polysorbate 65
tween 65
 
Notes:
Emulsifier, stabiliser, defoamer Polysorbates are a class of emulsifiers used in some pharmaceuticals and food preparation. They are often used in cosmetics to solubilize essential oils into water-based products. Polysorbates are oily liquids derived from PEG-ylated sorbitan (a derivative of sorbitol) esterified with fatty acids. (Wikipedia)
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CAS Number: 9005-71-4 
Other(deleted CASRN): 9015-61-6
FDA UNII: 14BGY2Y3MJ
MDL: MFCD00165348
Molecular Weight: 1844.62378000
Formula: C100 H194 O28
Category: emulsifiers, surfactants
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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 FDA/DG SANTE Petitions, Reviews, Notices:
EU SANCO Polysorbates View - review
EU SANCO Polyoxyethylene sorbitan tristearate (polysorbate 65) View - review
JECFA Food Additive: Polyoxyethylene (20) Sorbitan Tristearate
GSFA Codex: Polyoxyethylene (20) sorbitan tristearate (436)
DG SANTE Food Additives: polysorbate 65
DG SANTE Food Contact Materials: polysorbate 65
FDA Mainterm (SATF):9005-71-4 ; POLYSORBATE 65
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart I--Multipurpose Additives
Sec. 172.836 Polysorbate 60.


FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart I--Multipurpose Additives
Sec. 172.838 Polysorbate 65.


FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart I--Multipurpose Additives
Sec. 172.840 Polysorbate 80.


FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart I--Multipurpose Additives
Sec. 172.842 Sorbitan monostearate.


FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION
Subpart D--Specific Usage Additives
Sec. 173.340 Defoaming agents.


FDA PART 178 -- INDIRECT FOOD ADDITIVES: ADJUVANTS, PRODUCTION AIDS, AND SANITIZERS
Subpart D--Certain Adjuvants and Production Aids
Sec. 178.3400 Emulsifiers and/or surface-active agents.


FDA PART 73 -- LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION
Subpart B--Drugs
Sec. 73.1001 Diluents in color additive mixtures for drug use exempt from certification.
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Physical Properties:
Food Chemicals Codex Listed: No
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: surfactants
surfactant - emulsifying
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Suppliers:
Chemical-navi - Nikkol
NIKKOL TS-30V
Odor: characteristic
Use: Emulsifier; water dispersible; plant-derived
Covalent Chemical
Polysorbate 65
Graham Chemical
Polysorbate 65
Kao Corporation
RHEODOL TW-S320V
Odor: characteristic
Use: Emulsifier for pharmaceuticals and cosmetics, Stabilizer for color materials, Stabilizer for emulsion polymerizations, Emulsifier for adjuvant of agrochemicals, Emulsifier for water based metal process cutting oils, Surface coating type antistatic agents.
Lonza Group
Glycosperse™ TS-20 KFG
Lonza Group
Lonzest™ STS-20
Sigma-Aldrich: Sigma
For experimental / research use only.
TWEEN® 65
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: emulsifiers, surfactants
Recommendation for polysorbate 65 usage levels up to:
 not for fragrance use.
 
Recommendation for polysorbate 65 flavor usage levels up to:
 not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
Scientific Opinion on the re-evaluation of polyoxyethylene sorbitan monolaurate (E 432), polyoxyethylene sorbitan monooleate (E 433), polyoxyethylene sorbitan monopalmitate (E 434), polyoxyethylene sorbitan monostearate (E 435) and polyoxyethylene
View page or View pdf
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 9005-71-4
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 1
Chemidplus: 0009005714
RTECS: WG2934600 for cas# 9005-71-4
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References:
Canada Domestic Sub. List: 9005-71-4
Pubchem (sid): 135323707
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Other Information:
FDA Substances Added to Food (formerly EAFUS): View
FDA Indirect Additives used in Food Contact Substances:View
HMDB (The Human Metabolome Database): Search
FooDB: FDB016185
FDA Listing of Food Additive Status: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 emulsifying agents 
 surfactants 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 glycosperse TS-20 KFG
 hetsorb TS-20
 liposorb TS-20
 lonzest STS-20
 nikkol TS-30V
 poe-20 sorbitan tristearate
 polyethyleneglycol sorbitan tristearate
 polyoxyethylene (20) sorbitan tristearate
 rheodol TW-S320V
 tween 65
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Articles:
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PubMed: [The effect of Tween-80 on the differentiation of Trichophyton mentagrophytes and Trichophyton rubrum strains with FT-IR spectroscopy].
PubMed: Comparison of the safety and immunogenicity of an MF59®-adjuvanted with a non-adjuvanted seasonal influenza vaccine in elderly subjects.
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PubMed: Microstructure characterization of a food-grade U-type microemulsion system by differential scanning calorimetry and electrical conductivity techniques.
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PubMed: Long-term and cross-reactive immunogenicity of inactivated trivalent influenza vaccine in the elderly: MF59-adjuvanted vaccine versus unadjuvanted vaccine.
PubMed: Comparison of micronuclei frequency in bone marrow cells of three rat lines.
PubMed: A novel method to produce solid lipid nanoparticles using n-butanol as an additional co-surfactant according to the o/w microemulsion quenching technique.
PubMed: MF59-adjuvanted and virosomal influenza vaccines for preventing influenza hospitalization in older people: comparative effectiveness using the Valencia health care information system.
PubMed: Development of micellar reactive oxygen species assay for photosafety evaluation of poorly water-soluble chemicals.
PubMed: AS03-adjuvanted versus non-adjuvanted inactivated trivalent influenza vaccine against seasonal influenza in elderly people: a phase 3 randomised trial.
PubMed: Gastrodin production from p-2-hydroxybenzyl alcohol through biotransformation by cultured cells of Aspergillus foetidus and Penicillium cyclopium.
PubMed: Influenza A/H1N1 MF59 adjuvanted vaccine in pregnant women and adverse perinatal outcomes: multicentre study.
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PubMed: Accelerated polymer biodegradation of risperidone poly(D, L-lactide-co-glycolide) microspheres.
PubMed: Films of starch and poly(butylene adipate co-terephthalate) added of soybean oil (SO) and Tween 80.
PubMed: Effectiveness of adjuvanted influenza vaccination in elderly subjects in northern Italy.
PubMed: Adsorption of lipid liquid crystalline nanoparticles: effects of particle composition, internal structure, and phase behavior.
PubMed: Comparison of the adverse events associated with MF59-adjuvanted and non-adjuvanted H1N1 vaccines in healthy young male Korean soldiers.
PubMed: MF59 formulated with CpG ODN as a potent adjuvant of recombinant HSP65-MUC1 for inducing anti-MUC1+ tumor immunity in mice.
PubMed: Superior immunogenicity of seasonal influenza vaccines containing full dose of MF59 (®) adjuvant: results from a dose-finding clinical trial in older adults.
PubMed: Vaccines for cytomegalovirus.
PubMed: Characterization of ergocalciferol loaded solid lipid nanoparticles.
PubMed: Preparation and evaluation of niosomes containing autoclaved Leishmania major: a preliminary study.
PubMed: MF59 adjuvanted seasonal and pandemic influenza vaccines.
PubMed: Role of non-ionic surfactants and plant oils on the solubilization of organochlorine pesticides by oil-in-water microemulsions.
PubMed: Effect of F-File on removal of the smear layer: a scanning electron microscope study.
PubMed: Immunogenicity and safety of the influenza A/H1N1 2009 inactivated split-virus vaccine in young and older adults: MF59-adjuvanted vaccine versus nonadjuvanted vaccine.
PubMed: Pharmacoeconomic evaluation of the MF59--adjuvanted influenza vaccine in the elderly population in Italy.
PubMed: Immunogenicity and safety of AS03-adjuvanted H1N1 pandemic vaccines in children and adolescents.
PubMed: A phase III, randomized, open-label study to assess the tolerability and immunogenicity of an H5N1 influenza vaccine administered to healthy adults with a 1-, 2-, 3-, or 6-week interval between first and second doses.
PubMed: Assessment of bioburden on human and animal tissues: Part 1--results of method development and validation studies.
PubMed: Preparation of niosomes as an ocular delivery system for naltrexone hydrochloride: physicochemical characterization.
PubMed: [Effect of surfactant on the evaporation of p-chloronitrobenzene and naphthalene in the turbulent process].
PubMed: Eliminating inhibition of enzymatic hydrolysis by lignosulfonate in unwashed sulfite-pretreated aspen using metal salts.
PubMed: Chitosan hydrogel with terbinafine--an evaluation of drug release.
PubMed: Identification of variables and value optimization for optimum lipase production by Bacillus pumilus RK31 using statistical methodology.
PubMed: Evaluation of non-inferiority of intradermal versus adjuvanted seasonal influenza vaccine using two serological techniques: a randomised comparative study.
PubMed: The sealing ability of resilon and gutta-parcha following different smear layer removal methods: an ex vivo study.
PubMed: Growth inhibiting activity of volatile oil from Cistus creticus L. against Borrelia burgdorferi s.s. in vitro.
PubMed: Fast and sensitive determination of Polysorbate 80 in solutions containing proteins.
PubMed: Gold nanoparticle extraction followed by capillary electrophoresis to determine the total, free, and protein-bound aminothiols in plasma.
PubMed: Optimization of mono and diacylglycerols production from enzymatic glycerolysis in solvent-free systems.
PubMed: New approach to hydrophobic cyanine-type photosensitizer delivery using polymeric oil-cored nanocarriers: hemolytic activity, in vitro cytotoxicity and localization in cancer cells.
PubMed: Remediation of polluted soil by a two-stage treatment system: desorption of phenanthrene in soil and electrochemical treatment to recover the extraction agent.
PubMed: MF59-adjuvanted versus non-adjuvanted influenza vaccines: integrated analysis from a large safety database.
PubMed: Preparation of a fast dissolving oral thin film containing dexamethasone: a possible application to antiemesis during cancer chemotherapy.
PubMed: A quantitative kinetic study of polysorbate autoxidation: the role of unsaturated fatty acid ester substituents.
PubMed: Mobilizing agents enhance fungal degradation of polycyclic aromatic hydrocarbons and affect diversity of indigenous bacteria in soil.
PubMed: Monitoring the effects of component structure and source on formulation stability and adjuvant activity of oil-in-water emulsions.
PubMed: [Preparation of docetaxel liposomes and their pharmacokinetics in rabbits].
PubMed: The influence of cosurfactants and oils on the formation of pharmaceutical microemulsions based on PEG-8 caprylic/capric glycerides.
PubMed: Increased bioavailability of a transdermal application of a nano-sized emulsion preparation.
PubMed: Quantitative nuclear magnetic resonance spectroscopic determination of the oxyethylene group content of polysorbates.
PubMed: Influence of surfactant supplementation and maceration on the feeding value of rice straw in growing-finishing diets for Holstein steers.
PubMed: Vaccines for seasonal and pandemic influenza.
PubMed: Controlled drug release from pellets containing water-insoluble drugs dissolved in a self-emulsifying system.
PubMed: Stability of thermostable alkaline protease from Bacillus licheniformis RP1 in commercial solid laundry detergent formulations.
PubMed: New pharmaceutical microemulsion system for encapsulation and delivery of diospyrin, a plant-derived bioactive quinonoid compound.
PubMed: Pharmacodynamics of piroxicam from self-emulsifying lipospheres formulated with homolipids extracted from Capra hircus.
PubMed: Immobilization of hydrocarbon-oxidizing bacteria in poly(vinyl alcohol) cryogels hydrophobized using a biosurfactant.
PubMed: In vitro evaluation of drug release from self micro-emulsifying drug delivery systems using a biodegradable homolipid from Capra hircus.
PubMed: Designing and testing of an effective oil-in-water microemulsion drug delivery system for in vivo application.
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PubMed: Influence of the washing buffer composition on the sensitivity of an enzyme-linked immunosorbent assay using mycobacterial glycolipids as capture antigens.
PubMed: An improvement of double emulsion technique for preparing bovine serum albumin-loaded PLGA microspheres.
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PubMed: Effectiveness of the MF59-adjuvanted influenza vaccine in preventing emergency admissions for pneumonia in the elderly over 64 years of age.
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PubMed: Bioavailability enhancement of a poorly water-soluble drug by solid dispersion in polyethylene glycol-polysorbate 80 mixture.
PubMed: Effect of MTAD on flexural strength and modulus of elasticity of dentin.
PubMed: [Drug delivery to the brain with nanoparticles].
PubMed: The use of solid self-emulsifying systems in the delivery of diclofenac.
PubMed: A novel method for the reduction of numbers of Listeria monocytogenes cells by freezing in combination with an essential oil in bacteriological media.
PubMed: The effect of various surfactants on the release rate of propranolol hydrochloride from hydroxypropylmethylcellulose (HPMC)-Eudragit matrices.
PubMed: Influence of some polysorbates on hydrocortisone release from hydrophilic gels considered as two-compartment models.
PubMed: Characterization and physicochemical properties of a lipase from Pseudomonas mendocina 3121-1.
PubMed: Remarkably enhanced inhibitory effects of three-component hybrid liposomes including sugar surfactants on the growth of lung carcinoma cells.
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PubMed: Effectiveness of spraying with tween 20 and lactic acid in decontaminating inoculated Escherichia coli O157:H7 and indigenous Escherichia coli biotype I on beef.
PubMed: Increased immunogenicity of the MF59-adjuvanted influenza vaccine compared to a conventional subunit vaccine in elderly subjects.
PubMed: Conversion of milled pine wood by manganese peroxidase from Phlebia radiata.
PubMed: Development of hexachlorobenzene-dechlorinating mixed cultures using polysorbate surfactants as a carbon source.
PubMed: Nanoparticulate systems for brain delivery of drugs.
PubMed: Purification of recombinant and human apolipoprotein A-1 using surfactant micelles in aqueous two-phase systems: recycling of thermoseparating polymer and surfactant with temperature-induced phase separation.
PubMed: Phospholipase digestion of bound cardiolipin reversibly inactivates bovine cytochrome bc1.
PubMed: Virus passage through track-etch membranes modified by salinity and a nonionic surfactant.
PubMed: Bacteriophage inactivation at the air-water-solid interface in dynamic batch systems.
PubMed: In vitro comparison of NALC-NaOH, tween 80, and C18-carboxypropylbetaine for processing of specimens for recovery of mycobacteria.
PubMed: Influence of surfactants on oral bioavailability of albendazole based on the formation of the sulphoxide metabolites in rats.
PubMed: The adjuvant MF59 increases the immunogenicity and protective efficacy of subunit influenza vaccine in mice.
PubMed: MF59 adjuvant enhances antibody responses of infant baboons immunized with Haemophilus influenzae type b and Neisseria meningitidis group C oligosaccharide-CRM197 conjugate vaccine.
PubMed: Spermine modulation of specific [3H]-gabapentin binding to the detergent-solubilized porcine cerebral cortex alpha 2 delta calcium channel subunit.
PubMed: Effect of carriers and hydrophilic agents on papaverine spheres bioavailability.
PubMed: Factors affecting the release of papaverine from spheres.
PubMed: Renaturation and ligand blotting of the major subunit of the rat asialoglycoprotein receptor after denaturing polyacrylamide gel electrophoresis.
PubMed: Inhibition of etoposide elimination in the isolated perfused rat liver by Cremophor EL and Tween 80.
PubMed: [Development of a selective differential medium for the isolation of Corynebacterium urealyticum (group D-2)].
PubMed: NTP Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies).
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PubMed: The effect of tween-65 and tween-80 on gastrointestinal motility in man.
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