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Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 134.50 °C. @ 760.00 mm Hg
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| Boiling Point: | 596.99 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 3.240000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 576.00 °F. TCC ( 302.30 °C. ) (est)
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| logP (o/w): | 2.780 |
| Soluble in: |
| | water, 22 mg/L @ 25 °C (exp) | | | water, 28.38 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-human TDLo 5600 mg/kg KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED Journal of Laboratory and Clinical Medicine. Vol. 80, Pg. 224, 1972.
oral-man TDLo 5714 ug/kg/4D- LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)"
BLOOD: CHANGES IN CELL COUNT (UNSPECIFIED)
BLOOD: AGRANULOCYTOSIS Drug Intelligence and Clinical Pharmacy. Vol. 21, Pg. 974, 1987.
oral-man TDLo 7500 ug/kg/3W- BLOOD: AGRANULOCYTOSIS Australian and New Zealand Journal of Medicine. Vol. 30, Pg. 515, 2000.
intraperitoneal-mouse LD50 260 mg/kg Drugs in Japan Vol. 6, Pg. 381, 1982.
intravenous-mouse LD50 260 mg/kg Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967.
oral-mouse LD50 > 1000 mg/kg Journal of Environmental Pathology and Toxicology. Vol. 1(5), Pg. 641, 1978.
intraperitoneal-rabbit LD50 866 mg/kg Journal of Environmental Pathology and Toxicology. Vol. 1(5), Pg. 641, 1978.
oral-rabbit LD50 > 1000 mg/kg Journal of Environmental Pathology and Toxicology. Vol. 1(5), Pg. 641, 1978.
intraperitoneal-rat LD50 277 mg/kg Drugs in Japan Vol. 6, Pg. 381, 1982.
oral-rat LD50 > 1000 mg/kg Drugs in Japan Vol. 6, Pg. 381, 1982.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis |
| Recommendation for spironolactone usage levels up to: | | | not for fragrance use.
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| Recommendation for spironolactone flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 52-01-7 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 5833 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| | S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-yl] ethanethioate |
| Chemidplus: | 0000052017 |
| RTECS: | TU4725000 for cas# 52-01-7 |
References:
| | S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-yl] ethanethioate |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 5833 |
| Pubchem (sid): | 134972759 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C07310 |
| HMDB (The Human Metabolome Database): | Search |
| Export Tariff Code: | 2932.29.5050 |
| MedlinePlusSupp: | View |
| ChemSpider: | View |
| Wikipedia: | View |
Formulations/Preparations: •spironolactone & hydrochlorothiazide: aldactazide (searle). oral: each tablet contains spironolactone 25 mg & hydrochlorothiazide 25 mg.
•oral: tablets, film-coated: 25 mg aldactone (with povidone), (pfizer) spironolactone tablets (mutual), spironolactone tablets (mylan), spironolactone tablets (sandoz), spironolactone tablets (udl), spironolactone tablets, (united research); 50 mg aldactone (with povidone; scored), (pfizer), spironolactone tablets (actavis), spironolactone tablets (mutual), spironolactone tablets (mylan), spironolactone tablets (united research); 100 mg aldactone (with povidone; scored), (pfizer), spironolactone tablets (actavis), spironolactone tablets (mutual), spironolactone tablets (mylan), spironolactone tablets (united research).
•aldactone
•aldactone a
•spiresis
•spiridon
•spirolang
•spirone
•uractone
•verospiron
•verospirone
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Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | abbolactone | | 3'-(3-oxo-7-alpha- | acetyl thio-17-beta-hydroxyandrost-4-en-17-beta-yl) propionic acid lactone | | 7-alpha- | acetyl thio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-carbolactone | | 3-(3-oxo-7a- | acetylthio-17b-hydroxy-4-androsten-17a-yl)propionic acid g-lactone | | (7a,17a)-7-( | acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid g-lactone | | | aldace | | | aldactide | | | aldactone | | | aldopur | | | almatol | | | aquareduct | | | deverol | | | diatensec | | S-[(7R,8R,9S,10R,13S,14S,17R)-10,13- | dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-yl] ethanethioate | | | duraspiron | | | euteberol | | 17- | hydroxy-7a-mercapto-3-oxo-17a-pregn-4-ene-21-carboxylic acid g-lactone acetate | | 17- | hydroxy-7alpha-mercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylic acid gamma-lactone acetate | | | lacalmin | | | lacdene | | | laractone | | | melarcon | | | nefurofan | | | osiren | | | sagisal | | | sincomen | | | spiretic | | | spiridon | | | spiroctanie | | | spiroderm | | | spirolakton | | | spirolone | | | sprioderm | | | supra-puren | | | uractone | | | urusonin | | | verospiron | | | verospirone | | | xenalon |
Articles:
| PubMed: | Serum potassium in stage 5 CKD patients on their first presentation in a dialysis service of a county hospital in western Romania. |
| PubMed: | Ask the doctor. The June 2013 issue states on page 3 that "it's important to increase potassium intake, particularly if you take a diuretic." But on page 5, it says that if you take spironolactone (which I do), you should avoid high-potassium foods. I'm confused--should I be eating bananas and other potassium-rich foods or not? |
| PubMed: | Diuretic Exposure in Premature Infants from 1997 to 2011. |
| PubMed: | A high-throughput chemical screen with FDA approved drugs reveals that the antihypertensive drug Spironolactone impairs cancer cell survival by inhibiting homology directed repair. |
| PubMed: | Use of different parameters and equations for calculation of IC₅₀ values in efflux assays: potential sources of variability in IC₅₀ determination. |
| PubMed: | High salt intake does not produce additional impairment in the coronary artery relaxation of spontaneously hypertensive aged rats. |
| PubMed: | Activation of an apoptotic signal transduction pathway involved in the upregulation of calpain and apoptosis-inducing factor in aldosterone-induced primary cultured cardiomyocytes. |
| PubMed: | Drug-induced gynecomastia. |
| PubMed: | Ethics and eplerenone. |
| PubMed: | 11Beta-hydroxylase deficiency and other syndromes of mineralocorticoid excess as a rare cause of endocrine hypertension. |
| PubMed: | Clinical variability in approaches to polycystic ovary syndrome. |
| PubMed: | The association between drospirenone and hyperkalemia: a comparative-safety study. |
| PubMed: | [Pseudoaldosteronism in an elderly man believed to be caused by the health food Shin-Gojoshin]. |
| PubMed: | Eplerenone prevents salt-induced vascular stiffness in Zucker diabetic fatty rats: a preliminary report. |
| PubMed: | [An elderly man with known heart failure admitted with cardiogenic shock]. |
| PubMed: | Recurrent duodenal ulcer due to nonsteroidal anti-inflammatories following the suspension of antiulcer medication. |
| PubMed: | Should dermatologists prescribe hormonal contraceptives for acne? |
| PubMed: | PCOS. |
| PubMed: | Drug treatments for polycystic ovary syndrome. |
| PubMed: | Risk of hyperkalemia in women taking ethinylestradiol/drospirenone and other oral contraceptives. |
| PubMed: | Management strategies for premenstrual syndrome/premenstrual dysphoric disorder. |
| PubMed: | Influence of spironolactone therapy on thiamine blood levels in patients with heart failure. |
| PubMed: | Effects of a novel Y5 antagonist in obese mice: combination with food restriction or sibutramine. |
| PubMed: | Drospirenone/ethinyl estradiol. |
| PubMed: | Premenstrual syndrome. |
| PubMed: | Heart failure. |
| PubMed: | Effects of eplerenone and salt intake on left ventricular remodeling after myocardial infarction in rats. |
| PubMed: | Reports of hyperkalemia after publication of RALES--a pharmacovigilance study. |
| PubMed: | Treatment of premenstrual disorders. |
| PubMed: | Preclinical development of new drugs that enhance thyroid hormone metabolism and clearance: inadequacy of using rats as an animal model for predicting human risks in an IND and NDA. |
| PubMed: | Agents ameliorating or augmenting the nephrotoxicity of cisplatin and other platinum compounds: a review of some recent research. |
| PubMed: | Bone loss in rats with aldosteronism. |
| PubMed: | Diuretics and bone loss in rats with aldosteronism. |
| PubMed: | Clinical experience with spironolactone in pediatrics. |
| PubMed: | Eplerenone prevents salt-induced vascular remodeling and cardiac fibrosis in stroke-prone spontaneously hypertensive rats. |
| PubMed: | New developments in the management of hypertension. |
| PubMed: | Primary aldosteronism - treatment options. |
| PubMed: | Selective aldosterone blockade reduces mortality after MI. |
| PubMed: | Aldosterone receptor antagonists: focus on eplerenone. |
| PubMed: | Eplerenone. |
| PubMed: | Eplerenone: a new aldosterone receptor antagonist--are the FDAs restrictions appropriate? |
| PubMed: | Functional activities of the colon of the desert gerbil (Gerbillus cheesmani). |
| PubMed: | [Simultaneous analysis of four diuretic drugs by HPLC and its application to health food supplements advertising weight reduction]. |
| PubMed: | Atypical dose-route-dependent food effects of eplerenone in the dog: presence of food effects following intravenous dosing and lack of food effects of following oral dosing. |
| PubMed: | Cardiac damage prevention by eplerenone: comparison with low sodium diet or potassium loading. |
| PubMed: | Serum leptin levels in patients with primary hyperaldosteronism before and after treatment: relationships to insulin sensitivity. |
| PubMed: | Report from the 94th Cardiovascular and Renal Drugs Advisory Committee Meeting, October 11, 2001. |
| PubMed: | Evaluation of a unique oral contraceptive in the treatment of premenstrual dysphoric disorder. |
| PubMed: | Reversal of cardiac and renal fibrosis by pirfenidone and spironolactone in streptozotocin-diabetic rats. |
| PubMed: | Cardiovascular and renal effects of central administration of a mineralocorticoid receptor antagonist in conscious female rats. |
| PubMed: | Rapid and sensitive reporter gene assays for detection of antiandrogenic and estrogenic effects of environmental chemicals. |
| PubMed: | Reversal of cardiac fibrosis in deoxycorticosterone acetate-salt hypertensive rats by inhibition of the renin-angiotensin system. |
| PubMed: | Inhibition of tissue repair by spironolactone: role of mineralocorticoids in fibrous tissue formation. |
| PubMed: | From GnRH to SSRIs and Beyond: Weighing the Options for Drug Therapy in Premenstrual Syndrome. |
| PubMed: | Repeated blockade of mineralocorticoid receptors, but not of glucocorticoid receptors impairs food rewarded spatial learning. |
| PubMed: | Approach to generalized weakness and peripheral neuromuscular disease. |
| PubMed: | Involvement of type I corticosteroid receptor in the effects of ovariectomy on energy balance. |
| PubMed: | Treatment of premenstrual syndrome by spironolactone: a double-blind, placebo-controlled study. |
| PubMed: | Type II corticosteroid receptor stimulation increases NPY gene expression in basomedial hypothalamus of rats. |
| PubMed: | Electrolyte manipulation in female body-builders. |
| PubMed: | Steroids and "the pill": early steroid research at Searle. |
| PubMed: | Dietary restriction sensitizes the rat distal colon to aldosterone. |
| PubMed: | Effect of chronic treatment with clonidine and spironolactone on cold-induced elevation of blood pressure. |
| PubMed: | Aldosterone is a physiologically significant kaliuretic hormone. |
| PubMed: | The metabolism and biopharmaceutics of spironolactone in man. |
| PubMed: | Influence of food on the bioavailability of spironolactone. |
| PubMed: | Salt appetite is suppressed by interference with angiotensin II and aldosterone. |
| PubMed: | Influence of food intake on antihypertensive drugs: spironolactone. |
| PubMed: | Hormonal and metabolic adaptation to protein-supplemented fasting in obese subjects. |
| PubMed: | Therapeutic implications of drug interactions with acetaminophen and aspirin. |
| PubMed: | Metabolic alkalosis in identical twins receiving a low-chloride formula (pseudo-Bartter's syndrome). |
| PubMed: | [Comparative study of relative biovailability of several spironolactone formulations in a steady-state test (author's transl)]. |
| PubMed: | Influence of food on the bioavailability of drugs. |
| PubMed: | Spironolactone: disposition, metabolism, pharmacodynamics, and bioavailability. |
| PubMed: | Enhancement by food of canrenone bioavailability from spironolactone. |
| PubMed: | Spironolactone. III. Canrenone--maximum and minimum steady-state plasma levels. |
| PubMed: | [Contemporary animal nutrition and its potential hazards to human health (author's transl)]. |
| PubMed: | Salt preference in patients with untreated and treated essential hypertension. |
| PubMed: | [Sodium balance during fasting and realimentation with special reference to a form of therapy for obesity]. |
| PubMed: | [Instinctive food selection as a disease-regulating factor]. |
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