potassium nitrite
nitrous acid, potassium salt (1:1)
 
Notes:
Preservative for red meat and poultry products
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CAS Number: 7758-09-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 231-832-4
FDA UNII: 794654G42L
Nikkaji Web: J4.518G
MDL: MFCD00011408
Molecular Weight: 85.10370000
Formula: K N O2
NMR Predictor: Predict (works with chrome or firefox)
Category: color fixatives and preservative agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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 FDA/DG SANTE Petitions, Reviews, Notices:
EU SANCO Nitrites View - review
JECFA Food Additive: Potassium Nitrite
GSFA Codex: Potassium nitrite (249)
DG SANTE Food Additives: potassium nitrite
FDA Mainterm (SATF):7758-09-0 ; POTASSIUM NITRITE
FDA Regulation:
FDA PART 181 -- PRIOR-SANCTIONED FOOD INGREDIENTS
Subpart B--Specific Prior-Sanctioned Food Ingredients
Sec. 181.33 Sodium nitrate and potassium nitrate.


FDA PART 181 -- PRIOR-SANCTIONED FOOD INGREDIENTS
Subpart B--Specific Prior-Sanctioned Food Ingredients
Sec. 181.34 Sodium nitrite and potassium nitrite.
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Physical Properties:
Appearance: white to pale yellow granules (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Specific Gravity: 1.91500 @  25.00 °C.
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
Insoluble in:
 alcohol
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
EMD Millipore
For experimental / research use only.
Potassium Nitrite
Santa Cruz Biotechnology
For experimental / research use only.
Potassium Nitrite
Sigma-Aldrich
For experimental / research use only.
Potassium nitrite ACS reagent, ≥96.0%
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rabbit LD50  200 mg/kg
Southwestern Veterinarian. Vol. 27, Pg. 246, 1974.

oral-human TDLo  1428 ug/kg
SENSE ORGANS AND SPECIAL SENSES: TINNITUS: EAR CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(1), Pg. 62, 1983.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
inhalation-mouse LC50 85000 mg/m3
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(1), Pg. 62, 1983.

inhalation-mouse LC50 85000 mg/m3/2H
BEHAVIORAL: SLEEP BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(1), Pg. 62, 1983.

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Safety in Use Information:
Category: color fixatives and preservative agents
Recommendation for potassium nitrite usage levels up to:
 not for fragrance use.
 
Recommendation for potassium nitrite flavor usage levels up to:
 not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
Opinion of the Scientific Panel on biological hazards (BIOHAZ) related to the effects of Nitrites/Nitrates on the Microbiological Safety of Meat Products
View page or View pdf
Statement on nitrites in meat products
View page or View pdf
Re-evaluation of potassium nitrite (E 249) and sodium nitrite (E 250) as food additives
View page or View pdf
Outcome of a public consultation on the draft risk assessment of nitrate and nitrite in feed
View page or View pdf
EPI System: View
NIOSH International Chemical Safety Cards: search
Chemical Carcinogenesis Research Information System: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 7758-09-0
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 516910
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 potassium nitrite
Chemidplus: 0007758090
EPA/NOAA CAMEO: hazardous materials
RTECS: 7758-09-0
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References:
 potassium nitrite
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 7758-09-0
Pubchem (cid): 516910
Pubchem (sid): 134989987
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS): View
CHEMBL: View
HMDB (The Human Metabolome Database): Search
FooDB: FDB015408
Export Tariff Code: 2834.10.5000
FDA Listing of Food Additive Status: View
ChemSpider: View
Wikipedia: View
Formulations/Preparations:
•grade: cp; technical; reagent; fcc. •nitrite of commerce usually contains about 85% potassium nitrite, remainder consisting chiefly of nitrate
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 nitrous acid potassium salt (1:1)
 nitrous acid, potassium salt
 nitrous acid, potassium salt (1:1)
 potassium nitrite (1:1)
 potassium nitrite [UN1488] [Oxidizer]
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Articles:
PubMed: Plant-fungal ecology. Niche engineering demonstrates a latent capacity for fungal-algal mutualism.
PubMed: Cu(OTf)2-catalyzed selective arene C-H bond hydroxylation and nitration with KNO2 as an ambident O- and N-nucleophile via a Cu(II)-Cu(III)-Cu(I) mechanism.
PubMed: Detection and identification of 2-nitro-morphine and 2-nitro-morphine-6-glucuronide in nitrite adulterated urine specimens containing morphine and its glucuronides.
PubMed: Heterotrophic nitrifying and oxygen tolerant denitrifying bacteria from greenwater system of coastal aquaculture.
PubMed: Effect of oxidizing adulterants on human urinary steroid profiles.
PubMed: 2-Nitro-6-monoacetylmorphine: potential marker for monitoring the presence of 6-monoacetylmorphine in urine adulterated with potassium nitrite.
PubMed: Effect of diet composition and mixture of selected food additives on the erythrocytic system and iron metabolism in peripheral blood of male rats.
PubMed: Characterization of a diesel-degrading strain isolated from a hydrocarbon-contaminated site.
PubMed: Generation of nitric oxide from nitrite by carbonic anhydrase: a possible link between metabolic activity and vasodilation.
PubMed: Citrus co-products as technological strategy to reduce residual nitrite content in meat products.
PubMed: Photooxidation of halides by chlorophyll at the air-salt water interface.
PubMed: Pseudoazurin dramatically enhances the reaction profile of nitrite reduction by Paracoccus pantotrophus cytochrome cd1 and facilitates release of product nitric oxide.
PubMed: Beta-MnO2 3D nanostructures: mineralizer-assisted synthesis, characterization, and growth mechanism.
PubMed: Electrochemical oxidation of nitrite and the oxidation and reduction of NO2 in the room temperature ionic liquid [C2mim][NTf2].
PubMed: [Effects of potassium salts on direct induction of microtubers in Pinellia ternata].
PubMed: Genotoxicity testing of four food preservatives and their combinations in the Drosophila wing spot test.
PubMed: Transcriptional regulation of nir and nor operons of Paracoccus denitrificans.
PubMed: Comparison of spot tests with AdultaCheck 6 and Intect 7 urine test strips for detecting the presence of adulterants in urine specimens.
PubMed: [Effect of nitrite-anions on Ca2+ transport into the sarcolemma of myometrium].
PubMed: Rapid spot tests for detecting the presence of adulterants in urine specimens submitted for drug testing.
PubMed: Potassium nitrite reaction with 11-nor-delta 9-tetrahydrocannabinol-9-carboxylic acid in urine in relation to the drug screening analysis.
PubMed: NO-dependent regulation of lectin- and menadione-induced H2O2 production by cells from pleural effusions of lung cancer patients and by immune cells.
PubMed: Helicobacter pylori is killed by nitrite under acidic conditions.
PubMed: A randomized trial of acidified nitrite cream in the treatment of tinea pedis.
PubMed: Effect of nitrite on blood pressure in anaesthetized and free-moving rats.
PubMed: Nitrite-induced adrenal effects in rats and the consequences for the no-observed-effect level.
PubMed: The nitrosation of hexetidine and hexedine: characterization of the major nitrosamine from common antimicrobial agents.
PubMed: Synthesis and evaluation of antimicrobial activity of new 4-nitroso and 4-diazopyrazole derivatives.
PubMed: Effect of nitrite ingestion on the bioavailability of folate in the rat.
PubMed: Bacterial mutagenicity testing of 49 food ingredients gives very few positive results.
PubMed: 4-week oral toxicity study of a combination of eight chemicals in rats: comparison with the toxicity of the individual compounds.
PubMed: Evaluation of the oral toxicity of potassium nitrite in a 13-week drinking-water study in rats.
PubMed: Free radical scavenging and the expression of potentially lethal damage in X-irradiated repair-deficient Escherichia coli.
PubMed: Oxidation reaction of human oxyhemoglobin with nitrite: a reexamination.
PubMed: [Growth in weaned piglets and levels of iodothyronines in the blood during the administration of thyroactive substances].
PubMed: Protective action of ascorbic acid against mutagenicity of aminopyrine plus nitrite.
PubMed: The role of hydroxyl radical scavengers in preventing DNA strand breaks induced by X irradiation of toluene-treated Escherichia coli.
PubMed: [Nitrification in soil columns subjected to continuous flow].
PubMed: Methylation of liver DNA of rat and mouse by N-nitrosodimethylamine formed in vivo from dimethylamine and nitrite.
PubMed: Mutagenicity of oxytetracycline.
PubMed: Polarographic determination of butorphanol tartrate.
PubMed: Synthesis of protein, nucleosides and other organic compounds from cyanamide and potassium nitrite under possible primitive earth conditions.
PubMed: Some physiological studies on Penicillium expansum Link.
PubMed: Reproduction in the guinea pig as affected by chronic administration of potassium nitrate and potassium nitrite.
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