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Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.17400 @ 25.00 °C.
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| Melting Point: | 24.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 222.05 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.104000 mmHg @ 25.00 °C. (est) |
| Flash Point: | > 230.00 °F. TCC ( > 110.00 °C. )
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| logP (o/w): | 1.645 (est) |
| Soluble in: |
| | water, 1867 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LDLo 250 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
BEHAVIORAL: COMA Proceedings of the Society for Experimental Biology and Medicine. Vol. 115, Pg. 198, 1964.
intraperitoneal-rat LD50 350 mg/kg Bollettino Chimico Farmaceutico. Vol. 112, Pg. 53, 1973.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis |
| Recommendation for thiobenzoic acid usage levels up to: | | | not for fragrance use.
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| Recommendation for thiobenzoic acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | benzenecarbothioic acid | | | benzenecarbothioic S-acid | | | benzoic acid, thio- |
Articles:
| US Patents: | 3,931,270 - Process for producing 2-thia substituted 1,4 diones |
| PubMed: | Role of keto-enol tautomerization in a chiral phosphoric acid catalyzed asymmetric thiocarboxylysis of meso-epoxide: a DFT study. |
| PubMed: | Facile Access to 5'-S-(4,4'-Dimethoxytrityl)-2',5'-Dideoxyribonucleosides via Stable Disulfide Intermediates. |
| PubMed: | Synthesis and structures of cadmium carboxylate and thiocarboxylate compounds with a sulfur-rich coordination environment: carboxylate exchange kinetics involving tris(2-mercapto-1-t-butylimidazolyl)hydroborato cadmium complexes, [Tm(Bu(t))]Cd(O2CR). |
| PubMed: | Far- and near-field properties of gold nanoshells studied by photoacoustic and surface-enhanced Raman spectroscopies. |
| PubMed: | Simultaneous solid phase extraction and derivatization of aliphatic primary amines prior to separation and UV-absorbance detection. |
| PubMed: | Novel o-naphthoquinones induce apoptosis of EL-4 T lymphoma cells through the increase of reactive oxygen species. |
| PubMed: | Synthesis, spectroscopic, thermal and antimicrobial studies of toluene-3,4-dithiolatoarsenic(III) derivatives with some oxygen and sulphur donor ligands. |
| PubMed: | A SABATH Methyltransferase from the moss Physcomitrella patens catalyzes S-methylation of thiols and has a role in detoxification. |
| PubMed: | New chemotypes acting as isozyme-selective carbonic anhydrase inhibitors with low affinity for the offtarget cytosolic isoform II. |
| PubMed: | Fabrication of nano-indented cavities on Au for the detection of chemically-adsorbed DTNB molecular probes through SERS effect. |
| PubMed: | Biotransformation of prasugrel, a novel thienopyridine antiplatelet agent, to the pharmacologically active metabolite. |
| PubMed: | Synthesis and characterization of toluene-3,4-dithiolatoantimony(III) derivatives with some oxygen and/or sulphur donor ligands. |
| PubMed: | Linker effects on monolayer formation and long-range electron transfer in helical peptide monolayers. |
| PubMed: | Anti-VEGF receptor antagonist (VGA1155) reduces infarction in rat permanent focal brain ischemia. |
| PubMed: | Cytotoxicity of triorganophosphinegold(i) complexes of thiobenzoate. |
| PubMed: | Determination of total and oxidized glutathione in human whole blood with a sequential injection analysis system. |
| PubMed: | Expeditious synthesis of steroids containing a 2-methylsulfanyl-acetyl side chain as potential glucocorticoid receptor imaging agents. |
| PubMed: | Colorimetric activity measurement of a recombinant putrescine N-methyltransferase from Datura stramonium. |
| PubMed: | Towards high capacity latex-coated porous polymer monoliths as ion-exchange stationary phases. |
| PubMed: | NMR spectra and dynamics of the sodium salt of per(6-thiobenzoic acid)-gamma-cyclodextrin. |
| PubMed: | 11C-Radiosynthesis and preliminary human evaluation of the disposition of the ACE inhibitor [11C]zofenoprilat. |
| PubMed: | A stereospecific colorimetric assay for (S,S)-adenosylmethionine quantification based on thiopurine methyltransferase-catalyzed thiol methylation. |
| PubMed: | Hydrogen peroxide-induced apoptosis of HL-60 human leukemia cells is mediated by the oxidants hypochlorous acid and chloramines. |
| PubMed: | Differential regulation of three catalytic activities of platelet-activating factor (PAF)-dependent transacetylase. |
| PubMed: | Fluorescence characterization of structural transitions at the strong actin binding motif in skeletal myosin affinity labeled at cysteine 540 with novel spectroscopic cysteaminyl mixed disulfides. |
| PubMed: | Quenching of beta-lactoglobulin fluorescence by 2-nitro-5-thiobenzoic acid. |
| PubMed: | Detection of nucleotide- and F-actin-induced movements in the switch II helix of the skeletal myosin using its differential oxidative cleavage mediated by an iron-EDTA complex disulfide-linked to the strong actin binding site. |
| PubMed: | Preparation of 2-nitro-5-thiobenzoic acid using immobilized Tris(2-carboxyethyl)phosphine. |
| PubMed: | Interaction of nitric oxide with 2-thio-5-nitrobenzoic acid: implications for the determination of free sulfhydryl groups by Ellman's reagent. |
| PubMed: | Roles for the two cysteine residues of AhpC in catalysis of peroxide reduction by alkyl hydroperoxide reductase from Salmonella typhimurium. |
| PubMed: | Determination of the myeloperoxidase-hydrogen peroxide-halide system activity following the respiratory burst of human neutrophils. |
| PubMed: | Analysis of disulfide-linked homo- and hetero-peptide dimers with a strong cation-exchange sulfoethyl aspartamide column. |
| PubMed: | Labeling of cysteine-containing peptides with 2-nitro-5-thiobenzoic acid. |
| PubMed: | Evidence for distinct sulfhydryl groups associated with steroid- and DNA-binding domains of rat thymus glucocorticoid receptors. |
| PubMed: | Inhibition of anion transport in human red blood cells by 5,5'-dithiobis(2-nitrobenzoic acid). |
| PubMed: | Crosslinking by thiol disulfide interchange of 5,5'-dithiobis(2-nitrobenzoic acid)-treated light chain and heavy chain of rabbit skeletal myosin. |
| PubMed: | Spectrophotometric determination of bromopyruvate by reaction with 2-nitro-5-thiobenzoic acid. |
| PubMed: | Aerobic oxidation of p-hydroquinone by horse radish peroxidase in the presence of a thiol and MnCl2. |
| PubMed: | A rapid assay for catechol oxidase and lactase using 2-nitro-5-thiobenzoic acid. |
| PubMed: | Photochemical transformations. XXX. Photolysis of thiobenzoic acid O-esters. I. Photolysis of O-cholesteryl thiobenzoate. |
| PubMed: | Determination of benzoyl bisulphide by desulphurisation and solvolysis. |
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