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Category: information only not used for fragrances or flavors
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | information only not used for fragrances or flavors |
| Recommendation for zinc protoporphyrin usage levels up to: | | | not for fragrance use.
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| Recommendation for zinc protoporphyrin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| ClinicalTrials.gov: | search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 15442-64-5 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 455799 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| | zinc;3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid |
| Chemidplus: | 0015442645 |
References:
| | zinc;3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 455799 |
| Pubchem (cas): | 15442-64-5 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | dihydrogen (3,8,13,17-tetramethyl-7,12-divinyl-21H,23H-porphine-2,18-dipropionato(4-)-N21,N22,N23,N24)zincate(4-) | | | protoporphyrin IX zinc | | | protoporphyrin IX, zinc chelate | | | zinc;3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid |
Articles:
| PubMed: | Influence of meat source, pH and production time on zinc protoporphyrin IX formation as natural colouring agent in nitrite-free dry fermented sausages. |
| PubMed: | Subcritical water-hydrolyzed fish collagen ameliorates survival of endotoxemic mice by inhibiting HMGB1 release in a HO-1-dependent manner. |
| PubMed: | Lotus Root Extract Stimulates BDNF Gene Expression Through Potential Mechanism Depending on HO-1 Activity in C6 Glioma Cells. |
| PubMed: | Daily home fortification with iron as ferrous fumarate versus NaFeEDTA: a randomised, placebo-controlled, non-inferiority trial in Kenyan children. |
| PubMed: | 15-Deoxy-Δ(12,14)-prostaglandin J2 stabilizes hypoxia inducible factor-1α through induction of heme oxygenase-1 and direct modification ofprolyl-4-hydroxylase 2. |
| PubMed: | Fermented Brown Rice Extract Stimulates BDNF Gene Transcription in C6 Glioma Cells: Possible Connection with HO-1 Expression. |
| PubMed: | 4-Hydroxyestradiol induces mammary epithelial cell transformation through Nrf2-mediated heme oxygenase-1 overexpression. |
| PubMed: | Curcumin attenuates quinocetone induced apoptosis and inflammation via the opposite modulation of Nrf2/HO-1 and NF-kB pathway in human hepatocyte L02 cells. |
| PubMed: | Impact of small-quantity lipid-based nutrient supplement on hemoglobin, iron status and biomarkers of inflammation in pregnant Ghanaian women. |
| PubMed: | Baicalein protects C6 glial cells against hydrogen peroxide-induced oxidative stress and apoptosis through regulation of the Nrf2 signaling pathway. |
| PubMed: | Antioxidant, Anti-Tyrosinase and Anti-Inflammatory Activities of Oil Production Residues from Camellia tenuifloria. |
| PubMed: | Formation of naturally occurring pigments during the production of nitrite-free dry fermented sausages. |
| PubMed: | An exploration of the antioxidant effects of garlic saponins in mouse-derived C2C12 myoblasts. |
| PubMed: | Antagonistic effects of acetylshikonin on LPS-induced NO and PGE2 production in BV2 microglial cells via inhibition of ROS/PI3K/Akt-mediated NF-κB signaling and activation of Nrf2-dependent HO-1. |
| PubMed: | The Cytoprotective Effect of Petalonia binghamiae Methanol Extract against Oxidative Stress in C2C12 Myoblasts: Mediation by Upregulation of Heme Oxygenase-1 and Nuclear Factor-Erythroid 2 Related Factor 2. |
| PubMed: | Blood pressure and occupational exposure to noise and lead (Pb): A cross-sectional study. |
| PubMed: | [Prevalence of deficiency and dietary intake of iron, zinc and copper in Chilean childbearing age women]. |
| PubMed: | Anti-Inflammatory Activity of Butein and Luteolin Through Suppression of NFκB Activation and Induction of Heme Oxygenase-1. |
| PubMed: | Sargassum horneri methanol extract rescues C2C12 murine skeletal muscle cells from oxidative stress-induced cytotoxicity through Nrf2-mediated upregulation of heme oxygenase-1. |
| PubMed: | Highly sensitive fluorescence assay of DNA methyltransferase activity by methylation-sensitive cleavage-based primer generation exponential isothermal amplification-induced G-quadruplex formation. |
| PubMed: | A comparative study of zinc protoporphyrin IX-forming properties of animal by-products as sources for improving the color of meat products. |
| PubMed: | In-home fortification with 2.5 mg iron as NaFeEDTA does not reduce anaemia but increases weight gain: a randomised controlled trial in Kenyan infants. |
| PubMed: | Anti-inflammatory effect and mechanism of the green fruit extract of Solanum integrifolium Poir. |
| PubMed: | Anti-inflammatory effect of methanol extract from Erigeron Canadensis L. may be involved with upregulation of heme oxygenase-1 expression and suppression of NFκB and MAPKs activation in macrophages. |
| PubMed: | Monosodium urate crystals trigger Nrf2- and heme oxygenase-1-dependent inflammation in THP-1 cells. |
| PubMed: | Ultrasensitive fluorescence detection of nucleic acids using exonuclease III-induced cascade two-stage isothermal amplification-mediated zinc (II)-protoporphyrin IX/G-quadruplex supramolecular fluorescent nanotags. |
| PubMed: | Crucial role of heme oxygenase-1 in the sensitivity of acute myeloid leukemia cell line Kasumi-1 to ursolic acid. |
| PubMed: | Iron status biomarkers and C-reactive protein in children aged 19 to 72 months in Chile. |
| PubMed: | 5-Hydroxy-3,6,7,8,3'4'-hexamethoxyflavone inhibits nitric oxide production in lipopolysaccharide-stimulated BV2 microglia via NF-κB suppression and Nrf-2-dependent heme oxygenase-1 induction. |
| PubMed: | Curcumin ameliorates the permeability of the blood-brain barrier during hypoxia by upregulating heme oxygenase-1 expression in brain microvascular endothelial cells. |
| PubMed: | Iron status and systemic inflammation, but not gut inflammation, strongly predict gender-specific concentrations of serum hepcidin in infants in rural Kenya. |
| PubMed: | Bilirubin participates in protecting of heme oxygenase-1 induction by quercetin against ethanol hepatotoxicity in cultured rat hepatocytes. |
| PubMed: | Dietary flavonoid genistein induces Nrf2 and phase II detoxification gene expression via ERKs and PKC pathways and protects against oxidative stress in Caco-2 cells. |
| PubMed: | Iron fortification of whole wheat flour reduces iron deficiency and iron deficiency anemia and increases body iron stores in Indian school-aged children. |
| PubMed: | Baicalein protects against 6-OHDA-induced neurotoxicity through activation of Keap1/Nrf2/HO-1 and involving PKCα and PI3K/AKT signaling pathways. |
| PubMed: | Effects of different storage conditions on quality related porphyrin fluorescence signatures of pork slices. |
| PubMed: | [Acute lead poisoning: a singular case of hemolytic anemia and lead colic]. |
| PubMed: | Hydroxytyrosol induces proliferation and cytoprotection against oxidative injury in vascular endothelial cells: role of Nrf2 activation and HO-1 induction. |
| PubMed: | Efficacy of a microencapsulated iron pyrophosphate-fortified fruit juice: a randomised, double-blind, placebo-controlled study in Spanish iron-deficient women. |
| PubMed: | In vivo uptake of a haem analogue Zn protoporphyrin IX by the human malaria parasite P. falciparum-infected red blood cells. |
| PubMed: | Efficacy of pandesal baked from wheat flour fortified with iron and vitamin a in improving the iron and anthropometric status of anemic schoolchildren in the Philippines. |
| PubMed: | Nitric oxide inhibits the formation of zinc protoporphyrin IX and protoporphyrin IX. |
| PubMed: | Neurotrophic and cytoprotective action of luteolin in PC12 cells through ERK-dependent induction of Nrf2-driven HO-1 expression. |
| PubMed: | Formation of zinc protoporphyrin IX in Parma-like ham without nitrate or nitrite. |
| PubMed: | Heme induces DNA damage and hyperproliferation of colonic epithelial cells via hydrogen peroxide produced by heme oxygenase: a possible mechanism of heme-induced colon cancer. |
| PubMed: | The plant phenolic diterpene carnosol suppresses sodium nitroprusside-induced toxicity in c6 glial cells. |
| PubMed: | Color formation in nitrite-free dried hams as related to Zn-protoporphyrin IX and Zn-chelatase activity. |
| PubMed: | Oral supplementation with NaFeEDTA reduces blood lead in postmenopausal but not premenopausal Korean women with anemia. |
| PubMed: | Determinants of anemia among preschool children in the Philippines. |
| PubMed: | Luteolin suppresses cisplatin-induced apoptosis in auditory cells: possible mediation through induction of heme oxygenase-1 expression. |
| PubMed: | Adiposity in women and children from transition countries predicts decreased iron absorption, iron deficiency and a reduced response to iron fortification. |
| PubMed: | Intragastric administration with recombinant Lactococcus lactis producing heme oxygenase-1 prevents lipopolysaccharide-induced endotoxemia in rats. |
| PubMed: | Evaluation of serum transferrin receptor for iron deficiency in women of child-bearing age. |
| PubMed: | Quantification of zinc-porphyrin in dry-cured ham products by spectroscopic methods Comparison of absorption, fluorescence and X-ray fluorescence spectroscopy. |
| PubMed: | Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1. |
| PubMed: | Isoflavone and the heme oxygenase system in ischemic acute kidney injury in rats. |
| PubMed: | A cohort study of haemoglobin and zinc protoporphyrin levels in term Zambian infants: effects of iron stores at birth, complementary food and placental malaria. |
| PubMed: | Anaemia and abdominal pain due to occupational lead poisoning. |
| PubMed: | Mild riboflavin deficiency is highly prevalent in school-age children but does not increase risk for anaemia in Côte d'Ivoire. |
| PubMed: | Iron fortification reduces blood lead levels in children in Bangalore, India. |
| PubMed: | Protective effects of Korean herbal remedy against oxidative stress in cardiomyocytes. |
| PubMed: | Feeding practices and factors contributing to wasting, stunting, and iron-deficiency anaemia among 3-23-month old children in Kilosa district, rural Tanzania. |
| PubMed: | Nutritional risk factors for iron-deficiency anaemia in children 12-24 months old in the area of Thessalia in Greece. |
| PubMed: | Cultural and environmental barriers to adequate iron intake among northern Kenyan schoolchildren. |
| PubMed: | Induction of heme oxygenase-1 in human hepatocytes to protect them from ethanol-induced cytotoxicity. |
| PubMed: | [Effects of iron supplementation on human serum level of transferrin receptor]. |
| PubMed: | Processed complementary food does not improve growth or hemoglobin status of rural tanzanian infants from 6-12 months of age in Kilosa district, Tanzania. |
| PubMed: | The protective effect of delta-aminolevulinic acid dehydratase 1-2 and 2-2 isozymes against blood lead with higher hematologic parameters. |
| PubMed: | Iron, zinc, and copper concentrations in breast milk are independent of maternal mineral status. |
| PubMed: | Iron deficiency and risk factors for lower iron stores in 6-24-month-old New Zealanders. |
| PubMed: | Iron deficiency is unacceptably high in refugee children from Burma. |
| PubMed: | Cross-sectional study of blood lead effects on iron status in Korean lead workers. |
| PubMed: | Dual fortification of salt with iodine and microencapsulated iron: a randomized, double-blind, controlled trial in Moroccan schoolchildren. |
| PubMed: | Iron and zinc status of women and men who followed cholesterol-lowering diets. |
| PubMed: | Longitudinal study of diet and iron deficiency anaemia in infants during the first two years of life. |
| PubMed: | Community-based dietary phytate reduction and its effect on iron status in Malawian children. |
| PubMed: | Prevalence of iron deficiency with and without concurrent anemia in population groups with high prevalences of malaria and other infections: a study in Côte d'Ivoire. |
| PubMed: | Supplemental sodium phytate and microbial phytase influence iron availability in growing rats. |
| PubMed: | The role of prophylactic iron supplementation in pregnancy. |
| PubMed: | Effect of calcium supplementation on daily nonheme-iron absorption and long-term iron status. |
| PubMed: | Factors affecting iron stores in infants 4-18 months of age. |
| PubMed: | Effects of discontinuing coffee intake on iron status of iron-deficient Guatemalan toddlers: a randomized intervention study. |
| PubMed: | Inhibition of hemozoin formation in Plasmodium falciparum trophozoite extracts by heme analogs: possible implication in the resistance to malaria conferred by the beta-thalassemia trait. |
| PubMed: | Lead intoxication epidemic caused by ingestion of contaminated ground paprika. |
| PubMed: | Mechanisms of chlorophyllin anticarcinogenesis against aflatoxin B1: complex formation with the carcinogen. |
| PubMed: | Effect of lead exposure on patterns of food intake in weanling rats. |
| PubMed: | Absorption of non-haem iron from food during normal pregnancy. |
| PubMed: | Use of lead-glazed ceramics is the main factor associated to high lead in blood levels in two Mexican rural communities. |
| PubMed: | [Lead and health]. |
| PubMed: | Seizures in a 10-week-old infant: lead poisoning from an unexpected source. |
| PubMed: | Iron fortification of infant milk formula: the effect on iron status and immune function. |
| PubMed: | Relationship between the levels of biological indicators of lead exposure in children and their mothers environmentally exposed to lead. |
| PubMed: | Mechanisms by which lead depresses linear and ponderal growth in weanling rats. |
| PubMed: | Indicators of lead, zinc and cadmium exposure in cattle: II. Controlled feeding and recovery. |
| PubMed: | Low dose lead effects in calves fed a whole milk diet. |
| PubMed: | Performance and exposure indices of rats exposed to low concentrations of lead. |
| PubMed: | [Chronic lead exposure. Its repercussion on indicators of heme synthesis and iron metabolism]. |
| PubMed: | Exposure to lead and cadmium of the general population of Malta. |
| PubMed: | Widening perspectives of lead toxicity. A review of health effects of lead exposure in adults. |
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