|
Category: cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white powder (est) |
| Assay: | 95.00 to 100.00 %
|
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 330.00 °C. @ 760.00 mm Hg (est)
|
| Vapor Pressure: | 0.000034 mmHg @ 25.00 °C. (est) |
| Flash Point: | 32.00 °F. TCC ( 0.00 °C. ) (est)
|
| logP (o/w): | -1.031 (est) |
| Soluble in: |
| | water | | | water, 7.75e+004 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor Strength: | none |
| |
| |
| Odor and/or flavor descriptions from others (if found). |
| |
| |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | cosmetic agents |
| Recommendation for zinc sulfate monohydrate usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for zinc sulfate monohydrate flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
| European Food Safety Authority (EFSA) reference(s): |
Scientific Opinion on safety and efficacy of zinc compounds (E6) as feed additives for all animal species: Zinc sulphate monohydrate, based on a dossier submitted by Helm AG View page or View pdf |
Scientific Opinion on safety and efficacy of zinc compounds (E6) as feed additive for all species: zinc sulphate monohydrate, based on a dossier submitted by Grillo-Werke AG/EMFEMA View page or View pdf |
Scientific Opinion on the safety and efficacy of zinc compounds (E6) as feed additives for all animal species (zinc acetate, dihydrate; zinc chloride, anhydrous; zinc oxide; zinc sulphate, heptahydrate; zinc sulphate, monohydrate; zinc chelate of amino acids, hydrate; zinc chelate of glycine, hydrate), based on a dossier submitted by FEFANA asbl View page or View pdf |
| EPI System: | View |
| Daily Med: | search |
| EPA Substance Registry Services (TSCA): | 7446-19-7 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 62639 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WISER: | UN 3077 |
| WGK Germany: | 3 |
| | zinc sulfate hydrate |
| Chemidplus: | 0007446197 |
| RTECS: | ZH5300000 for cas# 7446-19-7 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | sulfuric acid zinc salt (1:1), monohydrate | | | sulfuric acid, zinc salt (1:1), monohydrate | | | zinc sulfate hydrate | | | zinc sulfate hydrate (1:1:1) | | | zinc sulfate monohydrate USP FCC | | | zinc sulfate, monohydrate | | | zinc sulphate monohydrate | | | zincsulfatemonohydrate |
Articles:
| PubMed: | Zinc supplementation in pre-diabetes: study protocol for a randomized controlled trial. |
| PubMed: | Effect of zinc methionine or zinc sulfate supplementation on milk production and composition of milk in lactating dairy cows. |
| PubMed: | Long-term feeding of high zinc sulfate diets to lactating and gestating dairy cows. |
| PubMed: | Oral zinc therapy of acne. Absorption and clinical effect. |
| PubMed: | Bitterness suppression with zinc sulfate and na-cyclamate: a model of combined peripheral and central neural approaches to flavor modification. |
| PubMed: | Effect of peripheral anosmia in dogs trained as flavor validators. |
| PubMed: | Oral Zinc Supplementation Positively Affects Linear Growth, But not Weight, in Children 6-24 Months of Age. |
| PubMed: | Rice fortification with zinc during parboiling may improve the adequacy of zinc intakes in Bangladesh. |
| PubMed: | Preparation and antibacterial properties of titanium-doped ZnO from different zinc salts. |
| PubMed: | Quantum dots as a possible oxygen sensor. |
| PubMed: | Evaluation and comparison of zinc absorption level from 2-Alkyle 3-Hydroxy pyranon-zinc complexes and zinc sulfate in rat in vivo. |
| PubMed: | Prediction of serum IgG concentration by indirect techniques with adjustment for age and clinical and laboratory covariates in critically ill newborn calves. |
| PubMed: | Zinc supplementation reduces morbidity and mortality in very-low-birth-weight preterm neonates: a hospital-based randomized, placebo-controlled trial in an industrialized country. |
| PubMed: | [Development of Clostridium perfringens selective chromogenic medium]. |
| PubMed: | Effect of zinc supplementation on serum zinc and calcium levels in postmenopausal osteoporotic women in Tabriz, Islamic Republic of Iran. |
| PubMed: | Effect of zinc sulphate on gelling properties of phosphorylated protein isolate from yellow stripe trevally. |
| PubMed: | Effect of increasing levels of zinc fortificant on the iron absorption of bread co-fortified with iron and zinc consumed with a black tea. |
| PubMed: | Zinc modulates drought-induced biochemical damages in tea [Camellia sinensis (L) O Kuntze]. |
| PubMed: | Effects of zinc supplementation on efficacy of antidepressant therapy, inflammatory cytokines, and brain-derived neurotrophic factor in patients with major depression. |
| PubMed: | Antioxidant and micronutrient-rich milk formula reduces lead poisoning and related oxidative damage in lead-exposed mice. |
| PubMed: | Bioavailability of zinc oxide added to corn tortilla is similar to that of zinc sulfate and is not affected by simultaneous addition of iron. |
| PubMed: | Zinc supplementation in pre-diabetes: study protocol for a randomized controlled trial. |
| PubMed: | Effect of zinc sulfate fortificant on iron absorption from low extraction wheat flour co-fortified with ferrous sulfate. |
| PubMed: | Acrodermatitis due to zinc deficiency after combined vertical gastroplasty with jejunoileal bypass: case report. |
| PubMed: | Zn(2+) and L-isoleucine induce the expressions of porcine β-defensins in IPEC-J2 cells. |
| PubMed: | Selenium and zinc internalized by Lactobacillus buchneri Lb26 (DSM 16341) and Bifidobacterium lactis Bb1 (DSM 17850): improved bioavailability using a new biological approach. |
| PubMed: | Effect of Consuming Zinc-fortified Bread on Serum Zinc and Iron Status of Zinc-deficient Women: A Double Blind, Randomized Clinical Trial. |
| PubMed: | Effect of increasing concentrations of zinc on the absorption of iron from iron-fortified milk. |
| PubMed: | Effects of iron and zinc foliar applications on rice plants and their grain accumulation and grain nutritional quality. |
| PubMed: | Maternal zinc intake of Wistar rats has a protective effect in the alloxan-induced diabetic offspring. |
| PubMed: | Effect of zinc fortification on Cheddar cheese quality. |
| PubMed: | Effect of zinc sulfate fortification in germinated brown rice on seed zinc concentration, bioavailability, and seed germination. |
| PubMed: | Bioavailability of two organic forms of zinc in comparison to zinc sulphate for weaning pigs fed a diet composed mainly of wheat, barley and soybean meal. |
| PubMed: | Zinc as an appetite stimulator - the possible role of zinc in the progression of diseases such as cachexia and sarcopenia. |
| PubMed: | Effect of Helicobacter pylori infection on iron absorption in asymptomatic adults consuming wheat flour fortified with iron and zinc. |
| PubMed: | Effects of intracellular zinc depletion on the expression of VDAC in cultured hippocampal neurons. |
| PubMed: | Recycling coffee grounds and tea leaf wastes to improve the yield and mineral content of grains of paddy rice. |
| PubMed: | Improving neuropathy scores in type 2 diabetic patients using micronutrients supplementation. |
| PubMed: | Effect of zinc and iron fortification of the feed on liver and thyroid function in rats. |
| PubMed: | The influence of zinc and copper on the latency period for feeding and the food uptake in common carp, Cyprinus carpio L. |
| PubMed: | Effect of mineral fortification on plasma biochemical profile in rats. |
| PubMed: | Reduction of blood lead levels in lead-exposed mice by dietary supplements and natural antioxidants. |
| PubMed: | The effect of zinc sulphate and zinc carnosine on genome stability and cytotoxicity in the WIL2-NS human lymphoblastoid cell line. |
| PubMed: | Genetic improvement of grass pea for low neurotoxin (β-ODAP) content. |
| PubMed: | Frequency of intestinal parasites among food-handlers in Khartoum, Sudan. |
| PubMed: | [The role of zinc in the treatment of hyperactivity disorder in children]. |
| PubMed: | Changing the zinc:iron ratio in a cereal-based nutritional supplement has no effect on percent absorption of iron and zinc in Sri Lankan children. |
| PubMed: | [Study of zinc on the modulation of Uch-L1 expression in hippocampus of growing rats]. |
| PubMed: | Sensory attributes of complex tasting divalent salts are mediated by TRPM5 and TRPV1 channels. |
| PubMed: | Comparison of sample preparation methods for analysis of isoflavones in foodstuffs. |
| PubMed: | Orally administered zinc increases food intake via vagal stimulation in rats. |
| PubMed: | [Effect of selenium and zinc on the proliferation of human esophageal cancer Eca109 cell line in vitro]. |
| PubMed: | The effect of Ginkgo biloba on the expression of intermediate-early antigen (c-fos) in the experimentally induced anosmic mouse. |
| PubMed: | Preference for dried bonito broth in olfactory-blocked or taste nerve-sectioned mice in the two-bottle choice test. |
| PubMed: | The effects of zinc supplementation on serum zinc, alkaline phosphatase activity and fracture healing of bones. |
| PubMed: | Depletion of intracellular zinc down-regulates expression of Uch-L1 mRNA and protein, and CREB mRNA in cultured hippocampal neurons. |
| PubMed: | The distributions and correlates of serum albumin levels in institutionalised individuals with intellectual and/or motor disabilities. |
| PubMed: | Zinc-induced G2/M blockage is p53 and p21 dependent in normal human bronchial epithelial cells. |
| PubMed: | Effect of nutrition on toxicity of contaminants to the epibenthic amphipod Melita plumulosa. |
| PubMed: | Zinc bioavailability from zinc-fortified foods. |
| PubMed: | [Zinc and copper content in individual components used to prepare pediatric total nutrition mixtures]. |
| PubMed: | Lesion of the main olfactory epithelium facilitates maternal behavior in virgin rabbits. |
| PubMed: | New insights about iron bioavailability inhibition by zinc. |
| PubMed: | [Determination of acrylamide in foods by gas chromatography-mass spectrometry]. |
| PubMed: | Cytotoxicity of nitric oxide is alleviated by zinc-mediated expression of antioxidant genes. |
| PubMed: | DESCRIPTIVE ANALYSIS OF DIVALENT SALTS. |
| PubMed: | Bitterness suppression with zinc sulfate and na-cyclamate: a model of combined peripheral and central neural approaches to flavor modification. |
| PubMed: | Interaction of arsenic with zinc and organics in a rice (Oryza sativa L.)--cultivated field in India. |
| PubMed: | Effect of different zinc sources and levels on inhibition of the apoptosis induced by glucocorticoid of thymocytes in vitro. |
| PubMed: | Nutritional and technological behavior of stabilized iron-gluconate in wheat flour. |
| PubMed: | The effect of selenium and zinc fortification on the quality of Turkish white cheese. |
| PubMed: | Normal growth rate in rats is recovered after a period of zinc deficiency by restoration of zinc supply by means of a zinc-fortified Petit Suisse cheese. |
| PubMed: | Olfactory stimulation with scent of lavender oil affects autonomic nerves, lipolysis and appetite in rats. |
| PubMed: | Zinc absorption from zinc oxide, zinc sulfate, zinc oxide + EDTA, or sodium-zinc EDTA does not differ when added as fortificants to maize tortillas. |
| PubMed: | Olfactory stimulation with scent of grapefruit oil affects autonomic nerves, lipolysis and appetite in rats. |
| PubMed: | Effect of zinc sulphate and zinc methionine on growth, plasma growth hormone concentration, growth hormone receptor and insulin-like growth factor-I gene expression in mice. |
| PubMed: | Longitudinal measurements of zinc absorption in Peruvian children consuming wheat products fortified with iron only or iron and 1 of 2 amounts of zinc. |
| PubMed: | Characterization of the hsp70 response in lymphoblasts from aged and centenarian subjects and differential effects of in vitro zinc supplementation. |
| PubMed: | Effect of a micronutrient fortificant mixture and 2 amounts of calcium on iron and zinc absorption from a processed food supplement. |
| PubMed: | Intramuscular injections of male pheromone 5 alpha-androstenol change the secretory ovarian function in gilts during sexual maturation. |
| PubMed: | Absorption of zinc from wheat products fortified with iron and either zinc sulfate or zinc oxide. |
| PubMed: | Development of alimentary zinc deficiency in growing rats is retarded at low dietary protein levels. |
| PubMed: | Effects of zinc histidine and zinc sulfate on natural human keratinocytes. |
| PubMed: | Bioavailability of zinc in fiber-enriched bread fortified with zinc sulphate. |
| PubMed: | Cofortification of iron-fortified flour with zinc sulfate, but not zinc oxide, decreases iron absorption in Indonesian children. |
| PubMed: | Bioavailability of zinc from cooked philippine milled, undermilled, and brown rice, as assessed in rats by using growth, bone zinc, and zinc-65 retention. |
| PubMed: | The effects of zinc supplementation on serum zinc and cholesterol concentrations in hemodialysis patients. |
| PubMed: | [Effects of cooking methods on iodine content in iodized salt]. |
| PubMed: | Purification and characterization of a carboxypeptidase from squid hepatopancreas (Illex illecebrosus). |
| PubMed: | Preference for corn oil in olfactory-blocked mice in the conditioned place preference test and the two-bottle choice test. |
| PubMed: | Investigation of excretion and absorption of different zinc salts in puppies. |
| PubMed: | A fortifier comprising protein, vitamins, and calcium-glycerophosphate for preterm human milk. |
| PubMed: | Bioavailability of zinc and its binding to casein in milks and formulas. |
| PubMed: | Bioavailability, biodistribution, and toxicity of BioZn-AAS(1): a new zinc source. comparative studies in rats. |
| PubMed: | The effects of zinc supplementation on serum zinc concentration and protein catabolic rate in hemodialysis patients. |
| PubMed: | Zinc supplementation for infants. |
| PubMed: | Gastric mucosal damage induced by arecoline seizure in rats. |
| PubMed: | Importance of histamine, glutathione and oxyradicals in modulating gastric haemorrhagic ulcer in septic rats. |
| PubMed: | Bioavailability of zinc in several sources of zinc oxide, zinc sulfate, and zinc metal. |
| PubMed: | [Effects of high dietary zinc on mice (II)--Influence on growth, blood composition and immune function]. |
| PubMed: | Metallothionein-null mice absorb less Zn from an egg-white diet, but a similar amount from solutions, although with altered intertissue Zn distribution. |
| PubMed: | Effect of zinc supplementation on growth and body composition of Ugandan preschool children: a randomized, controlled, intervention trial. |
| PubMed: | Elaboration and evaluation of an intraoral controlled release delivering system. |
| PubMed: | Short time effect of Chemiron (a combination iron preparation), single iron, and different magnesium salts on plasma. Magnesium concentration during early pregnancy in Nigerian women. A preliminary report. |
| PubMed: | Elevated intakes of zinc in infant formulas don not interfere with iron absorption in premature infants. |
| PubMed: | Iron and zinc interactions in humans. |
| PubMed: | [Development and evaluation of an active substance controlled-release device for use in the oral cavity]. |
| PubMed: | Daily zinc supplementation effect on zinc deficiency in rats during prolonged restriction of motor activity. |
| PubMed: | Zinc supplementation affects the activity patterns of rural Guatemalan infants. |
| PubMed: | Impact of zinc supplementation on morbidity from diarrhea and respiratory infections among rural Guatemalan children. |
| PubMed: | Zinc status relates to hematological deficits in women endurance runners. |
| PubMed: | Lack of effect of zinc supplementation on antipyrine clearance in alcoholic liver disease. |
| PubMed: | Development of obesity following inactivation of a growth hormone transgene in mice. |
| PubMed: | Bioavailability of zinc from inorganic and organic sources for pigs fed corn-soybean meal diets. |
| PubMed: | Effects of intranasal ZnSO4 irrigation on olfactory and trigeminal cues. |
| PubMed: | Role of olfaction in starch and oil preference. |
| PubMed: | Growth and plasma zinc responses of young pigs fed pharmacologic levels of zinc. |
| PubMed: | Research note: responses of laying hens on saline drinking water to dietary supplementation with various zinc compounds. |
| PubMed: | Zinc deficiency and childhood-onset anorexia nervosa. |
| PubMed: | Symptomatic zinc deficiency in a one-year-old child precipitated by changing from formula to cow's milk. |
| PubMed: | Research note: maintenance of duodenum weight during a molt induced by dietary zinc in a low-calcium diet. |
| PubMed: | Vomeronasal and/or olfactory mediation of ultrasonic calling and scent marking by female golden hamsters. |
| PubMed: | Methodology for assessing zinc bioavailability: efficacy estimates for zinc-methionine, zinc sulfate, and zinc oxide. |
| PubMed: | [The efficacy of the use of lactic acid lactobacterin enriched with zinc in the treatment of patients with celiac disease]. |
| PubMed: | Effects of animal and supplement characteristics on average daily gain of grazing beef cattle. |
| PubMed: | [Field survey of sarcocystis infection in the Tibet autonomous region]. |
| PubMed: | Effects of dietary zinc and cadmium on tissue selenium concentration and glutathione peroxidase activity in rats fed DL-selenomethionine or sodium selenite. |
| PubMed: | Advances in the control of foot rot in sheep. |
| PubMed: | Stud male protection of implantation in food-deprived mice: evaluation of the involvement of olfactory-vomeronasal systems. |
| PubMed: | Anticipatory wheel-running in behaviorally anosmic rats. |
| PubMed: | Oral zinc supplementation in persistent diarrhoea in infants. |
| PubMed: | [Skin changes in alimentary zinc deficiency caused by artificial infant food]. |
| PubMed: | Clinical zinc deficiency during zinc-supplemented formula. |
| PubMed: | A controlled trial on utility of oral zinc supplementation in acute dehydrating diarrhea in infants. |
| PubMed: | Acute effects of a zinc supplement taken before a glucose load. |
| PubMed: | Effects of intranasal ZnSO4 irrigation are mitigated by the presence of untreated littermates. |
| PubMed: | [Enhancing effect of zinc supplementation on the growth of formula-fed children]. |
| PubMed: | [Food search by mice solving an extrapolation problem after suppression of smell by zinc sulfate]. |
| PubMed: | Clinical zinc deficiency during long-term total enteral nutrition. |
| PubMed: | Inactivation of metalloenzymes by lysinoalanine, phenylethylaminoalanine, alkali-treated food proteins, and sulfur amino acids. |
| PubMed: | Effect of wheat bran on zinc absorption. |
| PubMed: | Zinc deficiency in pheasant chicks fed practical diets. |
| PubMed: | Effect of peripheral anosmia in dogs trained as flavor validators. |
| PubMed: | Improved 4-aminoantipyrine colorimetry for detection of residual hydrogen peroxide in noodles, fish paste, dried fish, and herring roe. |
| PubMed: | Chemical coagulation of industrial animal blood using aluminum sulfate, zinc sulfate, methanol, and acetone. |
| PubMed: | Gas-liquid chromatographic determination of nitrate and nitrite in cheese, ham, fish sausage, cod roes, and salmon roes. |
| PubMed: | Bioavailability of zinc in milk and soy protein-based infant formulas. |
| PubMed: | Olfactory basis for the delayed onset of maternal behavior in virgin female rats: experimential effects. |
| PubMed: | Effect of foodstuffs on the absorption of zinc sulfate. |
| PubMed: | The effect of dietary zinc sulfate supplements on the healing of experimental extraction wounds. |
|