Articles:
4-pregnen-3,20-dione
Notes:
the major progestational steroid that is secreted primarily by the corpus luteum and the placenta. progesterone acts on the uterus, the mammary glands and the brain. it is required in embryo implantation; pregnancy maintenance, and the development of mammary tissue for milk production. progesterone, converted from pregnenolone, also serves as an intermediate in the biosynthesis of gonadal steroid hormones and adrenal corticosteroids. Progestational hormone secreted by corpus luteum during menstrual cycle. Also found in the gonads and haemolymph of crustaceans, e.g. Artemia, Euphosia, Homarus, Pandalus and Penaeus spp (CCD)
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BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 57-83-0 Progesterone ≥98% Progesterone, synthesized from cholesterol by the sequential action of desmolase in the mitochondria, plays an important role in brain function as a endogenous progesterone receptor (PR) agonist (EC50 = 0.5 nM). Endogenous progesterone receptor (PR) agonist
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Glentham Life Sciences Ltd The Chemical, Biochemical & Research Essentials Supplier Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK. With a Glentham Life Sciences account you can view more product details, request quotes and order products online. Email: Info Email: Sales Email: Tech Support Voice: +44 (0) 1225 667798 Fax: +44 (0) 2033 978909 Facebook Twitter Linkedin Google+ News Distribution Products List: View Product(s): GP3663 Progesterone
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Penta International Corporation Chemistry innovation At Penta, our products and services help businesses do business better. For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes. US Email: Technical Services US Email: Sales US Voice: (973) 740-2300 US Fax: (973) 740-1839 Product(s): 16-65900 PROGESTERONE MICRONIZED POWDER USP 16-65910 PROGESTERONE WETTABLE POWDER USP
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WholeChem, LLC Connecting Innovators To the Building Blocks Of the Universe Custom manufacturer and distributor of specialty ingredients. We make global local. SQF-Certified Supplier We owe our success to our integrity, our dedication to the industry, and our commitment to our clients. We invite your inquiries regarding our current product list and any other products you may be having trouble sourcing. Email: Info Email: Orders Voice: +1 (262) 995.8668 Certification Our Services Products List: View Product(s): Progesterone
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| CAS Number: | 57-83-0 |  3D/inchi
|
| Other(deleted CASRN): | 257630-50-5 | |
| ECHA EINECS - REACH Pre-Reg: | 200-350-6 | |
| FDA UNII: | 4G7DS2Q64Y | |
| Nikkaji Web: | J2.329I | |
| Beilstein Number: | 1915950 | |
| MDL: | MFCD00003658 | |
| XlogP3: | 3.90 (est) | |
| Molecular Weight: | 314.46850000 | |
| Formula: | C21 H30 O2 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Appearance: | white powder (est) |
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 121.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 447.15 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure: | 3.590000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 332.00 °F. TCC ( 166.70 °C. ) (est) |
| logP (o/w): | 3.870 |
| Soluble in: | |
| water, 8.81 mg/L @ 25 °C (exp) | |
| water, 5.003 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| Alfa Biotechnology |
| For experimental / research use only. |
| Progesterone 98% |
| BOC Sciences |
| For experimental / research use only. |
| Progesterone ≥98%
Odor: characteristic Use: Progesterone, synthesized from cholesterol by the sequential action of desmolase in the mitochondria, plays an important role in brain function as a endogenous progesterone receptor (PR) agonist (EC50 = 0.5 nM).
Endogenous progesterone receptor (PR) agonist |
| Glentham Life Sciences |
| Progesterone |
| Indis NV |
| For experimental / research use only. |
| Progesterone |
| Maypro Industries |
| Progesterone |
| Meafo |
| For experimental / research use only. |
| Progesterone |
| Penta International |
| PROGESTERONE MICRONIZED POWDER USP |
| Penta International |
| PROGESTERONE WETTABLE POWDER USP |
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| Progesterone ≥99% |
| WholeChem |
| Progesterone |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intravenous-mouse LDLo 100 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA Journal of Medicinal Chemistry. Vol. 11, Pg. 117, 1968. intraperitoneal-rat LD50 327 mg/kg Drugs in Japan Vol. -, Pg. 1183, 1995. | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis | ||
| Recommendation for progesterone usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for progesterone flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA GENetic TOXicology: | Search |
| EPA Substance Registry Services (TSCA): | 57-83-0 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 5994 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| (8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one | |
| Chemidplus: | 0000057830 |
| EPA/NOAA CAMEO: | hazardous materials |
| RTECS: | TW0175000 for cas# 57-83-0 |
References:
| (8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 5994 |
| Pubchem (sid): | 134971194 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| Golm Metabolome Database: | Search |
| Metabolomics Database: | Search |
| KEGG (GenomeNet): | C00410 |
| HMDB (The Human Metabolome Database): | HMDB01830 |
| FooDB: | FDB001871 |
| Export Tariff Code: | 2937.92.8020 |
| MedlinePlusSupp: | View |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
| Formulations/Preparations: •progesterone is available in an oily solution for injection, as pessaries or suppositories and as an intrauterine device. •prochieve is available in two strengths: 4% gel (45 mg of progesterone) and 8% gel (90 mg of progesterone). •progesterone injection, (projestaject, others) contains 25 to 100 mg progesterone per ml of vegetable oil. aqueous suspensions of progesterone are particularly painful & are seldom used. progesterone is also available in a t-shaped intrauterine contraceptive device that provides continuous delivery of progesterone in the uterine cavity for 1 yr. this is marketed under the name of progestasert and contains 38 mg of progesterone. •vials (aqueous solution and in oil), 25 mgml, 50 mgml, and 100 mgml. intrauterine system, 38 mg, provides contraceptive effectiveness for a period of one year. •grade: national formulary •progesterone exists in two crystalline forms (alpha- and beta-) of equal physiological activity. •alza corp...developed and intrauterine device, progestasert, designed to release progesterone by diffusion through a rate-controlling membrane for up to one year. | |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| apple Search Trop Picture | |
| bean mung bean Search Trop Picture | |
| not found in nature | |
| onion Search Trop Picture | |
| pea Search Trop Picture | |
| phaseolus angularis Search Trop Picture | |
| potato Search Trop Picture | |
| rice Search Trop Picture | |
| tomato Search Trop Picture |
Synonyms:
| (8S,9S,10R,13S,14S,17S)-17- | acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one |
| agolutin | |
| akrolutin | |
| bio-luton | |
| colprosterone | |
| corlutin | |
| corluvite | |
| corporin | |
| crinone | |
| cyclogest | |
| duraprogen | |
| endometrin | |
| estima | |
| flavolutan | |
| fologenon | |
| gesterol 100 | |
| gesterol 50 | |
| gestiron | |
| gestone | |
| gestormone | |
| gestron | |
| glanducorpin | |
| gynlutin | |
| gynoluton | |
| hormoflaveine | |
| hormoluton | |
| lingusorbs | |
| lipolutin | |
| lucorteum | |
| lugesteron | |
| luteodyn | |
| luteol | |
| luteosan | |
| luteostab | |
| luteovis | |
| luteum | |
| lutociclina | |
| lutocuclin M | |
| lutocyclin | |
| nalutron | |
| percutacrine | |
| piaponon | |
| pregn-4-en-3,20-dione | |
| (S)- | pregn-4-en-3,20-dione |
| pregn-4-ene-3,20-dione | |
| 4- | pregnen-3,20-dione |
| (S)-4- | pregnene-3,20-dione |
| progeffik | |
| progestan | |
| progestasert | |
| (S)- | progesterone |
| progestogel | |
| progestol | |
| prontogest | |
| syngesterone | |
| synovex S | |
| utrogest | |
| vitarrine |