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methanaminium, N-[7-(dimethylamino)-3H-phenothiazin-3-ylidene]-N-methyl-, chloride (1:1)
Notes:
a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. solutions in water or alcohol have a deep blue color. methylene blue is used as a bacteriologic stain and as an indicator. it inhibits guanylate cyclase, and has been used to treat cyanide poisoning and to lower levels of methemoglobin.
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| CAS Number: | 61-73-4 |  3D/inchi
|
| Other(deleted CASRN): | 105504-42-5 | |
| ECHA EINECS - REACH Pre-Reg: | 200-515-2 | |
| FDA UNII: | 8NAP7826UB | |
| Beilstein Number: | 3599847 | |
| MDL: | MFCD00012111 | |
| Molecular Weight: | 319.85746000 | |
| Formula: | C16 H18 Cl N3 S | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| FDA Mainterm (IAUFC): | 61-73-4 ; METHYLENE BLUE |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 105.00 °C. @ 760.00 mm Hg |
| Vapor Pressure: | 1.300000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 32.00 °F. TCC ( 0.00 °C. ) (est) |
| Soluble in: | |
| water, 4.36E+04 mg/L @ 25 °C (exp) | |
| water, 1.659e+004 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| Abbey Color |
| Basic Blue 9 |
| BOC Sciences |
| For experimental / research use only. |
| Methylene Blue |
| ECSA Chemicals |
| METHYLENE BLUE SATURATED SOLUTION RPE-FOR AN |
| ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY |
| ECSA Chemicals |
| METHYLENE BLUE |
| EMD Millipore |
| For experimental / research use only. |
| Methylene Blue |
| Glentham Life Sciences |
| Methylene Blue solution, 0.5% in water |
| Glentham Life Sciences |
| Methylene Blue, anhydrous (C.I. 52015) |
| Indis NV |
| For experimental / research use only. |
| Methylene Blue |
| Penta International |
| METHYLENE BLUE POWDER |
| Sigma-Aldrich |
| For experimental / research use only. |
| Methylene blue, certified by the Biological Stain Commission |
| TCI AMERICA |
| For experimental / research use only. |
| Methylene Blue [Ion association reagent for spectrophotometric analysis] >98.0%(T) |
Safety Information:
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intravenous-cat LDLo 41 mg/kg Annals of Internal Medicine. Vol. 7, Pg. 738, 1933. intravenous-dog LDLo 50 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1366, 1935. oral-dog LDLo 500 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1366, 1935. intraperitoneal-mouse LD50 150 mg/kg National Technical Information Service. Vol. AD691-490 intravenous-mouse LD50 77 mg/kg Cesko-Slovenska Farmacie. Vol. 12, Pg. 94, 1963. oral-mouse LD50 3500 mg/kg Cesko-Slovenska Farmacie. Vol. 12, Pg. 94, 1963. oral-rabbit LDLo 1000 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1366, 1935. intraperitoneal-rat LD50 180 mg/kg Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 204, Pg. 288, 1947. intravenous-rat LD50 1250 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 676, 1968. oral-rat LD50 1180 mg/kg "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1334, 1986. | |
| Dermal Toxicity: | |
|
subcutaneous-guinea pig LDLo 300 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1366, 1935. subcutaneous-man TDLo 28 uL/kg SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" British Journal of Clinical Practice. Vol. 28, Pg. 289, 1974. subcutaneous-rat LD50 190 mg/kg Drugs in Japan Vol. -, Pg. 1185, 1990. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis | ||
| Recommendation for methylene blue (c.i. 52015) usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for methylene blue (c.i. 52015) flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| European Food Safety Authority (EFSA) reference(s): | |
| Dyes used in aquaculture View page or View pdf | |
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA GENetic TOXicology: | Search |
| EPA Substance Registry Services (TSCA): | 61-73-4 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 6099 |
| National Institute of Allergy and Infectious Diseases: | Data |
| SCCNFP: | opinion |
| [7-(dimethylamino)phenothiazin-3-ylidene]-dimethylazanium;chloride | |
| Chemidplus: | 0000061734 |
| RTECS: | SO5600000 for cas# 61-73-4 |
References:
| [7-(dimethylamino)phenothiazin-3-ylidene]-dimethylazanium;chloride | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 61-73-4 |
| Pubchem (cid): | 6099 |
| Pubchem (sid): | 134971203 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C00220 |
| HMDB (The Human Metabolome Database): | Search |
| Export Tariff Code: | 3204.13.8000 |
| MedlinePlusSupp: | View |
| ChemSpider: | View |
| Wikipedia: | View |
| Formulations/Preparations: oral: tablets: 65 mg methblue (manne), urolene blue (star). parenteral injection, for iv use: 10 mgml (available by nonproprietary name). | |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| hair dyeing agents |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| basic blue 9 | |
| basic blue 9 (c.i. 52015) | |
| basic blue trihydrate | |
| basic lake blue | |
| bleu de methylene | |
| c.i. 52015 | |
| C.I. basic blue 9 | |
| calcozine blue ZF | |
| ceruleum methylenum | |
| chromosmon | |
| ci 52015 | |
| CI basic blue 9 | |
| D and C blue no. 1 | |
| D&C blue no. 1 | |
| 7-( | dimethylamino)-3-(methylimino)-3H-phenothiazine 3-methochloride |
| 7-( | dimethylamino)-N,N-dimethyl-3H-phenothiazin-3-iminium chloride |
| [7-( | dimethylamino)dibenzo[b,e]1,4-thiazin-3-yl]dimethylamine, chloride |
| 3,7-bis( | dimethylamino)phenazathionium chloride |
| [7-( | dimethylamino)phenothiazin-3-ylidene]-dimethylazanium;chloride |
| [7-( | dimethylamino)phenothiazin-3-ylidene]dimethylamine, chloride |
| 3,7-bis( | dimethylamino)phenothiazin-5-ium chloride |
| (7- | dimethylaminophenothiazin-3-ylidene)-dimethyl-azanium chloride |
| duasyn basic blue IAD | |
| ehrlich's reagent III | |
| external blue 1 | |
| hidaco methylene blue salt free | |
| leather pure blue HB | |
| methanaminium, N-[7-(dimethylamino)-3H-phenothiazin-3-ylidene]-N-methyl-, chloride (1:1) | |
| methyl thioninium chloride | |
| phenothiazin-5-ium, 3,7-bis(dimethylamino)-, chloride | |
| 3H- | phenothiazine, 7-(dimethylamino)-3-(methylimino)-, 3-methochloride |
| phenothiazinium, 3,7-bis(dimethylamino)-, chloride (1:1) | |
| rember | |
| sandocryl blue BRL | |
| schultz 1038 | |
| schultz no. 1038 | |
| solvent blue 8 | |
| swiss blue | |
| tetramethylene blue | |
| urolene blue |