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Category: special dietary and nutritional additives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 99.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Optical Rotation: | -23.00 to -19.00
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| Melting Point: | 105.00 to 108.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 453.60 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 442.00 °F. TCC ( 227.78 °C. )
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| logP (o/w): | -0.885 (est) |
| Soluble in: |
| | water, 3.07E+05 mg/L @ 25 °C (exp) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | None - None found. |
S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes.
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intravenous-mouse LD50 435 mg/kg Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 262, 1970.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | special dietary and nutritional additives |
| Recommendation for acetyl-laevo-methionine usage levels up to: | | | not for fragrance use.
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| Recommendation for acetyl-laevo-methionine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| European Food Safety Authority (EFSA) reference(s): |
Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a request from the Commission related to N-Acetyl-L-methionine for use in foods for special medical purposes. View page or View pdf |
| EPI System: | View |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 65-82-7 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 448580 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| | (2S)-2-acetamido-4-methylsulfanylbutanoic acid |
| Chemidplus: | 0000065827 |
| RTECS: | PD0480000 for cas# 65-82-7 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
| | biological additives | |
| | skin conditioning | |
Occurrence (nature, food, other): note
Synonyms:
| | Ac-DL-Met-OH | | | Ac-Met-OH | | (2S)-2- | acetamido-4-(methylsulfanyl)butanoic acid | | (2S)-2- | acetamido-4-methylsulfanylbutanoic acid | | | acetyl methionine | | | acetyl-L-methionine | | N- | acetyl-L-methionine | | | acetyl-laevo-methionine | | N- | acetyl-laevo-methionine | | N- | acetyl-methionine | | L-(N- | acetyl)methionine | | laevo-(N- | acetyl)methionine | | 2- | acetylamino-4-methylsulfanyl-butyric acid | | 2-( | acetylamino)-4-(methylthio)butanoic acid | | | acetylmethionine | | N- | acetylmethionine | | | methionine, N-acetyl- | | L- | methionine, N-acetyl- | | | thiomedon |
Articles:
| PubMed: | Effect of N-acetyl-l-methionine supplementation on lactation performance and plasma variables in mid-lactating dairy cows |
| PubMed: | Grafted hyaluronic acid N-acetyl-l-methionine for targeting of LAT1 receptor: In-silico, synthesis and microscale thermophoresis studies |
| PubMed: | Effects of excess dietary l-methionine and N-acetyl-l-methionine on growing rats |
| PubMed: | Plasma and urinary methionine levels in one-year-old infants after oral loading with L-methionine and N-acetyl-L-methionine |
| PubMed: | Plasma methionine levels in normal adult subjects after oral loading with L-methionine and N-acetyl-L-methionine |
| PubMed: | Influence of supplementing a methionine derivative, N-acetyl-l-methionine, in dairy diets on production and ruminal fermentation by lactating cows during early to mid lactation |
| PubMed: | Potential roles of flavin-containing monooxygenases in sulfoxidation reactions of l-methionine, N-acetyl-l-methionine and peptides containing l-methionine |
| PubMed: | Portal and vena caval plasma methionine concentrations in young pigs administered L-methionine, N-acetyl-L-methionine and N-acetyl-D-methionine |
| PubMed: | L-methionine inhibits reaction of DNA with anticancer cis-diamminedichloroplatinum(II) |
| PubMed: | Comparative metabolism of L-methionine and N-acetylated derivatives of methionine |
| PubMed: | N-acetyl-L-methionine is a superior protectant of human serum albumin against post-translational oxidation as compared to N-acetyl-L-tryptophan |
| PubMed: | [Hydrolysis of N-acetyl-L- and N-acetyl-D,L-methionine by microbial aminacylase] |
| PubMed: | Nitrogen retention in men fed isolated soybean protein supplemented with L-methionine, D-methionine, N-acetyl-L-methionine, or inorganic sulfate |
| PubMed: | Bis-pentafluorobenzyl derivatives of N-acetyl-L-methionine and N-acetyl-L-selenomethionine for the quantitative determination in human plasma by gas chromatography-negative ion chemical ionisation m |
| PubMed: | N-acetyl-l-methionine is a superior protectant of human serum albumin against photo-oxidation and reactive oxygen species compared to N-acetyl-L-tryptophan |
| PubMed: | Crystallographic analysis of the ternary complex of octanoate and N-acetyl-l-methionine with human serum albumin reveals the mode of their stabilizing interactions |
| PubMed: | Acylase I-catalyzed deacetylation of N-acetyl-L-cysteine and S-alkyl-N-acetyl-L-cysteines |
| PubMed: | In vivo metabolism of L-methionine in mice: evidence for stereoselective formation of methionine-d-sulfoxide and quantitation of other major metabolites |
| PubMed: | Acetylmethionine as a source of methionine for the rat |
| PubMed: | Investigation of antioxidative effects of a cardioprotective solution in heart tissue |
| PubMed: | Molecular cloning and biochemical characterization of L-N-carbamoylase from Sinorhizobium meliloti CECT4114 |
| PubMed: | Antioxidant Solution in Combination with Angiotensin-(1-7) Provides Myocardial Protection in Langendorff-Perfused Rat Hearts |
| PubMed: | Nutritional value and safety of methionine derivatives, isomeric dipeptides and hydroxy analogs in mice |
| PubMed: | Efficacy of the D- and L-isomers of N-acetylmethionine for chicks fed diets containing either crystalline amino acids or intact protein |
| PubMed: | Characterization of prolidase I and II purified from normal human erythrocytes: comparison with prolidase in erythrocytes from a patient with prolidase deficiency |
| PubMed: | Purification and properties of thermostable N-acylamino acid racemase from Amycolatopsis sp. TS-1-60 |
| PubMed: | Effects of geometric isomerism in dinuclear antitumor platinum complexes on their interactions with N-acetyl-L-methionine |
| PubMed: | Sulfur amino acid requirements of immature Beagle dogs |
| PubMed: | [Kinetics and thermodynamics of the hydrolysis-synthesis reaction of acetyl-L-methionine catalyzed by acylase I from hog kidney] |
| PubMed: | Bioavailability of acetylated derivatives of methionine, threonine, and lysine |
| PubMed: | Purification and characterization of a novel aminoacylase from Streptomyces mobaraensis |
| PubMed: | Chemical Characteristics of Electron Shuttles Affect Extracellular Electron Transfer: Shewanella decolorationis NTOU1 Simultaneously Exploiting Acetate and Mediators |
| PubMed: | Specific enhancement of acylase I and acylpeptide hydrolase activities by the corresponding N-acetylated substrates in primary rat hepatocyte cultures |
| PubMed: | Growth inhibition of subcutaneously transplanted hepatomas without cachexia by alteration of the dietary arginine-methionine balance |
| PubMed: | Importance of product inhibition in the kinetics of the acylase hydrolysis reaction by differential stopped flow microcalorimetry |
| PubMed: | Physicochemical and catalytic properties of acylase I from aspergillus melleus immobilized on amino- and carbonyl-grafted st”ber silica |
| PubMed: | Method development and validation for the analysis of a new anti-cancer infusion solution via HPLC |
| PubMed: | Assessment of ionic liquids' toxicity through the inhibition of acylase I activity on a microflow system |
| PubMed: | (13)C MR reporter probe system using dynamic nuclear polarization |
| PubMed: | Characterization of an aminoacylase from the hyperthermophilic archaeon Pyrococcus furiosus |
| PubMed: | Properties and localization of N-acetylglutamate deacetylase from Pseudomonas aeruginosa |
| PubMed: | Modulation of the chemical and biological properties of trans platinum complexes: monofunctional platinum complexes containing one nucleobase as potential antiviral chemotypes |
| PubMed: | Trichinella spiralis: proteinases in the larvae |
| PubMed: | Electrophoretic patterns of aminoacylase-1 (ACY-1) isozymes in vertebrate cells and histochemical procedure for detecting ACY-1 activity |
| PubMed: | Structural basis for catalytic racemization and substrate specificity of an N-acylamino acid racemase homologue from Deinococcus radiodurans |
| PubMed: | Vitamin B6 utilization in active and inactive young men |
| PubMed: | Temperature dependence of the kinetics of the acylase hydrolysis reaction by differential stopped flow microcalorimetry |
| PubMed: | Enzyme histochemical discrimination between tryptase and chymase in mast cells of human gut |
| PubMed: | Human and porcine aminoacylase I overproduced in a baculovirus expression vector system: evidence for structural and functional identity with enzymes isolated from kidney |
| PubMed: | Interaction of the synthetic ultimate carcinogens, N-sulfonoxy- and N-acetoxy-2-acetylaminofluorene, and of enzymatically activated N-hydroxy-2-acetylaminofluorene with nucleophiles |
| PubMed: | [Method of measuring activity of amino acid acylase] |
| PubMed: | Pyridine-carboxylate complexes of platinum. Effect of N,O-chelate formation on model bifunctional DNA-DNA and DNA-protein interactions |
| PubMed: | A kinetic study of hog kidney aminoacylase |
| PubMed: | Alteration of metal ions improves the activity and thermostability of aminoacylase from hyperthermophilic archaeon Pyrococcus horikoshii |
| PubMed: | Ring-Opened Adducts of the Anticancer Drug Carboplatin with Sulfur Amino Acids |
| PubMed: | Investigation of proteinases in the digestive tract using 4-methoxy-2-naphthylamine (MNA) substrates |
| PubMed: | Probing the catalytic center of porcine aminoacylase 1 by site-directed mutagenesis, homology modeling and substrate docking |
| PubMed: | Interaction of nucleophiles with the enzymatically-activated carcinogen, N-hydroxy-2-acetylaminofluorene, and with the model ester, N-acetoxy-2-acetylaminofluorene |
| PubMed: | Centrifugal partition chromatographic reaction for the production of chiral amino acids |
| PubMed: | The catalytic effect of bovine serum albumin on the ortho rearrangement of the potential ultimate carcinogen, N-(sulfooxy)-2-(acetylamino)fluorene, generated enzymatically from N-hydroxy-2-(acetylam |
| PubMed: | Solvolysis and metabolic degradation, by rat liver, of the ultimate carcinogen, N-sulfonoxy-2-acetylaminofluorene |
| PubMed: | Localisation of esteroproteases in 'resting' salivary glands from different species and the effects of the organophosphorus inhibitor E600 |
| PubMed: | Isolation and partial characterization of rat urinary esterase A2 |
| PubMed: | Histochemical demonstration of mouse submandibular esterproteases with a new chromogenic substrate |
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