|
Category: food contact resinous and polymeric coatings
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white to gray crystalline solid (est) |
| Assay: | 95.00 to 100.00 %
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | 185.00 to 186.00 °C. @ 0.00 mm Hg
|
| logP (o/w): | 4.640 (est) |
| Soluble in: |
| | alcohol | | | ether | | | propylene glycol | | | water, 4.969 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
Organoleptic Properties:
| |
| Odor and/or flavor descriptions from others (if found). |
| |
| |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 2000 mg/kg Journal of the American Oil Chemists' Society. Vol. 54, Pg. 239, 1977.
oral-mouse LD50 2000 mg/kg Journal of the American Oil Chemists' Society. Vol. 54, Pg. 239, 1977.
intraperitoneal-mouse LD50 550 mg/kg Advances in Food Research. Vol. 3, Pg. 197, 1951.
oral-guinea pig LD50 830 mg/kg Advances in Food Research. Vol. 3, Pg. 197, 1951.
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | food contact resinous and polymeric coatings |
| Recommendation for nordihydroguaiaretic acid usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for nordihydroguaiaretic acid flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 4534 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| | 4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol |
| Chemidplus: | 0000500389 |
| RTECS: | UX1750000 for cas# 500-38-9 |
References:
| | 4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 4534 |
| Pubchem (sid): | 134977974 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 1,2- | benzenediol, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis- | | | butane, 1,4-bis(3,4-dihydroxyphenyl)-2,3-dimethyl- | | 2,3-bis(3,4- | dihydroxybenzyl)butane | | 2,3-bis(3,4- | dihydroxyphenyl methyl) butane | | 1,4-bis(3,4- | dihydroxyphenyl)-2,3-dimethylbutane | | 4-[4-(3,4- | dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol | | 2,3-bis(3,4- | dihydroxyphenylmethyl)butane | | 4,4'-(2,3- | dimethyl tetramethylene) dipyrocatechol | | 2,3- | dimethyl-1,4-bis(3,4-dihydroxyphenyl)butane | | 1,4,4'-(2,3- | dimethyl-1,4-butanediyl)bis- | | 4,4'-(2,3- | dimethyl-1,4-butanediyl)bis-1,2-benzenediol | | 4,4'-(2,3- | dimethyl-1,4-butanediyl)bis(1,2-benzenediol) | | 4,3- | dimethyl-1,4-butanediyl)bis(pyrocatechol) | | 4,4'-(2,3- | dimethyl-1,4-butanediyl)bis(pyrocatechol) | | 4,4'-[2,3- | dimethyl-1,4-butanediyl]-bis[1,2-benzenediol | | 4,3- | dimethyltetramethylene)dipyrocatechol | | 4,4'-(2,3- | dimethyltetramethylene)dipyrocatechol |
Articles:
| PubMed: | Metmyoglobin reduction by polyphenols and mechanism of the conversion of metmyoglobin to oxymyoglobin by quercetin. |
| PubMed: | Anticholinesterase activity of phenolic acids and their derivatives. |
| PubMed: | Ovariectomized mouse uterotrophic assay of 36 chemicals. |
| PubMed: | Structure and function of the oxidation products of polyphenols and identification of potent lipoxygenase inhibitors from Fe-catalyzed oxidation of resveratrol. |
| PubMed: | Argentinean Andean propolis associated with the medicinal plant Larrea nitida Cav. (Zygophyllaceae). HPLC-MS and GC-MS characterization and antifungal activity. |
| PubMed: | Inhibition of rat mammary microsomal oxidation of ethanol to acetaldehyde by plant polyphenols. |
| PubMed: | In vitro growth-inhibitory effect of plant-derived extracts and compounds against Paenibacillus larvae and their acute oral toxicity to adult honey bees. |
| PubMed: | Jasmonic acid is induced in a biphasic manner in response of pea seedlings to wounding. |
| PubMed: | Single-laboratory validated method for determination of nordihydroguaiaretic acid in chaparral-containing dietary supplements. |
| PubMed: | Nordihydroguaiaretic acid attenuates potassium dichromate-induced oxidative stress and nephrotoxicity. |
| PubMed: | Monensin causes transient calcium ion influx into mouse splenic lymphocytes in a sodium ion-independent fashion. |
| PubMed: | Baicalein induction of hydroxyl radical formation via 12-lipoxygenase in human platelets: an ESR study. |
| PubMed: | Prooxidant activity and toxicity of nordihydroguaiaretic acid in clone-9 rat hepatocyte cultures. |
| PubMed: | Inhibition of 12- and 15-lipoxygenase activities and protection of human and tilapia low density lipoprotein oxidation by I-Tiao-Gung (Glycine tomentella). |
| PubMed: | Conjugated linoleic acid, cis-9,trans-11, is a substrate for pulmonary 15-lipoxygenase-1 in rat. |
| PubMed: | Determination and confirmation of five phenolic antioxidants in foods by LC/MS and GC/MS. |
| PubMed: | Larrea tridentata (Creosote bush), an abundant plant of Mexican and US-American deserts and its metabolite nordihydroguaiaretic acid. |
| PubMed: | Oxidant-stimulated chloride secretion in rat jejunum in vitro is mediated by eicosanoids. |
| PubMed: | [Simultaneous determination of five antioxidants in food by HPLC with fluorescence detection]. |
| PubMed: | Lipoxygenase inhibitors inhibit heparin-releasable lipoprotein lipase activity in 3T3-L1 adipocytes and enhance body fat reduction in mice by conjugated linoleic acid. |
| PubMed: | trans-10,cis-12-Conjugated linoleic acid reduces leptin secretion from 3T3-L1 adipocytes. |
| PubMed: | Effect of a restricted diet on the metabolism of glucose in uteri isolated from immature rats: influence of indomethacin and nordihydroguaiaretic acid. |
| PubMed: | Stimulation of the stress-induced expression of stress proteins by curcumin in cultured cells and in rat tissues in vivo. |
| PubMed: | Lipoxygenase-1 from soybean seed inhibiting the activity of pancreatic lipase. |
| PubMed: | Proliferative responses of normal human mammary and MCF-7 breast cancer cells to linoleic acid, conjugated linoleic acid and eicosanoid synthesis inhibitors in culture. |
| PubMed: | Characterization of the pattern of inflammatory cell influx in chicks following the intraperitoneal administration of live Salmonella enteritidis and Salmonella enteritidis-immune lymphokines. |
| PubMed: | Suppression of hydroperoxide-induced cytotoxicity by polyphenols. |
| PubMed: | Characteristics and specificity of the inhibition of liver glucose-6-phosphatase by arachidonic acid. Lesser inhibitability of the enzyme of diabetic rats. |
| PubMed: | Suppression of hydrogen peroxide-induced mammalian cytotoxicity by nordihydroguaiaretic acid. |
| PubMed: | Effect of chronic underfeeding on uterine glycogen of rats. Influence of indomethacin and nordihydroguaiaretic acid. |
| PubMed: | Comparison of the cytotoxicity of different hydroperoxides to V79 cells. |
| PubMed: | Compound interactions effects of plant antioxidants in combination with carbaryl on performance ofTrichoplusia ni (Cabbage Looper). |
| PubMed: | Inhibition of 12-O-tetradecanoylphorbol-13-acetate-enhanced transformation in vitro by inhibitors of phospholipid metabolism. |
| PubMed: | Oxidant-induced haemoprotein degradation in rat tissue slices: effect of bromotrichloromethane, antioxidants and chelators. |
| PubMed: | Liquid chromatographic determination of seven antioxidants in dry food. |
| PubMed: | Arachidonic acid metabolism of cultured peritoneal rat macrophages and its manipulation by nonsteroidal antiinflammatory agents. |
| PubMed: | Initiation of lipid peroxidation in biological systems. |
| PubMed: | High performance liquid chromatographic determination of seven antioxidants in oil and lard: collaborative study. |
| PubMed: | Effects of antioxidants on lipid peroxide formation in irradiated synthetic diets. |
| PubMed: | Liquid chromatography with amperometric detection for determinging phenolic preservatives. |
| PubMed: | High performance liquid chromatographic determination of nine phenolic antioxidants in oils, lards, and shortenings. |
| PubMed: | A rapid gas-liquid chromatographic method for the multi-determination of antioxidants in fats, oils and dried food products. |
| PubMed: | A cystic nephropathy induced by nordihydroguaiaretic acid in the rat. Light and electron microscopic investigations. |
| PubMed: | Toxic properties of nordihydroguaiaretic acid. |
|