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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 300.40 °C. @ 760.00 mm Hg (est)
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| Flash Point: | > 230.00 °F. TCC ( > 110.00 °C. )
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| logP (o/w): | 3.380 (est) |
| Soluble in: |
| | water, 52.04 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for precocene II usage levels up to: | | | not for fragrance use.
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| Recommendation for precocene II flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | ageratochromene | | 2H-1- | benzopyran, 6,7-dimethoxy-2,2-dimethyl- | | 6,7- | dimethoxy-2,2-dimethyl-2H-benzo(b)pyran | | 6,7- | dimethoxy-2,2-dimethyl-2H-chromene | | 6,7- | dimethoxy-2,2-dimethylchromene | | | precocen 2 | | | precocene 2 | | | preconene II | | | pricocene II |
Articles:
| PubMed: | Volatile composition and sensory properties of Indian herbal medicine-Pavonia odorata-used in Ayurveda. |
| PubMed: | Correlation of ATP citrate lyase and acetyl CoA levels with trichothecene production in Fusarium graminearum. |
| PubMed: | [Antijuvenile influence of the precocene on the development of adult antennae in the apple surface eating tortricid Archips podana Scop. (Lepidoptera: Tortricidae)]. |
| PubMed: | [Analyze on chemical compositions of Dalbergia odorifera essential oils extracted by CO2-supercritical-fluid-extraction and steam distillation extraction]. |
| PubMed: | A new chromene isolated from Ageratum conyzoides. |
| PubMed: | Sensitivity of last larval stadium of Chrysomya megacephala (Fabricius) to anti-allatin ageratochromene Precocene II. |
| PubMed: | Volatile oils from the plant and hairy root cultures of Ageratum conyzoides L. |
| PubMed: | Acaricidal properties of the essential oil and precocene II obtained from Calea serrata (Asteraceae) on the cattle tick Rhipicephalus (Boophilus) microplus (Acari: Ixodidae). |
| PubMed: | Enhancement of trichothecene production in Fusarium graminearum by cobalt chloride. |
| PubMed: | Composition of essential oils in subterranean organs of three species of Valeriana L. |
| PubMed: | Chemical composition and antibacterial activity of essential oils of Lantana camara, Ageratum houstonianum and Eupatorium adenophorum. |
| PubMed: | Changes in the corpora allata and epidermal proliferation along the fourth instar of the Chagas disease vector Triatoma infestans. |
| PubMed: | Ageratum conyzoides essential oil as aflatoxin suppressor of Aspergillus flavus. |
| PubMed: | New synthetic precocenoids as potential insect control agents. |
| PubMed: | Isolation and identification of precocenes and piperitone from essential oils as specific inhibitors of trichothecene production by Fusarium graminearum. |
| PubMed: | [Influence of precocene II on the sensory system of antennae and mouthparts in larvae of the fruit tree tortricid Archips podana Scop. (Lepidoptera: Tortricidae)]. |
| PubMed: | Comparison of radioimmunoassay and liquid chromatography tandem mass spectrometry for determination of juvenile hormone titers. |
| PubMed: | Multigeneration effects of insect growth regulators on the springtail Folsomia candida. |
| PubMed: | The pupal specifier broad directs progressive morphogenesis in a direct-developing insect. |
| PubMed: | Volatile allelochemicals in the Ageratum conyzoides intercropped citrus orchard and their effects on mites Amblyseius newsami and Panonychus citri. |
| PubMed: | Effects of insect growth regulators on the nontarget soil arthropod Folsomia candida (Collembola). |
| PubMed: | Synthesis and insect antifeedant activity of precocene derivatives with lactone moiety. |
| PubMed: | Effect of precocene II on fatty acid metabolism in the pea aphid, Acyrthosiphon pisum, under cold stress. |
| PubMed: | Effect of precocene on development of ovarian follicles in flesh fly, Sarcophaga ruficornis F. |
| PubMed: | [Effect of plants synthesizing biologically active substances-precocenes on insects]. |
| PubMed: | Juvenile hormone regulates the expression of the gene encoding ceratotoxin a, an antibacterial peptide from the female reproductive accessory glands of the medfly Ceratitis capitata. |
| PubMed: | Sensitive periods for wing development and precocious metamorphosis after precocene treatment of the brown planthopper, Nilaparvata lugens. |
| PubMed: | Identification and action of juvenile hormone III from sexually mature alate females of the red imported fire ant, Solenopsis invicta. |
| PubMed: | Efficacy of BaySir-8514 and precocene II against the grey flesh fly Parasarcophaga dux (Thomson) (Diptera: Sarcophagidae). |
| PubMed: | Perturbed turnover of microtubule-based nutritive tubes in ovarioles of virgin and precocene-treated Dysdercus fasciatus. |
| PubMed: | Analysis of precocenes in the essential oil of Ageratum spp. by reverse-phase high-performance liquid chromatography. |
| PubMed: | Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential. |
| PubMed: | Lack of Effect of Medium Supplementation With Pyruvate and Hormones on Cytochrome P450-mediated Activity of Rat Hepatocytes in Primary Culture. |
| PubMed: | A Preliminary Comparison of LiverBeads™ with a Conventional Rat Hepatocyte Culture Preparation: Some Aspects of Xenobiotic Metabolism and Related Toxicity. |
| PubMed: | Involvement of cytochrome P4502E1 in the toxicity of dichloropropanol to rat hepatocyte cultures. |
| PubMed: | Effects of culture duration, cytochrome P-450 inhibition and glutathione depletion on toxicity of diverse xenobiotics. |
| PubMed: | Mechanism of toxicity of precocene II in rat hepatocyte cultures. |
| PubMed: | Toxicity of precocene II in rat hepatocyte cultures: effects of serum and culture time. |
| PubMed: | Maintenance of xenobiotic metabolism and toxicity in rat hepatocyte cultures after cell preservation at 4 degrees. |
| PubMed: | Effect of serum-free medium on cytochrome P450-dependent metabolism and toxicity in rat cultured hepatocytes. |
| PubMed: | Effects of precocenes on vitellogenesis in the adult female tick, Ornithodoros moubata (Acari: Argasidae). |
| PubMed: | Maintenance of monooxygenase activities and detection of cytochrome P-450-mediated cytotoxicity in Mongolian gerbil hepatocyte cultures. |
| PubMed: | [Variations induced by juvenile hormone and precocene II in the metabolic rate of 3 species of insects]. |
| PubMed: | The use of hepatocytes cultured from inducer-treated rats in the detection of cytochrome P-450-mediated cytotoxicity. |
| PubMed: | Effects of proallatotoxins (precocenes) on the development and reproduction of Rhodnius prolixus: some data. |
| PubMed: | Role of corpus allatum on the modulation of feeding rhythm in the semilooper caterpillar, Achaea janata (L). |
| PubMed: | [Effects of juvenile hormone and precocene II on the metabolic rate of the digestive system, fat body and ovaries of the insect Oncopeltus fasciatus]. |
| PubMed: | Distribution and pharmacokinetics of precocene-II in the tick Ornithodoros parkeri (Acari: Argasidae). |
| PubMed: | Genotoxicity of the anti-juvenile hormone agent precocene II as revealed by the Drosophila wing spot test. |
| PubMed: | Effects of precocene analogs on the nematode Caenorhabditis remanei (var. Bangaloreiensis). II. Competitions with a juvenile hormone analog (Methoprene). |
| PubMed: | Effects of precocene analogs on the nematode Caenorhabditis remanei (var. Bangaloreiensis). I. Structure/activity relations. |
| PubMed: | Purification and characterization of a soybean flour-induced cytochrome P-450 from Streptomyces griseus. |
| PubMed: | Alteration of precocene II-induced hepatotoxicity by modulation of hepatic glutathione levels. |
| PubMed: | Xenobiotic oxidation by cytochrome P-450-enriched extracts of Streptomyces griseus. |
| PubMed: | Cytoprotective effects of modulators of oxidative xenobiotic metabolism in precocene II-induced hepatotoxicity. |
| PubMed: | Microbial transformation of precocene II: oxidative reactions by Streptomyces griseus. |
| PubMed: | Structure-activity studies of the hepatocarcinogenicities of alkenylbenzene derivatives related to estragole and safrole on administration to preweanling male C57BL/6J x C3H/HeJ F1 mice. |
| PubMed: | Secretory activity and endocrine regulation of male accessory glands in the blood-sucking bug Panstrongylus megistus (Hemiptera: Reduviidae). |
| PubMed: | Effects of precocene and azadirachtin in Rhodnius prolixus: some data on development and reproduction. |
| PubMed: | Effects of precocenes on ovarian development of the seed bug, Oxycarenus lavaterae (F.). |
| PubMed: | The effects of precocene treatment on egg wax production in Gené's organ and egg viability in the cattle tick Boophilus microplus (Acarina Ixodidae): an ultrastructural study. |
| PubMed: | [Biomorphogenetic changes caused by the application of precocene II in nymphs of Triatoma infestans (Klug, 1834) (Hemiptera, Reduviidae, Triatominae)]. |
| PubMed: | The effect of precocene II and 20-OH-ecdysone on Litomosoides carinii and Dipetalonema viteae in vivo. |
| PubMed: | Effects of the juvenile hormone antagonist precocene II and the moulting hormone 20-OH-ecdysone on Litomosoides carinii and Dipetalonema viteae in vitro. |
| PubMed: | Induction of DNA damage and repair synthesis in freshly isolated rat hepatocytes by the proallatocidin precocene II. |
| PubMed: | Effects of juvenile hormone analogue on ecdysis prevention induced by precocene in Rhodnius prolixus (Hemiptera:Reduviidae). |
| PubMed: | [Morphogenetic effects of precocene II on nymphs of Rhodnius prolixus (Stal, 1859) (Hemiptera-Triatominae)]. |
| PubMed: | High-performance liquid chromatographic methods designed for metabolic studies of the proallatocidin precocene II. |
| PubMed: | Toxicity of precocene-2 for the American dog tick, Dermacentor variabilis (acari: Ixodidae). |
| PubMed: | [Morphological changes induced by the use of precocene II in Panstrongylus megistus (Burmeister, 1835), (Hemiptera, Reduviidae, Triatominae)]. |
| PubMed: | Toxicological significance of dihydrodiol metabolites. |
| PubMed: | Precocene II nephrotoxicity in the rat. |
| PubMed: | The effects of precocene II on reproduction and development of triatomine bugs (Reduviidae: Triatominae). |
| PubMed: | Metabolic fate of the hepatotoxic anti-juvenile hormone precocene II in the rat. |
| PubMed: | Competition between juvenile hormone antagonist precocene II and juvenile hormone analog: methoprene in the nematode Caenorhabditis elegans. |
| PubMed: | Precocene-induced effects and possible role of juvenile hormone during embryogenesis of the milkweed bug Oncopeltus fasciatus. |
| PubMed: | Immediate and latent effects induced by the antiallatotropin precocene 2(P2) on embryonic Dermacentor variabilis (Say) (Acari: Ixodidae). |
| PubMed: | Hepatotoxicity of the anti-juvenile hormone precocene II and the generation of dihydrodiol metabolites. |
| PubMed: | Effects of ecdysone on the metamorphosis and ecdysis prevention induced by precocene II in Rhodnius prolixus. |
| PubMed: | [Action of development inhibitors on Aedes aegypti L. mosquitoes and Rhodnius prolixus Stal. bugs. IV. The activity of precocenes]. |
| PubMed: | Active vitellogenesis in precocene-treated Locusta migratoria. |
| PubMed: | Insecticidal effect of precocene II on the human body louse, Pediculus humanus. |
| PubMed: | Activity of precocenes on the Chagas's disease vector, Panstrongylus megistus. |
| PubMed: | Precocene-induced necrosis and haemocyte-mediated breakdown of corpora allata in nymps of the locust Locusta migratoria. |
| PubMed: | Distribution and metabolism of precocene II in the brown cockroach (Periplaneta brunnea Burmeister). |
| PubMed: | Effect of precocene II on the endocrine regulation of development and reproduction in the bug, Oncopeltus fasciatus. |
| PubMed: | Morphogenetic effects of precocene II on the immature stages of Rhodnius prolixus. |
| PubMed: | Radiosynthesis and metabolism of the insect antijuvenile hormone, precocene II. |
| PubMed: | Precocene II inhibits juvenile hormone biosynthesis by cockroach corpora allata in vitro. |
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