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Category: solvents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless to pale yellow clear liquid (est) |
| Assay: | 98.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.46300 @ 25.00 °C.
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| Melting Point: | 87.00 to 88.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 87.20 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 69.000000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 54.00 °F. TCC ( 12.10 °C. ) (est)
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| logP (o/w): | 2.420 |
| Soluble in: |
| | water, 1280 mg/L @ 25 °C (exp) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 4920 mg/kg Industrial Health. Vol. 32, Pg. 145, 1994.
intraperitoneal-rat LD50 1282 mg/kg Environmental Research. Vol. 40, Pg. 411, 1986.
oral-cat LDLo 5864 mg/kg "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 76, 1959.
intraperitoneal-dog LD50 1900 mg/kg LIVER: LIVER FUNCTION TESTS IMPAIRED Toxicology and Applied Pharmacology. Vol. 10, Pg. 119, 1967.
intravenous-dog LDLo 150 mg/kg Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934.
oral-human LDLo 7000 mg/kg Archives of Toxicology. Vol. 35, Pg. 295, 1976.
oral-man TDLo 1 mL/kg BEHAVIORAL: COMA
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: TREMOR Toxicological Sciences. Vol. 41, Pg. 157, 1998.
oral-man TDLo 2143 mg/kg GASTROINTESTINAL: OTHER CHANGES "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 602, 1969.
intravenous-mouse LD50 33900 ug/kg "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 6, Pg. 141, 1954.
oral-mouse LD50 2402 mg/kg BEHAVIORAL: ATAXIA
SKIN AND APPENDAGES (SKIN): HAIR: OTHER
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) National Technical Information Service. Vol. AD-A080-636
oral-rabbit LDLo 7330 mg/kg "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 76, 1959.
intratracheal-rat LDLo 150 mg/kg National Technical Information Service. Vol. OTS0520615
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| Dermal Toxicity: |
subcutaneous-dog LDLo 150 mg/kg "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 76, 1959.
subcutaneous-mouse LD50 16000 mg/kg BEHAVIORAL: ATAXIA
BEHAVIORAL: SLEEP Journal of Pharmacology and Experimental Therapeutics. Vol. 123, Pg. 224, 1958.
skin-rabbit LD50 > 20000 mg/kg National Technical Information Service. Vol. AD-A062-138
subcutaneous-rabbit LDLo 1800 mg/kg Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934.
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| Inhalation Toxicity: |
inhalation-mouse LC50 8450 ppm/4H Acta Pharmacologica et Toxicologica. Vol. 9, Pg. 303, 1953.
inhalation-cat LCLo 32500 mg/m3/2H PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
BEHAVIORAL: GENERAL ANESTHETIC
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Archiv fuer Hygiene und Bakteriologie. Vol. 116, Pg. 131, 1936.
inhalation-guinea pig LCLo 37200 ppm/40M "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 76, 1959.
inhalation-human TCLo 160 ppm/83M BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" American Industrial Hygiene Association Journal. Vol. 23, Pg. 167, 1962.
inhalation-human TCLo 500 ppm/16.1Y- KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI
KIDNEY, URETER, AND BLADDER: PROTEINURIS Archives of Toxicology. Vol. 73, Pg. 246, 1999.
inhalation-human TCLo 812 mg/kg GASTROINTESTINAL: OTHER CHANGES
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED" British Medical Journal. Vol. 2, Pg. 689, 1945.
inhalation-human TCLo 6900 mg/m3/10M BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Archiv fuer Hygiene und Bakteriologie. Vol. 116, Pg. 131, 1936.
inhalation-man LCLo 2900 ppm New Zealand Medical Journal. Vol. 50, Pg. 119, 1951.
inhalation-man TCLo 110 ppm/8H BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE British Journal of Industrial Medicine. Vol. 28, Pg. 293, 1971.
inhalation-rabbit LCLo 11000 ppm FAO Nutrition Meetings Report Series. Vol. 48A, Pg. 121, 1970.
inhalation-rat LCLo 4800 ppm/4H AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 469, 1951.
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Safety in Use Information:
| Category: | solvents |
| Recommendation for trichloroethylene usage levels up to: | | | not for fragrance use.
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| Recommendation for trichloroethylene flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| UM BBD: | Search |
| KEGG (GenomeNet): | C06790 |
| HMDB (The Human Metabolome Database): | HMDB29593 |
| FooDB: | FDB000752 |
| Export Tariff Code: | 2903.22.0000 |
| ChemSpider: | View |
| Wikipedia: | View |
Formulations/Preparations: •medicinal trichloroethylene may contain thymol as a preservative; industrial grades may contain stabilizers, such as triethylamine.
•grades: usp; technical; high purity; electronic; metal degreasing; extraction.
•trichloroethylene is available in the usa in high-purity, electronic usp, technical, metal degreasing and extraction grades
•commercial grades of trichloroethylene, formulated to meet use requirements, differ in the amount and type of added inhibitor. typical grades contain >99% trichloroethylene; they include a neutrally inhibited vapor-degreasing grade and a technical grade for use in formulations.
•stabilizers that have been used in formulations of trichloroethylene include neutral inhibitors and free-radical scavengers, amyl alcohol, n-propanol, isobutanol, 2-pentanol, diethylamine, triethylamine, dipropylamine, diisopropylamine, diethanolamine, triethanolamine, morpholine, n-methylmorpholine, aniline, acetone, ethyl acetate, borate esters, ethylene oxide, propylene oxide, 1,2-epoxybutane, cyclohexene oxide, butadiene dioxide, styrene oxide, pentene oxide, 2,3-epoxy-1-propenol, 3-methoxy-1,2-epoxypropane, stearates, 2,2,4-trimethyl-1-pentene, 2-methyl-1,2-epoxypropanol, epoxycyclopentanol, epichlorohydrin, tetrahydrofuran, tetrahydropyran, 1,4-dioxane, dioxalane, trioxane, alkoxyaldehyde hydrazones, methyl ethyl ketone, nitromethanes, nitropropanes, phenol, ortho-cresol, thymol, para-tert-butylphenol, para-tert-amylphenol, isoeugenol, pyrrole, n-methylpyrrole, n-ethylpyrrole, (2-pyrryl)trimethylsilane, glycidyl acetate, isocyanates and thiazoles.
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Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 1- | chloro-2,2-dichloroethylene | | 1,1- | dichloro-2-chloroethylene | | | ethene, 1,1,2-trichloro- | | | ethylene trichloride | | | trichloroethene | | 1,1,2- | trichloroethene | | 1,1,2- | trichloroethylene | | 1,2,2- | trichloroethylene | | | trilene |
Articles:
| PubMed: | The Potential of the Ni-Resistant TCE-Degrading Pseudomonas putida W619-TCE to Reduce Phytotoxicity and Improve Phytoremediation Efficiency of Poplar Cuttings on A Ni-TCE Co-Contamination. |
| PubMed: | "Cutaneous adverse drug reactions" are not always drug-induced. |
| PubMed: | Ultra sound assisted one step rapid derivatization and dispersive liquid-liquid microextraction followed by gas chromatography-mass spectrometric determination of amino acids in complex matrices. |
| PubMed: | Protistan predation affects trichloroethene biodegradation in a bedrock aquifer. |
| PubMed: | Solvent tolerance acquired by Brevibacillus brevis during an olive-waste vermicomposting process. |
| PubMed: | The use of nonregular fractional factorial designs in combination toxicity studies. |
| PubMed: | Effect of trichloroethylene (TCE) toxicity on the enzymes of carbohydrate metabolism, brush border membrane and oxidative stress in kidney and other rat tissues. |
| PubMed: | Risk assessment of exposure to volatile organic compounds in groundwater in Taiwan. |
| PubMed: | Insight into the variation in calculated human exposure to soil contaminants using seven different European models. |
| PubMed: | Uses of and exposure to trichloroethylene in U.S. industry: a systematic literature review. |
| PubMed: | Use of beer bran as an adsorbent for the removal of organic compounds from wastewater. |
| PubMed: | Continuous treatment of gas-phase trichloroethylene by Burkholderia cepacia G4 in a two-stage continuous stirred tank reactor/trickling biofilter system. |
| PubMed: | Biochemical reaction network modeling: predicting metabolism of organic chemical mixtures. |
| PubMed: | An ecological study of the association of environmental chemicals on breast cancer incidence in Texas. |
| PubMed: | [Two-dimensional electrophoresis and mass spectrometry analysis on effects of trichloroethylene on protein of L-02 liver cells]. |
| PubMed: | Analysis of dichloroacetic acid in rat blood and tissues by hydrophilic interaction liquid chromatography with tandem mass spectrometry. |
| PubMed: | Liver regeneration: a critical toxicodynamic response in predictive toxicology. |
| PubMed: | Final report of the amended safety assessment of Dioscorea Villosa (Wild Yam) root extract. |
| PubMed: | A search for residual behavioral effects of trichloroethylene (TCE) in rats exposed as young adults. |
| PubMed: | Acrylamide and cancer risk--expert risk assessments and the public debate. |
| PubMed: | Toxicokinetics of chloral hydrate in ad libitum-fed, dietary-controlled, and calorically restricted male B6C3F1 mice following short-term exposure. |
| PubMed: | Development and operation of a trickling biofilter system for continuous treatment of gas-phase trichloroethylene. |
| PubMed: | Lipid peroxidation and cell death mechanisms in rats and human cells induced by chloral hydrate. |
| PubMed: | Solanidine hydrolytic extraction and separation from the potato (Solanum tuberosum L.) vines by using solid-liquid-liquid systems. |
| PubMed: | The use of in vitro metabolic parameters and physiologically based pharmacokinetic (PBPK) modeling to explore the risk assessment of trichloroethylene. |
| PubMed: | Potential food contaminants and associated health risks. |
| PubMed: | Modelling the responses to biological reactive intermediates: establishing the borderlines of risk. |
| PubMed: | Sorption and biodegradation of vapor-phase organic compounds with wastewater sludge and food waste compost. |
| PubMed: | Guar gum reduces trichloroethylene accumulation in the body by reducing TCE absorption and fat tissue mass. |
| PubMed: | Efficiency of rice bran for removal of organochlorine compounds and benzene from industrial wastewater. |
| PubMed: | Studies on defatted seed removal efficiency for organochlorine compounds. |
| PubMed: | [Prevention of renal carcinoma: the nutri-genetic approach]. |
| PubMed: | Cytotoxicity of MEIC Chemicals Nos. 11-30 in 3T3 Mouse Fibroblasts with and without Microsomal Activation. |
| PubMed: | Behavioral components of tolerance to repeated inhalation of trichloroethylene (TCE) in rats. |
| PubMed: | Cubé resin insecticide: identification and biological activity of 29 rotenoid constituents. |
| PubMed: | National Human Exposure Assessment Survey (NHEXAS): distributions and associations of lead, arsenic and volatile organic compounds in EPA region 5. |
| PubMed: | Effects of sodium alginate and fish oil to reduce trichloroethylene accumulation in rats. |
| PubMed: | Estimation of toxicity of chemical mixtures through modeling of chemical interactions. |
| PubMed: | Shoddy practices shut down oxygen supplier. |
| PubMed: | Trichloroethene and tetrachloroethene in ground waters of Zagreb, Croatia. |
| PubMed: | Concentration-time relationships for the effects of inhaled trichloroethylene on signal detection behavior in rats. |
| PubMed: | Development of a priority list of chemical mixtures occurring at 1188 hazardous waste sites, using the HazDat database. |
| PubMed: | Toxicity of mixtures of nephrotoxicants with similar or dissimilar mode of action. |
| PubMed: | Economical designs for detecting and characterizing departure from additivity in mixtures of many chemicals. |
| PubMed: | Characterization of presystemic elimination of trichloroethylene and its nonlinear kinetics in rats. |
| PubMed: | Continuous degradation of trichloroethylene by Xanthobacter sp. strain Py2 during growth on propene. |
| PubMed: | Population-based exposure measurements in EPA region 5: a phase I field study in support of the National Human Exposure Assessment Survey. |
| PubMed: | An epidemic in Cuba of optic neuropathy, sensorineural deafness, peripheral sensory neuropathy and dorsolateral myeloneuropathy. |
| PubMed: | Should chloral hydrate be banned? |
| PubMed: | Assessment of exposure to trichloroethylene and tetrachloroethylene in the population of Zagreb, Croatia. |
| PubMed: | Consideration of the target organ toxicity of trichloroethylene in terms of metabolite toxicity and pharmacokinetics. |
| PubMed: | Uptake by foods of tetrachloroethylene, trichloroethylene, toluene, and benzene from air. |
| PubMed: | Health assessment of hazardous air pollutants The Netherlands. |
| PubMed: | NTP Carcinogenesis Studies of Trichloroethylene (Without Epichlorohydrin) (CAS No. 79-01-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies). |
| PubMed: | Rapid gas-chromatographic determination of trichloroethylene and/or tetrachloroethylene in lettuce by direct head-space analysis. |
| PubMed: | [Trichloroethylene poisoning. Presentation of 3 cases and review of the literature]. |
| PubMed: | Determination of fumigants in cereals and cereal products by capillary gas chromatography. |
| PubMed: | Rapid determination of fumigant and industrial chemical residues in food. |
| PubMed: | Residues of volatile halocarbons in margarines. |
| PubMed: | Issues and current applications of interspecies extrapolation of carcinogenic potency as a component of risk assessment. |
| PubMed: | Determining multifumigants in whole grains and legumes, milled and low-fat grain products, spices, citrus fruit, and beverages. |
| PubMed: | The in vivo-in vitro hepatocyte assay for assessing DNA repair and DNA replication: studies in the CD-1 mouse. |
| PubMed: | Purge and trap method for determination of volatile halocarbons and carbon disulfide in table-ready foods. |
| PubMed: | Unpredictability: an essay in toxicology. |
| PubMed: | [Effects of one-day food restriction on the metabolism and toxicity of organic solvents in rats]. |
| PubMed: | Human exposure to volatile halogenated hydrocarbons from the general environment. |
| PubMed: | Enhanced metabolism of volatile hydrocarbons in rat liver following food deprivation, restricted carbohydrate intake, and administration of ethanol, phenobarbital, polychlorinated biphenyl and 3-methylcholanthrene: a comparative study. |
| PubMed: | Neurophysiological and psychological disorders and occupational exposure to organic solvents. |
| PubMed: | Personal exposure to volatile organic compounds. I. Direct measurements in breathing-zone air, drinking water, food, and exhaled breath. |
| PubMed: | Human exposure to potentially carcinogenic compounds. |
| PubMed: | Chlorinated aliphatic hydrocarbons used in the foods industry: the comparative pharmacokinetics of methylene chloride, 1,2 dichloroethane, chloroform and trichloroethylene after I.V. administration in the rat. |
| PubMed: | Modification of the AOAC method for determination of fumigants in wheat. |
| PubMed: | [Comparison of 4 methods of determination of fat in cooked meals]. |
| PubMed: | Trichloroethylene: hepatic effects, metabolism and elimination. |
| PubMed: | Electrical self-stimulation of the brain: a model for the behavioral evaluation of toxic agents. |
| PubMed: | Gas chromatographic determination of residual methylene chloride and trichloroethylene in decaffeinated instant and ground coffee with electrolytic conductivity and electron capture detection. |
| PubMed: | Trichloroethylene. I. An overview. |
| PubMed: | Determination of hexachloro-1,3-butadiene in spinach, eggs, fish, and milk by electron capture gas-liquid chromatography. |
| PubMed: | Carcinogenesis bioassay of trichloroethylene. |
| PubMed: | Behavioral toxicology in the evaluation of food safety. |
| PubMed: | Determination of methylene chloride, ethylene dichloride, and trichloroethylene as solvent residues in spice oleoresins, using vacuum distillation and electron capture gas chromatography. |
| PubMed: | The temperature effect on fumigant descrption from cereal grain. |
| PubMed: | Separation of permitted and non-permitted solvents for use in foodstuffs by gas chromatography and the use of a solid sampler for the estimation of residual solvents in oils and oleoresins. |
| PubMed: | Trichloroethylene effects on animal behavior. The effects of trichloroethylene vapors on a food motivated conditioned climbing reaction of rats. |
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