Articles:
| Info: | Melatonin |
acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]- (9CI)
Notes:
a biogenic amine that is found in animals and plants. in mammals, melatonin is produced by the pineal gland. its secretion increases in darkness and decreases during exposure to light. melatonin is implicated in the regulation of sleep, mood, and reproduction. melatonin is also an effective antioxidant. Melatonin, also known chemically as N-acetyl-5-methoxytryptamine, is a naturally occurring compound found in animals, plants and microbes. In animals, circulating levels of the hormone melatonin vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions. (Wikipedia)
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BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 73-31-4 Melatonin >98% Melatonin is a hormone produced in the brain by the pineal gland from the amino acid tryptophan.
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Charkit Chemical Corporation The Specialty Chemical Specialists Explore this website to discover the products and services that Charkit provides for your industry and please contact us directly to find out how we can be of service to you. about: Since 1982, Charkit has been committed to expanding the markets we serve as our roster of products and services continues to grow with us. Our substantial portfolio of personal care ingredients now include a wide array of luxury and exotic components to compliment the key products we have always offered. We have expanded our offerings to the nutraceutical, industrial, and resin markets with a growing roster of versatile and unique ingredients. We continue to lead the way in our traditional markets such as Metal and Water Treatment, Imaging, Flavor & Fragrance, Aroma and Food. Our Pharmaceutical offerings continue to expand, still anchored by the Boronic Derivatives that meet the demands of Suzuki coupling reactions. Please contact us to learn how we can help you reach your goals. Email: Sales Voice: 203-299-3220 Fax: 203-299-1355 Facebook Twitter Linkedin Latest News Events Blog Products List: View Product(s): MELATONIN
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Glentham Life Sciences Ltd The Chemical, Biochemical & Research Essentials Supplier Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK. With a Glentham Life Sciences account you can view more product details, request quotes and order products online. Email: Info Email: Sales Email: Tech Support Voice: +44 (0) 1225 667798 Fax: +44 (0) 2033 978909 Facebook Twitter Linkedin Google+ News Distribution Products List: View Product(s): GP8408 Melatonin
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| CAS Number: | 73-31-4 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 200-797-7 | |
| FDA UNII: | JL5DK93RCL | |
| Nikkaji Web: | J5.258B | |
| Beilstein Number: | 0205542 | |
| MDL: | MFCD00005655 | |
| XlogP3: | 0.80 (est) | |
| Molecular Weight: | 232.28292000 | |
| Formula: | C13 H16 N2 O2 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: antioxidants
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 117.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 512.83 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure: | 1.370000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 507.00 °F. TCC ( 264.00 °C. ) (est) |
| logP (o/w): | 1.043 (est) |
| Soluble in: | |
| water, 1164 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| CosIng: | cosmetic data |
| Cosmetic Uses: |
antioxidants |
Suppliers:
| AIDP |
| Melatonin (China) 99% min. |
| Alfa Biotechnology |
| For experimental / research use only. |
| Melatonine 98% |
| BOC Sciences |
| For experimental / research use only. |
| Melatonin >98%
Odor: characteristic Use: Melatonin is a hormone produced in the brain by the pineal gland from the amino acid tryptophan. |
| Changsha Organic Herb |
| Melatonin |
| Charkit Chemical |
| MELATONIN |
| Glentham Life Sciences |
| Melatonin |
| Indis NV |
| For experimental / research use only. |
| Melatonin |
| Maypro Industries |
| Melatonin |
| Sigma-Aldrich: Aldrich |
| For experimental / research use only. |
| Melatonin ≥99.5% |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intraperitoneal-mouse LD50 1375 mg/kg Pharmaceutical Chemistry Journal Vol. 17, Pg. 559, 1983. intravenous-mouse LD50 180 mg/kg U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#02739 oral-mouse LD50 1250 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 227, Pg. 587, 1983. intraperitoneal-rat LD50 1131 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 227, Pg. 587, 1983. intravenous-rat LD50 356 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 227, Pg. 587, 1983. oral-rat LD50 > 3200 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 227, Pg. 587, 1983. | |
| Dermal Toxicity: | |
|
subcutaneous-mouse LD50 > 1600 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 227, Pg. 587, 1983. subcutaneous-rat LD50 > 1600 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 227, Pg. 587, 1983. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | antioxidants | ||
| Recommendation for melatonin usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for melatonin flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 896 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 2 |
| N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide | |
| Chemidplus: | 0000073314 |
| RTECS: | AC5955000 for cas# 73-31-4 |
References:
| N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 896 |
| Pubchem (sid): | 134972795 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| Golm Metabolome Database: | Search |
| KEGG (GenomeNet): | C01598 |
| HMDB (The Human Metabolome Database): | HMDB01389 |
| FooDB: | FDB004234 |
| Export Tariff Code: | 2933.90.8000 |
| FDA Listing of Food Additive Status: | View |
| MedlinePlusSupp: | View |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
| Formulations/Preparations: melatonex (sun source); mela-t (alacer); night rest (source naturals)[pdrhealth | |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| apple fruit Search Trop Picture | |
| barley seed Search Trop Picture | |
| butterbur shoot Search Trop Picture | |
| corn seed Search Trop Picture | |
| ginger rhizome Search Trop Picture | |
| oat seed Search Trop Picture | |
| onion bulb Search Trop Picture | |
| pomegranate fruit juice Search Trop Picture | |
| walnut english walnut nut Search Trop Picture |
Synonyms:
| acetamide, {N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-} | |
| acetamide, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)- | |
| acetamide, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)- (9CI) | |
| acetamide, N-(2-(5-methoxyindol-3-yl)ethyl)- | |
| acetamide, N-[2- (5-methoxy-1H-indol-3-yl)ethyl]- | |
| acetamide, N-[2- (5-methoxyindol-3-yl)ethyl]- | |
| acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]- (9CI) | |
| acetamide, N-[2-(5-methoxyindol-3-yl)ethyl]- | |
| acetamide, N-[2-(5-methoxyindol-3-yl)ethyl]- (6CI,8CI) | |
| N- | acetyl-5-methoxy-tryptamine |
| N- | acetyl-5-methoxytryptamine |
| circadin | |
| melatol | |
| melatonex | |
| melatonin (china) 99% min. | |
| melatonine | |
| melovine | |
| N-[2-(5- | methoxy-1H-indol-3-yl)-ethyl]-acetamide |
| N-(2-(5- | methoxy-1H-indol-3-yl)ethyl)acetamide |
| N-[2-(5- | methoxy-1H-indol-3-yl)ethyl]-acetamide |
| N-[2-(5- | methoxy-1H-indol-3-yl)ethyl]acetamide |
| 5- | methoxy-N-acetyltryptamine |
| N-(2-(5- | methoxyindol-3-yl)ethyl)-Acetamide |
| N-(2-(5- | methoxyindol-3-yl)ethyl)acetamide |
| N-(2-(5- | methoxyindol-3-yl)ethyl)acetamide |
| N-[2-(5- | methoxyindol-3-yl)ethyl]-acetamide |
| N-[2-(5- | methoxyindol-3-yl)ethyl]acetamide |
| regulin |