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Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white crystalline powder (est) |
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 274.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 576.96 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 577.00 °F. TCC ( 302.70 °C. ) (est)
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| logP (o/w): | -0.070 |
| Soluble in: |
| | water, 722 mg/L @ 25 °C (exp) | | | water, 1292 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intravenous-dog LD50 250 mg/kg "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 124, 1973.
oral-man TDLo 12857 ug/kg/9D GASTROINTESTINAL: NAUSEA OR VOMITING
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD American Journal of Medicine. Vol. 70, Pg. 1163, 1981.
oral-man TDLo 75 mg/kg/30W-I BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
BEHAVIORAL: MUSCLE WEAKNESS
GASTROINTESTINAL: OTHER CHANGES Rinsho Shinkeigaku. Clinical Neurology. Vol. 17, Pg. 162, 1977.
intraperitoneal-mouse LD50 578 mg/kg "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 77, 1965.
intravenous-mouse LD50 590 mg/kg PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 134, Pg. 273, 1961.
oral-mouse LD50 1175 mg/kg Farmatsevtichnii Zhurnal Vol. (1), Pg. 44, 1983.
unreported-mouse LD50 1100 mg/kg Farmatsevtichnii Zhurnal Vol. (5), Pg. 26, 1983.
intravenous-rabbit LD50 461 mg/kg "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 124, 1973.
intraperitoneal-rat LD50 234 mg/kg "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 124, 1973.
intravenous-rat LD50 990 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 140, Pg. 249, 1963.
oral-rat LD50 2750 mg/kg Toxicology and Applied Pharmacology. Vol. 1, Pg. 333, 1959.
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| Dermal Toxicity: |
subcutaneous-mouse LD50 1470 mg/kg "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 124, 1973.
subcutaneous-rat LD50 1270 mg/kg "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 124, 1973.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis |
| Recommendation for hydrochlorothiazide usage levels up to: | | | not for fragrance use.
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| Recommendation for hydrochlorothiazide flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | 6-chloro-1,1-dioxo-3,4-dihydro-2H-1lamda6,2,4-benzothiadiazine-7-sulfonamide |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 58-93-5 |
| Pubchem (cid): | 3639 |
| Pubchem (sid): | 134972118 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C07041 |
| HMDB (The Human Metabolome Database): | HMDB01928 |
| FooDB: | FDB022745 |
| MedlinePlusSupp: | View |
| ChemSpider: | View |
| Wikipedia: | View |
Formulations/Preparations: •capsules: 12.5 mg: hydrochlorothiazide capsules, mylan; microzide, watson. oral solution: 50 mg5 ml: hydrochlorothiazide solution, roxane. tablets: 25 mg: aquazide-25, western research; hydrodiuril (scored), merck; oretic, abbott; 50 mg: aquazide-h, western research; ezide, economed; hydrodiuril (scored), merck; 100 mg: hydrochlorothiazide tablets, ivax.
•oral tablets, film-coated, 250 mg methylodopa and hydrochlorothiazide 15 mg: aldoril (with propylene glycol), merck; methyldopa and hydrochlorothiazide tablets, endo, major, mylan. 250 mg methyldopa and hydrochlorothiazide 25 mg, aldoril (with propylene glycol), merck; methyldopa and hydrochlorothiazide tablets, endo, major, mylan; 500 mg methyldopa and hydrochlorothiazide 30 mg, aldoril d (with propylene glycol), merck. methyldopa and hydrochlorothiazide
•oral capsules, extended-release: 80 mg propranolol hydrochloride and hydrochlorothiazide 50 mg: inderide la, wyeth-ayerst; 120 mg propranolol hyrochloride hydrochlorothiazide 50 mg: inderide la, wyeth-ayerst; 160 mg propranolol hydrochloride and hydrochlorothiazide 50 mg: inderide la, wyeth-ayerst. tablets: 40 mg propranolol hydrochloride and hydrochlorothiazide 25 mg, inderide (scored), wyeth-ayerst; propranolol hydrochloride and hydrochlorothiazide tablets, barr, mylan, purepac, sidmak; 80 mg propranolol hydrochloride and hydrochlorothazide 25 mg: inderide (scored), wyeth-ayerst; propranolol hydrochloride and hydrochlorothiazide tablets, barr, mylan, purepac, sidmak. propranolol hydrochloride and hydrochlorothiazide
•oral capsules: 37.5 mg triamterene and hydrochlorothiazide 25 mg: dyazide (with benzyl alcohol and povidone), glaxosmithkline; 50 mg triamterene and hydrochlorothiazide 25 mg: triameterene and hydrochlorothiazide capsules, geneva, ivax, major, martex; oral tablets: 37.5 mg triamterene and hydrochlorothiazide 25 mg: maxzide (scored), bertek; 75 mg triamterene and hydrochlorothiazide 50 mg, maxzide (scored), bertek. triamterene and hydrochlorothiazide (co-triamterzide)
•oral capsules: 25 mg with hydralazine hydrochloride 25 mg: hydralazine hydrochloride with hydrochlorothiazide capsules, major, united research; hydra-zide, par; 50 mg with hydralazine hydrochloride 50 mg: hydra-zide, par; 50 mg with hydralazine hydrochloride 100 mg: hydra-zide, par. tablets: 6.25 mg with benazepril 5 mg: lotensin hct (scored), novartis; 12.5 mg with benazepril 10 mg: lotensin hct (scored), novartis; 12.5 mg with benazepril 20 mg: lotensin hct (scored), novartis; 12.5 mg with irbesartan 150 mg, avalide, bristol-myers squibb (also promoted by sanofi-synthelabo); 12.5 mg with irbesartan 300 mg, avalide, briston-meyers squibb (also promoted by sanofi-synthelabo); 12.5 mg with lisinopril 10 mg: prinzide, merck; zestoretic, astrazeneca; 12.5 mg with lisinopril 20 mg: prinzide, merck; zestoretic, astrazeneca; 12.5 mg with valsartan 80 mg: diovan hct, novartis; 12.5 mg with valsartan 160 mg: diovan hct, novartis; 15 mg with hydralazine hydrochloride 25 mg and reserpine 0.1 mg; 25 mg with benazepril 20 mg: lotensin hct (scored), novartis; 25 mg with lisinopril 20 mg: prinzide, merck; zestoretic, astrazeneca. tablets, film-coated: 6.25 mg with bisoprolol fumarate 2.5 mg: ziac, lederle; 6.25 mg with bisoprolol fumarate 5 mg: ziac, lederle; 6.25 mg with bisoprolol fumarate 10 mg: ziac, lederle; 12.5 mg with losartan potassium 50 mg: hyzaar, merck; 12.5 mg with moexipril hydrochloride 7.5 mg: uniretic (scored), schwarz; 12.5 mg with quinapril hydrochloride 10 mg (of quinapril): accuretic (with povidone; scored), parke-davis; 12.5 mg with quinapril hydrochloride 20 mg (of quinapril): accuretic (with povidone; scored), parke-davis; 25 mg with losartan potassium 100 mg: hyzaar, merck; 25 mg with moexipril hydrochloride 15 mg: uniretic (scored), schwarz; 25 mg with quinapril hydrochloride 20 mg (of quinapril): accuretic (with povidone; scored), parke-davis. hydrochlorothiazide combinations
•oral tablets: 25 mg captopril and hydrochlorothiazide 15 mg: capozide (scored), bristol-myers squibb; 25 mg captopril and hydrochlorothiazide 25 mg: capozide (scored), bristol-mayers squibb; captopril and hydrochlorothiazide tablets, endo, geneva, ivax, mylan, teva; 50 mg captopril and hydrochlorothiazide 15 mg: capozide (scored), bristol-meyers squibb; captopril and hydrochlorothiazide tablets, endo, geneva, ivax, mylan, teva; 50 mg captopril and hydrochlorothiazide 25 mg: capozide (scored), briston-meyers squibb; captopril and hydrochlorothiazide tablets, endo, geneva, ivax, mylan, teva. captopril and hydrochlorothiazide
•oral tablets: 50 mg metoprolol tartrate and hydrochlorothiazide 25 mg: lopressor hct (with povidone; scored), novartis; 100 mg metoprolol tartrate and hydrochlorothiazide 25 mg: lopressor hct (with povidone; scored), novartis; 100 mg metoprolol tartrate and hydrochlorothiazide 50 mg: loperssor hct (with povidone; scored), novartis. metoprolol tartrate and hydrochlorothiazide
•tablets, 25, 50, and 100 mg. oral solution, 50 mg5 ml. concentrated oral solution, 100 mgml.
•oral tablets: 5 mg of anhydrous amiloride hydrochloride and hydrochlorothiazide 50 mg, moduretic (scored), merck. amiloride hydrochloride and hydrochlorothiazide
•oral tablets: 10 mg timolol maleate and hydrochlorothiazide 25 mg: timolide (with povidone; scored), merck. timolol maleate and hydrochlorothiazide
•oral tablets: 25 mg spironolacton adn hydrochlorothiazide 25 mg. tablets, film-coated: 25 mg spironolactone and hydrochlorothiazide 25 mg: aldactazide (with povidone), pharmacia; spironolactone and hydrochlorothiazide tablers, major, mutual, mylan, udl, url; 50 mg spironolactone and hydrochlorothiazide 50 mg: aldactazide (with povidone; scored), pharmacia. spironolactone and hydrochlorothiazide
•oral tablets: 5 mg enalapril maleate and hydrochlorothiazide 12.5 mg: vaseretic, merck; 10 mg enalapril maleate and hydrochlorothiazide 25 mg: vaseretic, merck. enalapril maleate and hydrochlorothiazide
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Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | accuretic | | | acuilix | | | acuretic | | | aldactazide | | | aldazida | | | aldectazide 50/50 | | | aldoril | | | apo-hydro | | | apresazide | | | apresoline-esidrix | | | aquarills | | | aquarius | | | aquazide H | | | aquazide-H | | | avalide | | 2H-1,2,4- | benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1, 1-dioxide | | | bremil | | | briazide | | | CAM-AP-ES | | | caplaril | | | carozide | | | catiazida | | 6- | chlor-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-sulfonamid-1,1-dioxid | | | chlorizide | | 6- | chloro-1,1-dioxo-1,2,3,4-tetrahydro-1lamda*6*-benzo[1,2,4]thiadiazine-7-sulfonic acid amide | | 6- | chloro-1,1-dioxo-1,2,3,4-tetrahydro-1lamda6-benzo[1,2,4]thiadiazine-7-sulfonic acid amide | | 6- | chloro-1,1-dioxo-2H,3H,4H-benzo[e]1,2,4-thiadiazine-7-sulfonamide | | 6- | chloro-1,1-dioxo-3,4-dihydro-2H-1lamda6,2,4-benzothiadiazine-7-sulfonamide | | 6- | chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide | | 6- | chloro-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide | | 6- | chloro-3,4-dihydro-7-sulfamoyl-2H-1,2, 4-benzothiadiazine 1,1-dioxide | | 6- | chloro-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide | | 6- | chloro-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine-1,1-dioxide | | 6- | chloro-7-sulfamoyl-3, 4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide | | 6- | chloro-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide | | 6- | chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide | | 6- | chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide | | | chlorosulphadil | | | chlorosulthiadil | | | chlorsulfonamidodihydrobenzothiadiazine dioxide | | | chlorzide | | | chlothia | | | cidrex | | | clorana | | neo | codema | | neo- | codema | | | concor plus | | | condiuren | | | diaqua | | | dichlorosal | | | dichlothiazide | | | dichlotiazid | | | dichlotride | | | diclot ride | | | diclotride | | | didral | | | dihydran | | 3,4- | dihydro-6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide | | 3,4- | dihydro-6-chloro-7-sulfamyl-1,2, 4-benzothiadiazine-1,1-dioxide | | 3,4- | dihydro-6-chloro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide | | | dihydrochlorothiazid | | 3,4- | dihydrochlorothiazide | | | dihydrochlorurite | | | dihydroxychlorothiazidum | | | direma | | | disalunil | | | disothiazid | | | diu-melusin | | | diurogen | | | dixidrasi | | | drenol | | | dyazide | | | esidrex | | | esidrix | | | esimil | | | esoidrina | | neo | flumen | | neo- | flumen | | | fluvin | | | hidril | | | hidro-niagrin | | | hidrochlortiazid | | | hidroronol | | | hidrosaluretil | | | hidrotiazida | | | hyclosid | | | hydra-zide | | | hydrap-ES | | | hydril | | | hydro par | | | hydro-aquil | | | hydro-chlor | | | hydro-D | | | hydro-reserp | | | hydro-ride | | | hydro-saluric | | | hydro-T | | | hydrochloro thiazide | | | hydrochlorothiazid | | | hydrochlorthiazide | | | hydrochlorthiazidum | | | hydrocot | | | hydrodiuretic | | | hydrodiuril | | | hydrosaluric | | | hydrothide | | | hydrozide | | | hypothaizide | | | hypothiazid | | | hytrid | | | hyzaar | | | idrotiazide | | | inderide | | | indroclor | | | ivaugan | | | jen-diril | | | lopressor HCT | | | lotensin HCT | | | manuril | | | maschitt | | | maxzide | | | mazide 25 mg | | | medozide | | | megadiuril | | | microzide | | | mictrin | | | mikorten | | neo- | minzil | | | modurcen | | | moduretic | | | monopril-HCT | | | natrinax | | | nefrix | | | nefrol | | | newtolide | | | normozide | | | novodiurex | | | oretic | | | pantemon | | | panurin | | | prinzide | | | quinaretic | | | raunova plus | | | ro-hydrazide | | | saldiuril | | | sectrazide | | | selozide | | | ser-a-gen | | | ser-ap-es | | | servithiazid | | | spironazide | | | tandiur | | | thiaretic | | | thiuretic | | | thlaretic | | | timolide | | | unazid | | | unipres | | | uniretic | | | urodiazin | | | urozide | | | vaseretic | | | vasoretic | | | vetid rex | | | vetidrex | | | viskazide | | | zestoretic | | | ziac | | | zide |
Articles:
| PubMed: | Diuretic Exposure in Premature Infants from 1997 to 2011. |
| PubMed: | Multi-residue analytical methodology-based liquid chromatography-time-of-flight-mass spectrometry for the analysis of pharmaceutical residues in surface water and effluents from sewage treatment plants and hospitals. |
| PubMed: | Study on diuretic activity of saffron (stigma of Crocus sativus L.) Aqueous extract in rat. |
| PubMed: | Application of the Dynamic Gastric Model to evaluate the effect of food on the drug release characteristics of a hydrophilic matrix formulation. |
| PubMed: | Impact of TCF7L2 single nucleotide polymorphisms on hydrochlorothiazide-induced diabetes. |
| PubMed: | What can we do to make antihypertensive medications taste better for children? |
| PubMed: | Azilsartan/chlorthalidone combination therapy for blood pressure control. |
| PubMed: | Determination of diuretics and laxatives as adulterants in herbal formulations for weight loss. |
| PubMed: | Pharmaco-nutrient interactions - a systematic review of zinc and antihypertensive therapy. |
| PubMed: | Azilsartan, aliskiren, and combination antihypertensives utilizing Renin-Angiotensin-aldosterone system antagonists. |
| PubMed: | [Study on the proficiency testing program of pharmaceutical preparation analysis]. |
| PubMed: | When one drug affects 2 patients: a review of medication for the management of nonlabor-related pain, sedation, infection, and hypertension in the hospitalized pregnant patient. |
| PubMed: | How well do aliskiren's purported mechanisms track its effects on cardiovascular and renal disorders? |
| PubMed: | Palatability of crushed ß-blockers, converting enzyme inhibitors and thiazides. |
| PubMed: | Aliskiren: An orally active renin inhibitor. |
| PubMed: | Herb-drug interaction between the extract of Hibiscus sabdariffa L. and hydrochlorothiazide in experimental animals. |
| PubMed: | Suitability of a flat die press for the manufacture of pharmaceutical pellets by extrusion/spheronization. |
| PubMed: | [Simultaneous determination of five illegal drugs in weight control foods with solid phase extraction-high performance liquid chromatography]. |
| PubMed: | Annual drug update: 2010 in review. |
| PubMed: | LC-MS determination and pharmacokinetics of p-coumaric acid in rat plasma after oral administration of p-coumaric acid and freeze-dried red wine. |
| PubMed: | The potential benefits of a garlic and hydrochlorothiazide combination as antihypertensive and cardioprotective in rats. |
| PubMed: | Phenylalanine ammonia-lyase, polyphenol oxidase, and phenol concentration in fruits of Olea europaea L. cv. Picual, Verdial, Arbequina, and Frantoio during ripening. |
| PubMed: | The potential for interaction of hydrochlorothiazide with garlic in rats. |
| PubMed: | Investigation of some factors contributing to negative food effects. |
| PubMed: | Liquid chromatographic-tandem mass spectrometric method for the simultaneous quantitation of telmisartan and hydrochlorothiazide in human plasma. |
| PubMed: | Aliskiren. |
| PubMed: | An online field-amplification sample stacking method for the determination of diuretics in urine by capillary electrophoresis-amperometric detection. |
| PubMed: | [Interaction of calcium drug and vitamin D3 with some medicines used in coronary heart disease therapy]. |
| PubMed: | Aliskiren-hydrochlorothiazide combination for the treatment of hypertension. |
| PubMed: | Effects of the angiotensin II receptor blockers telmisartan versus valsartan in combination with hydrochlorothiazide: a large, confirmatory trial. |
| PubMed: | Hyponatremia as a complication of selective serotonin reuptake inhibitors. |
| PubMed: | Nebivolol: new therapy update. |
| PubMed: | Clinical pharmacokinetics of losartan. |
| PubMed: | The effect of food on the relative bioavailability of rapidly dissolving immediate-release solid oral products containing highly soluble drugs. |
| PubMed: | Bone loss in rats with aldosteronism. |
| PubMed: | Pharmacology of irbesartan. |
| PubMed: | Bladder epithelial cell proliferation of rats induced by terephthalic acid-calculi. |
| PubMed: | Sodium appetite induced in rats by chronic administration of a thiazide diuretic. |
| PubMed: | Trandolapril: a newer angiotensin-converting enzyme inhibitor. |
| PubMed: | Drug interactions with irbesartan. |
| PubMed: | Isolation of a 2:1 hydrochlorothiazide-formaldehyde adduct impurity in hydrochlorothiazide drug substance by preparative chromatography and characterization by electrospray ionization LC-MS. |
| PubMed: | ['Licorice hypertension' also caused by licorice tea]. |
| PubMed: | Clinical pharmacokinetics of angiotensin II (AT1) receptor blockers in hypertension. |
| PubMed: | Perindopril ameliorates glomerular and renal tubulointerstitial injury in the SHR/N-corpulent rat. |
| PubMed: | Identification of chlorothiazide and hydrochlorothiazide UV-A photolytic decomposition products. |
| PubMed: | Effects of enalapril and hydrochlorothiazide on the salt-induced cardiac and renal hypertrophy in normotensive rats. |
| PubMed: | A multifactorial trial design to assess combination therapy in hypertension. Treatment with bisoprolol and hydrochlorothiazide. |
| PubMed: | Captopril and hydrochlorothiazide (Capozide) combine to enhance the reduction in voluntary alcohol intake in rats. |
| PubMed: | The effects of blood pressure reduction on cyclosporine nephrotoxicity in the rat. |
| PubMed: | Large differences in the biological half-life and volume of distribution of hydrochlorothiazide in normal subjects from eleven studies. Correlation with their last blood sampling times. |
| PubMed: | [Effect of XKJ-001, a crude drug preparation, on body water distribution and water excretion in mice]. |
| PubMed: | Blood pressure hyperreactivity in non-human primates during dietary sodium combined with behavioral stress. |
| PubMed: | Risk factor changes after cessation of intervention in the Multiple Risk Factor Intervention Trial. The MRFIT Research Group. |
| PubMed: | Clinical pharmacology of cilazapril. |
| PubMed: | Clinical pharmacology of cilazapril. |
| PubMed: | Lisinopril: a new angiotensin-converting enzyme inhibitor. |
| PubMed: | Determination of reserpine and hydrochlorothiazide in commercial tablets by liquid chromatography with fluorescence and UV absorption detectors in series. |
| PubMed: | Pathologic effects of chronic administration of hydrochlorothiazide, with and without sodium nitrite, to F344 rats. |
| PubMed: | Effects of formulation and food on the absorption of hydrochlorothiazide and triamterene or amiloride from combination diuretic products. |
| PubMed: | The influence of dietary potassium on the renal tubular effect of hydrochlorothiazide in the rat. |
| PubMed: | The clinical pharmacology of lisinopril. |
| PubMed: | Acute effects of various diuretics on lithium clearance. Studies in rats on medium and low sodium diet. |
| PubMed: | Susceptibilities of drugs to nitrosation under simulated gastric conditions. |
| PubMed: | Kinetics of hydrochlorothiazide absorption in humans. |
| PubMed: | [Decreased renal excretory capacity of uric acid in rats fed a low sodium diet under consecutive administration of thiazide diuretics]. |
| PubMed: | Enalapril: a review of human pharmacology. |
| PubMed: | Drug use in the United States in 1981. |
| PubMed: | Efficacy and tolerance of a fixed ratio combination of hydrochlorothiazide, amiloride and timolol, taken before or after food, in the treatment of hypertension. |
| PubMed: | Role of dietary potassium and magnesium in diuretic-treated patients with cardiac insufficiency. |
| PubMed: | Sodium balance and antidiuresis in thiazide-treated rats with diabetes insipidus. |
| PubMed: | Multi-centre clinical investigation of indapamide in the United States: a review. |
| PubMed: | The antidiuretic effect of chronic hydrochlorothiazide treatment in rats with diabetes insipidus: water and electrolyte balance. |
| PubMed: | Managing diuretic-induced hypokalemia in ambulatory hypertensive patients. |
| PubMed: | Influence of the dietary potassium intake on the natriuretic effect of hydrochlorothiazide in rats. |
| PubMed: | Influence of food on the bioavailability of drugs. |
| PubMed: | Gastrointestinal absorption of hydrochlorothiazide enhanced by concomitant intake of food. |
| PubMed: | Spironolactone: disposition, metabolism, pharmacodynamics, and bioavailability. |
| PubMed: | Metabolic balances of 210 Pb and 210Po at natural levels. |
| PubMed: | Effect of hydrochlorothiazide on preference threshold of rats for NaCl solutions. |
| PubMed: | [Electrolyte metabolism in hypertension]. |
| PubMed: | TREATMENT OF HYPERTENSION WITH MEBUTAMATE ALONE AND IN COMBINATION WITH HYDROCHLOROTHIAZIDE. |
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