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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 169 mg/L @ 25 °C (exp) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for protoporphyrin IX usage levels up to: | | | not for fragrance use.
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| Recommendation for protoporphyrin IX flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethyl-22,23-dihydroporphyrin-2-yl]propanoic acid |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 4971 |
| Pubchem (cas): | 553-12-8 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 3-[18-(2- | carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethyl-22,23-dihydroporphyrin-2-yl]propanoic acid | | | ooporphyrin | | 21H,23H- | porphine-2,18-dipropanoic acid, 7,12-diethenyl-3,8,13,17-tetramethyl- | | 2,18- | porphinedipropionic acid, 3,8,13,17-tetramethyl-7,12-divinyl- (8CI) | | 3,3'-(3,7,12,17- | tetramethyl-8,13-divinylporphine-2,18-diyl)di(propionic acid) |
Articles:
| PubMed: | Influence of meat source, pH and production time on zinc protoporphyrin IX formation as natural colouring agent in nitrite-free dry fermented sausages. |
| PubMed: | Subcritical water-hydrolyzed fish collagen ameliorates survival of endotoxemic mice by inhibiting HMGB1 release in a HO-1-dependent manner. |
| PubMed: | Upregulation of heme oxygenase-1 mediates the anti-inflammatory activity of casein glycomacropeptide (GMP) hydrolysates in LPS-stimulated macrophages. |
| PubMed: | Heme-oxygenase-1 Production by Intestinal CX3CR1(+) Macrophages Helps to Resolve Inflammation and Prevents Carcinogenesis. |
| PubMed: | Egg production and egg quality in free-range laying hens housed at different outdoor stocking densities. |
| PubMed: | Hydroxypyridinone and 5-Aminolaevulinic Acid Conjugates for Photodynamic Therapy. |
| PubMed: | Effect of 4-hydroxy-2-nonenal on myoglobin-mediated lipid oxidation when varying histidine content and hemin affinity. |
| PubMed: | Effects of Processing Temperature on Color Properties of Dry-Cured Hams Made without Nitrite. |
| PubMed: | Bisphenol A effects on the chlorophyll contents in soybean at different growth stages. |
| PubMed: | 15-Deoxy-Δ(12,14)-prostaglandin J2 stabilizes hypoxia inducible factor-1α through induction of heme oxygenase-1 and direct modification ofprolyl-4-hydroxylase 2. |
| PubMed: | Mg-Protoporphyrin IX Signals Enhance Plant's Tolerance to Cold Stress. |
| PubMed: | Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms. |
| PubMed: | CdTe/CdSe quantum dot-based fluorescent aptasensor with hemin/G-quadruplex DNzyme for sensitive detection of lysozyme using rolling circle amplification and strand hybridization. |
| PubMed: | Curcumin attenuates quinocetone induced apoptosis and inflammation via the opposite modulation of Nrf2/HO-1 and NF-kB pathway in human hepatocyte L02 cells. |
| PubMed: | Intracellular Dual Fluorescent Lightup Bioprobes for Image-Guided Photodynamic Cancer Therapy. |
| PubMed: | Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development. |
| PubMed: | Measurement of haem and total iron in fish, shrimp and prawn using ICP-MS: Implications for dietary iron intake calculations. |
| PubMed: | A Label-Free and Sensitive Fluorescent Qualitative Assay for Bisphenol A Based on Rolling Circle Amplification/Exonuclease III-Combined Cascade Amplification. |
| PubMed: | Formation of naturally occurring pigments during the production of nitrite-free dry fermented sausages. |
| PubMed: | Tenuigenin exhibits anti-inflammatory activity via inhibiting MAPK and NF-κB and inducing Nrf2/HO-1 signaling in macrophages. |
| PubMed: | Magnetic nanoparticles-cooperated fluorescence sensor for sensitive and accurate detection of DNA methyltransferase activity coupled with exonuclease III-assisted target recycling. |
| PubMed: | Microglial HO-1 induction by curcumin provides antioxidant, antineuroinflammatory, and glioprotective effects. |
| PubMed: | The Cytoprotective Effect of Petalonia binghamiae Methanol Extract against Oxidative Stress in C2C12 Myoblasts: Mediation by Upregulation of Heme Oxygenase-1 and Nuclear Factor-Erythroid 2 Related Factor 2. |
| PubMed: | Assessment of the action spectrum for photooxidation in full fat bovine milk. |
| PubMed: | Sargassum horneri methanol extract rescues C2C12 murine skeletal muscle cells from oxidative stress-induced cytotoxicity through Nrf2-mediated upregulation of heme oxygenase-1. |
| PubMed: | Identification and characterization of [6]-shogaol from ginger as inhibitor of vascular smooth muscle cell proliferation. |
| PubMed: | Design, synthesis and biological evaluation of 5-aminolaevulinic acid/3-hydroxypyridinone conjugates as potential photodynamic therapeutical agents. |
| PubMed: | Determination of selected protoporphyrins in parma ham with use of 5,10,15,20-tetra(4-hydroxyphenyl)porphyrin as a surrogate standard in the recovery study. |
| PubMed: | A DNA nanomachine based on rolling circle amplification-bridged two-stage exonuclease III-assisted recycling strategy for label-free multi-amplified biosensing of nucleic acid. |
| PubMed: | Highly sensitive fluorescence assay of DNA methyltransferase activity by methylation-sensitive cleavage-based primer generation exponential isothermal amplification-induced G-quadruplex formation. |
| PubMed: | A comparative study of zinc protoporphyrin IX-forming properties of animal by-products as sources for improving the color of meat products. |
| PubMed: | Effects of bisphenol A on chlorophyll synthesis in soybean seedlings. |
| PubMed: | Myoglobin and haemoglobin-mediated lipid oxidation in washed muscle: observations on crosslinking, ferryl formation, porphyrin degradation, and haemin loss rate. |
| PubMed: | Monosodium urate crystals trigger Nrf2- and heme oxygenase-1-dependent inflammation in THP-1 cells. |
| PubMed: | Type 2 diabetic conditions in Otsuka Long-Evans Tokushima Fatty rats are ameliorated by 5-aminolevulinic acid. |
| PubMed: | Ultrasensitive fluorescence detection of nucleic acids using exonuclease III-induced cascade two-stage isothermal amplification-mediated zinc (II)-protoporphyrin IX/G-quadruplex supramolecular fluorescent nanotags. |
| PubMed: | Heme oxygenase-1 induction alters chemokine regulation and ameliorates human immunodeficiency virus-type-1 infection in lipopolysaccharide-stimulated macrophages. |
| PubMed: | The protective effect of alpha-lipoic Acid in lipopolysaccharide-induced acute lung injury is mediated by heme oxygenase-1. |
| PubMed: | Lipid oxidation in trout muscle is strongly inhibited by a protein that specifically binds hemin released from hemoglobin. |
| PubMed: | Dye Sensitizers for Photodynamic Therapy. |
| PubMed: | Bilirubin participates in protecting of heme oxygenase-1 induction by quercetin against ethanol hepatotoxicity in cultured rat hepatocytes. |
| PubMed: | Polygonum viviparum L. inhibits the lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages through haem oxygenase-1 induction and activation of the Nrf2 pathway. |
| PubMed: | Heme binding to human alpha-1 proteinase inhibitor. |
| PubMed: | Effects of different storage conditions on quality related porphyrin fluorescence signatures of pork slices. |
| PubMed: | Hydroxytyrosol induces proliferation and cytoprotection against oxidative injury in vascular endothelial cells: role of Nrf2 activation and HO-1 induction. |
| PubMed: | Anti-inflammatory activity of Angelica dahurica ethanolic extract on RAW264.7 cells via upregulation of heme oxygenase-1. |
| PubMed: | Regulation and gene expression of heme synthesis under heavy metal exposure--review. |
| PubMed: | In vivo uptake of a haem analogue Zn protoporphyrin IX by the human malaria parasite P. falciparum-infected red blood cells. |
| PubMed: | Nitric oxide inhibits the formation of zinc protoporphyrin IX and protoporphyrin IX. |
| PubMed: | Assessment of the quality attributes of cod caviar paste by means of front-face fluorescence spectroscopy. |
| PubMed: | Formation of zinc protoporphyrin IX in Parma-like ham without nitrate or nitrite. |
| PubMed: | The plant phenolic diterpene carnosol suppresses sodium nitroprusside-induced toxicity in c6 glial cells. |
| PubMed: | Color formation in nitrite-free dried hams as related to Zn-protoporphyrin IX and Zn-chelatase activity. |
| PubMed: | Luteolin suppresses cisplatin-induced apoptosis in auditory cells: possible mediation through induction of heme oxygenase-1 expression. |
| PubMed: | Intragastric administration with recombinant Lactococcus lactis producing heme oxygenase-1 prevents lipopolysaccharide-induced endotoxemia in rats. |
| PubMed: | Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1. |
| PubMed: | Effects of manipulating the nitric oxide/cyclic GMP pathway on bovine oocyte meiotic resumption in vitro. |
| PubMed: | Mass spectrometric evidence for a zinc-porphyrin complex as the red pigment in dry-cured Iberian and Parma ham. |
| PubMed: | Possible role of creatine concentrations in the brain in regulating appetite and weight. |
| PubMed: | Protective effects of Korean herbal remedy against oxidative stress in cardiomyocytes. |
| PubMed: | The weight loss elicited by cobalt protoporphyrin is related to decreased activity of nitric oxide synthase in the hypothalamus. |
| PubMed: | Optimal fluorescence excitation and emission bands for detection of fecal contamination. |
| PubMed: | The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria. |
| PubMed: | Synthesis, herbicidal activity, and mode of action of IR 5790. |
| PubMed: | Singlet oxygen-triggered immediate preprogrammed apoptosis. |
| PubMed: | Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress. |
| PubMed: | Red meat and colon cancer: the cytotoxic and hyperproliferative effects of dietary heme. |
| PubMed: | Cytotoxic and porphyrinogenic effects of diphenyl ethers in cultured rat hepatocytes: chlornitrofen (CNP), CNP-amino, chlomethoxyfen and bifenox. |
| PubMed: | UVA1 radiation triggers two different final apoptotic pathways. |
| PubMed: | Inhibition of hemozoin formation in Plasmodium falciparum trophozoite extracts by heme analogs: possible implication in the resistance to malaria conferred by the beta-thalassemia trait. |
| PubMed: | [The chemistry of porphyrins and their precursors on the heme biosynthetic chain]. |
| PubMed: | Mechanisms of chlorophyllin anticarcinogenesis against aflatoxin B1: complex formation with the carcinogen. |
| PubMed: | Influence of dietary calcium on lead poisoning in mallard ducks (Anas platyrynchos). |
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