Articles:
| Info: | Dichlorodifluoromethane |
methane, dichlorodifluoro-
Notes:
refrigerant,aerosol propellant. Direct contact freezing agent for foods. Refrigerant, aerosol propellant
Dichlorodifluoromethane (R-12), usually sold under the brand name Freon-12, is a chlorofluorocarbon halomethane (CFC), used as a refrigerant and aerosol spray propellant. Complying with the Montreal Protocol, its manufacture was banned in the United States along with many other countries in 1994 due to concerns about damage to the ozone layer. It is soluble in many organic solvents.
| CAS Number: | 75-71-8 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 200-893-9 | |
| FDA UNII: | OFM06SG1KO | |
| Nikkaji Web: | J1.462A | |
| XlogP3-AA: | 2.30 (est) | |
| Molecular Weight: | 120.91180640 | |
| Formula: | C Cl2 F2 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: direct-contact freezing agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| FDA Mainterm (SATF): | 75-71-8 ; DICHLORODIFLUOROMETHANE |
| FDA Regulation: | |
| FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION Subpart D--Specific Usage Additives Sec. 173.355 Dichlorodifluoromethane. | |
Physical Properties:
| Assay: | 98.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Boiling Point: | -29.77 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure: | 4850.000000 mmHg @ 25.00 °C. |
| Flash Point: | -101.00 °F. TCC ( -74.00 °C. ) (est) |
| logP (o/w): | 2.160 |
| Soluble in: | |
| water, 280 mg/L @ 25 °C (exp) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| None found |
Safety Information:
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
oral-rat LD50 > 5600 mg/kg Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 52(3), Pg. 73, 1987. oral-rat LD > 5600 ug/kg Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 52(3), Pg. 73, 1987. | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
|
inhalation-rat LC50 > 80 pph/4H National Technical Information Service. Vol. OTS0520424 inhalation-rabbit LC50 80 pph/4H European Journal of Toxicology and Environmental Hygiene. Vol. 9, Pg. 385, 1976. inhalation-mouse LC50 3348 gm/m3/3H Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 28(6), Pg. 95, 1963. inhalation-guinea pig LC50 80 pph/30M European Journal of Toxicology and Environmental Hygiene. Vol. 9, Pg. 385, 1976. inhalation-human TCLo 200000 ppm/30M SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE LUNGS, THORAX, OR RESPIRATION: FIBROSING ALVEOLITIS LIVER: OTHER CHANGES European Journal of Toxicology and Environmental Hygiene. Vol. 9, Pg. 385, 1976. inhalation-mouse LC50 3348000 mg/m3/3H BEHAVIORAL: SLEEP BEHAVIORAL: TREMOR BEHAVIORAL: EXCITEMENT Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 28(6), Pg. 95, 1963. inhalation-rabbit LC50 80 pph/30M European Journal of Toxicology and Environmental Hygiene. Vol. 9, Pg. 385, 1976. | |
Safety in Use Information:
| Category: | direct-contact freezing agents | ||
| Recommendation for dichlorodifluoromethane usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for dichlorodifluoromethane flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| EPA-Iris: | IRIS |
| NIOSH International Chemical Safety Cards: | search |
| NIOSH Pocket Guide: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| Carcinogenic Potency Database: | Search |
| EPA GENetic TOXicology: | Search |
| EPA Substance Registry Services (TSCA): | 75-71-8 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 6391 |
| National Institute of Allergy and Infectious Diseases: | Data |
| dichloro(difluoro)methane | |
| Chemidplus: | 0000075718 |
| EPA/NOAA CAMEO: | hazardous materials |
| RTECS: | 75-71-8 |
References:
| dichloro(difluoro)methane | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 75-71-8 |
| Pubchem (cid): | 6391 |
| Pubchem (sid): | 134971060 |
| Pherobase: | View |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | D03789 |
| HMDB (The Human Metabolome Database): | HMDB29570 |
| FooDB: | FDB000725 |
| FDA Listing of Food Additive Status: | View |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
| Formulations/Preparations: •usepaopp pesticide code 000014; trade names: freon 12; propellant 12; frigen 12; arcton 12; fc 12; genetron 12; ledon 12; and eskimon 12. former trade names •99.9% min purity | |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| found in food but not in nature |
Synonyms:
| carbon dichloride difluoride | |
| chladone 12 | |
| chlorofluorocarbon 12 | |
| dichloro(difluoro)methane | |
| dichlorodifluormethane | |
| dichlorodifluoromethane [R12] [UN1028] [Nonflammable gas] | |
| difluorodichloromethane | |
| fluorocarbon 12 | |
| forane 12 | |
| freon 12 | |
| freon F-12 | |
| frigen R12 | |
| genetron 12 | |
| halocarbon 12 | |
| halon | |
| isceon 122 | |
| khladon 12 | |
| methane, dichlorodifluoro- | |
| refrigerant R12 |