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Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white crystalline powder (est) |
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 403.00 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.000001 mmHg @ 25.00 °C. (est) |
| Flash Point: | 388.00 °F. TCC ( 197.50 °C. ) (est)
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| logP (o/w): | 3.565 (est) |
| Soluble in: |
| | water, 2.639e+004 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-rat LD50 76 mg/kg "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 19, 1969.
oral-rat LD50 318 mg/kg "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 19, 1969.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis |
| Recommendation for brompheniramine maleate usage levels up to: | | | not for fragrance use.
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| Recommendation for brompheniramine maleate flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 980-71-2 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 5281067 |
| National Institute of Allergy and Infectious Diseases: | Data |
| | 3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine;(Z)-but-2-enedioic acid |
| Chemidplus: | 0000980712 |
| RTECS: | US4025000 for cas# 980-71-2 |
References:
| | 3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine;(Z)-but-2-enedioic acid |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 5281067 |
| Pubchem (sid): | 135049025 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | allent | | 2-(p- | bromo-a-(2-(dimethylamino)ethyl)benzyl)pyridine maleate | | 2-(p- | bromo-a-(2-(dimethylamino)ethyl)benzyl)pyridine maleate (1:1) | | 2-(p- | bromo-a-(2-dimethylaminoethyl)benzyl)pyridine maleate | | (±)-2-[p- | bromo-a-(2-dimethylaminoethyl)benzyl]pyridine maleate | | 1-(p- | bromophenyl)-1-(2-pyridyl)-3-dimethylaminopropane maleate | | 3-(p- | bromophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine maleate | | 3-(4- | bromophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine maleate | | 3-(4- | bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine (2Z)-but-2-enedioate | | 3-(4- | bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine (2Z)-but-2-enedioate (1:1) | | 3-(4- | bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine maleate | | 3-(4- | bromophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine | | 3-(4- | bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine (2Z)-but-2-enedioate | | 3-(4- | bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine;(Z)-but-2-enedioic acid | | (2Z)- | but-2-endisäure--3-(4-bromphenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amin(1:1) | | | dexchlorpheniramine maleate | | | dimetane | | | dimetapp allergy | | | dimetapp cold & flu | | | dimetapp DM | | | drauxin | | | ebalin | | | gammistin | | | ilvin maleate | | | lodrane LD | | | parabromodylamine maleate | | 2- | pyridinepropanamine, g-(4-bromophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1) | | | rolabromophen | | | spentane | | | veltane |
Articles:
| PubMed: | Combined use of ionic liquid and hydroxypropyl-β-cyclodextrin for the enantioseparation of ten drugs by capillary electrophoresis. |
| PubMed: | Combined use of ionic liquid and β-CD for enantioseparation of 12 pharmaceuticals using CE. |
| PubMed: | Tannate complexes of antihistaminic drug: sustained release and taste masking approaches. |
| PubMed: | Chemical stability of brompheniramine maleate in an oral liquid dosage form. |
| PubMed: | The effect of achiral calixarenes on chiral separation of propranolol-HCl and brompheniramine maleate in capillary electrophoresis using cyclodextrin as chiral selector. |
| PubMed: | Development of a validated capillary electrophoresis method for enantiomeric purity testing of dexchlorpheniramine maleate. |
| PubMed: | Brompheniramine maleate: a double-blind, placebo-controlled comparison with terfenadine for symptoms of allergic rhinitis. |
| PubMed: | Efficacy of brompheniramine maleate for the treatment of rhinovirus colds. |
| PubMed: | Is an antihistamine-decongestant combination effective in temporarily relieving symptoms of the common cold in preschool children? |
| PubMed: | Withdrawal symptoms after discontinuation of long-acting brompheniramine maleate. |
| PubMed: | Mast-cell histamine is angiogenic through receptors for histamine1 and histamine2. |
| PubMed: | Effect of food on bioavailability of pseudoephedrine and brompheniramine administered from a gastrointestinal therapeutic system. |
| PubMed: | Nasal pharmacodynamics of brompheniramine in perennial rhinitis. |
| PubMed: | Terfenadine and brompheniramine maleate in urticaria and dermographism. |
| PubMed: | A placebo-controlled comparative study of sustained-release brompheniramine maleate against clemastine fumarate in the treatment of chronic urticaria. |
| PubMed: | X-ray powder diffraction data for selected drugs: furosemide, hydrochlorothiazide, naproxen, naproxen sodium, propranolol hydrochloride, and the halopheniramine maleates. |
| PubMed: | Adverse effects of brompheniramine on pulmonary function in a subset of asthmatic children. |
| PubMed: | Acute otitis media in children: are decongestants or antihistamines necessary? |
| PubMed: | Differences in performance impairment due to brompheniramine maleate as a function of the sustained-release system. |
| PubMed: | Facial dyskinesia from overdose of an antihistamine. |
| PubMed: | Prevention and treatment of serous otitis media with an oral antihistamine. A double-blind study in pediatric practice. |
| PubMed: | Negative middle ear pressure and hearing thresholds in secretory otitis media. A double-blind crossover study with Lunerin. |
| PubMed: | Ion-pair reversed-phase high-pressure liquid chromatography of cough-cold syrups I: pseudoephedrine hydrochloride, brompheniramine maleate, and dextromethorphan hydrobromide. |
| PubMed: | Effect of the antihistamines, brompheniramine maleate and triprolidine hydrochloride, on performance in man. |
| PubMed: | Semiautomated method for the analysis of formulations of chlorpheniramine maleate and brompheniramine maleate. |
| PubMed: | Quantitative determinations of two decongestants and an antihistamine in combination using paired ion high-pressure liquid chromatography. |
| PubMed: | Quantitative determination of four antihistamines in combination by high-pressure liquid chromatography. |
| PubMed: | Hemolysis of erythrocytes by primary pharmacologic agents, part 2: influence of the vehicle. |
| PubMed: | Aggregation of antihistamines in aqueous solution: effect of counterions on self-association of pyridine derivatives. |
| PubMed: | Treatment of children with perennial rhinitis with brompheniraminemaleate and phenylpropanolaminehydrochloride (lunerin mite) |
| PubMed: | Crystal structure of dl-brompheniramine maleate (1-(p-bromophenyl)-1-(2-pyridyl)-3-N,N-dimethylpropylamine maleate). |
| PubMed: | Effect of glycopyrrolate and brompheniramine maleate on the recurrence rate of duodenal ulcer. |
| PubMed: | A clinical trial of brompheniramine maleate in chronic urticaria. |
| PubMed: | BROMPHENIRAMINE maleate. |
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