phenolphthalein
1(3H)-isobenzofuranone, 3,3-bis(4-hydroxyphenyl)-
 
Notes:
an acid-base indicator which is colorless in acid solution, but turns pink to red as the solution becomes alkaline. it is used medicinally as a cathartic.
  • American International Chemical, LLC.
    • American International Chemical, Inc.
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      127342 Phenolphthalein
       
  • Augustus Oils
    • Augustus Oils Ltd
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      Phenolphthalein White
       
  • BOC Sciences
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      77-09-8 Phenolphthalein
       
  • ECSA Chemicals
    • ECSA Chemicals
      Human Chemistry
      ECSA Chemicals has been active since 1913 in the trading and international commerce of raw materials. With an organisation divided into industrial segments managed by specialists, it has become one of the largest distributors worldwide.
      ECSA Chemicals is the largest Swiss-owned company in terms of warehouses for the distribution of chemical products. We have been distributing chemical products for over 100 years and we have a special interest in protecting the environment and in the safety of our facilities and collaborators.
      Established in 1913 as a small grocery store, in its over 100 years of activity ECSA Chemicals has become one of the most important Swiss-owned distributors of chemical products. The company, which is active in international distribution and trading, is organised into industrial segments that are managed by teams of specialists and experts. They guarantee professional and customised consultancy and services. With our experience, we can rapidly and safely connect you with the best suppliers on the market, providing you with a complete search, consulting and assistance service. The focus of our approach and operations is you, our customers. We strive every day to find the best products that satisfy your needs as quickly as possible. Your satisfaction is our greatest success. WHY CHOOSE ECSA? EXPERIENCE We have been working for 100 years. QUALITY We have obtained many certifications (ISO, SQAS, GDP, Responsible Care, Bio-Inspecta, RSPO, etc.). We guarantee full compliance with the current laws and continuous training for our staff. SAFETY We constantly carry out risk analyses for each infrastructure, defining safety levels and implementing corrective measures promptly wherever they are needed. WIDESPREAD DISTRIBUTION We have warehouses in strategic locations to supply goods to Switzerland and to the rest of the world. STORAGE CAPACITY The 3 ECSA-owned warehouses guarantee considerable storage area and capacity in each warehouse, with full availability of products (base chemicals and speciality chemicals). SPEED Presence all over the country, staff dedicated to sourcing raw materials and considerable storage capacity guarantee that goods are rapidly obtained and supplied. CONSULTANCY Our specialists - in-depth knowledge of the market and products allows us to provide full consulting services, from the purchase to the supply of raw materials.
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      RE-451154 PHENOLPHTHALEIN RPE-ACS-FOR ANALYSIS, G 100
      RE-451191 PHENOLPHTHALEIN SOLUTION 1% IN ETHANOL RPE-F
       
  • Glentham Life Sciences
  • Penta International
    • Penta International Corporation
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      16-18400 PHENOLPHTHALEIN WHITE POWDER
       
  • TCI AMERICA
    • TCI AMERICA
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      Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 70 years of synthesis experience and multi-purpose plants enable TCI to offer more than 30,000 products as well as custom synthesis.
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      Product(s):
      P0094 Phenolphthalein >98.0%(T)
       
Synonyms   Articles   Notes   Search
CAS Number: 77-09-8Picture of molecule3D/inchi
Other(deleted CASRN): 390417-24-0
ECHA EINECS - REACH Pre-Reg: 201-004-7
FDA UNII: 6QK969R2IF
Nikkaji Web: J4.502K
Beilstein Number: 284423
MDL: MFCD00005913
XlogP3: 3.60 (est)
Molecular Weight: 318.32838000
Formula: C20 H14 O4
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Appearance: white or yellowish-white to pale orange fine crystalline powder (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 262.50 °C. @ 760.00 mm Hg
Boiling Point: 557.79 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 6.700000 mmHg (est)
Flash Point: 404.00 °F. TCC ( 206.50 °C. ) (est)
logP (o/w): 2.410
Soluble in:
 water, 400 mg/L @ 25 °C (exp)
 water, 318.6 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
None found
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Suppliers:
Alfa Biotechnology
For experimental / research use only.
Phenolphthalein 98%
Allan Chemical
Phenolphthalein
American International Chemical, LLC.
Phenolphthalein
Augustus Oils
Phenolphthalein White
Services
BOC Sciences
For experimental / research use only.
Phenolphthalein
ECSA Chemicals
PHENOLPHTHALEIN RPE-ACS-FOR ANALYSIS, G 100
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
ECSA Chemicals
PHENOLPHTHALEIN SOLUTION 1% IN ETHANOL RPE-F
EMD Millipore
For experimental / research use only.
Phenolphthalein
George Uhe Company
Phenolphthalein
Glentham Life Sciences
Phenolphthalein
Penta International
PHENOLPHTHALEIN WHITE POWDER
Sigma-Aldrich
For experimental / research use only.
Phenolphthalein pH indicator
TCI AMERICA
For experimental / research use only.
Phenolphthalein >98.0%(T)
Universal Preserv-A-Chem Inc.
PHENOLPHTHALEIN USP ACS POWDER
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-man TDLo  29 mg/kg
GASTROINTESTINAL: GASTRITIS GASTROINTESTINAL: NAUSEA OR VOMITING KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION
Postgraduate Medical Journal. Vol. 60, Pg. 491, 1984.

oral-rat LD  > 1000 mg/kg
National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 25, 1953.

intraperitoneal-rat LDLo  500 mg/kg
National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 30, 1953.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: pharmaceuticals / chemical synthisis
Recommendation for phenolphthalein usage levels up to:
 not for fragrance use.
 
Recommendation for phenolphthalein flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
ClinicalTrials.gov: search
Chemical Carcinogenesis Research Information System: Search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Carcinogenic Potency Database: Search
EPA GENetic TOXicology: Search
EPA Substance Registry Services (TSCA): 77-09-8
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 4764
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 3,3-bis(4-hydroxyphenyl)-2-benzofuran-1-one
Chemidplus: 0000077098
EPA/NOAA CAMEO: hazardous materials
RTECS: SM8380000 for cas# 77-09-8
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References:
 3,3-bis(4-hydroxyphenyl)-2-benzofuran-1-one
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 77-09-8
Pubchem (cid): 4764
Pubchem (sid): 134972149
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C14286
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2932.99.7000
MedlinePlusSupp: View
ChemSpider: View
Wikipedia: View
EFSA Update of results on the monitoring of furan levels in food: Read Report
EFSA Previous report: Results on the monitoring of furan levels in food: Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food: Read Report
Formulations/Preparations:
•tablets nf: 60 & 120 mg •grades: techinical, pure reagent; nf •available in white or yellow forms; the monosodium salt is the most common form sold commercially.
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 oral care agents 
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 not found in nature
Synonyms   Articles   Notes   Search   Top
Synonyms:
 agoral
 alophen
 ap-la-day
1(3H)-isobenzofuranone, 3,3-bis(4-hydroxyphenyl)-
 chocolax
 colax
 correctol
a-di(p-hydroxyphenyl)phthalide
 doxan
 doxidan
 espotabs
 euchessina
 evac-q-kit
 evac-q-kwik
 evac-q-tabs
 evac-u-gen
 evac-v-lax
 ex-lax
 feen-a-mint
 feen-a-mint laxative mints
 femilax
 figsen
3,3-bis-(4-hydroxy-phenyl)-3H-isobenzofuran-1-one
3,3-bis(4-hydroxyphenyl)-1(3H)-isobenzofuranone
3,3-bis(4-hydroxyphenyl)-1(3H)-isobenzofurunone
3,3-bis(4-hydroxyphenyl)-2-benzofuran-1-one
3,3-bis(4-hydroxyphenyl)-2-benzofuran-1(3H)-one
3,3-bis(4-hydroxyphenyl)-3-hydroisobenzofuran-1-one
a-(p-hydroxyphenyl)-a-(4-oxo-2,5-cyclohexadien-1-ylidine)-o-toluic acid
3,3-bis(4-hydroxyphenyl)isobenzofuran-1(3H)-one
3,3-bis(4-hydroxyphenyl)phthalide
3,3-bis(p-hydroxyphenyl)phthalide
3,3-bis(para-hydroxyphenyl)phthalide
 koprol
 laxatone
 laxcaps
 laxettes
 laxin
 laxogen
 lilo
 medilax
 modane
 phenolax
white phenolphthalein
 phillips gelcaps
 phthalide 3,3,-bis(p-hydroxyphenyl)-
 phthalimetten
 purga
 purgen
 purgophen
 spulmako-lax
 thalinol
 trilax
Synonyms   Articles   Notes   Search   Top
Articles:
PubMed: Effects of cyclodextrins on the flavor of goat milk and its yogurt.
PubMed: Identification and determination of synthetic pharmaceuticals as adulterants in eight common herbal weight loss supplements.
PubMed: [Simultaneous determination of 25 illegally added drugs in diet health foods by ultra-high performance liquid chromatography].
PubMed: [Analysis and identification of illegal constituents in health food products implicitly advertizing tonic or slimming effect in the National Institute of Health Sciences in Japan].
PubMed: Screening for multiple weight loss and related drugs in dietary supplement materials by flow injection tandem mass spectrometry and their confirmation by liquid chromatography tandem mass spectrometry.
PubMed: Determination of diuretics and laxatives as adulterants in herbal formulations for weight loss.
PubMed: [Detection of phenolphthalein added illegally into anti-obesity and healthcare food by TLC-FTIR].
PubMed: Detection and quantitation of trace phenolphthalein (in pharmaceutical preparations and in forensic exhibits) by liquid chromatography-tandem mass spectrometry, a sensitive and accurate method.
PubMed: Ovariectomized mouse uterotrophic assay of 36 chemicals.
PubMed: Toxicology study of senna (CAS No. 8013-11-4) in C57BL/6NTAC Mice and toxicology and carcinogenesis study of senna in genetically modified C3B6.129F1/Tac-Trp53tm1Brd haploinsufficient mice (Feed Studies).
PubMed: Qualitative screening for adulterants in weight-loss supplements by ion mobility spectrometry.
PubMed: Tenside-free preparation of nanogels with high functional β-cyclodextrin content.
PubMed: Rapid screening of illicit additives in weight loss dietary supplements with desorption corona beam ionisation (DCBI) mass spectrometry.
PubMed: Effects of cyclodextrins on the flavor of goat milk and its yogurt.
PubMed: Study on detection of drugs in slimming health foods using GC-MS/MS.
PubMed: Detection of hazardous weight-loss substances in adulterated slimming formulations using ultra-high-pressure liquid chromatography with diode-array detection.
PubMed: Interaction of microbial β-glucuronidase with vegetable pectins.
PubMed: Use of a pharmaceutically adulterated dietary supplement, Pai You Guo, among Brazilian-born women in the United States.
PubMed: [Methodological study on magnetic affinity immunoassay for detecting chloramphenicol].
PubMed: Analysis of adulterated herbal medicines and dietary supplements marketed for weight loss by DOSY 1H-NMR.
PubMed: Phenolphthalein treatment in pregnant women and congenital abnormalities in their offspring: A population-based case-control study.
PubMed: The toxicology and carcinogenesis study of phenolphthalein (CAS No. 77-09-8) in genetically modified haploinsufficient p16(Ink4a)/p19(Arf) mice (feed study).
PubMed: Analysis of six synthetic adulterants in herbal weight-reducing dietary supplements by LC electrospray ionization-MS.
PubMed: Granule enzyme exocytosis assay for cytotoxic T lymphocyte activation.
PubMed: [Establishment of chemiluminescence immunoassay for detecting Staphylococcal enterotoxin B and C1].
PubMed: An accurate and reproducible method for the quantitative analysis of isoflavones and their metabolites in rat plasma using liquid chromatography/mass spectrometry combined with photodiode array detection.
PubMed: Sequential injection titration with spectrophotometric detection for the assay of acidity in fruit juices.
PubMed: Skin breakdown and blisters from senna-containing laxatives in young children.
PubMed: Chemical method for determination of carbon dioxide content in egg yolk and egg albumen.
PubMed: Evaluation of the TOPKAT system for predicting the carcinogenicity of chemicals.
PubMed: Selective medium for primary isolation of members of the tribe Proteeae.
PubMed: Determination of carbon dioxide evolution rates using a novel noninstrumental microrespirometer.
PubMed: Laxative drug products for over-the-counter human use. Food and Drug Administration, HHS. Final rule.
PubMed: Effect of gum arabic in an oral rehydration solution on recovery from diarrhea in rats.
PubMed: Poly(acrylic acid) microspheres containing beta-cyclodextrin: loading and in vitro release of two dyes.
PubMed: Modified starch enhances absorption and accelerates recovery in experimental diarrhea in rats.
PubMed: An evaluation of the hemizygous transgenic Tg.AC mouse for carcinogenicity testing of pharmaceuticals. I. Evidence for a confounding nonresponder phenotype.
PubMed: A laxative ingredient is linked to CA.
PubMed: Chemical test for mammalian feces in ground black pepper: collaborative study.
PubMed: Renal failure associated with laxative abuse.
PubMed: Diagnosis of magnesium-induced diarrhea.
PubMed: Effects of short-term and long-term administration of amiodarone on hepatobiliary function in male rats.
PubMed: Chemical test for mammalian feces in grain products: collaborative study.
PubMed: Effect of endrin and endrin derivatives on hepatobiliary function and carbon tetrachloride-induced hepatotoxicity in male and female rats.
PubMed: Colorimetric determination of alkaline phosphatase as indicator of mammalian feces in corn meal: collaborative study.
PubMed: Glucuronidation in the reindeer: dietary modification in the UDP-glucuronosyltransferase activity with 4-nitrophenol, 1-naphthol and phenolphthalein as acceptors.
PubMed: Spectrophotometric determination of the protonation constants of o-cresolphthalexone and the formation constants of its alkaline-earth-metal comple.
PubMed: Chemical test for mammalian feces: collaborative study.
PubMed: A note on the development of a polymyxin-mannitol-phenolphthalein diphosphate agar for the selective enumeration of coagulase positive staphylococci in foods.
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