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Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | yellowish to reddish or brown clear liquid (est) |
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.09200 @ 25.00 °C.
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| Melting Point: | 6.20 °C. @ 760.00 mm Hg
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| Boiling Point: | 224.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 0.088000 mmHg @ 25.00 °C. (est) |
| Vapor Density: | 4.25 ( Air = 1 ) |
| Flash Point: | 210.00 °F. TCC ( 98.89 °C. )
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| logP (o/w): | 1.180 |
| Soluble in: |
| | water, 1.40E+04 mg/L @ 20 °C (exp) | | | water, 9598 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-bird - wild LD50 422 mg/kg Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
oral-mouse LD50 1400 mg/kg BLOOD: NORMOCYTIC ANEMIA
KIDNEY, URETER, AND BLADDER: OTHER CHANGES
BLOOD: OTHER CHANGES IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. Vol. 27, Pg. 63, 1982.
oral-rabbit LD50 870 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES
BLOOD: NORMOCYTIC ANEMIA
BLOOD: OTHER CHANGES IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. Vol. 27, Pg. 63, 1982.
oral-rat LD50 1150 mg/kg Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. Vol. 128, Pg. 14, 1979.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis |
| Recommendation for ortho-anisidine usage levels up to: | | | not for fragrance use.
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| Recommendation for ortho-anisidine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 1- | amino-2-methoxybenzene | | 2- | aminoanisole | | o- | aminoanisole | | ortho- | aminoanisole | | | aniline, 2-methoxy- | | 2- | anisidine | | o- | anisidine | | | benzenamine, 2-methoxy- | | 2- | methoxyaniline | | 2- | methoxybenzenamine | | 2- | methoxyphenylamine | | o- | methoxyphenylaniline | | o- | methoyxaniline |
Articles:
| PubMed: | Synthesis of silver embedded poly(o-anisidine) molybdophosphate nano hybrid cation-exchanger applicable for membrane electrode. |
| PubMed: | Investigations on the performance of poly(o-anisidine)/graphene nanocomposites for the electrochemical detection of NADH. |
| PubMed: | Formation, persistence, and identification of DNA adducts formed by the carcinogenic environmental pollutant o-anisidine in rats. |
| PubMed: | Comet assay evaluation of six chemicals of known genotoxic potential in rats. |
| PubMed: | Human cytochrome-P450 enzymes metabolize N-(2-methoxyphenyl)hydroxylamine, a metabolite of the carcinogens o-anisidine and o-nitroanisole, thereby dictating its genotoxicity. |
| PubMed: | A novel sensor for cephalosporins based on electrocatalytic oxidation by poly(o-anisidine)/SDS/Ni modified carbon paste electrode. |
| PubMed: | Identification of rat cytochromes P450 metabolizing N-(2-methoxyphenyl)hydroxylamine, a human metabolite of the environmental pollutants and carcinogens o-anisidine and o-nitroanisole. |
| PubMed: | Re-analysis results using medians of the data from the JaCVAM-organized international validation study of the in vivo rat alkaline comet assay. |
| PubMed: | o-Anisidine and its hydrochloride. |
| PubMed: | Redox sorption and recovery of silver ions as silver nanocrystals on poly(aniline-co-5-sulfo-2-anisidine) nanosorbents. |
| PubMed: | Synthesis of poly(o-anisidine)/H(2)SO(4) film for the development of glucose biosensor. |
| PubMed: | Identification of a genotoxic mechanism for the carcinogenicity of the environmental pollutant and suspected human carcinogen o-anisidine. |
| PubMed: | Oxidative DNA damage induced by a metabolite of carcinogenic o-anisidine: enhancement of DNA damage and alteration in its sequence specificity by superoxide dismutase. |
| PubMed: | Redox cycling in the metabolism of the environmental pollutant and suspected human carcinogen o-anisidine by rat and rabbit hepatic microsomes. |
| PubMed: | Carcinogenic pollutants o-nitroanisole and o-anisidine are substrates and inducers of cytochromes P450. |
| PubMed: | Tissue distribution, excretion and metabolism of o-anisidine in rats. |
| PubMed: | Mechanism of peroxidase-mediated oxidation of carcinogenic o-anisidine and its binding to DNA. |
| PubMed: | Evidence for activation of carcinogenic o-anisidine by prostaglandin H synthase: 32P-postlabelling analysis of DNA adduct formation. |
| PubMed: | The aromatic amine carcinogens o-toluidine and o-anisidine induce free radicals and intrachromosomal recombination in Saccharomyces cerevisiae. |
| PubMed: | Organ-specific genotoxicity of the potent rodent bladder carcinogens o-anisidine and p-cresidine. |
| PubMed: | The non-genotoxicity to rodents of the potent rodent bladder carcinogens o-anisidine and p-cresidine. |
| PubMed: | Direct oxidation of beta-aryl substituted aldehydes to alpha,beta-unsaturated aldehydes promoted by an o-anisidine-Pd(OAc)2 co-catalyst. |
| PubMed: | Ag nanobelts: synthesis, morphological evolution, and their use as electrocatalysts for oxygen reduction. |
| PubMed: | Mutagenicity of o-anisidine to the bladder of lacI- transgenic B6C3F1 mice: absence of 14C or 32P bladder DNA adduction. |
| PubMed: | ortho-anisidine. |
| PubMed: | Genotoxic mechanisms for the carcinogenicity of the environmental pollutants and carcinogens o-anisidine and 2-nitroanisole follow from adducts generated by their metabolite N-(2-methoxyphenyl)-hydroxylamine with deoxyguanosine in DNA. |
| PubMed: | Effects of cytochrome P450 inhibitors on peroxidase activity. |
| PubMed: | Self-stabilized nanoparticles of intrinsically conducting copolymers from 5-sulfonic-2-anisidine. |
| PubMed: | Cytochrome P450-mediated metabolism of N-(2-methoxyphenyl)-hydroxylamine, a human metabolite of the environmental pollutants and carcinogens o-anisidine and o-nitroanisole. |
| PubMed: | o-Anisidine hydrochloride. |
| PubMed: | o-Anisidine hydrochloride. |
| PubMed: | Comments on the paper 'The non-genotoxicity to rodents of the potent bladder carcinogens o-anisidine and p-cresidine'. |
| PubMed: | Bioassay of o-anisidine hydrochloride for possible carcinogenicity. |
| PubMed: | Synthesis and anti-inflammatory activity of antioxidants, 4-alkylthio-o-anisidine derivatives. |
| PubMed: | Bioassay of 5-nitro-o-anisidine for possible carcinogenicity. |
| PubMed: | Monoarylamines in the general population--a cross-sectional population-based study including 1004 Bavarian subjects. |
| PubMed: | Synthesis and Characterization of Organic-Inorganic Nanocomposite Poly-o-anisidine Sn(IV) Arsenophosphate: Its Analytical Applications as Pb(II) Ion-Selective Membrane Electrode. |
| PubMed: | 5-Nitro-ortho-anisidine. |
| PubMed: | Naphthol AS-BI (7-bromo-3-hydroxy-2-naphtho-o-anisidine) phosphatase and naphthol AS-BI beta-D-glucuronidase in Chinese hamster ovary cells: biochemical and flow cytometric studies. |
| PubMed: | Treatment of olive mill wastewater by photooxidation with ZrO2 doped TiO2 nanocomposite and it's reuse capability. |
| PubMed: | The urinary bladder carcinogen propoxur does not produce genotoxic effects in the urinary bladder of Wistar male rats. |
| PubMed: | Layer-by-layer assembly of aqueous dispersible, highly conductive poly(aniline-co-o-anisidine)/poly(sodium 4-styrenesulfonate)/MWNTs core-shell nanocomposites. |
| PubMed: | Inter-laboratory comparison study on the determination of primary aromatic amines in cold water extracts of coloured paper napkins. |
| PubMed: | Synthesis, cytotoxicity, docking study, and tubulin polymerization inhibitory activity of novel 1-(3,4-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-3-carboxanilides. |
| PubMed: | Nanojacketing and dejacketing of ds-DNA: a nondestructive characterization of a nanojacketed sample by impedance spectroscopy. |
| PubMed: | Dephenolization, dearomatization and detoxification of olive mill wastewater with sonication combined with additives and radical scavengers. |
| PubMed: | Enhanced mutagenicity of anisidine isomers in bacterial strains containing elevated N-acetyltransferase activity. |
| PubMed: | Synthesis, structure and inhibitory activity of a stereoisomer of oseltamivir carboxylate. |
| PubMed: | Measurement of hexoses and pentoses, singly or in combination, with o-anisidine. |
| PubMed: | Microextraction by packed sorbent and salting-out-assisted liquid-liquid extraction for the determination of aromatic amines formed from azo dyes in textiles. |
| PubMed: | CYP-450 isoenzymes catalyze the generation of hazardous aromatic amines after reaction with the azo dye Sudan III. |
| PubMed: | Strong adsorbability of mercury ions on aniline/sulfoanisidine copolymer nanosorbents. |
| PubMed: | Structure-activity relationships of several anisidine and dibenzanthracene isomers in the w/w+ somatic assay of Drosophila melanogaster. |
| PubMed: | Effect of ionic liquid on the determination of aromatic amines as contaminants in hair dyes by liquid chromatography coupled to electrochemical detection. |
| PubMed: | Reduced graphene oxide conjugated Cu2O nanowire mesocrystals for high-performance NO2 gas sensor. |
| PubMed: | A comparison of cell-collecting methods for the Comet assay in urinary bladders of rats. |
| PubMed: | Oxidative detoxication of carcinogenic 2-nitroanisole by human, rat and rabbit cytochrome P450. |
| PubMed: | Identification of a genotoxic mechanism for 2-nitroanisole carcinogenicity and of its carcinogenic potential for humans. |
| PubMed: | Genetic toxicity in relation to receptor-mediated carcinogenesis. |
| PubMed: | [Determination of seven aromatic amines in hair dyes by capillary electrophoresis coupled with field-amplified sample stacking]. |
| PubMed: | Simultaneous determination of various aromatic amines and metabolites of aromatic nitro compounds in urine for low level exposure using gas chromatography-mass spectrometry. |
| PubMed: | The use of initiated cells as a test system for the detection of inhibitors of gap junctional intercellular communication. |
| PubMed: | Mono and binuclear Ag(I), Cu(II), Zn(II) and Hg(II) complexes of a new azo-azomethine as ligand: synthesis, potentiometric, spectral and thermal studies. |
| PubMed: | Enantioselective ring opening of meso-epoxides by aromatic amines catalyzed by lanthanide iodo binaphtholates. |
| PubMed: | Haemoglobin adducts from aromatic amines in children in relation to area of residence and exposure to environmental tobacco smoke. |
| PubMed: | N-oxidation of aromatic amines by intracellular oxidases. |
| PubMed: | Phenotypic classes of phenoloxidase-negative mutants of the lignin-degrading fungus Phanerochaete chrysosporium. |
| PubMed: | 4-Chloro-N-(2-methoxy-phen-yl)benzamide. |
| PubMed: | Self assembly of poly(o-methoxy aniline) with RNA and RNA/DNA hybrids: physical properties and conformational change of poly(o-methoxy aniline). |
| PubMed: | Nongenotoxic carcinogens: development of detection methods based on mechanisms: a European project. |
| PubMed: | Formation of silver nanoparticles in deoxyribonucleic acid-poly(o-methoxyaniline) hybrid: a novel nano-biocomposite. |
| PubMed: | Thermal stability of poly(o-methoxyaniline) layer-by-layer films investigated by neutron reflectivity and UV-VIS spectroscopy. |
| PubMed: | Dynamic scale theory for characterizing surface morphology of layer-by-layer films of poly(o-methoxyaniline). |
| PubMed: | Contribution of conformational change of polymer structure to electrochemomechanical deformation based on polyaniline. |
| PubMed: | Site-specific consultation for a chemical mixture. |
| PubMed: | ortho- and para-Anisidine and their hydrochlorides. |
| PubMed: | Polymerization of 2-methylaniline and 2-methoxyaniline in water/pentane biphasic system. |
| PubMed: | In situ UV-visible spectroelectrochemical studies on the copolymerization of diphenylamine with ortho-methoxy aniline. |
| PubMed: | An evaluation of the E. coli K-12 uvrB/recA DNA repair host-mediated assay. II. In vivo results for 36 compounds tested in the mouse. |
| PubMed: | [Toxicological and hygienic characteristics of ortho- and para-anisidines]. |
| PubMed: | [Cosmetic colorants. Toxicology and regulation]. |
| PubMed: | Analysis of the involvement of human N-acetyltransferase 1 in the genotoxic activation of bladder carcinogenic arylamines using a SOS/umu assay system. |
| PubMed: | Analysis of aromatic amines in cigarette smoke. |
| PubMed: | Assessing the predictiveness of the Syrian hamster embryo cell transformation assay for determining the rodent carcinogenic potential of single ring aromatic/nitroaromatic amine compounds. |
| PubMed: | NTP Toxicology and Carcinogenesis Studies of o-Nitroanisole (CAS No. 91-23-6) in F344 Rats and B6C3F1 Mice (Feed Studies). |
| PubMed: | Synergism of environmental carcinogens and promoters on bladder cancer development initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine in F344 rats. |
| PubMed: | Measurement of unscheduled DNA synthesis in rat kidney cells following in vivo treatment with genotoxic agents. |
| PubMed: | Dynamic assay of enzyme activities in single cells by flow cytometry. |
| PubMed: | The use of homocarnosine as a spacer in indirect haemagglutination. |
| PubMed: | Mutagenicity of benzidine and related compounds employed in the detection of hemoglobin. |
| PubMed: | Intramolecular electron transfer versus substrate oxidation in lactoperoxidase: investigation of radical intermediates by stopped-flow absorption spectrophotometry and (9-285 GHz) electron paramagnetic resonance spectroscopy. |
| PubMed: | Polymer - supported cobalt (II) catalysts for the oxidation of alkenes. |
| PubMed: | Enzymes involved in the metabolism of the carcinogen 2-nitroanisole: evidence for its oxidative detoxication by human cytochromes P450. |
| PubMed: | Preparation of silver nanocrystals in the presence of aniline. |
| PubMed: | Morphological transformation and effect on gap junction intercellular communication in Syrian hamster embryo cells as screening tests for carcinogens devoid of mutagenic activity. |
| PubMed: | Tumor promoters induce inhibition of gap junctional intercellular communication in mouse epidermal cells by affecting the localization of connexin43 and E-cadherin. |
| PubMed: | Homologous expression of recombinant manganese peroxidase in Phanerochaete chrysosporium. |
| PubMed: | Reactive intermediates formed during the peroxidative oxidation of anisidine isomers. |
| PubMed: | Bioassay of 2,4-dimethoxyaniline hydrochloride for possible carcinogenicity. |
| PubMed: | The cytochemical demonstration of beta-glucuronidase in colon neoplasms of rats exposed to azoxymethane. |
| PubMed: | Personal air sampling for vapors of aniline compounds. |
| PubMed: | [Demonstration of isoenzymes of human serum N-acetyl-beta-D-hexosaminidases, during pregnancy]. |
| PubMed: | Optical and electrochemical properties of poly(o-toluidine) multiwalled carbon nanotubes composite Langmuir-Schaefer films. |
| PubMed: | Haemoglobin adducts from aromatic amines and tobacco specific nitrosamines in pregnant smoking and non smoking women. |
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