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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 144.50 °C. @ 760.00 mm Hg
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| Boiling Point: | 378.20 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 361.00 °F. TCC ( 182.50 °C. ) (est)
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| logP (o/w): | 2.260 (est) |
| Soluble in: |
| | water, 97.76 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intramuscular-mouse LD50 123 mg/kg Journal of Drug Research. Vol. 7(2), Pg. 1, 1975.
oral-rat LD50 832 mg/kg Journal of Drug Research. Vol. 7(2), Pg. 1, 1975.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for visnagin usage levels up to: | | | not for fragrance use.
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| Recommendation for visnagin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: | View |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 6716 |
| National Institute of Allergy and Infectious Diseases: | Data |
| | 4-methoxy-7-methylfuro[3,2-g]chromen-5-one |
| Chemidplus: | 0000082575 |
| RTECS: | LV1420000 for cas# 82-57-5 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | desmethoxykhellin | | 5H- | furo(3,2-g)(1)benzopyran-5-one, 4-methoxy-7-methyl-
| | 5- | methoxy-2-methylfuranochromone | | 4- | methoxy-7-methyl furo(3,2-g)chromen-5-one | | 4- | methoxy-7-methyl-5H-furo(3,2-g)(1)-benzopyran-5-one | | 4- | methoxy-7-methylfuro[3,2-g]chromen-5-one | | | visnagidin | | | visnagine
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Articles:
| Google Patents: | Method for the preparation of visnagin from chellol and new compositions of matter |
| PubMed: | Validated HPLC method for simultaneous estimation of khellol glucoside, khellin and visnagin in Ammi visnaga L. fruits and pharmaceutical preparations. |
| PubMed: | Khellin and visnagin differentially modulate AHR signaling and downstream CYP1A activity in human liver cells. |
| PubMed: | Aflatoxin B1: toxicity, bioactivation and detoxification in the polyphagous caterpillar Trichoplusia ni. |
| PubMed: | Pharmacokinetic evaluation of visnagin and Ammi visnaga aqueous extract after oral administration in rats. |
| PubMed: | Antitumor and antimicrobial activities of some hetero aromatic benzofurans derived from naturally occurring visnagin. |
| PubMed: | Nonlinear pharmacokinetics of visnagin in rats after intravenous bolus administration. |
| PubMed: | DNA binding, antiviral activities and cytotoxicity of new furochromone and benzofuran derivatives. |
| PubMed: | Synthesis of new visnagen and khellin furochromone pyrimidine derivatives and their anti-inflammatory and analgesic activity. |
| PubMed: | Neuroprotective Effect of Visnagin on Kainic Acid-induced Neuronal Cell Death in the Mice Hippocampus. |
| PubMed: | Anti-inflammatory effect of visnagin in lipopolysaccharide-stimulated BV-2 microglial cells. |
| PubMed: | Prevention of renal crystal deposition by an extract of Ammi visnaga L. and its constituents khellin and visnagin in hyperoxaluric rats. |
| PubMed: | An aqueous extract of Ammi visnaga fruits and its constituents khellin and visnagin prevent cell damage caused by oxalate in renal epithelial cells. |
| PubMed: | Determination of visnagin in rat plasma by liquid chromatography with tandem mass spectrometry and its application to in vivo pharmacokinetic studies. |
| PubMed: | A new steroid glycoside and furochromones from Cyperus rotundus L. |
| PubMed: | Synthesis of 6- and 9-alkylaminomethyl furoflavones as gastroprotective agents. |
| PubMed: | Nanosecond time-resolved infrared studies of visnagin and khellin triplets and radical ions. |
| PubMed: | Ultraviolet photoionization of the photosensitizers khellin and visnagin in aqueous solution and in micelles: one-photon ionization is a minor process. |
| PubMed: | The chemical investigations on the ripe fruits of Ammi visnaga (Lam.) Lamarck growing in Turkey. |
| PubMed: | Stimulation of furanochromone accumulation in callus cultures of Ammi visnaga L. by addition of elicitors. |
| PubMed: | Fluorometric determination of khellin in human urine and serum by high-performance liquid chromatography using postcolumn photoirradiation. |
| PubMed: | Photosynthesis of furocoumarin- and furochromone-types potential intercalative alkylating and oxidizing agents of DNA through photooxidations using gamma-ray. |
| PubMed: | Effect of psoralens on Fenton-like reaction generating reactive oxygen species. |
| PubMed: | A new synthesis of oxadiazole, thiazolidinone, N-phthalimidoamino carbonyl and arylidene derivatives with potential antimicrobial activity. |
| PubMed: | Epoxidation of some natural furocoumarins and furochromones using gamma-ray. |
| PubMed: | Determination of khellin and visnagin in Ammi visnaga fruits by capillary electrophoresis. |
| PubMed: | Furanochromone radical cations: generation, characterization and interaction with DNA. |
| PubMed: | Cardiovascular effects of visnagin on rats. |
| PubMed: | Effects of visnagin on cyclic nucleotide phosphodiesterases and their role in its inhibitory effects on vascular smooth muscle contraction. |
| PubMed: | Inhibition of metabolic activation of the promutagens, benzo[a]pyrene, 2-aminofluorene and 2-aminoanthracene by furanochromones in Salmonella typhimurium. |
| PubMed: | Determination of furanochromones and pyranocoumarins in drugs and Ammi visnaga fruits by combined solid-phase extraction-high-performance liquid chromatography and thin-layer chromatography-high-performance liquid chromatography. |
| PubMed: | Photophysical properties and photobiological activity of the furanochromones visnagin and khellin. |
| PubMed: | Studies on the photobiological activity of two naturally occurring furochromones, visnagin and khellin, in Chlamydomonas reinhardtii. |
| PubMed: | Inhibition of the mutagenicity of 2-nitrofluorene, 3-nitrofluoranthene and 1-nitropyrene by flavonoids, coumarins, quinones and other phenolic compounds. |
| PubMed: | Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. |
| PubMed: | Vasodilator effects of visnagin in isolated rat vascular smooth muscle. |
| PubMed: | The involvement of a Ca2+ channel blocking mode of action in the pharmacology of Ammi visnaga fruits. |
| PubMed: | Photosensitized cleavage and cross-linking of pBR322 DNA with khellin and visnagin. |
| PubMed: | Improved high-performance liquid chromatographic determination of khellin and visnagin in Ammi visnaga fruits and pharmaceutical formulations. |
| PubMed: | Inhibition of aflatoxin production inAspergillus flavus by natural coumarins and chromones. |
| PubMed: | Photosensitization of DNA of defined sequence by furochromones, khellin and visnagin. |
| PubMed: | High performance liquid chromatographic determinations of khellin, phenobarbitone and dipyrone combination in tablets. |
| PubMed: | Ammi visnaga: Somatic Embryo Induction and Furanochromone Production in Embryos, Seedlings, and Plants. |
| PubMed: | Plant photosensitizers with antiviral properties. |
| PubMed: | The mechanism of antiviral phototoxicity of the furanochromones visnagin and khellin. |
| PubMed: | The mechanisms of interaction between furanochromones and DNA. A heteronuclear Overhauser effect study on the khellin-thymidine model system. |
| PubMed: | [Production of oxygen radicals and the UV spectrum of furanocoumarins]. |
| PubMed: | High performance liquid chromatography analysis of the furanochromones khellin and visnagin in various organs of Ammi visnaga (L.) Lam. at different developmental stages. |
| PubMed: | Differential effects of photoactive furanyl compounds on virus functions. |
| PubMed: | Active oxygen forms in photoreaction between DNA and furanochromones khellin and visnagin. |
| PubMed: | Native American food and medicinal plants, 5. Isolation of the lipid altering visnagin from Musineon divaricatum. |
| PubMed: | Rapid separation and quantitative determination of khellin and visnagin in Ammi visnaga (L.) Lam. fruits by high-performance liquid chromatography. |
| PubMed: | Genotoxicity of the natural furochromones, khellin and visnagin and the identification of a khellin-thymine photoadduct. |
| PubMed: | Simultaneous TLC separation of khellin and visnagin and their assay in Ammi visnaga fruits, extracts, and formulations. |
| PubMed: | The biosynthesis of radioactive khellin and visnagin from C14-acetate by Ammi visnaga plants. |
| PubMed: | The biosynthesis of visnagin from 2-14C-acetate by Ammi visnaga suspension cultures and the metabolism of 14C-visnagin and 14C-khellin by A. visnaga and A. majus. |
| PubMed: | Visnagin: biosynthesis and isolation from Ammi visnagi suspension cultures. |
| PubMed: | [A COLOR REACTION FOR THE IDENTIFICATION OF 2-METHYLCHROMONE AND FOR THE DETECTION OF VISNAGIN]. |
| PubMed: | [Bronchodilatory effects of visnagin]. |
| PubMed: | [Treatment of angina pectoris with visnagin]. |
| PubMed: | [Treatment of angina pectoris with a new principle of ammi visnaga: or visnagin; chemical, pharmacological and clinical study]. |
| PubMed: | New tests for the identification of khellin, visnagin and khellol-glucoside. |
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