhimurium (TA 1535/pSK 1002). |
| PubMed: | Interactions in indices of vitamin A, zinc and copper status when these nutrients are fed to rats at adequate and increased levels. |
| PubMed: | Effect of retinyl acetate, ascorbic acid and tocopherol supplementation of the feed on egg vitamin A content in Japanese quail. |
| PubMed: | Pigment cholelithiasis induced by vitamin A and its prevention by butylated hydroxytoluene. |
| PubMed: | Strain variation in vitamin A (retinol) status of streptozotocin-induced diabetic rats. |
| PubMed: | Consumption of excess vitamin A, but not excess beta-carotene, causes accumulation of retinol that exceeds the binding capacity of cellular retinol-binding protein, type II in rat intestine. |
| PubMed: | The effect of excessive dietary vitamin A on performance and vitamin E status in swine fed diets varying in dietary vitamin E. |
| PubMed: | Haemorrhagic toxicity of a large dose of alpha-, beta-, gamma- and delta-tocopherols, ubiquinone, beta-carotene, retinol acetate and L-ascorbic acid in the rat. |
| PubMed: | Glucuronidation of all-trans-retinoic acid in liposomal membranes. |
| PubMed: | The influence of dietary levels of vitamin A and fat on colon cancer. |
| PubMed: | Effects of dietary retinyl acetate on the promotion of hepatic enzyme-altered foci by polybrominated biphenyls in initiated rats. |
| PubMed: | Modification of retinyl acetate toxicity in rats by coadministration of menhaden oil. |
| PubMed: | Relationship of vitamin A and vitamin E intake to fasting plasma retinol, retinol-binding protein, retinyl esters, carotene, alpha-tocopherol, and cholesterol among elderly people and young adults: increased plasma retinyl esters among vitamin A-supplement users. |
| PubMed: | Retinyl acetate inhibits estrogen-induced mammary carcinogenesis in female ACI rats. |
| PubMed: | Effects of simultaneous treatment with various chemicals on BHA-induced development of rat forestomach hyperplasia--complete inhibition by diethylmaleate in a 5-week feeding study. |
| PubMed: | Zinc-vitamin A interaction in pregnant and fetal rats: supplemental vitamin A does not prevent zinc-deficiency-induced teratogenesis. |
| PubMed: | Effect of moderate vitamin A supplementation and lack of dietary vitamin A on the development of mammary tumors in female rats treated with low carcinogenic dose levels of 7,12-dimethylbenz(a)anthracene. |
| PubMed: | Effects of vitamin A on cyclophosphamide mutagenicity in vitro (Ames test) and in vivo (mouse micronucleus test). |
| PubMed: | Fat and vitamin A stability in the presence of Ronoxan A and other antioxidants. |
| PubMed: | Localization of tritiated vitamin A in lymph nodes of the mouse: an autoradiographic study of vitamin A-storing cells. |
| PubMed: | Vitamin A - application technology. |
| PubMed: | Hypervitaminosis A combined with calcium deficiency in rats. |
| PubMed: | Studies on urinary arylsulphatase activity in vitamin A deficient rats. |
| PubMed: | Influence of excess vitamin E on vitamin A toxicity in rats. |
| PubMed: | Polarography of conjugated unsaturated lipids. |
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