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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless prisms (est) |
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 537.30 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 534.00 °F. TCC ( 278.70 °C. ) (est)
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| logP (o/w): | -0.370 (est) |
| Soluble in: |
| | water, 9.019e+005 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
unreported-mammal (species unspecified) LDLo 60 mg/kg Pharmacological Reviews. Vol. 22, Pg. 429, 1970.
intraperitoneal-mouse LD50 259 mg/kg Toxicology and Applied Pharmacology. Vol. 59, Pg. 424, 1981.
intravenous-mouse LD50 261 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 75, Pg. 78, 1942.
intravenous-rat LD50 92 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 83, Pg. 265, 1945.
oral-rat LD50 66 mg/kg LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" Toxicology and Applied Pharmacology. Vol. 18, Pg. 387, 1971.
intraperitoneal-rat LDLo 130 mg/kg LIVER: OTHER CHANGES
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Chemico-Biological Interactions. Vol. 12, Pg. 299, 1976.
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| Dermal Toxicity: |
subcutaneous-rat LD50 60 mg/kg Toxicology and Applied Pharmacology. Vol. 23, Pg. 470, 1972.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for monocrotaline usage levels up to: | | | not for fragrance use.
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| Recommendation for monocrotaline flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| European Food Safety Authority (EFSA) reference(s): |
Dietary exposure assessment to pyrrolizidine alkaloids in the European population View page or View pdf |
| EPI System: | View |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| Carcinogenic Potency Database: | Search |
| EPA GENetic TOXicology: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 9415 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| Chemidplus: | 0000315220 |
| RTECS: | QB3140000 for cas# 315-22-0 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| mono | crotalin | | (13-alpha,14-alpha)-14,19- | dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dione | | 12-beta,13-beta- | dihydroxy-12-alpha,13-alpha,14-alpha-trimethylcrotal-1-enine | | 20- | norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, (13alpha,14alpha)- | | (2,3,4-gh) | pyrrolizine-2,6(3H)-dione, (4,5,8,10,12,13,13a,13b)-octahydro-4,5-dihydroxy-3,4,5-trimethyl-2H-(1,6)dioxacycloundecino- |
Articles:
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