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Category: sequestrants
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | pale yellow clear liquid (est) |
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.43000 to 1.47100 @ 20.00 °C.
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| Pounds per Gallon - (est).: | 11.913 to 12.254
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| Boiling Point: | 578.76 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 579.00 °F. TCC ( 303.80 °C. ) (est)
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| logP (o/w): | -0.746 (est) |
| Soluble in: |
| | water, 690000 mg/L @ 20 °C (exp) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
| AquaChemie |
| For experimental / research use only. |
| 1-Hydroxyethylidene-1,1-Diphosphonic acid - HEDP
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| BOC Sciences |
| For experimental / research use only. |
| Etidronic acid >98%
Odor: characteristic Use: Etidronate (Didronel) is a human protein tyrosine phosphatase inhibitor with IC50 of 0.2 nM. |
| Charkit Chemical |
| DEQUEST 2010
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| Connect Chemicals |
| 1-Hydroxyethylidene-1,1-diphosphonic acid (HEDP)
Odor: characteristic Use: 1-Hydroxyethylidene-1,1-diphosphonic acid (HEDP) is a cost effective scale inhibitor used in various industrial applications such as industrial water treatment and detergents. It further shows good stability in presence of chlorine as well as corrosion inhibition properties in presence of zinc and other phosphates. HEDP can be also used as chelating agent in the textile industry. |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Etidronic Acid ≥90%
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| Shiva Chemicals and Pharmaceuticals |
| HEDP
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| Sigma-Aldrich: Aldrich |
| For experimental / research use only. |
| Etidronic Acid 60% aqueous solution
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| Strem Chemicals |
| For experimental / research use only. |
| 1-Hydroxyethylidene-1,1-diphosphonic acid, min. 95% HEDP
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| TCI AMERICA |
| For experimental / research use only. |
| 1-Hydroxyethane-1,1-diphosphonic Acid (ca. 60% in Water, ca. 4.2mol/L)
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| Universal Preserv-A-Chem Inc. |
| ETIDRONIC ACID
Odor: characteristic Use: Is a bisphosphonate used in detergents, water treatment, cosmetics and pharmaceutical treatment. Etidronic acid (Didronel -) is a bisphosphonate used to strengthen bone, treat osteoporosis, and treat Paget's disease of bone. |
| Zschimmer & Schwarz |
| Cublen HE-K 60
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Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-mouse LD50 1800 mg/kg Angewandte Chemie, International Edition in English. Vol. 14, Pg. 94, 1975.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | sequestrants |
| Recommendation for etidronic acid usage levels up to: | | | not for fragrance use.
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| Recommendation for etidronic acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| European Food Safety Authority (EFSA) reference(s): |
Scientific Opinion on the evaluation of the safety and efficacy of peroxyacetic acid solutions for reduction of pathogens on poultry carcasses and meat View page or View pdf |
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 2809-21-4 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 3305 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 2 |
| | (1-hydroxy-1-phosphonoethyl)phosphonic acid |
| Chemidplus: | 0002809214 |
| RTECS: | SZ8562100 for cas# 2809-21-4 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | acetodiphosphonic acid | | | cublen HE-K 60 | | | didronel IV | | oxy | ethylidenediphosphonic acid | | (1- | hydroxy-1-phosphono-ethyl)-phosphonic acid | | (1- | hydroxy-1-phosphonoethyl)phosphonic acid | | (1- | hydroxy-1,1-ethanediyl)bis(phosphonic acid) | | 1- | hydroxyethane-1,1-bisphosphonic acid | | 1- | hydroxyethane-1,1-diphosphonic acid | | (1- | hydroxyethane-1,1-diyl)bis(phosphonic acid) | | (1- | hydroxyethane-1,1-diyl)diphosphonic acid | | 1- | hydroxyethane-1,1,-diphosphonic acid | | 1- | hydroxyethanediphosphonic acid | | (1- | hydroxyethylene)diphosphonic acid | | 1- | hydroxyethylidene-1,1-diphosphonic acid | | 1- | hydroxyethylidene-1,1-diphosphonicacid | | (1- | hydroxyethylidene)bis(phosphonic acid) | | (1- | hydroxyethylidene)bisphonic acid | | (1- | hydroxyethylidene)bisphosphonic acid | | (1- | hydroxyethylidene)diphoshonic acid | | ( | hydroxyethylidene)diphosphonic acid | | (1- | hydroxyethylidene)diphosphonic acid | | 1- | hydroxyethylidenediphosphonic acid | | | phosphonic acid, (1-hydroxyethylidene)bis- |
Articles:
| PubMed: | Biosorption of heavy metal ions onto agricultural residues buckwheat hulls functionalized with 1-hydroxylethylidenediphosphonic acid. |
| PubMed: | Intravenous zoledronic acid: what are the indications for male osteoporosis? |
| PubMed: | Effect of osteoporosis treatment on mortality: a meta-analysis. |
| PubMed: | Comparison of the effects of once-monthly versus once-daily risedronate in postmenopausal osteoporosis: a phase II, 6-month, multicenter, randomized, double-blind, active-controlled, dose-ranging study. |
| PubMed: | Risedronate dosing before breakfast compared with dosing later in the day in women with postmenopausal osteoporosis. |
| PubMed: | Compatibility of risedronate sodium tablets with food thickeners. |
| PubMed: | Paget disease of bone: therapeutic options. |
| PubMed: | Nonvertebral fracture risk reduction with nitrogen-containing bisphosphonates. |
| PubMed: | Effects of risedronate 5 mg/d on bone mineral density and bone turnover markers in late-postmenopausal women with osteopenia: a multinational, 24-month, randomized, double-blind, placebo-controlled, parallel-group, phase III trial. |
| PubMed: | Evaluation of 41calcium as a new approach to assess changes in bone metabolism: effect of a bisphosphonate intervention in postmenopausal women with low bone mass. |
| PubMed: | Effect of administration site in the gastrointestinal tract on bioavailability of poorly absorbed drugs taken after a meal. |
| PubMed: | Importance of calcium co-medication in bisphosphonate therapy of osteoporosis: an approach to improving correct intake and drug adherence. |
| PubMed: | Pharmaceutical care and community pharmacists' understanding of bisphosphonate dosing information. |
| PubMed: | Clinical trial of risedronate in Japanese volunteers: a study on the effects of timing of dosing on absorption. |
| PubMed: | An approach to postmenopausal osteoporosis treatment: a case study review. |
| PubMed: | Prevention and treatment of osteoporosis. |
| PubMed: | Bone density changes with once weekly risedronate in postmenopausal women. |
| PubMed: | Treatment of hypercalcemia of malignancy with bisphosphonates. |
| PubMed: | Food-drug interactions. |
| PubMed: | Risedronate: a new oral bisphosphonate. |
| PubMed: | Gender differences in osteoporosis treatment: a review of clinical research. |
| PubMed: | Timing of cyclical etidronate. |
| PubMed: | Prevention and treatment of osteoporosis. |
| PubMed: | The effect of dosing regimen on the pharmacokinetics of risedronate. |
| PubMed: | Evaluation of the effects of risedronate on hepatic microsomal drug metabolizing enzyme activities following administration to rats for 14 days: lack of an induction response. |
| PubMed: | Risedronate released for Paget's disease. |
| PubMed: | Bisphosphonates: preclinical aspects and use in osteoporosis. |
| PubMed: | Adverse effects of bisphosphonates. A comparative review. |
| PubMed: | Osteoporosis: pathophysiology, prevention, diagnosis, and treatment. |
| PubMed: | Etidronate for hypercalcemia of malignancy and osteoporosis. |
| PubMed: | Absorption of oral diphosphonate in normal subjects. |
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