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Category: buffering agents, neutralizing agents, color fixatives, acidity regulators
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white crystalline powder (est) |
| Assay: | 98.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 1e+006 mg/L @ 25 °C (est) |
| Insoluble in: |
| | alcohol |
Organoleptic Properties:
Odor Description: at 100.00 %. | odorless |
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LDLo 4640 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
GASTROINTESTINAL: OTHER CHANGES National Technical Information Service. Vol. OTS0571153
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| Dermal Toxicity: |
skin-rabbit LD50 > 4640 mg/kg National Technical Information Service. Vol. OTS0571153
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | buffering agents, neutralizing agents, color fixatives, acidity regulators |
| Recommendation for potassium phosphate monobasic usage levels up to: | | | not for fragrance use.
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| Recommendation for potassium phosphate monobasic flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| European Food Safety Authority (EFSA) reference(s): |
Assessment of one published review on health risks associated with phosphate additives in food View page or View pdf |
Re-evaluation of phosphoric acid–phosphates – di-, tri- and polyphosphates (E 338–341, E 343, E 450–452) as food additives and the safety of proposed extension of use View page or View pdf |
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| NIOSH International Chemical Safety Cards: | search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 7778-77-0 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 516951 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 1 |
| | potassium dihydrogen phosphate |
| Chemidplus: | 0007778770 |
| RTECS: | 7778-77-0 |
References:
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| HMDB (The Human Metabolome Database): | Search |
| FooDB: | FDB013364 |
| Export Tariff Code: | 2835.24.0000 |
| FDA Listing of Food Additive Status: | View |
| ChemSpider: | View |
Formulations/Preparations: •injection, 4.4 meq of potassium ion and 3 mm of phosphorus (provided by potassium phosphate, monobasic 224 mg and potassium phosphate, dibasic 236 mgml.
•grades: technical, cp, fcc (food chemicals codex)
•first choice foliar supreme fungucide (loveland products, inc.) potassium phosphate, monobasic 31.1%, sulfur 31.1%
•ekspunge (lidochem, inc.) potassium phosphate, monobasic 100%
•first choice phortress fungicide (loveland products, inc.) potassium phosphate, monobasic 40.8%, mono- and di- potassium salts of phosphorous acid 28.1%
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Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | phosphoric acid potassium salt (1:1) | | | phosphoric acid, monopotassium salt | | | phosphoric acid, potassium salt | | | phosphoric acid, potassium salt (1:1) | | | potassium dihydrogen orthophosphate | | | potassium dihydrogen phosphate | | mono | potassium dihydrogen phosphate | | | potassium dihydrogenorthophosphate | | | potassium hydrogen phosphate (KH2PO4) | | mono | potassium monophosphate | | mono | potassium orthophosphate | | monobasic | potassium phosphate | | | potassium phosphate, monobasic | | | sorensen's potassium phosphate |
Articles:
| PubMed: | Pharmacokinetics of dronedarone in rat using a newly developed high-performance liquid chromatographic assay method. |
| PubMed: | Mobility and bioavailability reduction of soil TNT via sorption enhancement using monopotassium phosphate. |
| PubMed: | [Validation of a liquid chromatography method for rifampicin determination in human plasma]. |
| PubMed: | Bromination of aromatic compounds by residual bromide in sodium chloride matrix modifier salt during heated headspace GC/MS analysis. |
| PubMed: | A Single Gradient Stability-Indicating Reversed-Phase LC Method for the Estimation of Impurities in Omeprazole and Domperidone Capsules. |
| PubMed: | Development and validation of a stability-indicating size-indicating size-exclusion LC method for the determination of rhIFN-alpha2a in pharmaceutical formulations. |
| PubMed: | Estimation of standardized phosphorus retention for inorganic phosphate sources in broilers. |
| PubMed: | Simultaneous determination of morniflumate and its major active metabolite, niflumic acid, in human plasma by high-performance liquid chromatography in stability and pharmacokinetic studies. |
| PubMed: | Vacuum foam drying: an alternative to lyophilization for biomolecule preservation. |
| PubMed: | Photodegradation kinetics, cytotoxicity assay and determination by stability-indicating HPLC method of mianserin hydrochloride. |
| PubMed: | Cloning, purification, crystallization and preliminary X-ray crystallographic analysis of a cyclophilin A-like protein from Piriformospora indica. |
| PubMed: | Development and validation of a rapid HPLC method for simultaneous analysis of budesonide and its novel synthesized hemiesters in colon specific formulations. |
| PubMed: | Development and validation of a reversed-phase column liquid chromatographic method for the determination of five cephalosporins in pharmaceutical preparations. |
| PubMed: | Intrinsically fluorescent carbon dots with tunable emission derived from hydrothermal treatment of glucose in the presence of monopotassium phosphate. |
| PubMed: | Development and validation of an HPLC method for mefloquine hydrochloride determination in tablet dosage form. |
| PubMed: | Partition Efficiency of High-Pitch Locular Multilayer Coil for Countercurrent Chromatographic Separation of Proteins Using Small-Scale Cross-Axis Coil Planet Centrifuge and Application to Purification of Various Collagenases with Aqueous-Aqueous Polymer Phase Systems. |
| PubMed: | Application of liquid-liquid-liquid microextraction and high-performance liquid chromatography for the determination of alkylphenols and bisphenol-A in water. |
| PubMed: | Rapid determination of paeoniflorin from Paeonia sinjiang K. Y. Pan. by rapid resolution liquid chromatography. |
| PubMed: | Chitosan-dibasic orthophosphate hydrogel: a potential drug delivery system. |
| PubMed: | Countercurrent chromatographic separation and purification of various ribonucleases using a small-scale cross-axis coil planet centrifuge with aqueous-aqueous polymer phase systems. |
| PubMed: | [Effects of different forms of P fertilizers on phytoremediation for As-contaminated soils using As-hyperaccumulator Pteris vittata L]. |
| PubMed: | Validation of a model for growth of Lactococcus lactis and Listeria innocua in a structured gel system: effect of monopotassium phosphate. |
| PubMed: | HPLC detection of marker compounds during buccal permeation enhancement studies. |
| PubMed: | Determination of pitavastatin from human plasma using high performance liquid chromatography with fluorescence detection. |
| PubMed: | New small-scale cross-axis coil planet centrifuge. Partition efficiency and application to purification of bullfrog ribonuclease. |
| PubMed: | Determination of olanzapine in human plasma by reversed-phase high-performance liquid chromatography with ultraviolet detection. |
| PubMed: | Doubling calcium and phosphate concentrations in neonatal parenteral nutrition solutions using monobasic potassium phosphate. |
| PubMed: | Simultaneous determination of chlorpheniramine maleate and dexamethasone in a tablet dosage form by liquid chromatography. |
| PubMed: | Determination of albuterol sulfate and its related substances in albuterol sulfate inhalation solution, 0.5% by RP-HPLC. |
| PubMed: | Development and validation of a new HPLC method for determination of lamotrigine and related compounds in tablet formulations. |
| PubMed: | A stability-indicating HPLC assay for metronidazole benzoate. |
| PubMed: | Occlusion of dentin tubules by desensitizing agents. |
| PubMed: | Assay for the simultaneous determination of acetaminophen-caffeine-butalbital in human serum using a monolithic column. |
| PubMed: | [Determination of synthetic food dyes in food by capillary electrophoresis]. |
| PubMed: | Liquid chromatography determination of the anti-androgen vinclozolin and its metabolites in rat serum. |
| PubMed: | Mineralization of dentin induced by treatment with bioactive glass S53P4 in vitro. |
| PubMed: | Validation of a simple liquid chromatography assay for creatine suitable for pharmacokinetic applications, determination of plasma protein binding and verification of percent labeled claim of various creatine products. |
| PubMed: | Development of a HPLC method for the determination of cyclosporin-A in rat blood and plasma using naproxen as an internal standard. |
| PubMed: | LC method for the determination of oxcarbazepine in pharmaceutical preparations. |
| PubMed: | The Ca/P range of nanoapatitic calcium phosphate cements. |
| PubMed: | [RP-HPLC determination of adenosine in fermented Cordyceps]. |
| PubMed: | Optimization of nisin production by Lactococcus lactis. |
| PubMed: | [Determination of nitidine in different parts of Zanthoxylum nitidum]. |
| PubMed: | High-performance liquid chromatography assay of amiodarone in rat plasma. |
| PubMed: | Experimental study of phosphopeptide in promoting tooth remineralization. |
| PubMed: | Adsorption characteristics of proteins on calcium phosphates using liquid chromatography. |
| PubMed: | Validation of a method for the determination of zolpidem in human plasma using LC with fluorescence detection. |
| PubMed: | Determination of histidine and related compounds in rumen fluid by liquid chromatography. |
| PubMed: | Inositol hexaphosphate (IP6) as an anti-neoplastic and lipid-lowering agent. |
| PubMed: | Stability-indicating high-performance liquid chromatographic assay of buspirone HCl. |
| PubMed: | Bacillus stearothermophilus sporulation response to different composition media. |
| PubMed: | A split-mouth placebo-controlled study to determine the effect of amorphous calcium phosphate in the treatment of dentine hypersensitivity. |
| PubMed: | Determination of a new polymer-bound paclitaxel derivative (PNU 166945), free paclitaxel and 7-epipaclitaxel in dog plasma and urine by reversed-phase high-performance liquid chromatography with UV detection. |
| PubMed: | High performance liquid chromatographic determination of folic acid and its photodegradation products in the presence of riboflavin. |
| PubMed: | Simultaneous determination of the new anticancer agent amidox and its metabolites in rat bile and plasma by high-performance liquid chromatography. |
| PubMed: | Determination of metronidazole in vaginal tissue by high-performance liquid chromatography using solid-phase extraction. |
| PubMed: | Adsorption of [3H]-lipoteichoic acid to hydroxyapatite and its effect on crystal growth. |
| PubMed: | Development and validation of a high-performance liquid chromatographic method for the determination of methocarbamol in human plasma. |
| PubMed: | Determination of 5-fluorouracil and its main metabolites in plasma by high-performance liquid chromatography. |
| PubMed: | Simple high-performance liquid chromatographic method for the determination of PGT/1A, a new immunostimulating drug, in biological fluids. |
| PubMed: | Quantitation of urinary chlorobenzene metabolites by HPLC: concentrations of 4-chlorocatechol and chlorophenols in urine and of chlorobenzene in biological specimens of subjects exposed to chlorobenzene. |
| PubMed: | Role of the source of phosphate salt in improving the mineral balance of parenterally fed low birth weight infants. |
| PubMed: | High-performance liquid chromatographic analysis of doxacurium, a new long-acting neuromuscular blocker. |
| PubMed: | Liquid chromatographic determination of penicillin V potassium in tablets: collaborative study. |
| PubMed: | Assay of free and total tocainide by high performance liquid chromatography (HPLC) with ultraviolet (UV) detection. |
| PubMed: | Simple and rapid reversed-phase high-performance liquid chromatographic determination of baclofen in human plasma with ultraviolet detection. Application to a pharmacokinetic study. |
| PubMed: | High-performance liquid chromatographic assay of the aldose reductase inhibitor spiro-(2-fluoro-9H-fluorene-9,4'-imidazolidine)-2',5'-dione (AL01567) in plasma and urine and its pharmacokinetics in humans. |
| PubMed: | A simple, fast and reliable method for obtaining dopamine histofluorescence from mesencephalic cultures. |
| PubMed: | Simultaneous determination of urinary creatinine and metabolites of toluene, xylene, styrene, ethylbenzene and phenol by automated high performance liquid chromatography. |
| PubMed: | Determination of terbutaline sulfate in dosage forms by liquid chromatography with electrochemical detection. |
| PubMed: | Calcium and phosphate solubility in neonatal parenteral nutrient solutions containing Aminosyn PF. |
| PubMed: | Effect of buffers on testing of Candida species susceptibility to flucytosine. |
| PubMed: | Quantitation of urinary metabolites of toluene, xylene, styrene, ethylbenzene, benzene and phenol by automated high performance liquid chromatography. |
| PubMed: | Liquid chromatographic determination of penicillin V potassium in tablets and powders for oral solution. |
| PubMed: | Calcium and phosphate solubility in neonatal parenteral nutrient solutions containing TrophAmine. |
| PubMed: | Reverse phase liquid chromatographic determination of sulfathiazole residues in honey. |
| PubMed: | Simultaneous high-performance liquid chromatographic determination of theophylline, ephedrine hydrochloride, and phenobarbital in tablets. |
| PubMed: | Efficacy of intravenous phosphorus therapy in the severely hypophosphatemic patient. |
| PubMed: | Limulus amoebocyte lysate assay for detection and quantitation of endotoxin in a small-volume parenteral product. |
| PubMed: | A liquid medium for the production of Kabatiella zeae conidia. |
| PubMed: | Reverse phase high pressure liquid chromatographic determination of some iodoamino acid contaminants in sodium liothyronine or sodium levothyroxine. |
| PubMed: | Balance of net base in the rat. IV. Effects of oral calcium and phosphate loading. |
| PubMed: | Fluoride content of dental plaque before, during and after ingestion of sucrose modified with fluoride or bicarbonate-phosphate. |
| PubMed: | Bacterial growth inhibition by amniotic fluid. IV. Studies on the nature of bacterial inhibition with the use of plate-count determinations. |
| PubMed: | [Studies on murine leprosy bacillus. V. Growth in relation to concentrations of monopotassium phosphate, sodium glutamate and glycerol in the 1 per cent egg yolk medium, and in relation to pH of the medium]. |
| PubMed: | Studies on the murine leprosy bacillus. V. Growth in relation to concentrations of monopotassium phosphate, sodium glutamate, and glycerol in the 1 per cent egg yolk medium, and relation to pH of the medium. |
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