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Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 192.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 357.00 to 358.00 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.000027 mmHg @ 25.00 °C. (est) |
| Flash Point: | 338.00 °F. TCC ( 169.90 °C. ) (est)
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| logP (o/w): | -0.600 |
| Soluble in: |
| | alcohol | | | water, 1.50E+04 mg/L @ 25 °C (est) | | | water, 1.50E+04 mg/L @ 25 °C (exp) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 1680 mg/kg Chemotherapia. Vol. 5, Pg. 39, 1962.
oral-mouse LDLo 3000 mg/kg BEHAVIORAL: EXCITEMENT
BEHAVIORAL: ATAXIA American Review of Tuberculosis. Vol. 70, Pg. 423, 1954.
oral-rat LDLo 3000 mg/kg BEHAVIORAL: EXCITEMENT
BEHAVIORAL: ATAXIA American Review of Tuberculosis. Vol. 70, Pg. 423, 1954.
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| Dermal Toxicity: |
subcutaneous-mouse LD50 2973 mg/kg Drugs in Japan Vol. -, Pg. 1038, 1995.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis |
| Recommendation for pyrazinamide usage levels up to: | | | not for fragrance use.
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| Recommendation for pyrazinamide flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 2-( | aminocarbonyl)pyrazine | | 2- | carbamyl pyrazine | | 2- | carbamylpyrazine | | a- | pyrazinamide | | | pyrazine carboxylamide | | | pyrazine-2-carboxamide | | 2- | pyrazinecarboxamide | | | pyrazinecarboxylic acid amide | | | pyrazinoic acid amide |
Articles:
| PubMed: | Multiple drug-susceptibility screening in Mycobacterium bovis: new nucleotide polymorphisms in the embB gene among ethambutol susceptible strains. |
| PubMed: | Impact of food intake on the pharmacokinetics of first-line antituberculosis drugs in Taiwanese tuberculosis patients. |
| PubMed: | A review of tuberculosis: Focus on bedaquiline. |
| PubMed: | Provisional CDC guidelines for the use and safety monitoring of bedaquiline fumarate (Sirturo) for the treatment of multidrug-resistant tuberculosis. |
| PubMed: | Development and validation of a hydrophilic interaction liquid chromatography-tandem mass spectrometry method for the simultaneous determination of five first-line antituberculosis drugs in plasma. |
| PubMed: | Impact of a shortage of first-line antituberculosis medication on tuberculosis control - United States, 2012-2013. |
| PubMed: | Pharmacokinetics of first-line tuberculosis drugs in Tanzanian patients. |
| PubMed: | Optimization of a reversed-phase-high-performance thin-layer chromatography method for the separation of isoniazid, ethambutol, rifampicin and pyrazinamide in fixed-dose combination antituberculosis tablets. |
| PubMed: | [Pulmonary paragonimiasis]. |
| PubMed: | Tuberculosis (HIV-negative people). |
| PubMed: | Impact of food and antacids on the pharmacokinetics of anti-tuberculosis drugs: systematic review and meta-analysis. |
| PubMed: | Tuberculosis (HIV-negative people). |
| PubMed: | Molecular detection of drug-resistant Mycobacterium tuberculosis with a scanning-frame oligonucleotide microarray. |
| PubMed: | Discovery of pyrazine carboxamide CB1 antagonists: the introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series. |
| PubMed: | Differential effects of pyrazinamide and clofibrate on gene expression of rat hepatic alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, a key enzyme of the tryptophan-NAD pathway. |
| PubMed: | Molecular typing and virulence markers of Yersinia enterocolitica strains from human, animal and food origins isolated between 1968 and 2000 in Brazil. |
| PubMed: | Human Mycobacterium bovis infection in the United Kingdom: Incidence, risks, control measures and review of the zoonotic aspects of bovine tuberculosis. |
| PubMed: | [Pellagra]. |
| PubMed: | A cholesterol-rich diet accelerates bacteriologic sterilization in pulmonary tuberculosis. |
| PubMed: | Antioxidant action of Moringa oleifera Lam. (drumstick) against antitubercular drugs induced lipid peroxidation in rats. |
| PubMed: | Hepatoprotective activity of Moringa oleifera on antitubercular drug-induced liver damage in rats. |
| PubMed: | Treatment of tuberculous infection and disease in children: the North American perspective. |
| PubMed: | Evaluation of the teratogenic potential of pyrazinamide in Wistar rats. |
| PubMed: | Detection of substandard fixed-dose combination tuberculosis drugs using thin-layer chromatography. |
| PubMed: | Rifapentine: its role in the treatment of tuberculosis. |
| PubMed: | Pharmacokinetics of isoniazid under fasting conditions, with food, and with antacids. |
| PubMed: | Pharmacokinetics of rifampin under fasting conditions, with food, and with antacids. |
| PubMed: | Pharmacokinetics of pyrazinamide under fasting conditions, with food, and with antacids. |
| PubMed: | Probenecid, sulfinpyrazone and pyrazinamide do not inhibit urinary excretion of the beta 2-adrenoceptor agonist clenbuterol in cattle. |
| PubMed: | [Characteristics of Yersinia strains from clinical material and from other sources. I. Selected biochemical properties]. |
| PubMed: | Three-in-one TB drug approved. |
| PubMed: | Study of the effect of concomitant food on the bioavailability of rifampicin, isoniazid and pyrazinamide. |
| PubMed: | Molecular characterization of Yersinia enterocolitica by pulsed-field gel electrophoresis and hybridization of DNA fragments to ail and pYV probes. |
| PubMed: | From the Food and Drug Administration. |
| PubMed: | Molecular characterization of Yersinia strains isolated from human and environmental sources. |
| PubMed: | Clinical pharmacokinetic considerations in the treatment of patients with leprosy. |
| PubMed: | Package inserts for antituberculosis drugs and tuberculins. |
| PubMed: | Toxicity of morphazinamide compared with pyrazinamide. |
| PubMed: | [Liver damage after administration of pyrazinamide in animal experiments. 3. Biochemical changes in liver tissue and blood serum]. |
| PubMed: | Invitation to the gout. A consideration of the role of various predisposing and provocative factors in the genesis of acute gouty arthritis. |
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