Articles:
| None found yet. Try the PubMed Search. |
butanedioic acid, ((dimethoxyphosphinothioyl)thio)-, diethyl ester
Notes:
a wide spectrum aliphatic organophosphate insecticide widely used for both domestic and commercial agricultural purposes.
| CAS Number: | 121-75-5 |  3D/inchi
|
| Other: | 11096-67-6 | |
| ECHA EINECS - REACH Pre-Reg: | 204-497-7 | |
| FDA UNII: | U5N7SU872W | |
| Nikkaji Web: | J381F | |
| Beilstein Number: | 1804525 | |
| MDL: | MFCD00036233 | |
| XlogP3-AA: | 2.40 (est) | |
| Molecular Weight: | 330.36039200 | |
| Formula: | C10 H19 O6 P S2 | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: herbicides / pesticides
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Appearance: | yellow to dark-brown liquid (est) |
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 2.80 °C. @ 760.00 mm Hg |
| logP (o/w): | 2.360 |
| Soluble in: | |
| water, 143 mg/L @ 20 °C (exp) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| Sigma-Aldrich |
| For experimental / research use only. |
| Malathion PESTANAL®, analytical standard |
Safety Information:
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
oral-bird - wild LD50 400 mg/kg Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983. intraarterial-cat LDLo 1820 ug/kg "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964Vol. -, Pg. 693, 1964. oral-cattle LD50 53 mg/kg PERIPHERAL NERVE AND SENSATION: FASCICULATIONS BEHAVIORAL: REGIDITY BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Indian Veterinary Journal. Vol. 56, Pg. 650, 1979. unreported-cattle LD50 53 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: EXCITEMENT Indian Journal of Animal Sciences. Vol. 49, Pg. 314, 1979. oral-chicken LD50 600 mg/kg BEHAVIORAL: FOOD INTAKE (ANIMAL) Indian Journal of Experimental Biology. Vol. 9, Pg. 455, 1971. intraperitoneal-dog LD50 1857 mg/kg Toxicology and Applied Pharmacology. Vol. 15, Pg. 244, 1969. oral-duck LD50 1485 ug/kg Down to Earth. Vol. 35, Pg. 25, 1979. intraperitoneal-guinea pig LD50 271 mg/kg Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 236, Pg. 202, 1959. oral-guinea pig LD50 570 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 626, 1955. intraperitoneal-hamster LD50 2400 mg/kg Archives of Toxicology. Vol. 58, Pg. 152, 1986. unreported-mammal (species unspecified) LD50 500 mg/kg "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 357, 1971. oral-man LDLo 471 mg/kg LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: COMA VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION Archiv fuer Toxikologie. Vol. 23, Pg. 11, 1967. intravenous-man TDLo 14 uL/kg VASCULAR: OTHER CHANGES SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Japanese Journal of Acute Medicine. Vol. 16, Pg. 367, 1992. intraperitoneal-mouse LD50 193 mg/kg Proceedings of the Society for Experimental Biology and Medicine. Vol. 129, Pg. 699, 1968. intravenous-mouse LD50 184 mg/kg Bratislavske Lekarske Listy. Vol. 38, Pg. 151, 1958. oral-mouse LD50 190 mg/kg "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 56, 1982. unreported-mouse LD50 375 mg/kg Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 50(3), Pg. 4, 1985. oral-rabbit LDLo 1200 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION U.S. Army, Environmental Hygiene Agency Reports. Vol. 99-002-74/1976 intraperitoneal-rat LD50 250 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 1926, 1972. intravenous-rat LD50 50 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 626, 1955. oral-rat LD50 290 mg/kg "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 56, 1982. unreported-rat LD50 450 mg/kg Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 50(3), Pg. 4, 1985. | |
| Dermal Toxicity: | |
|
skin-guinea pig LD50 6700 mg/kg Toxicological Information on Cyanamid Insecticides. Vol. 8/1966 subcutaneous-guinea pig LD50 450 mg/kg BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 7, Pg. 122, 1965. skin-mouse LD50 2330 mg/kg Agricultural and Biological Chemistry. Vol. 27, Pg. 684, 1963. subcutaneous-mouse LD50 221 mg/kg Osaka Igaku Zasshi. Vol. 71, Pg. 6099, 1959. skin-rabbit LD50 4100 mg/kg "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969Vol. 5, Pg. 142, 1976. subcutaneous-rabbit LD50 280 mg/kg SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 7, Pg. 122, 1965. skin-rat LD50 > 4444 mg/kg Proceedings of the Annual Meeting of the New Jersey Mosquito Extermination Association. Vol. -, Pg. 155, 1957. subcutaneous-rat LD50 400 mg/kg SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 7, Pg. 122, 1965. | |
| Inhalation Toxicity: | |
|
inhalation-cat LCLo 10 mg/m3/4H "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 56, 1982. inhalation-rat LC50 43790 ug/m3/4H Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 56(2), Pg. 80, 1991. | |
Safety in Use Information:
| Category: | herbicides / pesticides | ||
| Recommendation for malathion usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for malathion flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| European Food Safety Authority (EFSA) reference(s): | |
| Retrospective analysis of the immunotoxic effects of plant protection products as reported in the Draft Assessment Reports for their peer review at EU level View page or View pdf | |
| Outcome of the consultation with Member States, the applicant and EFSA on the pesticide risk assessment for malathion in light of confirmatory data View page or View pdf | |
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| NIOSH International Chemical Safety Cards: | search |
| NIOSH Pocket Guide: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| Carcinogenic Potency Database: | Search |
| EPA GENetic TOXicology: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 4004 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| diethyl 2-dimethoxyphosphinothioylsulfanylbutanedioate | |
| Chemidplus: | 0000121755 |
| EPA/NOAA CAMEO: | hazardous materials |
| RTECS: | 121-75-5 |
References:
| diethyl 2-dimethoxyphosphinothioylsulfanylbutanedioate | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 121-75-5 |
| Pubchem (cid): | 4004 |
| Pubchem (sid): | 134973192 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| UM BBD: | Search |
| KEGG (GenomeNet): | C07497 |
| HMDB (The Human Metabolome Database): | Search |
| ChemSpider: | View |
| Wikipedia: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| S-(1,2-bis( | aethoxy-carbonyl)-aethyl)-O,O-dimethyl-dithiophosphat |
| american cyanamid 4,049 | |
| butanedioic acid, ((dimethoxyphosphinothioyl)-thio)-, diethyl ester, (+-)- | |
| butanedioic acid, ((dimethoxyphosphinothioyl)thio)-, diethyl ester | |
| camathion | |
| carbethoxy malathion | |
| S-(1,2-bis( | carbethoxy)ethyl) O,O-dimethyl dithiophosphate |
| carbetovur | |
| carbetox | |
| carbofos | |
| carbophos | |
| chemathion | |
| cimexan | |
| compound 4049 | |
| cythion | |
| detmol MA | |
| S-(1,2- | di(ethoxycarbonyl)ethyl) dimethyl phosphorothiolothionate |
| S-(1,2- | dicarbethoxyethyl) O,O-dimethyldithiophosphate |
| dicarboethoxyethyl O,O-dimethyl phosphorodithioate | |
| diethyl ((dimethoxyphosphinothioyl)thio)butanedioate | |
| diethyl (+-)-mercaptosuccinate, S-ester with O,O-dimethyl phosphorodithioate | |
| diethyl (dimethoxyphosphinothioylthio)succinate | |
| diethyl 2-dimethoxyphosphinothioylsulfanylbutanedioate | |
| diethyl mercaptosuccinate S-ester with O,O-dimethylphosphorodithioate | |
| diethyl mercaptosuccinate, O,O-dimethyl dithiophosphate, S-ester | |
| diethyl(dimethoxythiophosphorylthio)succinate | |
| (( | dimethoxyphosphinothioyl)thio)butanedioic acid diethyl ester |
| O,O- | dimethyl S-(1,2-bis(ethoxycarbonyl)ethyl) dithiophosphate |
| O,O- | dimethyl S-(1,2-dicarbethoxyethyl) dithiophosphate |
| O,O- | dimethyl S-(1,2-dicarbethoxyethyl)phosphorodithioate |
| O,O- | dimethyl S-1,2-di(ethoxycarbamyl)ethyl phosphorodithioate |
| O,O- | dimethyl-S-1,2-(dicarbaethoxyaethyl)-dithiophosphat |
| O,O- | dimethyl-S-1,2-dikarbetoxylethylditiofosfat |
| O,O- | dimethyldithiophosphate diethylmercaptosuccinate |
| dithiophosphate de O,O-dimethyle et de S-(1,2-dicarboethoxyethyle) | |
| dithiophosphate de O,O-dimethyle et de S-(1,2-dicarboethoxyethyle) [French] | |
| dorthion | |
| emmatos extra | |
| ethiolacar | |
| S-(1,2-bis( | ethoxy-carbonyl)-ethyl)-O,O-dimethyl-dithiofosfaat |
| forthion | |
| fosfothion | |
| fosfotion | |
| fosfotion 550 | |
| fyfanon | |
| hilthion | |
| insecticide no. 4049 | |
| karbofos | |
| kill-a-mite | |
| kop-thion | |
| kypfos | |
| latka 4049 | |
| malacide | |
| malafor | |
| malagran | |
| malakill | |
| malamar | |
| malamar 50 | |
| malaphos | |
| malaspray | |
| malathiazol | |
| malathion E50 | |
| malathyl | |
| malatol | |
| malatox | |
| maldison | |
| malphos | |
| mercaptosuccinic acid diethyl ester | |
| mercaptothion | |
| mercaptotion | |
| moscarda | |
| oleophosphothion | |
| phosphorodithioic acid, O,O-dimethyl ester, S-ester with diethyl mercaptosuccinate | |
| phosphothion | |
| sadofos | |
| sadophos | |
| succinic acid, mercapto-, diethyl ester, S-ester with O,O-dimethyl phosphorodithioate | |
| succinic acid, mercapto-, diethyl ester, S-ester with O,O-dimethylphosphorodithioate | |
| sumitox | |
| TAK | |
| taskil |