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Category: food-contact surface of paper and paperboard
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 286.00 to 287.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 340.60 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.000033 mmHg @ 25.00 °C. (est) |
| Flash Point: | 309.00 °F. TCC ( 154.10 °C. ) (est)
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| logP (o/w): | 7.154 (est) |
| Soluble in: |
| | water, 33.32 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intravenous-dog LDLo 10 mg/kg VASCULAR: THROMBOSIS DISTANT FROM INJECTION SITE Journal of Clinical Investigation. Vol. 42, Pg. 860, 1963.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | food-contact surface of paper and paperboard |
| Recommendation for sodium palmitate usage levels up to: | | | not for fragrance use.
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| Recommendation for sodium palmitate flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| European Food Safety Authority (EFSA) reference(s): |
Re-evaluation of sodium, potassium and calcium salts of fatty acids (E 470a) and magnesium salts of fatty acids (E 470b) as food additives View page or View pdf |
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 408-35-5 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 2735111 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 1 |
| | sodium hexadecanoate |
| Chemidplus: | 0000408355 |
| RTECS: | RT4945000 for cas# 408-35-5 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
| | emulsifying agents | |
| | surfactants | |
| | viscosity controlling agents | |
Occurrence (nature, food, other): note
Synonyms:
| | hexadecanoic acid sodium salt | | | hexadecanoic acid sodium salt (1:1) | | | hexadecanoic acid, sodium salt | | | hexadecanoic acid, sodium salt (1:1) | | | palmitic acid sodium salt | | | palmitic acid, sodium salt | | | sodium hexadecanoate | | | sodium pentadecane carboxylate | | | sodium pentadecanecarboxylate |
Articles:
| PubMed: | PDIA3 Knockdown Exacerbates Free Fatty Acid-Induced Hepatocyte Steatosis and Apoptosis. |
| PubMed: | Bee's honey attenuates non-alcoholic steatohepatitis-induced hepatic injury through the regulation of thioredoxin-interacting protein-NLRP3 inflammasome pathway. |
| PubMed: | The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice. |
| PubMed: | A novel benzenediamine derivative FC98 reduces insulin resistance in high fat diet-induced obese mice by suppression of metaflammation. |
| PubMed: | Preparation and properties of films cast from mixtures of poly(vinyl alcohol) and submicron particles prepared from amylose-palmitic acid inclusion complexes. |
| PubMed: | Modulation of physical properties of supramolecular hydrogels based on a hydrophobic core. |
| PubMed: | Inhibiting CB1 receptors improves lipogenesis in an in vitro non-alcoholic fatty liver disease model. |
| PubMed: | Bcl-2 maintains the mitochondrial membrane potential, but fails to affect production of reactive oxygen species and endoplasmic reticulum stress, in sodium palmitate-induced β-cell death. |
| PubMed: | Cyclooxygenase-2-dependent oxidative stress mediates palmitate-induced impairment of endothelium-dependent relaxations in mouse arteries. |
| PubMed: | Trimetazidine prevents palmitate-induced mitochondrial fission and dysfunction in cultured cardiomyocytes. |
| PubMed: | Inhibitory effects of sea buckthorn procyanidins on fatty acid synthase and MDA-MB-231 cells. |
| PubMed: | Saturated free fatty acid sodium palmitate-induced lipoapoptosis by targeting glycogen synthase kinase-3β activation in human liver cells. |
| PubMed: | Curcumin induces apoptosis of HepG2 cells via inhibiting fatty acid synthase. |
| PubMed: | Effect of amylopectin on the rheological properties of aqueous dispersions of starch-sodium palmitate complexes. |
| PubMed: | Preparation of starch-stabilized silver nanoparticles from amylose-sodium palmitate inclusion complexes. |
| PubMed: | The synthesis and characterization of fatty acid salts of chitosan as novel matrices for prolonged intragastric drug delivery. |
| PubMed: | Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways. |
| PubMed: | Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway. |
| PubMed: | Hydrophobically modified biomineralized polysaccharide alginate membrane for sustained smart drug delivery. |
| PubMed: | Bip overexpression, but not CHOP inhibition, attenuates fatty-acid-induced endoplasmic reticulum stress and apoptosis in HepG2 liver cells. |
| PubMed: | High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expression. |
| PubMed: | Ghrelin inhibits apoptosis induced by high glucose and sodium palmitate in adult rat cardiomyocytes through the PI3K-Akt signaling pathway. |
| PubMed: | Saturated fatty acids inhibit hepatic insulin action by modulating insulin receptor expression and post-receptor signalling. |
| PubMed: | Preparation and characterization of a new lipid nano-emulsion containing two cosurfactants, sodium palmitate for droplet size reduction and sucrose palmitate for stability enhancement. |
| PubMed: | Electron donor solvent effects provide biosensing with quantum dots. |
| PubMed: | Complex formation in alkyldimethylamine oxide/sodium palmitate/water mixtures. |
| PubMed: | Oligonucleosomal DNA fragmentation in MCF-7 cells undergoing palmitate-induced apoptosis. |
| PubMed: | Effect of glucose and fatty acid availability on neonatal and adult heart contractility. |
| PubMed: | Study on the lifetime and attenuation properties of microbubbles coated with carboxylic acid salts. |
| PubMed: | Production of isopropyl cis-6-hexadecenoate by regiospecific desaturation of isopropyl palmitate by a double mutant of a Rhodococcus strain. |
| PubMed: | Sodium palmitate induces partial mitochondrial uncoupling and reactive oxygen species in rat pancreatic islets in vitro. |
| PubMed: | Alterations in kidney enzyme pattern in acute hypervitaminosis A. |
| PubMed: | Incorporation of proteins in sphingomyelin-water gel phases. |
| PubMed: | Amplification of palmitate-induced inhibition of cholesterol biosynthesis in cultured rat hepatocytes by garlic-derived organosulfur compounds. |
| PubMed: | Inhibition of antibacterial activity of himastatin, a new antitumor antibiotic from Streptomyces hygroscopicus, by fatty acid sodium salts. |
| PubMed: | Thermodynamics of binding water and solute to powdered long-chain salts of fatty acids. |
| PubMed: | Alterations of cerebromicrovascular Na+,K(+)-ATPase activity due to fatty acids and acute hypertension. |
| PubMed: | Arachidonic acid regulates the binding of human interferon in human skin fibroblasts. |
| PubMed: | Chemical characterization and biologic properties of lipopolysaccharide from Bacteroides gingivalis strains W50, W83, and ATCC 33277. |
| PubMed: | Refolding human serum albumin at relatively high protein concentration. |
| PubMed: | Short-term effects of carbon tetrachloride on the lipoprotein secretion in isolated rat hepatocytes. |
| PubMed: | Biosynthesis of sex pheromone components and glycerolipid precursors from sodium [1-(14)C]acetate in redbanded leafroller moth. |
| PubMed: | Covalently linked fatty acids in gastric mucus glycoprotein of cystic fibrosis patients. |
| PubMed: | Effects of excess free fatty acids on the electrophysiological properties of ventricular specialized conducting tissue: a comparative study between the sheep and the dog. |
| PubMed: | Chemical and chromatographic analysis of lipopolysaccharide from an antibiotic-supersusceptible mutant of Pseudomonas aeruginosa. |
| PubMed: | Differential thermal analysis of dipalmitoylphosphatidylcholine--fatty acid mixtures. |
| PubMed: | [Effect of sodium palmitate on cardiac rhythm in rats]. |
| PubMed: | Selective and differential media for isolation and tentative identification of each species of Pityrosporum residing on normal or diseased human skin. |
| PubMed: | Effect of free fatty acid concentration on furosemide binding to human serum albumin. |
| PubMed: | Studies on new aminoglycoside antibiotics, istamycins, from an actinomycete isolated from a marine environment. II. Possible involvement of plasmid in istamycin production. |
| PubMed: | [Release of noradrenaline and ventricular arrhythmias in the isolated perfused working rat heart in the presence of fatty acids. Effect of coronary artery occlusion and re-perfusion (author's transl)]. |
| PubMed: | Arrhythmogenic effects of sodium palmitate on canine subendocardial Purkinje fibres as evidenced by recording transmembrane action potentials [proceedings]. |
| PubMed: | Effect of fatty acids on renal ammoniagenesis in in vivo and in vitro studies. |
| PubMed: | Influence of sodium palmitate on the cellular action of potentials of the left ventricle of isolated, perfused guinea-pig heart. |
| PubMed: | Influence of sodium palmitate in the solubilization of cholesterol in an in vitro model of bile. |
| PubMed: | Kinetics of the processes of desorption from fatty acid monolayers. |
| PubMed: | [Effect of ultraviolet light on sodium palmitate in the absence of oxygen]. |
| PubMed: | Platelet adhesiveness and euglobulin lysis time in dogs given repeated infusion of sodium palmitate. |
| PubMed: | Acylation of sn-glycerol 3-phosphate by cell fractions of rat liver. |
| PubMed: | Incorporation of 1-C14 sodium palmitate into lipids of the ovariole of Galleria mellonella. |
| PubMed: | Incorporation of 14-C-sodium palmitate into lipids and cell interaction in ovarioles of Galleria mellonella (Lepidoptera). |
| PubMed: | The interaction of human erythrocytes with sodium palmitate. |
| PubMed: | The phase nature of beta sodium palmitate. |
| PubMed: | EFFECT OF FATTY ACIDS ON THE RESISTANCE OF MICE TO TRANSPLANTED CANCER. |
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