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Category: certain adjuvants and production aids
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.00000 to 1.00400 @ 20.00 °C.
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| Pounds per Gallon - (est).: | 8.331 to 8.364
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| Refractive Index: | 1.45200 to 1.45600 @ 20.00 °C.
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| Boiling Point: | 128.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 10.396000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 96.00 °F. TCC ( 35.56 °C. )
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| logP (o/w): | -0.860 |
| Soluble in: |
| | water, 1000000 mg/L @ 25 °C (exp) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 1450 mg/kg Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 10, Pg. 25, 1968.
oral-guinea pig LDLo 100 mg/kg GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION Journal of Industrial Hygiene and Toxicology. Vol. 21, Pg. 236, 1939.
oral-mammal (species unspecified) LD50 1220 mg/kg Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 90, 1975.
intraperitoneal-mouse LD50 413 mg/kg Cancer Vol. 2, Pg. 1055, 1949.
oral-mouse LD50 525 mg/kg BEHAVIORAL: SLEEP
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Biomedica Biochimica Acta. Vol. 44, Pg. 795, 1985.
oral-rat LD50 1450 mg/kg Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 10, Pg. 25, 1968.
unreported-rat LDLo 1600 mg/kg "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 662, 1969.
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| Dermal Toxicity: |
skin-rabbit LD50 500 ul/kg AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 10, Pg. 61, 1954.
subcutaneous-mouse LD50 458 mg/kg United States Patent Document. Vol. #4576951
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| Inhalation Toxicity: |
inhalation-rat LC50 8000 ppm/8H Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 85, 1974.
inhalation-mammal (species unspecified) LC50 12000 mg/m3 Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 90, 1975.
inhalation-mouse LC50 1320 mg/m3/2H BEHAVIORAL: ATAXIA
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
LUNGS, THORAX, OR RESPIRATION: CYANOSIS Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 8, Pg. 60, 1966.
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Safety in Use Information:
| Category: | certain adjuvants and production aids |
| Recommendation for morpholine usage levels up to: | | | not for fragrance use.
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| Recommendation for morpholine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 1-oxa-4-aza | cyclohexane | | | diethylene imidoxide | | | diethylene oximide | | | diethyleneimide oxide | | | diethylenimide oxide | | 4- | oxazine; tetrahydro-p-oxazine | | | tetrahydro-1,4-isoxazine | | | tetrahydro-1,4-oxazine | | | tetrahydro-2H-1,4-oxazine | | | tetrahydro-p-oxazine | | | tetrahydro-para-oxazine |
Articles:
| PubMed: | Novel dispersive micro-solid-phase extraction combined with ultrahigh-performance liquid chromatography-high-resolution mass spectrometry to determine morpholine residues in citrus and apples. |
| PubMed: | Effect of granule organisation on the behaviour of starches in the NMMO (N-methyl morpholine N-oxide) solvent system. |
| PubMed: | Development and validation of a standardized method for the determination of morpholine residues in fruit commodities by liquid chromatography-mass spectrometry. |
| PubMed: | Evaluation of volatile metabolites as markers in Lycopersicon esculentum L. cultivars discrimination by multivariate analysis of headspace solid phase microextraction and mass spectrometry data. |
| PubMed: | Two 6-(propan-2-yl)-4-methyl-morpholine-2,5-diones as new non-purine xanthine oxidase inhibitors and anti-inflammatory agents. |
| PubMed: | 6-(Propan-2-yl)-3-methyl-morpholine-2,5-dione, a novel cyclodidepsipeptide with modulatory effect on rat thymocytes. |
| PubMed: | Stimulatory effect on rat thymocytes proliferation and antimicrobial activity of two 6-(propan-2-yl)-4-methyl-morpholine-2,5-diones. |
| PubMed: | 4-[(2'-Cyano-biphen-yl-4-yl)meth-yl]morpholin-4-ium tetra-fluoridoborate. |
| PubMed: | Gas chromatography-mass spectrometry assessment of amines in Port wine and grape juice after fast chloroformate extraction/derivatization. |
| PubMed: | Solvent effects on starch dissolution and gelatinization. |
| PubMed: | Connections between structure and performance of four cationic copolymers used as physically adsorbed coatings in capillary electrophoresis. |
| PubMed: | Selective hydrolysis of the 3,6-anhydrogalacotosidic linkage in red algal galactan: a combination of reductive acid hydrolysis and anhydrous mercaptolysis. |
| PubMed: | Risk assessment of domestic and industrial effluents unloaded into a freshwater environment. |
| PubMed: | Cytotoxic and genotoxic effects of some substituted tetrazolo[1,5-c]quinazolines. |
| PubMed: | Final report on the safety assessment of Cetethyl Morpholinium Ethosulfate. |
| PubMed: | Shellac formulations to reduce epiphytic survival of coliform bacteria on citrus fruit postharvest. |
| PubMed: | [Teratogenicity study of morpholine salts of fatty acids (oleic acid, 50% water solution) in rats by oral administration]. |
| PubMed: | Gas chromatographic-mass spectrometric method for the analysis of dimethomorph fungicide in dried hops. |
| PubMed: | In vitro inhibition studies of phytoene desaturase by bleaching ketomorpholine derivatives. |
| PubMed: | Chemopreventive effects of S-methylcysteine on rat hepatocarcinogenesis induced by concurrent administration of sodium nitrite and morpholine. |
| PubMed: | Carcinogenicity of methylurea or morpholine in combination with sodium nitrite in rat multi-organ carcinogenesis bioassay. |
| PubMed: | Potential nitrosamine formation and its prevention during biological denitrification of red beet juice. |
| PubMed: | Dietary secondary amines and liver hepatoma in Port Harcourt, Nigeria. |
| PubMed: | Comparison of the therapeutic effects of a new arotinoid, Ro 40-8757, and all-trans- and 13-cis-retinoic acids on rat breast cancer. |
| PubMed: | Inhibitory effect of diet related sulphydryl compounds on the formation of carcinogenic nitrosamines. |
| PubMed: | Macrophages produce nitrite, nitrate and nitrosamines after addition of catalase. |
| PubMed: | The formation, disposition, and hepatic metabolism of dimethylnitrosamine in the pig. |
| PubMed: | [The effect of lysine-enriched bread on the formation of N-nitrosamines from their precursors in the stomach of dogs]. |
| PubMed: | Mutagenicity of N-nitrosomorpholine biosynthesized from morpholine in the presence of nitrate and its inhibition by ascorbic acid. |
| PubMed: | Antiarrhythmic activity of the local anaesthetic fomocaine and some of its analogues. |
| PubMed: | Effects of lysosomotropic detergents on the human malarial parasite Plasmodium falciparum in in vitro culture. |
| PubMed: | [Assessment of the degree of carcinogenicity of small doses of nitrites]. |
| PubMed: | Combined chronic toxicity and carcinogenicity studies of morpholine oleic acid salt in B6C3F1 mice. |
| PubMed: | Determination of volatile nitrosamines in cheese and cured meat products. Model study of a temperature- and pH-dependent artefact formation phenomenon in alkaline medium. |
| PubMed: | Nitrate as a precursor of the in-vivo formation of N-nitrosomorpholine in the stomach of guinea-pigs. |
| PubMed: | Effects of phenol and 2,6-dimethoxyphenol (syringol) on in vivo formation of N-nitrosomorpholine in rats. |
| PubMed: | Analysis of the genotoxic activity of four N-nitroso compounds by the Drosophila mosaic test. |
| PubMed: | Tissue specificity of N-nitrosomorpholine metabolism in Sprague-Dawley rats. |
| PubMed: | [Mutagenicity of food additive morpholine (fatty acid salt)]. |
| PubMed: | Nitrosating properties of bis-methylthio-diiron-tetranitrosyl (Roussin's red methyl ester), a nitroso compound isolated from pickled vegetables consumed in northern China. |
| PubMed: | No volatile N-nitrosamines detected in blood and urine from patients ingesting daily large amounts of ammonium nitrate. |
| PubMed: | Mutagenicity of pyrolysates from guanidine, ureide, secondary amines and polyamines found by the Salmonella/mammalian-microsome test. |
| PubMed: | Inhibition by an antioxidant of the carcinogenic effect of nitrosomorpholine formed in vivo. |
| PubMed: | Discriminative stimulus properties of phencyclidine and five analogues in the squirrel monkey. |
| PubMed: | The sequential determination of nitrite, N-nitroso compounds and nitrate and its application. |
| PubMed: | Significance of in vivo formation of N-nitroso compounds. |
| PubMed: | Effect of sodium ascorbate on tumor induction in rats treated with morpholine and sodium nitrite, and with nitrosomorpholine. |
| PubMed: | Dose-response study of the carcinogenicity of dietary sodium nitrite and morpholine in rats and hamsters. |
| PubMed: | Induction of mouse lung adenomas by amines or ureas plus nitrite and by N-nitroso compounds: effect of ascorbate, gallic acid, thiocyanate, and caffeine. |
| PubMed: | Factors influencing the rate of formation of nitrosomorpholine from morpholine and nitrite. II. Rate enhancement in frozen solution. |
| PubMed: | Induction of liver and lung tumours in rats by the simultaneous administration of sodium nitrite and morpholine. |
| PubMed: | Factors influencing the rate of formation of nitrosomorpholine from morpholine and nitrite: acceleration by thiocyanate and other anions. |
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