Articles:
(4-((4-acetyloxyphenyl)-pyridin-2-ylmethyl)phenyl) acetate
Notes:
a diphenylmethane stimulant laxative used for the treatment of constipation and for bowel evacuation. (from martindale, the extra pharmacopoeia, 30th ed, p871)
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American International Chemical, Inc. Consistent sources North American supplier for globally sourced ingredients. AIC is a Westborough, MA based ISO Certified sales and marketing company serving the food, pharmaceutical, nutritional, personal care, biotech, and industrial markets of North America since 1972. Our success is a result of a company culture built on customer needs, along with partnerships with global manufacturers committed to the rigors and demands of the North American market. Our team of Sales Representatives, along with our network of strategically located warehouses are ready to supply product when and where you need it. Email: Info Voice: (800) 238-0001 Facebook Twitter Linkedin Products List: View Product(s): 129829 Bisacodyl
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BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 603-50-9 Bisacodyl >98% Bisacodyl (INN) is a stimulant laxative drug that works directly on the colon to produce a bowel movement.Bisacodyl works by stimulating enteric nerves to cause colonic contractions.
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Penta International Corporation Chemistry innovation At Penta, our products and services help businesses do business better. For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes. US Email: Technical Services US Email: Sales US Voice: (973) 740-2300 US Fax: (973) 740-1839 Product(s): 02-32250 BISACODYL USP
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| CAS Number: | 603-50-9 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 210-044-4 | |
| FDA UNII: | 10X0709Y6I | |
| Nikkaji Web: | J3.307C | |
| Beilstein Number: | 0323727 | |
| MDL: | MFCD00038039 | |
| XlogP3-AA: | 3.80 (est) | |
| Molecular Weight: | 361.39723000 | |
| Formula: | C22 H19 N O4 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 133.50 °C. @ 760.00 mm Hg |
| Boiling Point: | 492.33 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure: | 4.800000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 485.00 °F. TCC ( 251.60 °C. ) (est) |
| logP (o/w): | 3.453 (est) |
| Soluble in: | |
| water, 139.2 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| American International Chemical, LLC. |
| Bisacodyl |
| BOC Sciences |
| For experimental / research use only. |
| Bisacodyl >98%
Odor: characteristic Use: Bisacodyl (INN) is a stimulant laxative drug that works directly on the colon to produce a bowel movement.Bisacodyl works by stimulating enteric nerves to cause colonic contractions. |
| Penta International |
| BISACODYL USP |
| Sarchem Laboratories |
| For experimental / research use only. |
| Bisacodyl |
| Sigma-Aldrich |
| For experimental / research use only. |
| Bisacodyl
analytical standard, for drug analysis |
| Universal Preserv-A-Chem Inc. |
| BISACODYL USP |
Safety Information:
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intravenous-cat LDLo 40 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 19, 1953. oral-dog LD50 > 15000 mg/kg Drugs in Japan Vol. -, Pg. 854, 1990. intravenous-dog LDLo 40 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 19, 1953. oral-mouse LD50 17500 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: ATAXIA BLOOD: HEMORRHAGE Toxicology and Applied Pharmacology. Vol. 2, Pg. 243, 1960. intravenous-mouse LDLo 80 mg/kg Toxicology and Applied Pharmacology. Vol. 2, Pg. 243, 1960. intravenous-rabbit LDLo 40 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 19, 1953. oral-rat LD50 4320 mg/kg BLOOD: CHANGES IN SPLEEN GASTROINTESTINAL: OTHER CHANGES BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Toxicology and Applied Pharmacology. Vol. 2, Pg. 243, 1960. | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis | ||
| Recommendation for bisacodyl usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for bisacodyl flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 603-50-9 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 2391 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 1 |
| [4-[(4-acetyloxyphenyl)-pyridin-2-ylmethyl]phenyl] acetate | |
| Chemidplus: | 0000603509 |
| RTECS: | SM8750000 for cas# 603-50-9 |
References:
| [4-[(4-acetyloxyphenyl)-pyridin-2-ylmethyl]phenyl] acetate | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 2391 |
| Pubchem (sid): | 134976919 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | D00245 |
| HMDB (The Human Metabolome Database): | Search |
| MedlinePlusSupp: | View |
| ChemSpider: | View |
| Wikipedia: | View |
| Formulations/Preparations: •complex with tannin: bisacodyl tannex; clysodrast. •bisacodyl is available in an enteric-coated preparation given once daily, the usual oral dose for which is 10 to 15 mg for adults and 5 to 10 mg for children 6 to 12 years old. •bisacodyl enema is supplied in a 1.25 fluid ounce (37 ml) ready-to-use squeeze bottle. •bisacodyl stimulant laxative tablets are supplied in cartons of 25 tablets (5 mg each tablet) wrapped in a foil seal. •bisacodyl suppositories are supplied in cartons of 4 individually foil-wrapped suppositories. | |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| acetic acid 4-[(4-acetoxy-phenyl)-pyridin-2-yl-methyl]-phenyl ester | |
| bis(p- | acetoxyphenyl)-2-pyridylmethane |
| acetphenolpicoline | |
| 4-[(4- | acetyloxyphenyl)-2-pyridylmethyl]phenyl acetate |
| (4-((4- | acetyloxyphenyl)-pyridin-2-ylmethyl)phenyl) acetate |
| [4-[(4- | acetyloxyphenyl)-pyridin-2-ylmethyl]phenyl] acetate |
| bisacodyl USP | |
| brocalax | |
| broxalax | |
| di-(4-acetoxyphenyl)-2-pyridylmethane | |
| di-(p-acetoxyphenyl)-2-pyridylmethane | |
| (4,4'- | diacetoxydiphenyl)(2-pyridyl)methane |
| 2-(4,4'- | diacetoxydiphenylmethyl)pyridine |
| 4,4'- | diacetoxydiphenylpyridyl-2-methane |
| dulcolan | |
| dulcolax | |
| durolax | |
| endokolat | |
| eulaxan | |
| fenilaxan | |
| godalax | |
| hillcolax | |
| ivilax | |
| laxadin | |
| laxagetten | |
| laxanin N | |
| laxans | |
| laxine | |
| laxorex | |
| neolax | |
| nigalax | |
| perilax | |
| ( | pyridin-2-ylmethanediyl)dibenzene-4,1-diyl diacetate |
| ( | pyridin-2-ylmethylene)bis(4,1-phenylene) diacetate |
| ( | pyridin-2-ylmethylene)di-4,1-phenylene diacetate |
| (2- | pyridinylmethylene)di-4,1-phenylene diacetate |
| 4,4'-(2- | pyridylmethylene)bisphenol diacetate |
| pyrilax | |
| sanvacual | |
| telemin | |
| theralax | |
| ulcolax | |
| zetrax |