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imidazo[2,1-b]thiazole, 2,3,5,6-tetrahydro-6-phenyl-, (6S)-, hydrochloride (1:1)
Notes:
an antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and t-lymphocyte function. paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (from smith and reynard, textbook of pharmacology, 1991, p435-6)
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| CAS Number: | 16595-80-5 |  3D/inchi
|
| Other(deleted CASRN): | 24593-45-1 | |
| ECHA EINECS - REACH Pre-Reg: | 240-654-6 | |
| FDA UNII: | DL9055K809 | |
| MDL: | MFCD00012675 | |
| Molecular Weight: | 240.75561000 | |
| Formula: | C11 H13 Cl N2 S | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 344.40 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure: | 0.000066 mmHg @ 25.00 °C. (est) |
| Flash Point: | 324.00 °F. TCC ( 162.10 °C. ) (est) |
| logP (o/w): | 1.845 (est) |
| Soluble in: | |
| water, 1116 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Levamisole Hydrochloride 98% |
| Glentham Life Sciences |
| Levamisol hydrochloride |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Levamisole Hydrochloride ≥99% |
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| (-)-Tetramisole hydrochloride ≥99% (GC) |
| TCI AMERICA |
| For experimental / research use only. |
| Levamisole Hydrochloride >99.0%(T) |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
parenteral-frog LD50 363 mg/kg Archives Internationales de Pharmacodynamie et de Therapie. Vol. 289, Pg. 278, 1987. intramuscular-mouse LD50 121 mg/kg Fortschritte der Medizin. Vol. 94, Pg. 793, 1976. intraperitoneal-mouse LD50 34 mg/kg LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: TREMOR Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 3141, 1982. intravenous-mouse LD50 18 mg/kg LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: TREMOR Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 3141, 1982. oral-mouse LD50 223 mg/kg LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: TREMOR Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 3141, 1982. intraperitoneal-rat LD50 42 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 3141, 1982. intravenous-rat LD50 26 mg/kg BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 3141, 1982. oral-rat LD50 180 mg/kg Archives of Toxicology. Vol. 54, Pg. 275, 1983. | |
| Dermal Toxicity: | |
|
subcutaneous-mouse LD50 52 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: TREMOR Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 3141, 1982. subcutaneous-rat LD50 80 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: TREMOR Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 3141, 1982. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis | ||
| Recommendation for levamisole hydrochloride usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for levamisole hydrochloride flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 27944 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| (6S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole;hydrochloride | |
| Chemidplus: | 0016595805 |
| RTECS: | NJ5960000 for cas# 16595-80-5 |
References:
| (6S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole;hydrochloride | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 16595-80-5 |
| Pubchem (cid): | 27944 |
| Pubchem (sid): | 134991423 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C07906 |
| HMDB (The Human Metabolome Database): | Search |
| Export Tariff Code: | 2909.30.6000 |
| ChemSpider: | View |
| Wikipedia: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride, (-)- (8CI) | |
| imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride, (S)- | |
| imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride, L-(-)- | |
| imidazo[2,1-b]thiazole, 2,3,5,6-tetrahydro-6-phenyl-, (6S)-, hydrochloride (1:1) | |
| lecamisole HCl | |
| levamisol hydrochloride | |
| levomysol hydrochloride | |
| nilverm | |
| niratic hydrochloride | |
| niratic-puron hydrochloride | |
| (6S)-6- | phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole hydrochloride |
| (6S)-6- | phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole hydrochloride (1:1) |
| 6- | phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole hydrochloride (1:1) |
| (6S)-6- | phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole;hydrochloride |
| (6S)-6- | phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazolhydrochlorid |
| (S)-(-)-6- | phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride |
| (S)-6- | phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride |
| L-(-)-2,3,5,6- | tetrahydro-6-phenyl-imidazo(2,1-b)thiazole hydrochloride |
| (-)-2,3,5,6- | tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride |
| (-)-2,3,5,6- | tetrahydro-6-phenylimidazo[2,1-b]thiazole monohydrochloride |
| L-(-)-2,3,5,6- | tetrahydro-6-phenylimidazo[2,1-b]thiazole Monohydrochloride |
| tetramisole hydrochloride | |
| (-)- | tetramisole hydrochloride |
| L- | tetramisole hydrochloride |