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Category: special dietary and nutritional additives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 192.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 443.26 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 372.00 °F. TCC ( 188.90 °C. ) (est)
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| logP (o/w): | 4.220 |
| Soluble in: |
| | water, 7.915 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD > 200 mg/kg Journal of Medicinal Chemistry. Vol. 11, Pg. 117, 1968.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | special dietary and nutritional additives |
| Recommendation for pregnenolone usage levels up to: | | | not for fragrance use.
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| Recommendation for pregnenolone flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 8955 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| | 1-[(3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone |
| Chemidplus: | 0000145131 |
| RTECS: | TU5560700 for cas# 145-13-1 |
References:
| | 1-[(3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 8955 |
| Pubchem (sid): | 134974430 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 1-[(3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13- | dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone | | | enelone | | 17b-(1-keto | ethyl)-D5-androsten-3b-ol | | (3b)-3- | hydroxy-pregn-5-en-20-one | | (3b)-3- | hydroxypregn-5-en-20-one | | 3b- | hydroxypregn-5-en-20-one | | | natolone | | D5- | pregnen-3b-ol-20-one | | | pregnenolonum |
Articles:
| PubMed: | Clinical Evaluation of Abiraterone in the Treatment of Metastatic Prostate Cancer. |
| PubMed: | The nuclear receptors pregnane X receptor and constitutive androstane receptor contribute to the impact of fipronil on hepatic gene expression linked to thyroid hormone metabolism. |
| PubMed: | Pregnenolone rescues schizophrenia-like behavior in dopamine transporter knockout mice. |
| PubMed: | Endocrine-disrupting effects of thioxanthone photoinitiators. |
| PubMed: | Abiraterone and other novel androgen-directed strategies for the treatment of prostate cancer: a new era of hormonal therapies is born. |
| PubMed: | Phytochemical composition and toxicity of an antioxidant extract from Pimpinella brachycarpa (Kom.) Nakai. |
| PubMed: | Endogenous steroid profiling by gas chromatography-tandem mass spectrometry and multivariate statistics for the detection of natural hormone abuse in cattle. |
| PubMed: | Development of an LC-MS/MS method to quantify sex hormones in bovine milk and influence of pregnancy in their levels. |
| PubMed: | Influence of gender, feeding regimen, and exposure duration on gene expression associated with xenobiotic metabolism in fathead minnows (Pimephales promelas). |
| PubMed: | Bisphenol A impairs follicle growth, inhibits steroidogenesis, and downregulates rate-limiting enzymes in the estradiol biosynthesis pathway. |
| PubMed: | Determination of naturally occurring progestogens in bovine milk as their oxime derivatives using high performance liquid chromatography-electrospray ionization-tandem mass spectrometry. |
| PubMed: | Effects of genistein and equol on human and rat testicular 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase 3 activities. |
| PubMed: | Investigation of urinary steroid metabolites in calf urine after oral and intramuscular administration of DHEA. |
| PubMed: | The effect of ovarian steroids on oxytocin-stimulated secretion and synthesis of prostaglandins in bovine myometrial cells. |
| PubMed: | Metabolomics approach to anabolic steroid urine profiling of bovines treated with prohormones. |
| PubMed: | Chrysin, a natural flavonoid enhances steroidogenesis and steroidogenic acute regulatory protein gene expression in mouse Leydig cells. |
| PubMed: | Effects of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) hull extracts on the secretion of progesterone and estradiol in vivo and in vitro. |
| PubMed: | Intrahippocampal allopregnanolone decreases voluntary chronic alcohol consumption in non-selected rats. |
| PubMed: | Effects of crude adlay hull acetone extract on corticosterone release from rat zona fasciculata-reticularis cells. |
| PubMed: | Human adrenocarcinoma (H295R) cells for rapid in vitro determination of effects on steroidogenesis: hormone production. |
| PubMed: | Downregulation of progesterone biosynthesis in rat granulosa cells by adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) bran extracts. |
| PubMed: | The neurosteroid pregnenolone sulfate neutralized the learning impairment induced by intrahippocampal nicotine in alcohol-drinking rats. |
| PubMed: | Intrahippocampal nicotine and neurosteroids effects on the anxiety-like behaviour in voluntary and chronic alcohol-drinking rats. |
| PubMed: | Influence of progesterone, pregnenolone and 17beta-hydroxyprogesterone on the function of bovine luteal cells treated with luteinizing hormone, noradrenaline and prostaglandin E2. |
| PubMed: | Non-genomic effect of steroids on oxytocin-stimulated intracellular mobilization of calcium and on prostaglandin F2alpha and E2 secretion from bovine endometrial cells. |
| PubMed: | Differential expression and function of beacon in the rat adrenal cortex and medulla. |
| PubMed: | Nuclear receptor, pregname X receptor, is required for induction of UDP-glucuronosyltranferases in mouse liver by pregnenolone-16 alpha-carbonitrile. |
| PubMed: | A binary screening assay for pro-oestrogens in food: metabolic activation using hepatic microsomes and detection with oestrogen sensitive recombinant yeast cells. |
| PubMed: | Steroid hormone receptors and dietary ligands: a selected review. |
| PubMed: | Effects of fasting on corticosterone production by zona fasciculata-reticularis cells in ovariectomized rats. |
| PubMed: | Thiazolidinediones influence plasma steroids of male obese Zucker rats. |
| PubMed: | Decreased expression of steroidogenic acute regulatory protein: a novel mechanism participating in the leptin-induced inhibition of glucocorticoid biosynthesis. |
| PubMed: | Age, body mass index, race and other determinants of steroid hormone variability: the HERITAGE Family Study. |
| PubMed: | Mechanism of action of noradrenaline on secretion of progesterone and oxytocin by the bovine corpus luteum in vitro. |
| PubMed: | Dehydroepiandrosterone and related steroids alter 3T3-L1 preadipocyte proliferation and differentiation. |
| PubMed: | Alteration of acetaminophen metabolism by sulfate and steroids in primary monolayer hepatocyte cultures of rats and mice. |
| PubMed: | Leptin modulates the glucocorticoid-induced ovarian steroidogenesis. |
| PubMed: | Influence of sampling on steroid hormone patterns of beef from bulls and steers. |
| PubMed: | The role of GABA-A and mitochondrial diazepam-binding inhibitor receptors on the effects of neurosteroids on food intake in mice. |
| PubMed: | Differences in natural steroid hormone patterns of beef from bulls and steers. |
| PubMed: | Effect of a dopamine agonist on luteinizing hormone receptors, cyclic AMP production and steroidogenesis in rat Leydig cells. |
| PubMed: | A positive role for thymus-derived steroids in formation of the T-cell repertoire. |
| PubMed: | A colorimetric assay method for 3beta-hydroxy-delta5-steroid dehydrogenase. |
| PubMed: | Aminoglutethimide, a corticosteroid synthesis inhibitor, facilitates brain stimulation reward in food-restricted rats: an investigation of underlying mechanisms. |
| PubMed: | The hyperphagic effect of 3 alpha-hydroxylated pregnane steroids in male rats. |
| PubMed: | Androgen biosynthesis in the stomach: expression of cytochrome P450 17 alpha-hydroxylase/17,20-lyase messenger ribonucleic acid and protein, and metabolism of pregnenolone and progesterone by parietal cells of the rat gastric mucosa. |
| PubMed: | The effect of colupulone (a HOPS beta-acid) on hepatic cytochrome P-450 enzymatic activity in the rat. |
| PubMed: | Enzymatic sulfation of glycosides and their corresponding aglycones by arylsulfate sulfotransferase from a human intestinal bacterium. |
| PubMed: | Effects of feed additives and veterinary drugs on aldosterone production and release by porcine adrenal cells in vitro. |
| PubMed: | The effects of pregnenolone on acquisition and retention of a food search task. |
| PubMed: | On the origin of vertebrate-type steroids present in Locusta migratoria: do they originate from the food? |
| PubMed: | Effects of cadmium and zinc on steroid metabolism and steroid level in the sea star Asterias rubens L. |
| PubMed: | Increased permeability of the rat biliary tree by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) treatment and protection by hepatoactive agents. |
| PubMed: | Mutagens in cooked foods--metabolism and genetic toxicity. |
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