tromethamine
methylamine, 1,1,1-tris(hydroxymethyl)-
 
Notes:
an organic amine proton acceptor. it is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. (from merck, 11th ed; martindale, the extra pharmacopoeia, 30th ed, p1424)
  • BOC Sciences
    • BOC Sciences
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      Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
      BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services.
      BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies.
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      Product(s):
      77-86-1 Trometamol >98%
      Trometamol is a proton acceptor used to treat acidemia.
       
       
  • ECSA Chemicals
    • ECSA Chemicals
      Human Chemistry
      ECSA Chemicals has been active since 1913 in the trading and international commerce of raw materials. With an organisation divided into industrial segments managed by specialists, it has become one of the largest distributors worldwide.
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      Established in 1913 as a small grocery store, in its over 100 years of activity ECSA Chemicals has become one of the most important Swiss-owned distributors of chemical products. The company, which is active in international distribution and trading, is organised into industrial segments that are managed by teams of specialists and experts. They guarantee professional and customised consultancy and services. With our experience, we can rapidly and safely connect you with the best suppliers on the market, providing you with a complete search, consulting and assistance service. The focus of our approach and operations is you, our customers. We strive every day to find the best products that satisfy your needs as quickly as possible. Your satisfaction is our greatest success. WHY CHOOSE ECSA? EXPERIENCE We have been working for 100 years. QUALITY We have obtained many certifications (ISO, SQAS, GDP, Responsible Care, Bio-Inspecta, RSPO, etc.). We guarantee full compliance with the current laws and continuous training for our staff. SAFETY We constantly carry out risk analyses for each infrastructure, defining safety levels and implementing corrective measures promptly wherever they are needed. WIDESPREAD DISTRIBUTION We have warehouses in strategic locations to supply goods to Switzerland and to the rest of the world. STORAGE CAPACITY The 3 ECSA-owned warehouses guarantee considerable storage area and capacity in each warehouse, with full availability of products (base chemicals and speciality chemicals). SPEED Presence all over the country, staff dedicated to sourcing raw materials and considerable storage capacity guarantee that goods are rapidly obtained and supplied. CONSULTANCY Our specialists - in-depth knowledge of the market and products allows us to provide full consulting services, from the purchase to the supply of raw materials.
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      Product(s):
      RE-489983 TRIS (HYDROXYMETHYL)-AMINOMETHANE RPE-FOR AN
       
  • Glentham Life Sciences
Synonyms   Articles   Notes   Search
CAS Number: 77-86-1Picture of molecule3D/inchi
Other(deleted CASRN): 108195-86-4
ECHA EINECS - REACH Pre-Reg: 201-064-4
FDA UNII: 023C2WHX2V
Nikkaji Web: J4.214E
Beilstein Number: 741883
MDL: MFCD00004679
XlogP3-AA: -2.90 (est)
Molecular Weight: 121.13627000
Formula: C4 H11 N O3
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: buffering agents and neutralizing agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 171.00 to  172.00 °C. @ 760.00 mm Hg
Boiling Point: 357.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 0.000001 mmHg @ 25.00 °C. (est)
Flash Point: 337.00 °F. TCC ( 169.70 °C. ) (est)
logP (o/w): -2.515 (est)
Soluble in:
 water, 550000 mg/L @ 25 °C (exp)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: buffering agents
fragrance
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Suppliers:
BOC Sciences
For experimental / research use only.
Trometamol >98%
Odor: characteristic
Use: Trometamol is a proton acceptor used to treat acidemia.
Dow Chemical
TRIS AMINO™
ECSA Chemicals
TRIS (HYDROXYMETHYL)-AMINOMETHANE RPE-FOR AN
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
EMD Millipore
For experimental / research use only.
Tris(hydroxymethyl)aminomethane
Glentham Life Sciences
TRIS Ultrapure, 99.9%, Ph. Eur. grade
Glentham Life Sciences
TRIS
Santa Cruz Biotechnology
For experimental / research use only.
Tris base ≥99%
Sigma-Aldrich
For experimental / research use only.
Tris(hydroxymethyl)aminomethane ACS reagent, ≥99.8%
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  5900 mg/kg
Bollettino Chimico Farmaceutico. Vol. 110, Pg. 653, 1971.

intravenous-rat LD50  1800 mg/kg
Drugs in Japan Vol. -, Pg. 419, 1990.

intravenous-mouse LD50  1210 mg/kg
Acta Biologica et Medica Germanica. Vol. 17, Pg. 217, 1966.

oral-rabbit LDLo  1000 mg/kg
BEHAVIORAL: COMA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS
Journal of Industrial Hygiene and Toxicology. Vol. 22, Pg. 315, 1940.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: buffering agents and neutralizing agents
Recommendation for tromethamine usage levels up to:
 not for fragrance use.
 
Recommendation for tromethamine flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
ClinicalTrials.gov: search
Daily Med: search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 77-86-1
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 6503
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 1
 2-amino-2-(hydroxymethyl)propane-1,3-diol
Chemidplus: 0000077861
RTECS: TY2900000 for cas# 77-86-1
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References:
 2-amino-2-(hydroxymethyl)propane-1,3-diol
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 77-86-1
Pubchem (cid): 6503
Pubchem (sid): 134972802
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C07182
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2922.19.5000
ChemSpider: View
Wikipedia: View
Formulations/Preparations:
•tromethamine formulations: parenteral injection 36 mgml (18 g) tham, hospira. •tromethamine, nf (tham), is avail as 0.3 molar soln adjusted to ph 8.6 with acetic acid. it is also supplied as powder (tham-e) to be dissolved in 1 l of sterile water. each l contains 300 mmoles (36 g) of tromethamine, 30 mmoles of sodium chloride, & 5 mmoles of potassium chloride.
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 buffering agents 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
2-amino-2-(hydroxymethyl)-1,3-propane diol
2-amino-2-(hydroxymethyl)-1,3-propanediol
2-amino-2-(hydroxymethyl)propan-1,3-diol
2-amino-2-(hydroxymethyl)propane-1,3-diol
2-amino-2-hydroxymethyl-1,3-propanediol
2-amino-2-hydroxymethylpropane-1,3-diol
2-amino-2-methylol-1,3-propanediol
 aminotris(hydroxymethyl)methane
tris(hydroxymethyl) aminomethane
2-(hydroxymethyl)-2-amino-1,3-propanediol
1,1,1-tris(hydroxymethyl)-methanamine
tris(hydroxymethyl)aminomethane ACS
1,1,1-tris(hydroxymethyl)methanamine
tris(hydroxymethyl)methanamine
1,1,1-tris(hydroxymethyl)methylamine
tris(hydroxymethyl)methylamine
tris(hydroxymethyly)amino methane
 methanamine, 1,1,1-tris(hydroxymethyl)-
 methylamine, 1,1,1-tris(hydroxymethyl)-
1,3-propanediol, 2-amino-2- (hydroxymethyl)-
1,3-propanediol, 2-amino-2-(hydroxymethyl)-
 tri(hydroxymethyl)aminomethane
 trimethylol aminomethane
 tris amino
 trometamol
 trometamole
 tromethamolum
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PubMed: Assay of bradykinin metabolites in human body fluids by CE-LIF coupled with transient ITP preconcentration.
PubMed: Ocular permeation and inhibition of retinal inflammation: an examination of data and expert opinion on the clinical utility of nepafenac.
PubMed: [Change of glucose transporter 4 and its influence on glucose and fatty-acid metabolism in type 2 diabetic myocardium].
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PubMed: Process development for heme-enriched peptide by enzymatic hydrolysis of hemoglobin.
PubMed: A convenient one-step extraction of cellular ATP using boiling water for the luciferin-luciferase assay of ATP.
PubMed: Direct compression tablets containing a series of four beta-cyclodextrin complexes formed by neutralizing an acidic drug.
PubMed: Retrospective case-control evaluation of the use of parenteral ketorolac tromethamine in patients after surgery.
PubMed: The effect of food and an antacid on the bioavailability of dexketoprofen trometamol.
PubMed: Response of Salmonella choleraesuis LT2 spheroplasts and permeabilized cells to the bacteriocin AS-48.
PubMed: Comparative effects of ketorolac 0.5% or diclofenac 0.1% ophthalmic solutions on inflammation after cataract surgery.
PubMed: Single-dose treatment of acute cystitis with fosfomycin tromethamine.
PubMed: Prolonged central intravenous ketorolac continuous infusion in a cancer patient with intractable bone pain.
PubMed: New therapeutic agents marketed in 1993.
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PubMed: Comparison of a prostaglandin-F2alpha-based reproductive program with an estrus detection-based reproductive program on a large commercial dairy herd.
PubMed: Management of low back pain by analgesics and adjuvant drugs.
PubMed: Ketorolac tromethamine pharmacokinetics and metabolism after intravenous, intramuscular, and oral administration in humans and animals.
PubMed: Relative bioavailability of fosfomycin and of trometamol after administration of single dose by oral route of fosfomycin trometamol in fasting conditions and after a meal.
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PubMed: New drugs and new treatments.
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