protoporphyrin disodium
disodium protoporphyrin
 
Notes:
None found
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CAS Number: 50865-01-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 256-815-9
FDA UNII: 54N4UY1C7C
Nikkaji Web: J83.641I
Beilstein Number: 5227034
MDL: MFCD00151108
Molecular Weight: 606.63337856
Formula: C34 H32 N4 Na2 O4
NMR Predictor: Predict (works with chrome or firefox)
Category: information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Soluble in:
 water, 0.01294 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
Santa Cruz Biotechnology
For experimental / research use only.
Protoporphyrin IX disodium salt
Sigma-Aldrich: Aldrich
For experimental / research use only.
Protoporphyrin IX disodium salt ≥90% (HPLC)
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: information only not used for fragrances or flavors
Recommendation for protoporphyrin disodium usage levels up to:
 not for fragrance use.
 
Recommendation for protoporphyrin disodium flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
AIDS Citations: Search
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EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 71484
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 disodium;3-[18-(2-carboxylatoethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethyl-22,23-dihydroporphyrin-2-yl]propanoate
Chemidplus: 0050865015
RTECS: TS5450000 for cas# 50865-01-5
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References:
 disodium;3-[18-(2-carboxylatoethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethyl-22,23-dihydroporphyrin-2-yl]propanoate
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 71484
Pubchem (cas): 50865-01-5
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEMBL: View
KEGG (GenomeNet): D02265
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2933.90.9500
ChemSpider: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 disodium 3,8,13,17-tetramethyl-7,12-divinyl-21H,23H-porphine-2,18-dipropionate
 disodium protoporphyrin
 disodium;3-[18-(2-carboxylatoethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethyl-22,23-dihydroporphyrin-2-yl]propanoate
21H,23H-porphine-2,18-dipropanoic acid, 7,12-diethenyl-3,8,13,17-tetramethyl-, disodium salt
 protoporphyrin IX disodium salt
1,3,5,8-tetramethyl-2,4-divinylporphine-6,7-dipropionate
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Articles:
PubMed: Sonodynamic therapy induces apoptosis of human leukemia HL-60 cells in the presence of protoporphyrin IX.
PubMed: Inhibition of VDAC1 prevents Ca²⁺-mediated oxidative stress and apoptosis induced by 5-aminolevulinic acid mediated sonodynamic therapy in THP-1 macrophages.
PubMed: Structure of glutathione S-transferase 1 from the major human hookworm parasite Necator americanus (Na-GST-1) in complex with glutathione.
PubMed: [Outbreak of lead poisoning associated with Ayurvedic medicine].
PubMed: Total synthesis of hematoporphyrin and protoporphyrin; a conceptually new approach.
PubMed: Drug-induced liver injury in hospitalized patients with notably elevated alanine aminotransferase.
PubMed: Photomicronucleus assay of phototoxic and pseudophotoclastogenic chemicals in human keratinocyte NCTC2544 cells.
PubMed: Sonodynamic effects of protoporphyrin IX disodium salt on Ehrlich ascetic tumor cells.
PubMed: Determination of lead(II) in fly ash leachate using a newly developed simple spectrophotometric method.
PubMed: Synthesis of porphyrin-incorporated polymers and their application for simultaneous detection of multimetal components by using spectrophotometry.
PubMed: Sonodynamic antitumor effect of protoporphyrin IX disodium salt on S180 solid tumor.
PubMed: Hemin, an inducer of heme oxygenase-1, lowers intraocular pressure in rabbits.
PubMed: Sonodynamic effects of protoporphyrin IX disodium salt on isolated sarcoma 180 cells.
PubMed: YC-1-like potentiation of NO-dependent activation of soluble guanylate cyclase by derivatives of protoporphyrin IX.
PubMed: Microbial demetallization of crude oil: nickel protoporphyrin disodium as a model organo-metallic substrate.
PubMed: Lead-induced oxidative stress and hematological alterations and their response to combined administration of calcium disodium EDTA with a thiol chelator in rats.
PubMed: Extraction of protoporphyrin disodium and its inhibitory effects on HBV-DNA.
PubMed: Heme oxygenase-mediated vasodilation involves vascular smooth muscle cell hyperpolarization.
PubMed: Possible role of metal redistribution, hepatotoxicity and oxidative stress in chelating agents induced hepatic and renal metallothionein in rats.
PubMed: A vehicle for photodynamic therapy of skin cancer: influence of dimethylsulphoxide on 5-aminolevulinic acid in vitro cutaneous permeation and in vivo protoporphyrin IX accumulation determined by confocal microscopy.
PubMed: Mobilized plasma lead as an index of lead body burden and its relation to the heme-related indices.
PubMed: Compared effects of high oral Mg supplements and of EDTA chelating agent on chronic lead intoxication in rabbits.
PubMed: Lead intoxication epidemic caused by ingestion of contaminated ground paprika.
PubMed: Topical application of 5-aminolevulinic acid, DMSO and EDTA: protoporphyrin IX accumulation in skin and tumours of mice.
PubMed: Influence of methionine and zinc supplementation during chelation of lead in rats.
PubMed: Effects of calcium disodium versenate (CaNa2EDTA) chelation in moderate childhood lead poisoning.
PubMed: Anti-inflammatory properties of zinc protoporphyrin disodium (Zn-PP-2Na).
PubMed: Influence of simultaneous supplementation of zinc and copper during chelation of lead in rats.
PubMed: Need for the lead mobilization test in children with lead poisoning.
PubMed: Beneficial effects of zinc supplementation during chelation treatment of lead intoxication in rats.
PubMed: Effects of iron deficiency on lead excretion in children with moderate lead intoxication.
PubMed: Using unstimulated urinary lead excretion to assess the need for chelation in the treatment of lead poisoning.
PubMed: Chelation of lead during co-exposure to ethanol.
PubMed: Influence of methionine supplementation in chelation of lead in rats.
PubMed: Body burdens of lead in hypertensive nephropathy.
PubMed: The fall of zinc protoporphyrin levels in workers treated for chronic lead intoxication.
PubMed: Adult lead poisoning.
PubMed: Lead poisoning in a West Bank Arab Village.
PubMed: Reversible nephrotoxic reactions to a combined 2,3-dimercapto-1-propanol and calcium disodium ethylenediaminetetraacetic acid regimen in asymptomatic children with elevated blood lead levels.
PubMed: Diagnostic significance of edetate disodium calcium testing in children with increased lead absorption.
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