tyloxapol
triton A-20
 
Notes:
non-ionic detergent with surface-active properties; incompatible with metals; surfactant also used in inhalation therapy; n1 is from ca vol 90 form index.
  • BOC Sciences
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      Product(s):
      25301-02-4 Tyloxapol 95%
      Tyloxapol, a nonionic liquid polymer, is a surfactant to aid liquefaction.
       
       
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    • Penta International Corporation
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CAS Number: 25301-02-4Picture of molecule3D/inchi
Other(deleted CASRN): 9014-50-0
FDA UNII: Y27PUL9H56
MDL: MFCD00149002
Molecular Weight: 280.40776000
Formula: C17 H28 O3
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 282.30 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 0.001980 mmHg @ 25.00 °C. (est)
Flash Point: > 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w): 4.930 (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
BOC Sciences
For experimental / research use only.
Tyloxapol 95%
Odor: characteristic
Use: Tyloxapol, a nonionic liquid polymer, is a surfactant to aid liquefaction.
Carbosynth
For experimental / research use only.
Tyloxapol
Penta International
TYLOXAPOL USP
Santa Cruz Biotechnology
For experimental / research use only.
Tyloxapol
Sigma-Aldrich: Sigma
For experimental / research use only.
Tyloxapol BioXtra
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50  > 5000 mg/kg
Drugs in Japan Vol. 6, Pg. 467, 1982.

intravenous-mouse LD50  > 3800 mg/kg
Drugs in Japan Vol. 6, Pg. 467, 1982.

oral-mouse LD50  > 10000 mg/kg
Drugs in Japan Vol. 6, Pg. 467, 1982.

intraperitoneal-rat LD50  > 5000 mg/kg
Drugs in Japan Vol. 6, Pg. 467, 1982.

intravenous-rat LD50  1800 mg/kg
Drugs in Japan Vol. 6, Pg. 467, 1982.

oral-rat LD50  > 5000 mg/kg
Drugs in Japan Vol. 6, Pg. 467, 1982.

Dermal Toxicity:
subcutaneous-mouse LD50 > 5000 mg/kg
Drugs in Japan Vol. 6, Pg. 467, 1982.

subcutaneous-rat LD50 > 5000 mg/kg
Drugs in Japan Vol. 6, Pg. 467, 1982.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: pharmaceuticals / chemical synthisis
Recommendation for tyloxapol usage levels up to:
 not for fragrance use.
 
Recommendation for tyloxapol flavor usage levels up to:
 not for flavor use.
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Safety References:
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 71388
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 formaldehyde;oxirane;4-(2,4,4-trimethylpentan-2-yl)phenol
Chemidplus: 0025301024
RTECS: SM9750000 for cas# 25301-02-4
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References:
 formaldehyde;oxirane;4-(2,4,4-trimethylpentan-2-yl)phenol
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 25301-02-4
Pubchem (cid): 71388
Pubchem (sid): 135029958
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 3402.90.3000
ChemSpider: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 alevaire
 enuclene
 exosurf
 formaldehyde;oxirane;4-(2,4,4-trimethylpentan-2-yl)phenol
 macrocyclon
 superinone
 superiuone
 triton A-20
 triton WR 1339
 triton WR-1339
 tyloxypal
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Articles:
PubMed: Hippocampal lipoprotein lipase regulates energy balance in rodents.
PubMed: In vitro antioxidant and antihyperlipidemic activities of Toddalia asiatica (L) Lam. leaves in Triton WR-1339 and high fat diet induced hyperlipidemic rats.
PubMed: The effects of the decaffeination of coffee samples on platelet aggregation in hyperlipidemic rats.
PubMed: Acute central neuropeptide Y administration increases food intake but does not affect hepatic very low-density lipoprotein (VLDL) production in mice.
PubMed: Central nervous system neuropeptide Y signaling modulates VLDL triglyceride secretion.
PubMed: Glycoprotein (90 kDa) isolated from Opuntia ficus-indica var. saboten MAKINO lowers plasma lipid level through scavenging of intracellular radicals in Triton WR-1339-induced mice.
PubMed: Oligomerization state-dependent hyperlipidemic effect of angiopoietin-like protein 4.
PubMed: CP-346086: an MTP inhibitor that lowers plasma cholesterol and triglycerides in experimental animals and in humans.
PubMed: Hypolipidaemic activity of seaweed from Karachi coast.
PubMed: Surfactant-enhanced biodegradation of high molecular weight polycyclic aromatic hydrocarbons by stenotrophomonas maltophilia
PubMed: Alimentary lipemia is enhanced in fiber-fed rats.
PubMed: From the Food and Drug Administration.
PubMed: Voluntary food consumption and gastric emptying in rats given intravenous Triton WR-1339.
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