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2-naphthacenecarboxamide, 4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, monohydrochloride, (4S-(4a,4aa,5aa,12aa))-
Notes:
a tetracycline analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant staphylococcus infections.
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Glentham Life Sciences Ltd The Chemical, Biochemical & Research Essentials Supplier Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK. With a Glentham Life Sciences account you can view more product details, request quotes and order products online. Email: Info Email: Sales Email: Tech Support Voice: +44 (0) 1225 667798 Fax: +44 (0) 2033 978909 Facebook Twitter Linkedin Google+ News Distribution Products List: View Product(s): GA7395 Minocycline hydrochloride
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Penta International Corporation Chemistry innovation At Penta, our products and services help businesses do business better. For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes. US Email: Technical Services US Email: Sales US Voice: (973) 740-2300 US Fax: (973) 740-1839 Product(s): 13-80150 MINOCYCLINE HYDROCHLORIDE USP
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| CAS Number: | 13614-98-7 |  3D/inchi
|
| Other(deleted CASRN): | 1071702-75-4 | |
| ECHA EINECS - REACH Pre-Reg: | 237-099-7 | |
| FDA UNII: | 0020414E5U | |
| MDL: | MFCD00083669 | |
| Molecular Weight: | 493.94356000 | |
| Formula: | C23 H28 Cl N3 O7 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 659.40 °C. @ 760.00 mm Hg (est) |
| Flash Point: | 667.00 °F. TCC ( 352.60 °C. ) (est) |
| logP (o/w): | 0.808 (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Minocycline hydrochloride >98% by HPLC
Odor: characteristic Use: A salt prepared from minocycline; the preferred formulation for pharmaceutical applications; shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis. |
| Glentham Life Sciences |
| Minocycline hydrochloride |
| Penta International |
| MINOCYCLINE HYDROCHLORIDE USP |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Minocycline, Hydrochloride ≥98% |
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| Minocycline hydrochloride crystalline |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
oral-human TDLo 14286 ug/kg/10 LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION LUNGS, THORAX, OR RESPIRATION: DYSPNEA SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Archives of Internal Medicine. Vol. 154, Pg. 1633, 1994. intravenous-man TDLo 2857 ug/kg LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)" LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Internal Medicine. Vol. 33, Pg. 177, 1994. oral-man TDLo 11429 ug/kg/4D SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Archives of Dermatology. Vol. 123, Pg. 18, 1987. oral-man TDLo 3893 mg/kg/4Y- SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Archives of Dermatology. Vol. 122, Pg. 17, 1986. intraperitoneal-mouse LD50 299 mg/kg Drugs in Japan Vol. 6, Pg. 811, 1982. intravenous-mouse LD50 154 mg/kg Drugs in Japan Vol. 6, Pg. 811, 1982. oral-mouse LD50 3600 mg/kg Drugs in Japan Vol. 6, Pg. 811, 1982. parenteral-mouse LDLo 620 mg/kg Chemotherapy Vol. 24, Pg. 17, 1978. intraperitoneal-rat LD50 331 mg/kg Drugs in Japan Vol. 6, Pg. 811, 1982. intravenous-rat LD50 164 mg/kg Drugs in Japan Vol. 6, Pg. 811, 1982. oral-rat LD50 2380 mg/kg Drugs in Japan Vol. 6, Pg. 811, 1982. | |
| Dermal Toxicity: | |
|
subcutaneous-mouse LD50 2290 mg/kg Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 21, Pg. 319, 1990. subcutaneous-rat LD50 1700 mg/kg Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 21, Pg. 319, 1990. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis | ||
| Recommendation for minocycline hydrochloride hydrate usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for minocycline hydrochloride hydrate flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 54685925 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| (4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride | |
| Chemidplus: | 0011006272 |
| RTECS: | QI7630500 for cas# 13614-98-7 |
References:
| (4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 54685925 |
| Pubchem (sid): | 135175389 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEMBL: | View |
| KEGG (GenomeNet): | D00850 |
| HMDB (The Human Metabolome Database): | Search |
| Export Tariff Code: | 2941.30.0000 |
| MedlinePlusSupp: | View |
| ChemSpider: | View |
| Wikipedia: | View |
| Formulations/Preparations: •...minocycline hydrochloride, usp (minocin, vectrin)...is avail in wide variety of forms for oral, topical & parenteral admin. •some of the tetracyclines are...marketed as flavored powders, ophthalmic soln & ointments, soln for injection, sol salts for prepn of oral suspensions & drops, & syrups & elixirs for pediatric use. tetracyclines | |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| arestin | |
| (4S,4aS,5aR,12aR)-4,7-bis( | dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride |
| 4,7-bis( | dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride |
| (4S-(4a,4aa,5aa,12aa))-4,7-bis( | dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacene-2-carboxamide monohydrochloride |
| minocin | |
| minocycline chloride | |
| minocycline hydrochloride | |
| minomax | |
| minomycin | |
| mynocine hydrochloride | |
| 2- | naphthacenecarboxamide, 4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, monohydrochloride, (4S-(4a,4aa,5aa,12aa))- |
| tri-mino | |
| vectrin |