Articles:
4-aminobenzoic acid 2-(diethylamino)ethyl ester monohydrochloride
Notes:
a local anesthetic of the ester type that has a slow onset and a short duration of action. it is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (from martindale, the extra pharmacopoeia, 30th ed, p1016). contains mainly procaine & small amounts of benzoic acid, potassium metabisulfite & disodium phosphate.
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| CAS Number: | 51-05-8 |  3D/inchi
|
| Other(deleted CASRN): | 12663-50-2 | |
| ECHA EINECS - REACH Pre-Reg: | 200-077-2 | |
| FDA UNII: | 95URV01IDQ | |
| Beilstein Number: | 3917802 | |
| MDL: | MFCD00013000 | |
| Molecular Weight: | 272.77477000 | |
| Formula: | C13 H21 Cl N2 O2 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 155.50 °C. @ 760.00 mm Hg |
| Boiling Point: | 373.60 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure: | 0.000009 mmHg @ 25.00 °C. (est) |
| Flash Point: | 356.00 °F. TCC ( 179.80 °C. ) (est) |
| logP (o/w): | 2.364 (est) |
| Soluble in: | |
| water, 9.404e+005 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Procaine HCl >98%
Odor: characteristic Use: Procaine hydrochloride is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. |
| Glentham Life Sciences |
| Procaine hydrochloride |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Procaine Hydrochloride |
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| Procaine hydrochloride ≥97% |
| TCI AMERICA |
| For experimental / research use only. |
| Procaine Hydrochloride >98.0%(HPLC)(T) |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intravenous-cat LDLo 10 mg/kg CARDIAC: CHANGE IN RATE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 8, Pg. 385, 1916. intravenous-dog LD50 63 mg/kg CARDIAC: OTHER CHANGES VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Journal of Dental Research. Vol. 20, Pg. 425, 1941. intravenous-guinea pig LD50 51 mg/kg Archives Internationales de Pharmacodynamie et de Therapie. Vol. 113, Pg. 313, 1958. intramuscular-mouse LD50 500 mg/kg Therapie. Vol. 9, Pg. 332, 1954. intraperitoneal-mouse LD50 165 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 793, 1976. intravenous-mouse LD50 33 mg/kg Anesthesia Progress. Vol. 36, Pg. 79, 1989. oral-mouse LD50 175 mg/kg Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie. Vol. 6B, Pg. 183, 1951. parenteral-mouse LD50 192 mg/kg BEHAVIORAL: EXCITEMENT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA Antibiotics and Chemotherapy Vol. 4, Pg. 633, 1954. intravenous-rabbit LD50 43 mg/kg Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 791, 1979. unreported-rabbit LD50 41 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1957, 1974. intraperitoneal-rat LD50 160 mg/kg Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 791, 1979. intravenous-rat LD50 38 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Anesthesiology. Vol. 3, Pg. 398, 1942. oral-rat LD50 200 mg/kg Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie. Vol. 6B, Pg. 183, 1951. unreported-rat LD50 150 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 1012, 1967. | |
| Dermal Toxicity: | |
|
subcutaneous-guinea pig LD50 407 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 93, Pg. 388, 1948. subcutaneous-mammal (species unspecified) LD50 630 mg/kg Ceska a Slovenska Farmacie. Vol. 44, Pg. 210, 1995. subcutaneous-mouse LD50 339 mg/kg Bollettino Chimico Farmaceutico. Vol. 107, Pg. 310, 1968. subcutaneous-rabbit LD50 687 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 93, Pg. 388, 1948. subcutaneous-rat LD50 597 mg/kg Pharmaceutical Archives. Vol. 11, Pg. 81, 1940. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis | ||
| Recommendation for procaine hydrochloride usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for procaine hydrochloride flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA GENetic TOXicology: | Search |
| EPA Substance Registry Services (TSCA): | 51-05-8 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 5795 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| 2-(diethylamino)ethyl 4-aminobenzoate;hydrochloride | |
| Chemidplus: | 0000051058 |
| RTECS: | DG2275000 for cas# 51-05-8 |
References:
| 2-(diethylamino)ethyl 4-aminobenzoate;hydrochloride | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 51-05-8 |
| Pubchem (cid): | 5795 |
| Pubchem (sid): | 134972096 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C07894 |
| HMDB (The Human Metabolome Database): | Search |
| Export Tariff Code: | 2922.49.3700 |
| MedlinePlusSupp: | View |
| ChemSpider: | View |
| Wikipedia: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| allocaine | |
| 4- | aminobenzoic acid 2-(diethylamino)ethyl ester hydrochloride |
| 4- | aminobenzoic acid 2-(diethylamino)ethyl ester monohydrochloride |
| 4- | aminobenzoic acid 2-diethylaminoethyl ester |
| p- | aminobenzoic acid 2-diethylaminoethyl ester hydrochloride |
| p- | aminobenzoic acid diethylaminoethyl ester hydrochloride |
| p- | aminobenzoyldiethylaminoethanol hydrochloride |
| aminocaine | |
| anadolor | |
| atoxicocaine | |
| benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester, hydrochloride (1:1) | |
| benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester, monohydrochloride | |
| benzoic acid, p-amino-, 2-(diethylamino)ethyl ester, monohydrochloride | |
| bernacaine | |
| bernocaine | |
| chlorocaine | |
| 2-( | diethylamino)ethyl 4-aminobenzoate hydrochloride |
| 2-( | diethylamino)ethyl 4-aminobenzoate hydrochloride (1:1) |
| 2-( | diethylamino)ethyl 4-aminobenzoate, chloride |
| 2-( | diethylamino)ethyl 4-aminobenzoate;hydrochloride |
| 2-( | diethylamino)ethyl p-aminobenzoate monohydrochloride |
| 2- | diethylaminoethyl p-aminobenzoate hydrochloride |
| ethocaine | |
| geriocaine | |
| herocaine | |
| irocaine | |
| jenacaine | |
| juvocaine | |
| kerocaine | |
| lactocaine | |
| naucaine | |
| neocaine | |
| neotonocaine | |
| novocaine | |
| novocaine hydrochloride | |
| omnicain | |
| planocaine | |
| procaine HCl | |
| procaine, hydrochloride | |
| procainehydrochloride | |
| scurocaine | |
| sevicaine | |
| syncaine | |
| topokain | |
| westocaine |