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Category: information only not used for fragrances or flavors
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 186.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 511.00 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 530.00 °F. TCC ( 276.90 °C. ) (est)
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| logP (o/w): | 6.700 (est) |
| Soluble in: |
| | water, 0.377 mg/L @ 20 °C (est) | | | water, 0.1784 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-mouse LD50 3900 mg/kg Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. Vol. NCI-E-C-72-3252, Pg. 1973,
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | information only not used for fragrances or flavors |
| Recommendation for lithocholic acid usage levels up to: | | | not for fragrance use.
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| Recommendation for lithocholic acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: | View |
| Chemical Carcinogenesis Research Information System: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| Carcinogenic Potency Database: | Search |
| EPA GENetic TOXicology: | Search |
| EPA Substance Registry Services (TSCA): | 434-13-9 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 9903 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 2 |
| | (4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid |
| Chemidplus: | 0000434139 |
| EPA/NOAA CAMEO: | hazardous materials |
| RTECS: | FZ2275000 for cas# 434-13-9 |
References:
| | (4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 434-13-9 |
| Pubchem (cid): | 9903 |
| Pubchem (sid): | 134974329 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | cholan-24-oic acid, 3-hydroxy-, (3-alpha,5-beta)- (9CI) | | (4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3- | hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid | | 3-alpha- | hydroxy-5-beta-cholanic acid | | (3-alpha,5-beta)-3- | hydroxycholan-24-oic acid | | 17-beta-(1- | methyl-3-carboxypropyl)ethiocholan-3-alpha-ol |
Articles:
| PubMed: | Consumption of vitamin B(6) reduces fecal ratio of lithocholic acid to deoxycholic acid, a risk factor for colon cancer, in rats fed a high-fat diet. |
| PubMed: | Consumption of some polyphenols reduces fecal deoxycholic acid and lithocholic acid, the secondary bile acids of risk factors of colon cancer. |
| PubMed: | Structural relationship of lithocholic acid derivatives binding to the N-terminal 8-kDa domain of DNA polymerase beta. |
| PubMed: | Three-dimensional structural model analysis of the binding site of lithocholic acid, an inhibitor of DNA polymerase beta and DNA topoisomerase II. |
| PubMed: | Possible anti-tumour-promoting activity of components in Japanese soybean fermented food, Natto: effect on gap junctional intercellular communication. |
| PubMed: | The role of the gallbladder in humans. |
| PubMed: | Burdock fermented by Aspergillus awamori elevates cecal Bifidobacterium, and reduces fecal deoxycholic acid and adipose tissue weight in rats fed a high-fat diet. |
| PubMed: | Metabolomics of ginger essential oil against alcoholic fatty liver in mice. |
| PubMed: | Synergistic induction of human cathelicidin antimicrobial peptide gene expression by vitamin D and stilbenoids. |
| PubMed: | Determination of bile acids by hollow fibre liquid-phase microextraction coupled with gas chromatography. |
| PubMed: | Influence of breast feeding, and adapted and hydrolyzed formulas on biliary bile acids in newborn guinea pigs. |
| PubMed: | [Modification of fecal bile acid excretion by fish oil in healthy probands]. |
| PubMed: | Effect of taurine on total parenteral nutrition-associated cholestasis. |
| PubMed: | Small bowel resection and gastric acid hypersecretion. |
| PubMed: | Resolving self-assembly of bile acids at the molecular length scale. |
| PubMed: | In vitro transformation of cheno- and ursodeoxycholic acids and their 7-oleyl esters by human intestinal microflora. |
| PubMed: | Faecal pH, bile acid and sterol concentrations in premenopausal Indian and white vegetarians compared with white omnivores. |
| PubMed: | An international validation study of a Bhas 42 cell transformation assay for the prediction of chemical carcinogenicity. |
| PubMed: | Calcium supplementation modifies the relative amounts of bile acids in bile and affects key aspects of human colon physiology. |
| PubMed: | Dietary effects of barley fibre, wheat bran and rye bran on bile composition and gallstone formation in hamsters. |
| PubMed: | Effects of konjac glucomannan on putative risk factors for colon carcinogenesis in rats fed a high-fat diet. |
| PubMed: | Modulation of colonic xenobiotic metabolizing enzymes by feeding bile acids: comparative effects of cholic, deoxycholic, lithocholic and ursodeoxycholic acids. |
| PubMed: | Faecal steroid excretion in humans is affected by calcium supplementation and shows gender-specific differences. |
| PubMed: | Faecal weight, constituents, colonic motility, and lactose tolerance in the irritable bowel syndrome. |
| PubMed: | Effect of dried plums on colon cancer risk factors in rats. |
| PubMed: | Biochemical epidemiology of colon cancer: effect of types of dietary fiber on fecal mutagens, acid, and neutral sterols in healthy subjects. |
| PubMed: | Technical modification of the Balb/c 3T3 cell transformation assay: the use of serum-reduced medium to optimise the practicability of the protocol. |
| PubMed: | Effects of different types of dietary fiber preparations isolated from bamboo shoots, edible burdock, apple and corn on fecal steroid profiles of rats. |
| PubMed: | Cholelithiasis in hamsters: effects of cholic acid and calcium on gallstone formation. |
| PubMed: | Effects of a combined oestrogen-progestin preparation on gastric acid and pepsin secretion, serum gastrin concentration and biliary secretion of bile acids, phospholipids, and cholesterol in the cat. |
| PubMed: | Increasing ursodeoxycholic acid in the enterohepatic circulation of pigs through the administration of living bacteria. |
| PubMed: | Postprandial changes in serum unconjugated bile acid concentrations in healthy beagles. |
| PubMed: | Ursodiol: a cholesterol gallstone solubilizing agent. |
| PubMed: | Epimerization of the four 3,7-dihydroxy bile acid epimers by human fecal microorganisms in anaerobic mixed cultures and in feces. |
| PubMed: | Effect of cecum and appendix on 7 alpha-dehydroxylation and 7 beta-epimerization of chenodeoxycholic acid in the rabbit. |
| PubMed: | Age and diet effects on fecal bile acids in infants. |
| PubMed: | Determination of bile acids in human faecal samples using supercritical fluid extraction and high-performance liquid chromatography. |
| PubMed: | Serum unconjugated primary and secondary bile acids in patients with cholangiocarcinoma and hepatocellular carcinoma. |
| PubMed: | Simultaneous characterization of bile acid, sterols, and determination of acylglycerides in feces from soluble cellulose-fed hamsters using HPLC with evaporative light-scattering detection and APCI-MS. |
| PubMed: | Detection of initiating as well as promoting activity of chemicals by a novel cell transformation assay using v-Ha-ras-transfected BALB/c 3T3 cells (Bhas 42 cells). |
| PubMed: | Dietary fibre, physicochemical properties and their relationship to health. |
| PubMed: | Detection of tumor promoters by early antigen expression of EB virus in Raji cells using a fluorescence microplate-reader. |
| PubMed: | Transformation of sulfated bile acids by human intestinal microflora. |
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