Articles:
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chrysazin-3-carboxylic acid
Notes:
Present in Rheum palmatum (Chinese rhubarb)
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BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 478-43-3 Rhein >98% Rhein (Monorhein; NSC 38629; Rheic acid; Rheinic acid) is an anthraquinone compound enriched in the fresh rhizome of Rheum coreanum Nakai, showing anti-inflammation and antitumor activities.
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| CAS Number: | 478-43-3 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 207-521-4 | |
| FDA UNII: | YM64C2P6UX | |
| Nikkaji Web: | J12.584I | |
| Beilstein Number: | 2222155 | |
| MDL: | MFCD00009618 | |
| XlogP3-AA: | 2.20 (est) | |
| Molecular Weight: | 284.22396000 | |
| Formula: | C15 H8 O6 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Appearance: | white powder (est) |
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 321.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 597.00 to 598.00 °C. @ 760.00 mm Hg (est) |
| Flash Point: | 625.00 °F. TCC ( 329.40 °C. ) (est) |
| logP (o/w): | 4.290 (est) |
| Soluble in: | |
| water, 2.448 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| Alfa Biotechnology |
| For experimental / research use only. |
| Rhein 98% |
| BOC Sciences |
| For experimental / research use only. |
| Rhein >98%
Odor: characteristic Use: Rhein (Monorhein; NSC 38629; Rheic acid; Rheinic acid) is an anthraquinone compound enriched in the fresh rhizome of Rheum coreanum Nakai, showing anti-inflammation and antitumor activities. |
| Coompo |
| For experimental / research use only. |
| Rhein from Plants ≥95%
Odor: characteristic Use: Rhein, also known as cassic acid, is a substance in the anthraquinone group.
Rhein has been reevaluated as an antibacterial agent against Staphylococcus aureus in 2008. Synergy or partial synergy has been demonstrated between rhein and the antibiotics oxacillin and ampicillin.
The pharmacokinetics of rhein have not been intensively studied in humans, but at least one study in healthy male volunteers found that rhein was better absorbed from oral administration of rhubarb than from a retention enema. Rhein (at an oral dose of 50 mg twice per day) was shown to be safe when administered for five days to elderly patients with chronic congestive heart failure. |
| ExtraSynthese |
| For experimental / research use only. |
| Rhein (HPLC) ≥99% |
| Sigma-Aldrich: Aldrich |
| For experimental / research use only. |
| Rhein technical grade |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intravenous-mouse LD50 > 25 mg/kg Pharmacology and Toxicology Vol. 61, Pg. 153, 1987. oral-mouse LD50 > 5000 mg/kg Pharmacology and Toxicology Vol. 61, Pg. 153, 1987. | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | natural substances and extractives | ||
| Recommendation for cassic acid usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for cassic acid flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| Chemical Carcinogenesis Research Information System: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 10168 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 2 |
| 4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid | |
| Chemidplus: | 0000478433 |
| EPA/NOAA CAMEO: | hazardous materials |
| RTECS: | CA9516000 for cas# 478-43-3 |
References:
| 4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 10168 |
| Pubchem (sid): | 134973996 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C10401 |
| HMDB (The Human Metabolome Database): | HMDB32876 |
| FooDB: | FDB010856 |
| Export Tariff Code: | 2918.90.4000 |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| rhubarb root Search Trop Picture | |
| rubus spp. Search Trop Picture |
Synonyms:
| 2- | anthracenecarboxylic acid, 9,10-dihydro-4,5-dihydroxy-9, 10-dioxo- |
| 2- | anthracenecarboxylic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo- |
| 2- | anthroic acid, 9,10-dihydro-4,5-dihydroxy-9, 10-dioxo- |
| 2- | anthroic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo- |
| chrysazin-3-carboxylic acid | |
| 9,10- | dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracene carboxylic acid |
| 9,10- | dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid |
| 9,10- | dihydro-4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid |
| 4,5- | dihydroxy-2-anthraquinonecarboxylic acid |
| 1,8- | dihydroxy-3-carboxyanthraquinone |
| 1,8- | dihydroxy-3-carboxyl anthraquinone |
| 1,8- | dihydroxy-3-carboxyl-9,10-anthraquinone |
| 4,5- | dihydroxy-9,10-dioxo-9,10-dihydro-2-anthracenecarboxylic acid |
| 4,5- | dihydroxy-9,10-dioxo-9,10-dihydro-anthracene-2-carboxylic acid |
| 4,5- | dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid |
| 4,5- | dihydroxy-9,10-dioxoanthracene-2-carboxylic acid |
| 4,5- | dihydroxyanthraquinone-2-carboxylic acid |
| 1,8- | dihydroxyanthraquinone-3-carboxylic acid |
| parietic acid | |
| rheic acid | |
| rhein | |
| rhubarb yellow |