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Category: special dietary and nutritional additives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white powder (est) |
| Assay: | 98.50 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 261.00 to 263.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 311.50 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.000123 mmHg @ 25.00 °C. (est) |
| Flash Point: | 288.00 °F. TCC ( 142.22 °C. )
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| logP (o/w): | -1.036 (est) |
| Soluble in: |
| | alcohol | | | water | | | water, 1e+006 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
| A.M.G.L.T. |
| L-Lysine Hydrochloride
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| ADM |
| L-LYSINE MONOHYDROCHLORIDE 98.5% FEED GRADE
Flavor: characteristic ADM L-Lysine monohydrochloride is a high quality, granular product specifically designed for the feed industry. Produced from advanced technology, this product is composed of 100% isomerically pure L-lysine, which translates into 100% bioavailability for ruminants, swine, poultry, and other animals. |
| AIDP |
| L-Lysine HCl 98.5-101.5%
|
| Ajinomoto USA |
| AjiPure™ Lysine HCL
Flavor: characteristic Manufactured under cGMP conditions using no materials of animal origin. |
| Ajinomoto USA |
| L-Lysine HCl
Flavor: characteristic L-lysine is classified as an essential amino acid for humans and must be supplied in the diet. The male adult’s daily requirement is 12 mg per kg of body weight. It is extremely rare for a diet to contain insufficient quantities of lysine. Vegetarians who follow a macrobiotic diet and athletes who exercise vigorously on a frequent basis must take care to obtain sufficient L-lysine. Beans, peas and lentils are the best source of lysine. |
| Anhui Haibei |
| L-Lysine Hydrochloride
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| BBFY Industrial |
| L-Lysine Hydrochloride
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| BOC Sciences |
| For experimental / research use only. |
| H-Lys-OH.HCl
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| Charkit Chemical |
| LYSINE HYDROCHLORIDE, L-
|
| ECSA Chemicals |
| L.LYSINE MONO HCL
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| ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY |
| ExtraSynthese |
| For experimental / research use only. |
| L-Lysine Hydrochloride
|
| Foodchem International |
| L-Lysine Monohydrochloride
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| Glentham Life Sciences |
| L-Lysine monohydrochloride, GlenCell?, suitable for cell culture
|
| Glentham Life Sciences |
| L-Lysine monohydrochloride
|
| Indis NV |
| For experimental / research use only. |
| L-Lysine (Base, HCl, etc.)
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| OQEMA |
| L-Lysine HCL
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| Penta International |
| L-LYSINE HYDROCHLORIDE (HCL) NATURAL
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| Penta International |
| L-LYSINE HYDROCHLORIDE FCC GRADE
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| Penta International |
| L-LYSINE HYDROCHLORIDE USP FCC GRADE
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| Penta International |
| L-LYSINE HYDROCHLORIDE USP GRADE
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| Prinova |
| L-Lysine Monohydrochloride
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| Sigma-Aldrich |
| For experimental / research use only. |
| L-Lysine monohydrochloride reagent grade, ≥98% (TLC)
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| TCI AMERICA |
| For experimental / research use only. |
| L-(+)-Lysine Hydrochloride >98.0%(T)
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Safety Information:
| European information : |
| Most important hazard(s): | | None - None found. |
S 02 - Keep out of the reach of children. S 22 - Do not breath dust. S 24/25 - Avoid contact with skin and eyes.
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| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-rat LD50 4019 mg/kg LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BEHAVIORAL: COMA Archives of Biochemistry and Biophysics. Vol. 58, Pg. 253, 1955.
oral-rat LD50 10000 mg/kg BEHAVIORAL: ATAXIA
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
LUNGS, THORAX, OR RESPIRATION: DYSPNEA Journal of Pharmaceutical Sciences. Vol. 62, Pg. 49, 1973.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | special dietary and nutritional additives |
| Recommendation for laevo-lysine hydrochloride usage levels up to: | | | not for fragrance use.
|
| |
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 30.00 (μg/capita/day) |
| Modified Theoretical Added Maximum Daily Intake (mTAMDI): | 23000 (μg/person/day) |
| Threshold of Concern: | 1800 (μg/person/day) |
| Structure Class: | I |
| |
| Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i). |
| Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm. |
| | average usage mg/kg | maximum usage mg/kg |
| Dairy products, excluding products of category 02.0 (01.0): | - | - |
| Fats and oils, and fat emulsions (type water-in-oil) (02.0): | - | - |
| Edible ices, including sherbet and sorbet (03.0): | - | - |
| Processed fruit (04.1): | - | - |
| Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): | - | - |
| Confectionery (05.0): | - | - |
| Chewing gum (05.0): | - | - |
| Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): | - | - |
| Bakery wares (07.0): | - | - |
| Meat and meat products, including poultry and game (08.0): | - | - |
| Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): | - | - |
| Eggs and egg products (10.0): | - | - |
| Sweeteners, including honey (11.0): | - | - |
| Salts, spices, soups, sauces, salads, protein products, etc. (12.0): | - | - |
| Foodstuffs intended for particular nutritional uses (13.0): | - | - |
| Non-alcoholic ("soft") beverages, excl. dairy products (14.1): | 70.00000 | - |
| Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): | - | - |
| Ready-to-eat savouries (15.0): | - | - |
| Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): | - | - |
Safety References:
| European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
Amino acids from chemical group 34 Flavouring Group Evaluation 26, Revision 1 - Scientific opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
Flavouring Group Evaluation 29 (FGE29)[1] - Substance from the priority list: Vinylbenzene from chemical group 31 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) View page or View pdf |
Flavouring Group Evaluation 79, (FGE.79)[1] - Consideration of amino acids and related substances evaluated by JECFA (63rd meeting) structurally related to amino acids from chemical group 34 evaluated by EFSA in FGE.26Rev1 (2008) View page or View pdf |
Scientific opinion on the safety and efficacy of concentrated liquid L-lysine (base), concentrated liquid L-lysine monohydrochloride and L-lysine monohydrochloride produced by Escherichia coli (FERM BP-10941) for all animal species, based on three dossiers submitted by Ajinomoto Eurolysine SAS View page or View pdf |
Scientific Opinion on the safety and efficacy of L-lysine monohydrochloride produced by fermentation with Escherichia coli for all animal species based on a dossier submitted by HELM AG on behalf of Meihua Holdings Group Co. Ltd View page or View pdf |
Scientific Opinion on the safety and efficacy of L-lysine monohydrochloride, technically pure, produced with Escherichia coli CGMCC 3705 and L-lysine sulphate produced with Corynebacterium glutamicum CGMCC 3704 for all animal species, based on a dossier submitted by HELM AG View page or View pdf |
Safety and efficacy of concentrated liquid L-lysine (base), L-lysine monohydrochloride and L-lysine sulphate produced using different strains of Corynebacterium glutamicum for all animal species based on a dossier submitted by AMAC/EEIG View page or View pdf |
Safety of l-lysine monohydrochloride produced by fermentation with Escherichia coli CGMCC 7.57 for all animal species based on a dossier submitted by Feedway Europe NV View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 49, Revision 1 (FGE.49Rev1): xanthine alkaloids from the priority list View page or View pdf |
Safety and efficacy of l-lysine monohydrochloride and concentrated liquid l-lysine (base) produced by fermentation using Corynebacterium glutamicum strain NRRL B-50775 for all animal species based on a dossier submitted by ADM View page or View pdf |
Safety of concentrated l-lysine (base), l-lysine monohydrochloride and l-lysine sulfate produced using different strains of Corynebacterium glutamicum for all animal species based on a dossier submitted by FEFANA asbl View page or View pdf |
Safety and efficacy of l-lysine monohydrochloride and l-lysine sulfate produced using Corynebacterium glutamicum CCTCC M 2015595 for all animal species View page or View pdf |
Safety and efficacy of l-lysine monohydrochloride and concentrated liquid l-lysine (base) produced by fermentation using Corynebacterium glutamicum strain KCCM 10227 for all animal species View page or View pdf |
Safety and efficacy of l-lysine monohydrochloride and concentrated liquid l-lysine (base) produced by fermentation using Corynebacterium glutamicum strains NRRL-B-67439 or NRRL B-67535 for all animal species View page or View pdf |
Safety and efficacy of l-lysine monohydrochloride and l-lysine sulfate produced using Corynebacterium glutamicum CGMCC 7.266 for all animal species View page or View pdf |
Safety and efficacy of l-lysine monohydrochloride produced by fermentation with Corynebacterium glutamicum DSM 32932 for all animal species View page or View pdf |
Safety and efficacy of l-lysine monohydrochloride and concentrated liquid l-lysine (base) produced by fermentation with Corynebacterium glutamicum KCCM 80216 as feed additive for all animal species View page or View pdf |
Safety and efficacy of l-lysine monohydrochloride and concentrated liquid l-lysine (base) produced by fermentation with Corynebacterium glutamicumKCTC 12307BP as feed additives for all animal species View page or View pdf |
| EPI System: | View |
| Daily Med: | search |
| EPA Substance Registry Services (TSCA): | 657-27-2 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 69568 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 2 |
| | (2S)-2,6-diaminohexanoic acid hydrochloride |
| Chemidplus: | 0000657272 |
| RTECS: | OL5650000 for cas# 657-27-2 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
| | antioxidants | |
| | reducing agents | |
| | skin conditioning | |
Occurrence (nature, food, other): note
Synonyms:
| | darvyl | | (2S)-2,6- | diaminohexanoic acid hydrochloride | | (S)-2,6- | diaminohexanoic acid monohydrochloride | | | enisyl | | | lyamine | | L- | lysine chlorhydrate | | L- | lysine HCl | | | lysine hydrochloride | | L-mono | lysine hydrochloride | | laevo- | lysine hydrochloride | | L- | lysine hydrochloride (1:1) | | L- | lysine mono hydrochloride | | L- | lysine monohydrochloride | | L-(+)- | lysine monohydrochloride | | laevo- | lysine monohydrochloride | | L- | lysine, hydrochloride | | L- | lysine, hydrochloride (1:1) | | L- | lysine, monohydrochloride | | | lysine, monohydrochloride, L- | | L- | lysinehydrochloride | | | lysion |
Articles:
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