Articles:
3,4-pyridinedimethanol, 5-hydroxy-6-methyl-
Notes:
the 4-methanol form of vitamin b 6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. although pyridoxine and vitamin b 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (ee snell; ann ny acad sci, vol 585 pg 1, 1990). Found in rice husks, cane molasses, yeast, wheat germ and cod liver oils. Vitamin, dietary supplement, nutrient
Pyridoxine is one of the compounds that can be called vitamin B6, along with pyridoxal and pyridoxamine. It differs from pyridoxamine by the substituent at the '4' position. It is often used as 'pyridoxine hydrochloride'. (Wikipedia)
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BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 65-23-6 Pyridoxine >98%
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Jiangyin Healthway International Trade Co., Ltd Independent Ingredients Supplier We provide custom synthesis and contract manufacturing from milligrams to metric tonnes. Jiangyin Healthway International Trade Co., Ltd is a professional company, main engaged in manufacturing and exporting aroma chemicals ,food additives , cosmetic ingredient ,pharmaceutical intermediates & other fine chemicals; especially on aroma chemicals , as the major manufacturer of heterocyclic and sulphur aroma compounds , we are the leading independent ingredients supplier to the flavour and fragrance industries in China, can offer hundreds of different high quality aroma chemicals. Email: Info Email: Sales Voice: 86-510-86023169 Fax: 86-510-86023170 Mobile 0086-13093133011 Services Biochemical Natural Food Colour New functional food ingredients Product(s): 127959 Vitamin B6
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OQEMA With a focus on providing the highest level of service OQEMA has established itself at the forefront of the global chemical industry. The guiding principles of OQEMA have always been to establish long term relationships with customers and suppliers alike to build sustainable and profitable business for all parties. Through OQEMA’s business divisions the company tailors products and services to better support and service our customers requirements. This structure also allows the company to focus its marketing campaigns more effectively to certain industries. Over the last decade OQEMA has achieved strong growth as a result of the expansion of our business model. Going forward, the company will be expanding this business model into existing and new strategic territories. Email: Contact Us: US Email: Dean Matienzo Email: Sales US Email: Dean Matienzo - Sales Manager Voice: +44 1993 843081 Fax: +44 1993 841261 US Voice: +1 973 886 3778 US Fax: +1 973 346 1106 Linkedin Website Global Distribution Product(s): Vitamin B6
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| CAS Number: | 65-23-6 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 200-603-0 | |
| FDA UNII: | KV2JZ1BI6Z | |
| Nikkaji Web: | J2.356F | |
| Beilstein Number: | 139854 | |
| MDL: | MFCD00006335 | |
| XlogP3: | -0.80 (est) | |
| Molecular Weight: | 169.18027000 | |
| Formula: | C8 H11 N O3 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: special dietary and nutritional additives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| FDA/DG SANTE Petitions, Reviews, Notices: | |
| 1977 | Pyridoxine View - review |
| FDA Mainterm (SATF): | 65-23-6 ; PYRIDOXINE |
| FDA Regulation: | |
| FDA PART 101 -- FOOD LABELING Subpart A--General Provisions Sec. 101.9 Nutrition labeling of food. | |
Physical Properties:
| Appearance: | white crystalline powder (est) |
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 159.00 to 162.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 491.93 °C. @ 760.00 mm Hg (est) |
| Flash Point: | 484.00 °F. TCC ( 251.30 °C. ) (est) |
| logP (o/w): | -0.770 |
| Soluble in: | |
| water, 2.82e+005 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| CosIng: | cosmetic data |
| Cosmetic Uses: |
antistatic agents hair conditioning skin conditioning |
Suppliers:
| Alfa Biotechnology |
| For experimental / research use only. |
| Pyridoxine 98% |
| BOC Sciences |
| For experimental / research use only. |
| Pyridoxine >98% |
| DSM Nutritional |
| Vitamin B6 |
| EMD Millipore |
| For experimental / research use only. |
| Pyridoxine |
| Farbest-Tallman Foods |
| Pyridoxine 97-98% for DC |
| Foodchem International |
| Vitamin B6 |
| Graham Chemical |
| Vitamine B6 |
| Jiangyin Healthway |
| Vitamin B6 |
| New functional food ingredients |
| Kraft Chemical |
| Vitamin B6 |
| OQEMA |
| Vitamin B6 |
| Prinova |
| Vitamin B6 USP; FCC |
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| Pyridoxine ≥98% |
| Silver Fern Chemical |
| Vitamin B 6 |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
oral-rat LD50 4000 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Proceedings of the Society for Experimental Biology and Medicine. Vol. 43, Pg. 116, 1940. intravenous-rat LD50 657 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Proceedings of the Society for Experimental Biology and Medicine. Vol. 44, Pg. 147, 1940. oral-man TDLo 5143 mg/kg/17W PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC New England Journal of Medicine. Vol. 309, Pg. 445, 1983. intraperitoneal-mouse LD50 966 mg/kg Farmakologiya i Toksikologiya Vol. 40, Pg. 371, 1977. intravenous-mouse LD50 545 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 683, 1960. intraperitoneal-rat LD50 1500 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Proceedings of the European Society for the Study of Drug Toxicity. Vol. 4, Pg. 179, 1964. | |
| Dermal Toxicity: | |
|
subcutaneous-rat LD50 3100 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Proceedings of the Society for Experimental Biology and Medicine. Vol. 43, Pg. 116, 1940. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | special dietary and nutritional additives | ||
| Recommendation for pyridoxine usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for pyridoxine flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| European Food Safety Authority (EFSA) reference(s): | |
| Scientific Opinion on the substantiation of a health claim related to a combination of thiamin, riboflavin, niacin, pantothenic acid, pyridoxine, D-biotin and pumpkin seed oil and maintenance of normal hair pursuant to Article 13(5) of Regulation (EC) No 1924/2006 View page or View pdf | |
| Dietary Reference Values for vitamin B6 View page or View pdf | |
| Outcome of a public consultation on the Draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for vitamin B6 View page or View pdf | |
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 65-23-6 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 1054 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol | |
| Chemidplus: | 0000065236 |
| RTECS: | UV1300000 for cas# 65-23-6 |
References:
| 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 65-23-6 |
| Pubchem (cid): | 1054 |
| Pubchem (sid): | 134972472 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| CHEBI: | View |
| CHEMBL: | View |
| Golm Metabolome Database: | Search |
| Metabolomics Database: | Search |
| UM BBD: | Search |
| KEGG (GenomeNet): | C00314 |
| HMDB (The Human Metabolome Database): | HMDB00239 |
| FooDB: | FDB000574 |
| YMDB (Yeast Metabolome Database): | YMDB00037 |
| Export Tariff Code: | 2936.25.0000 |
| FDA Listing of Food Additive Status: | View |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
| Formulations/Preparations: •bonadoxin an anti-emetic; antispasmodic is mixture of meclizine & pyridoxine hcl. from table •dosage forms: injection usp: 50 & 100 mgml, 500 mg & 1 g10 ml, 3 g30 ml; tablets usp: 10, 25, 50, & 100 mg. •oral capsules, 500 mg, vitamin b-6 capsules, solgar; capsules, extended release, 100 mg, vitamin b-6 t.r. capsules, scherer; 150 mg, rodex(r) t.d., legere; tablets, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 250 mg, 500 mg, and tablets extended release, vitamin b-6 timed tablets, interstate. •parenteral injection, 100 mgml, beesix (r) (with benzyl alcohol), forest; hexa-betalin (r) (with chlorobutanol), lilly; rodex (r), legere. •pyridoxine hydrochloride is also commercially available in combination with other vitamins, minerals, amino acids, antihistamines, cerebral stimulants, enzymes, infant formulas, hormones, laxatives, protein supplements, sedatives, unsaturated fatty acids, and antituberculars. for iv infusion, pyridoxine hydrochloride is also commercially available in combination with other vitamins in caloric and electrolyte solutions. | |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| antistatic agents |
Occurrence (nature, food, other): note
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| bean butter bean seed Search Trop Picture | |
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| bean field bean seed Search Trop Picture | |
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| marango shoot Search Trop Picture | |
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| oat seed Search Trop Picture | |
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| orange fruit Search Trop Picture | |
| papaya fruit Search Trop Picture | |
| parsley plant Search Trop Picture | |
| parsnip root Search Trop Picture | |
| pea black-eyed pea seed Search Trop Picture | |
| pea fruit Search Trop Picture | |
| pea pigeon pea seed Search Trop Picture | |
| pea seed Search Trop Picture | |
| peach fruit Search Trop Picture | |
| peanut seed Search Trop Picture | |
| pear fruit Search Trop Picture | |
| pepper bell pepper fruit Search Trop Picture | |
| peppermint leaf Search Trop Picture | |
| pineapple fruit Search Trop Picture | |
| plum fruit Search Trop Picture | |
| pomegranate fruit Search Trop Picture | |
| poppy opium poppy seed Search Trop Picture | |
| potato sweet potato root Search Trop Picture | |
| potato tuber Search Trop Picture | |
| purslane plant Search Trop Picture | |
| radish root Search Trop Picture | |
| raspberry red raspberry fruit Search Trop Picture | |
| rice seed Search Trop Picture | |
| rosemary leaf Search Trop Picture | |
| rye seed Search Trop Picture | |
| sesame seed Search Trop Picture | |
| soursop fruit Search Trop Picture | |
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| spearmint leaf Search Trop Picture | |
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| squash summer squash fruit Search Trop Picture | |
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| watercress herb Search Trop Picture | |
| wheat seed Search Trop Picture |
Synonyms:
| adermine | |
| 3- | hydroxy-2-picoline-4,5-dimethanol |
| 3- | hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine |
| 3- | hydroxy-4,5-dimethylol-a-picoline |
| 3- | hydroxy-4,5-dimethylol-alpha-picoline |
| 5- | hydroxy-6-methyl-3,4-pyridine dimethanol |
| 5- | hydroxy-6-methyl-3,4-pyridinedimethanol |
| (5- | hydroxy-6-methylpyridine-3,4-diyl)dimethanol |
| 4,5-bis- | hydroxymethyl-2-methyl-pyridin-3-ol |
| 4,5-bis( | hydroxymethyl)-2-methyl-3-pyridinol |
| 4,5-bis( | hydroxymethyl)-2-methyl-pyridin-3-ol |
| 4,5-bis( | hydroxymethyl)-2-methylpyridin-3-ol |
| 2- | methyl-3-hydroxy-4,5-bis(hydroxy-methyl) pyridine |
| 2- | methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine |
| 2- | methyl-3-hydroxy-4,5-di(hydroxymethyl)pyridine |
| 2- | methyl-3-hydroxy-4,5-dihydroxymethylpyridine |
| 2- | methyl-4,5-bis(hydroxymethyl)-3-hydroxypyridine |
| 2- | picoline-4,5-dimethanol, 3-hydroxy- |
| 3,4- | pyridinedimethanol, 5-hydroxy-6-methyl- |
| vitamin B6 |