lapachol, 84-79-7

Articles:

PubMed:	Blood shizonticidal activities of phenazines and naphthoquinoidal compounds against Plasmodium falciparum in vitro and in mice malaria studies.
PubMed:	Determination of the depth profile distribution of guest species in microporous materials using the voltammetry of immobilized particles methodology: application to lapachol attachment to palygorskite and kaolinite.
PubMed:	Vasorelaxation induced by a new naphthoquinone-oxime is mediated by NO-sGC-cGMP pathway.
PubMed:	Selective modulation of plasmodial Hsp70s by small molecules with antimalarial activity.
PubMed:	The pterocarpanquinone LQB-118 inhibits tumor cell proliferation by downregulation of c-Myc and cyclins D1 and B1 mRNA and upregulation of p21 cell cycle inhibitor expression.
PubMed:	Isolation and identification of α-glucosidase and protein glycation inhibitors from Stereospermum colais.
PubMed:	Antiparasitic activities of novel ruthenium/lapachol complexes.
PubMed:	Chemical markers of occupational exposure to teak wood dust.
PubMed:	Cytotoxicity of lapachol metabolites produced by probiotics.
PubMed:	Selective binding of naphthoquinone derivatives to serum albumin proteins and their effects on cytotoxicity.
PubMed:	1,2,3-triazole-, arylamino- and thio-substituted 1,4-naphthoquinones: potent antitumor activity, electrochemical aspects, and bioisosteric replacement of C-ring-modified lapachones.
PubMed:	Electrochemical analysis in a liposome suspension using lapachol as a hydrophobic electro active species.
PubMed:	Growth inhibitory activity for cancer cell lines of lapachol and its natural and semi-synthetic derivatives.
PubMed:	Isolation of major components from the roots of Godmania aesculifolia and determination of their antifungal activities.
PubMed:	Structural elucidation of the metabolites of lapachol in rats by liquid chromatography-tandem mass spectrometry.
PubMed:	Beyond topoisomerase inhibition: antitumor 1,4-naphthoquinones as potential inhibitors of human monoamine oxidase.
PubMed:	Synthesis and anti-Trypanosoma cruzi activity of naphthoquinone-containing triazoles: electrochemical studies on the effects of the quinoidal moiety.
PubMed:	β-Lapachone activity in synergy with conventional antimicrobials against methicillin resistant Staphylococcus aureus strains.
PubMed:	Diterpenylquinone hybrids: synthesis and assessment of gastroprotective mechanisms of action in human cells.
PubMed:	Anti-diabetic activity of active fractions of Stereospermum tetragonum DC and isolation of active principles.
PubMed:	Cytotoxicity and In Vitro Antileishmanial Activity of Antimony (V), Bismuth (V), and Tin (IV) Complexes of Lapachol.
PubMed:	The antimicrobial activity of lapachol and its thiosemicarbazone and semicarbazone derivatives.
PubMed:	A conserved lysine residue controls iron-sulfur cluster redox chemistry in Escherichia coli fumarate reductase.
PubMed:	Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity.
PubMed:	Electronic structure and gas-phase chemistry of protonated α- and β-quinonoid compounds: a mass spectrometry and computational study.
PubMed:	Cytotoxicity of lapachol, β-lapachone and related synthetic 1,4-naphthoquinones against oesophageal cancer cells.
PubMed:	Gas-phase reactivity of 2-hydroxy-1,4-naphthoquinones: a computational and mass spectrometry study of lapachol congeners.
PubMed:	Addition of thiols to o-quinone methide: new 2-hydroxy-3-phenylsulfanylmethyl[1,4]naphthoquinones and their activity against the human malaria parasite Plasmodium falciparum (3D7).
PubMed:	A mechanistic study on the Hooker oxidation: synthesis of novel indane carboxylic acid derivatives from lapachol.
PubMed:	From body art to anticancer activities: perspectives on medicinal properties of henna.
PubMed:	Potential gastroprotective effect of novel cyperenoic acid/quinone derivatives in human cell cultures.
PubMed:	Quinones derived from plant secondary metabolites as anti-cancer agents.
PubMed:	Biomimetic in vitro oxidation of lapachol: a model to predict and analyse the in vivo phase I metabolism of bioactive compounds.
PubMed:	A proteomic insight into the effects of the immunomodulatory hydroxynaphthoquinone lapachol on activated macrophages.
PubMed:	Determination of lapachol in the presence of other naphthoquinones using 3MPA-CdTe quantum dots fluorescent probe.
PubMed:	β-Lapachone analogs with enhanced antiproliferative activity.
PubMed:	Lapacho tea (Tabebuia impetiginosa) extract inhibits pancreatic lipase and delays postprandial triglyceride increase in rats.
PubMed:	Lapachol as an epithelial tumor inhibitor agent in Drosophila melanogaster heterozygote for tumor suppressor gene wts.
PubMed:	A new type of pterocarpanquinone that affects Toxoplasma gondii tachyzoites in vitro.
PubMed:	Antimony(V) and bismuth(V) complexes of lapachol: synthesis, crystal structure and cytotoxic activity.
PubMed:	Synthesis and pharmacological activity of diterpenylnaphthoquinone derivatives.
PubMed:	Coordination of lapachol to bismuth(III) improves its anti-inflammatory and anti-angiogenic activities.
PubMed:	Genotoxicity of lapachol evaluated by wing spot test of Drosophila melanogaster.
PubMed:	Lapachol suppresses cell proliferation and secretion of interleukin-6 and plasminogen activator inhibitor-1 of fibroblasts derived from hypertrophic scars.
PubMed:	β-lapachone accelerates the recovery of burn-wound skin.
PubMed:	Screening for small molecule modulators of Hsp70 chaperone activity using protein aggregation suppression assays: inhibition of the plasmodial chaperone PfHsp70-1.
PubMed:	Natural products as starting points for future anti-malarial therapies: going back to our roots?
PubMed:	Synthetic lapachol derivatives relax guinea-pig ileum by blockade of the voltage-gated calcium channels.
PubMed:	Natural and synthetic naphthoquinones active against Trypanosoma cruzi: an initial step towards new drugs for Chagas disease.
PubMed:	The hydroxy-naphthoquinone lapachol arrests mycobacterial growth and immunomodulates host macrophages.
PubMed:	Combination of chiroptical, absorption and fluorescence spectroscopic methods reveals multiple, hydrophobicity-driven human serum albumin binding of the antimalarial atovaquone and related hydroxynaphthoquinone compounds.
PubMed:	Fragmentation studies and electrospray ionization mass spectrometry of lapachol: protonated, deprotonated and cationized species.
PubMed:	LQB-118, a pterocarpanquinone structurally related to lapachol [2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone]: a novel class of agent with high apoptotic effect in chronic myeloid leukemia cells.
PubMed:	Antiproliferative activity of synthetic naphthoquinones related to lapachol. First synthesis of 5-hydroxylapachol.
PubMed:	1,4-Naphthoquinones as inducers of oxidative damage and stress signaling in HaCaT human keratinocytes.
PubMed:	Lapachol induces clastogenic effects in rats.
PubMed:	Acanthamoeba castellanii Neff: In vitro activity against the trophozoite stage of a natural sesquiterpene and a synthetic cobalt(II)-lapachol complex.
PubMed:	1,2-Dihydr-oxy-2-(3-methyl-but-2-en-yl)-3-oxo-2,3-dihydro-1H-indene-1-carboxylic acid monohydrate.
PubMed:	Effect of hydroxy substituent on the prooxidant action of naphthoquinone compounds.
PubMed:	The trypanocidal activity of naphthoquinones: a review.
PubMed:	LC-APCI mass spectrometric method development and validation for the determination of atovaquone in human plasma.
PubMed:	Modulatory effects of Tabebuia impetiginosa (Lamiales, Bignoniaceae) on doxorubicin-induced somatic mutation and recombination in Drosophila melanogaster.
PubMed:	Crystal and molecular structure of manganese(II) lapacholate, a novel polymeric species undergoing temperature-reversible metal to ligand electron transfer.
PubMed:	Comparison of the cytotoxic effect of lapachol, alpha-lapachone and pentacyclic 1,4-naphthoquinones on human leukemic cells.
PubMed:	Toxicological assessment of beta-lapachone on organs from pregnant and non-pregnant rats.
PubMed:	Dolichandroside A, a new alpha-glucosidase inhibitor and DPPH free-radical scavenger from Dolichandrone falcata seem.
PubMed:	Red Lapacho (Tabebuia impetiginosa)--a global ethnopharmacological commodity?
PubMed:	Semisynthesis and antitumoral activity of 2-acetylfuranonaphthoquinone and other naphthoquinone derivatives from lapachol.
PubMed:	Antitumor activity of two derivatives from 2-acylamine-1, 4-naphthoquinone in mice bearing S180 tumor.
PubMed:	Antitumoral activity of new polyamine-naphthoquinone conjugates.
PubMed:	Development of lapachol topical formulation: anti-inflammatory study of a selected formulation.
PubMed:	Synthesis and anti-Trypanosoma cruzi activity of derivatives from nor-lapachones and lapachones.
PubMed:	Promotion or suppression of experimental metastasis of B16 melanoma cells after oral administration of lapachol.
PubMed:	Trypanosoma cruzi: activities of lapachol and alpha- and beta-lapachone derivatives against epimastigote and trypomastigote forms.
PubMed:	Antimicrobial activity of the methanolic extract and of the chemical constituents isolated from Newbouldia laevis.
PubMed:	Cytotoxic and DNA-topoisomerase effects of lapachol amine derivatives and interactions with DNA.
PubMed:	Quinones from plants of northeastern Brazil: structural diversity, chemical transformations, NMR data and biological activities.
PubMed:	Reproductive toxicity of lapachol in adult male Wistar rats submitted to short-term treatment.
PubMed:	Applications of counter-current chromatography in organic synthesis purification of heterocyclic derivatives of lapachol.
PubMed:	Antifungal chemical compounds identified using a C. elegans pathogenicity assay.
PubMed:	Novel rearranged abietane diterpenoids from the roots of Salvia sahendica.
PubMed:	Antiplasmodial activity of naphthoquinones related to lapachol and beta-lapachone.
PubMed:	Constituents of the root wood of Austroplenckia populnea var. ovata.
PubMed:	Tabebuia avellanedae naphthoquinones: activity against methicillin-resistant staphylococcal strains, cytotoxic activity and in vivo dermal irritability analysis.
PubMed:	Synthesis of naphthofuranquinones with activity against Trypanosoma cruzi.
PubMed:	Microwave-assisted rapid cyclization of lapachol, a main constituent of Heterophragma adenophyllum.
PubMed:	Newbouldiaquinone A: A naphthoquinone-anthraquinone ether coupled pigment, as a potential antimicrobial and antimalarial agent from Newbouldia laevis.
PubMed:	Antibacterial activity of Tabebuia impetiginosa Martius ex DC (Taheebo) against Helicobacter pylori.
PubMed:	Synthesis of 3-aryl-5-decapentyl-1,2,4-oxadiazoles possessing antiinflammatory and antitumor properties.
PubMed:	Larvicidal activity of Cybistax antisyphilitica against Aedes aegypti larvae.
PubMed:	New 1,2,3,4-tetrahydro-1-aza-anthraquinones and 2-aminoalkyl compounds from norlapachol with molluscicidal activity.
PubMed:	Acrosome reaction in bovine spermatozoa: role of reactive oxygen species and lactate dehydrogenase C4.
PubMed:	Newbouldiaquinone and newbouldiamide: a new naphthoquinone-anthraquinone coupled pigment and a new ceramide from Newbouldia laevis.
PubMed:	Selective growth-inhibiting effects of compounds identified in Tabebuia impetiginosa inner bark on human intestinal bacteria.
PubMed:	Cytotoxic pyranonaphthoquinones from Melloa quadrival vis (Bignoniaceae).
PubMed:	Antileishmanial activity of lapachol analogues.
PubMed:	Demonstration of the lapachol as a potential drug for reducing cancer metastasis.
PubMed:	Molluscicidal activity of synthetic lapachol amino and hydrogenated derivatives.
PubMed:	Photoreactions of 1,4-Naphthoquinones: effects of substituents and water on the intermediates and reactivity.
PubMed:	NO reductase from Bacillus azotoformans is a bifunctional enzyme accepting electrons from menaquinol and a specific endogenous membrane-bound cytochrome c551.
PubMed:	Isolation of colour components from native dye-bearing plants in northeastern India.
PubMed:	Antimalarial activity of phenazines from lapachol, beta-lapachone and its derivatives against Plasmodium falciparum in vitro and Plasmodium berghei in vivo.
PubMed:	Glutamate 87 is important for menaquinol binding in DmsC of the DMSO reductase (DmsABC) from Escherichia coli.
PubMed:	Monoarylhydrazones of alpha-lapachone: synthesis, chemical properties and antineoplastic activity.
PubMed:	Naphthoquinone derivatives and lignans from the Paraguayan crude drug "tayï pytá" (Tabebuia heptaphylla, Bignoniaceae).
PubMed:	Electrochemical study of oxygen interaction with lapachol and its radical anions.
PubMed:	Inhibitory effects of lapachol derivatives on epstein-barr virus activation.
PubMed:	Fetal growth in rats treated with lapachol.
PubMed:	The anatomy and chemistry of the colour bands of grasstree stems (Xanthorrhoea preissii) used for plant age and fire history determination.
PubMed:	New enamine derivatives of lapachol and biological activity.
PubMed:	Toxicity of lapachol and isolapachol and their potassium salts against Biomphalaria glabrata, Schistosoma mansoni cercariae, Artemia salina and Tilapia nilotica.
PubMed:	Synthesis and preliminary pharmacological evaluation of new (+/-) 1,4-naphthoquinones structurally related to lapachol.
PubMed:	Radermachera xylocarpa: the highly efficient source of lapachol and synthesis of its derivatives.
PubMed:	Toxicology of Lapachol in rats: embryolethality.
PubMed:	Molluscicidal and trypanocidal activities of lapachol derivatives.
PubMed:	Occupational allergic contact dermatitis caused by wood dusts.
PubMed:	Chemical reactivity studies with naphthoquinones from Tabebuia with anti-trypanosomal efficacy.
PubMed:	In vitro and in vivo Leishmanicidal activity of 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone (lapachol).
PubMed:	Molluscicidal activity of 2-hydroxy-3-alkyl-1,4-naphthoquinones and derivatives.
PubMed:	Chemical characterization and biological activity of Macfadyena unguis-cati (Bignoniaceae).
PubMed:	Chemical constituents of Avicennia alba. Isolation and structural elucidation of new naphthoquinones and their analogues.
PubMed:	Interceptive effect of Lapachol in rats.
PubMed:	Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid.
PubMed:	Potential antipsoriatic agents: lapacho compounds as potent inhibitors of HaCaT cell growth.
PubMed:	Antimicrobial and antiinflammatory activities of extracts and constituents of Oroxylum indicum (L.) Vent.
PubMed:	Inhibition of nitric oxide formation by neuronal nitric oxide synthase by quinones: nitric oxide synthase as a quinone reductase.
PubMed:	Hydroxylated naphthoquinones as substrates for Escherichia coli anaerobic reductases.
PubMed:	Bioactivation of lapachol responsible for DNA scission by NADPH-cytochrome P450 reductase.
PubMed:	The search for novel anticancer agents: a differentiation-based assay and analysis of a folklore product.
PubMed:	Bioactive furonaphtoquinones from Tabebuia barbata (Bignoniaceae).
PubMed:	Antibacterial and antifungal compounds from Kigelia pinnata.
PubMed:	[Tumors caused by methylcholanthrene and lapachol. Follow-up of development with cytology].
PubMed:	Activity of extracts of Kigelia pinnata against melanoma and renal carcinoma cell lines.
PubMed:	Comparison of antibacterial and antifungal activities of lapachol and beta-lapachone.
PubMed:	Radiosensitization by nickel lapachol.
PubMed:	Phytochemical and analgesic investigation of Tabebuia chrysotricha.
PubMed:	Screening in vitro of natural products against blood forms of Trypanosoma cruzi.
PubMed:	Antiinflammatory action of lapachol.
PubMed:	Vitamin K1 2,3-epoxide and quinone reduction: mechanism and inhibition.
PubMed:	Sulfaquinoxaline inhibition of vitamin K epoxide and quinone reductase.
PubMed:	Inhibition of potentially lethal DNA damage repair in human tumor cells by beta-lapachone, an activator of topoisomerase I.
PubMed:	In vitro activity of natural and synthetic naphthoquinones against erythrocytic stages of Plasmodium falciparum.
PubMed:	Effect of lapachol, a naphthaquinone isolated from Tectona grandis, on experimental peptic ulcer and gastric secretion.
PubMed:	Antiviral activity of naphthoquinones. I. Lapachol derivatives against enteroviruses.
PubMed:	Antiviral activity of naphthoquinones. I. Lapachol derivatives against enteroviruses.
PubMed:	Lapachol inhibition of DT-diaphorase (NAD(P)H:quinone dehydrogenase).
PubMed:	Isolation of lapachol from Diphysa robinoides.
PubMed:	Modulation of cytotoxicity of menadione sodium bisulfite versus leukemia L1210 by the acid-soluble thiol pool.
PubMed:	Partial transition-state inhibitors of glyoxalase I from human erythrocytes, yeast and rat liver.
PubMed:	Potentiation of antimetabolite action by uridylate trapping.
PubMed:	Uridylate-trapping sugar analogs in combination with inhibitors of uridylate synthesis de novo and 5-fluorouridine.
PubMed:	Lapachol inhibition of vitamin K epoxide reductase and vitamin K quinone reductase.
PubMed:	Oxidative ring fission of the naphthoquinones lapachol and dichloroallyl lawsone by Penicillium notatum.
PubMed:	Naturally occurring quinones as potential bioreductive alkylating agents.
PubMed:	Restoration of active transport of solutes and oxidative phosphorylation by naphthoquinones in irradiated membrane vesicles from Mycobacterium phlei.
PubMed:	Microbial transformations of natural antitumor agents: conversion of lapachol to dehydro-alpha-lapachone by Curvularia lunata.
PubMed:	Dichloroallyl lawsone.
PubMed:	In vitro and in vivo evaluation of the toxicity of 1,4-naphthoquinone and 1,2-naphthoquinone derivatives against Trypanosoma cruzi.
PubMed:	Microbial transformations of natural antitumor agents: oxidation of lapachol by Penicillium notatum.
PubMed:	The sensitizing capacity of naturally occurring quinones. Experimental studies in guinea pigs. I. Naphthoquinones and related compounds.
PubMed:	Schistosomiasis mansoni: blockage of cercarial skin penetration by chemical agents: i. naphthoquinones and derivatives.
PubMed:	Pharmacology of antitumor agents from higher plants.
PubMed:	Lapachol: a new acid-base indicator.
PubMed:	A lapachol derivative active against mouse lymphocytic leukemia P-388.
PubMed:	Early clinical studies with lapachol (NSC-11905).
PubMed:	Quinone natural products: streptonigrin (NSC-45383) and lapachol (NSC-11905) structure-activity relationships.
PubMed:	Schistosoma mansoni chemoprophylaxis with dietary lapachol.
PubMed:	[Antimicrobial substances from higher plants. XXXV. Antimicrobial or antineoplastic activity of lawsona (2-hydroxy-1,4-naphthoquinone) in comparison with lapachol (2-hydroxy-3-(-3-methyl-2-butanyl)-1,4-naphthoquinone].
PubMed:	Function of ubiquinone in electron transport from reduced nicotinamide adenine dinucleotide to nitrate and oxygen in Aerobacter aerogenes.
PubMed:	Oral toxicology studies with lapachol.
PubMed:	Fluorometric method for the determination of lapachol in serum.
PubMed:	The induction of ATP energized mitochondrial volume changes by the combination of the two antitumor age agents showdomycin and lapachol.
PubMed:	Lapachol.
PubMed:	Syntheses in the lapachol series.
PubMed:	Hooker's researches on lapachol in relation to new developments in the field of chemotherapy.