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Category: cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 4.31e+005 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 259 mg/kg Archives of Toxicology. Vol. 57, Pg. 212, 1985.
intraperitoneal-rat LD50 337 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arhiv za Higijenu Rada i Toksikologiju. Archives of Industrial Hygiene and Toxicology. Vol. 13, Pg. 295, 1962.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | cosmetic agents |
| Recommendation for HEDTA usage levels up to: | | | not for fragrance use.
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| Recommendation for HEDTA flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | 2-[2-[bis(carboxymethyl)amino]ethyl-(2-hydroxyethyl)amino]acetic acid |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 150-39-0 |
| Pubchem (cid): | 8773 |
| Pubchem (sid): | 134973075 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| N-( | carboxymethyl)-N'-(2-hydroxyethyl)-N,N'-ethylenediglycine | | 2-[2-[bis( | carboxymethyl)amino]ethyl-(2-hydroxyethyl)amino]acetic acid | | | CHEL DM acid | | | detarol | | | glycine, N-(2-(bis(carboxymethyl)amino)ethyl)-N-(2-hydroxyethyl)- | | | glycine, N-(carboxymethyl)-N'-(2-hydroxyethyl)-N,N'-ethylenedi- | | N-(2- | hydroxyethyl) ethylene diamine triacetic acid | | ( | hydroxyethyl)ethylenediaminetriacetic acid | | (2- | hydroxyethyl)ethylenediaminetriacetic acid | | N-( | hydroxyethyl)ethylenediaminetriacetic acid | | N-(2- | hydroxyethyl)ethylenediaminetriacetic acid | | 2- | hydroxyethylenediamine triacetate | | N-(beta- | hydroxyethylethylenediamine)-n,n',n'-triacetic acid | | (N- | hydroxyethylethylenedinitrilo)triacetic acid |
Articles:
| PubMed: | Synthesis of silver nanoparticles in aqueous aminopolycarboxylic acid solutions via γ-irradiation and hydrogen reduction. |
| PubMed: | The ruthenium nitric oxide donor, [Ru(HEDTA)NO], inhibits acute nociception in mice by modulating oxidative stress, cytokine production and activating the cGMP/PKG/ATP-sensitive potassium channel signaling pathway. |
| PubMed: | Synthesis and Crystal Structure of the Bioinorganic Complex [Sb(Hedta)]·2H2O. |
| PubMed: | In vivo epithelial wound repair requires mobilization of endogenous intracellular and extracellular calcium. |
| PubMed: | trans-[Ru(NO)Cl(cyclam)](PF6)2 and [Ru(NO)(Hedta)] incorporated in PLGA nanoparticles for the delivery of nitric oxide to B16-F10 cells: cytotoxicity and phototoxicity. |
| PubMed: | Calculated and measured [Ca(2+)] in buffers used to calibrate Ca(2+) macroelectrodes. |
| PubMed: | High performance ion chromatography of transition metal chelate complexes and aminopolycarboxylate ligands. |
| PubMed: | Synthesis and structural characterization of heterometallic thorium aluminum polynuclear molecular clusters. |
| PubMed: | Synthesis, spectroscopic analysis and photolabilization of water-soluble ruthenium(III)-nitrosyl complexes. |
| PubMed: | Combined effect of HEDTA and selenium against aluminum induced oxidative stress in rat brain. |
| PubMed: | Simultaneous extraction of Cr(VI) and Cu(II) from humic acid with new synthesized EDTA derivatives. |
| PubMed: | Combined treatment of HEDTA and propolis prevents aluminum induced toxicity in rats. |
| PubMed: | New coordination modes in potassium edta salts: K2[H2edta]2H2O, K3[Hedta]2H2O and K4[edta]·3.92H2O. |
| PubMed: | Chelator-buffered nutrient solution is ineffective in extracting Ni from seeds of Alyssum. |
| PubMed: | Identification of Fe-polycarboxylic complexes by electrospray ionization mass spectrometry and reduction of interferences by ion chromatography/inductively coupled plasma mass spectrometry with an octopole reaction system. |
| PubMed: | Antileishmanial activity of ruthenium(II)tetraammine nitrosyl complexes. |
| PubMed: | Study of solid-phase extraction for the determination of sequestering agents in river water by high-performance liquid chromatography. |
| PubMed: | Speciation of Zn-aminopolycarboxylic complexes by electrospray ionization mass spectrometry and ion chromatography with inductively coupled plasma mass spectrometry. |
| PubMed: | Separation of yttrium from heavy lanthanide by CA-100 using the complexing agent. |
| PubMed: | Leaching and efficiency of six organic zinc fertilizers applied to navy bean crop grown in a weakly acidic soil of Spain. |
| PubMed: | Solubility and accumulation of metals in Chinese brake fern, vetiver and rostrate sesbania using chelating agents. |
| PubMed: | Poly[μ-aqua-diaqua-(μ(3)-N'-carboxy-methyl-ethylenediamine-N,N,N'-tri-acetato)oxidopotassium(I)vanadium(IV)]. |
| PubMed: | Kosmotropes enhance the yield of antibody purified by affinity chromatography using immobilized bacterial immunoglobulin binding proteins. |
| PubMed: | Determination of sequestering agents in cosmetics and synthetic detergents by high-performance liquid chromatography with ultraviolet detection. |
| PubMed: | Confirmation of lead aminocarboxylic complex formation using electrospray ionization mass spectrometry and speciation by anion-exchange chromatography coupled with ICP-MS. |
| PubMed: | Separation of chelating agents as copper complexes by capillary zone electrophoresis using quaternary ammonium bromides as additives in N-methylformamide. |
| PubMed: | Behavior of zinc from six organic fertilizers applied to a navy bean crop grown in a calcareous soil. |
| PubMed: | Influence of soil type on the mobility and bioavailability of chelated zinc. |
| PubMed: | Confirmation of vanadium complex formation using electrospray mass spectrometry and determination of vanadium speciation by sample stacking capillary electrophoresis. |
| PubMed: | Determination of alternative and conventional chelating agents as copper(II) complexes by capillary zone electrophoresis--the first use of didecyldimethylammonium bromide as a flow reversal reagent. |
| PubMed: | Iron acquisition by phytosiderophores contributes to cadmium tolerance. |
| PubMed: | Effect of the methionine ligand on the reorganization energy of the type-1 copper site of nitrite reductase. |
| PubMed: | Determination of synthetic ferric chelates used as fertilizers by liquid chromatography-electrospray/mass spectrometry in agricultural matrices. |
| PubMed: | Effects of lead and chelators on growth, photosynthetic activity and Pb uptake in Sesbania drummondii grown in soil. |
| PubMed: | Improving sensitivity in simultaneous determination of copper carboxylates by nonaqueous capillary electrophoresis. |
| PubMed: | Equilibrium, kinetic and solvent effect studies on the reactions of [RuIII(Hedta)(H2O)] with thiols. |
| PubMed: | Inhibition of the Fenton reaction by nitrogen monoxide. |
| PubMed: | Macrocyclic lanthanide complexes as artificial nucleases and ribonucleases: effects of pH, metal ionic radii, number of coordinated water molecules, charge, and concentrations of the metal complexes. |
| PubMed: | Antioxidant defense in a lead accumulating plant, Sesbania drummondii. |
| PubMed: | Potential of Hemidesmus indicus for phytoextraction of lead from industrially contaminated soils. |
| PubMed: | The [Ru(Hedta)NO](0.1-) system: structure, chemical reactivity and biological assays. |
| PubMed: | Preparation of Gd3+-containing polymer complex as a novel magnetic resonance signal-enhancing coating material. |
| PubMed: | Protons block BK channels by competitive inhibition with K+ and contribute to the limits of unitary currents at high voltages. |
| PubMed: | Biogeochemistry of fluoride in a plant-solution system. |
| PubMed: | Functional and structural study on chelator-induced suppression of S2/S1 FTIR spectrum in photosynthetic oxygen-evolving complex. |
| PubMed: | Immobilization of Fe chelators on sepharose gel and its effect on their chemical properties. |
| PubMed: | Effect of N-hydroxyethyl-ethylenediamine-triacetic acid (HEDTA) on Cr(VI) reduction by Fe(II). |
| PubMed: | Isothermal titration calorimetric procedure to determine protein-metal ion binding parameters in the presence of excess metal ion or chelator. |
| PubMed: | Aluminum-induced oxidative stress in rat brain: response to combined administration of citric acid and HEDTA. |
| PubMed: | Lead phytoextraction from contaminated soil with high-biomass plant species. |
| PubMed: | Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. |
| PubMed: | On-column complexation and simultaneous separation of vanadium(IV) and vanadium(V) by capillary electrophoresis with direct UV detection. |
| PubMed: | Ruthenium(III) readily abstracts NO from L-arginine, the physiological precursor to NO, in the presence of H2O2. A remarkably simple model system for NO synthases. |
| PubMed: | Direct modulation of volume-regulated anion channels by Ca(2+) chelating agents. |
| PubMed: | Beneficial effects of humic acid on micronutrient availability to wheat. |
| PubMed: | Determination of strong binding chelators and their metal complexes by anion-exchange chromatography and inductively coupled plasma mass spectrometry. |
| PubMed: | Phytosiderophores influence on cadmium mobilization and uptake by wheat and barley plants. |
| PubMed: | 15N NMR and Electrochemical Studies of [Ru(II)(hedta)](-) Complexes of NO, NO(+), NO(2)(-), and NO(-). |
| PubMed: | A Proton-Induced N-1 to eta(2) Migration of the Fluxional Pyrazine in the [Ru(II)(hedta)(pz)](-) Complex. |
| PubMed: | EDTA and HEDTA effects on Cd, Cr, and Ni uptake by Helianthus annuus. |
| PubMed: | High-pressure pulse-radiolysis study of the formation and decomposition of complexes with iron-carbon sigma bonds: mechanistic comparison for different metal centers. |
| PubMed: | Biodegradability of ethylenediamine-based complexing agents and related compounds. |
| PubMed: | Biodegradability of ethylenediamine-based complexing agents. |
| PubMed: | Characterization of Fe(III)-deferoxamine and Mn(II)-pectin as magnetic resonance imaging contrast agents. |
| PubMed: | Fully automated measurement of total iron-binding capacity in serum. |
| PubMed: | Wanderlust kinetics and variable Ca(2+)-sensitivity of dSlo [correction of Drosophila], a large conductance CA(2+)-activated K+ channel, expressed in oocytes. |
| PubMed: | Wanderlust kinetics and variable Ca(2+)-sensitivity of Drosophila, a large conductance Ca(2+)-activated K+ channel, expressed in oocytes. |
| PubMed: | Volume Profile for Substitution in Labile Chromium(III) Complexes: Reactions of Aqueous [Cr(Hedta)OH(2)] and [Cr(edta)](-) with Thiocyanate Ion. |
| PubMed: | Labeling a hydrazino nicotinamide-modified cyclic IIb/IIIa receptor antagonist with 99mTc using aminocarboxylates as coligands. |
| PubMed: | Spectrophotometric determination of tin in copper-based alloys using pyrocatechol violet. |
| PubMed: | Reactions of low valent transition metal complexes with hydrogen peroxide. Are they "Fenton-like" or not? 4. The case of Fe(II)L, L = edta; hedta and tcma. |
| PubMed: | Relative efficacy of chelating agents on excretion and tissue distribution of manganese in mice. |
| PubMed: | In vitro and in vivo comparative studies on chelation of aluminum by some polyaminocarboxylic acids. |
| PubMed: | Mobilization and distribution of beryllium over the course of chelation therapy with some polyaminocarboxylic acids in the rat. |
| PubMed: | Iron assimilation in Cryptococcus neoformans. |
| PubMed: | Separation of yttrium and neodymium from samarium and the heavier lanthanides by cation-exchange chromatography with hydroxyethylenediaminetriacetate in monochloroacetate buffer. |
| PubMed: | Determination of lead by selective chelatometric titration with HEDTA after separation as its sulphate by an improved method of precipitation. |
| PubMed: | Na+-Ca2+ exchange in squid optic nerve membrane vesicles is activated by internal calcium. |
| PubMed: | Alleviation of nickel-induced biochemical alterations by chelating agents. |
| PubMed: | Correlation between calpain-mediated cytoskeletal degradation and expression of platelet procoagulant activity. A role for the platelet membrane-skeleton in the regulation of membrane lipid asymmetry? |
| PubMed: | The reaction between ferrous polyaminocarboxylate complexes and hydrogen peroxide: an investigation of the reaction intermediates by stopped flow spectrophotometry. |
| PubMed: | Samarium-153 chelate localization in malignant melanoma. |
| PubMed: | Calcium-dependent chloride currents in isolated cells from rat lacrimal glands. |
| PubMed: | Evaluation of LD50 of some polyaminocarboxylic acids used as chelating drugs in metal intoxication. |
| PubMed: | Screening of chelating agents for chemolysis. |
| PubMed: | Ascorbate autoxidation in the presence of iron and copper chelates. |
| PubMed: | Chelatometric titration of tin in non-ferrous alloys with hedta. |
| PubMed: | Chelatometric titration of bismuth with hedta. |
| PubMed: | Rapid and selective chelatometric titration of aluminium in non-ferrous alloys. |
| PubMed: | Glucagon effects on the membrane potential and calcium uptake rate of rat liver mitochondria. |
| PubMed: | 157Dy-HEDTA for skeletal imaging. By G. Subramanian, J.G. McAfee, R.J. Blair, R.E. O'Mara, M.W. Greene and E. Lebowitz. 1971. |
| PubMed: | The effect of EDTA and related chelating agents on the oxidation of methanol by the methylotrophic bacterium, Methylophilus methylotrophus. |
| PubMed: | Rapid and selective chelatometric titration of zinc in non-ferrous alloys. |
| PubMed: | The kinetics of the reaction of superoxide radical with Fe(III) complexes of EDTA, DETAPAC and HEDTA. |
| PubMed: | A survey of readily available chelators for buffering calcium ion concentrations in physiological solutions. |
| PubMed: | The effects of thiosalicylic and hydroxyethylethylenediaminetriacetic acids on the absorption and excretion of 54Mn and 65Zn in the duodenally dosed sheep. |
| PubMed: | Chelation in metal intoxication X: Influence of different polyaminocarboxylic acids and thiol chelators in the excretion and tissue distribution of 54Mn in rat. |
| PubMed: | Effect of chelating agents on the stability of injectable isoniazid solutions. |
| PubMed: | The effects of Ca2+ and Sr2+ on Ca2+-sensitive biochemical changes in human erythrocytes and their membranes. |
| PubMed: | Rat mast cells permeabilized with ATP secrete histamine in response to calcium ions buffered in the micromolar range. |
| PubMed: | Chelation in metal intoxication. IX. Influence of amino and thiol chelators on excretion of manganese in poisoned rabbits. |
| PubMed: | Stability of injection solutions of vitamin B1 Part 1: Influence of chelating agents. |
| PubMed: | Studies on the stability of injectable solutions of some phenothiazines. Part 2: Effect of chelating agents and antioxidants. |
| PubMed: | Evaluation of 167Tm HEDTA as a bone scanning agent in humans and its comparison with 18F. |
| PubMed: | 157 Dy-HEDTA for skeletal imaging. |
| PubMed: | THE MACROMOLECULAR NATURE OF THE FIRST COMPONENT OF HUMAN COMPLEMENT. |
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