Articles:
| None found yet. Try the PubMed Search. |
L-tyrosine, 3-hydroxy-
Notes:
the naturally occurring form of dihydroxyphenylalanine and the immediate precursor of dopamine. unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. it is rapidly taken up by dopaminergic neurons and converted to dopamine. it is used for the treatment of parkinsonian disorders and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system. Occurs in seedlings and pods of Vicia faba
L-DOPA (L-3,4-dihydroxyphenylalanine; INN levodopa; trade names Sinemet, Parcopa, Atamet, Stalevo, Madopar, Prolopa, etc.) is a naturally-occurring dietary supplement and psychoactive drug found in certain kinds of food and herbs (e.g., Mucuna pruriens, or velvet bean), and is synthesized from the amino acid L-tyrosine in the mammalian body and brain. (Wikipedia)
-
BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 59-92-7 Levodopa >98% Levodopa (Sinemet) is an amino acid precursor of dopamine with antiparkinsonian properties.
-
-
Glentham Life Sciences Ltd The Chemical, Biochemical & Research Essentials Supplier Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK. With a Glentham Life Sciences account you can view more product details, request quotes and order products online. Email: Info Email: Sales Email: Tech Support Voice: +44 (0) 1225 667798 Fax: +44 (0) 2033 978909 Facebook Twitter Linkedin Google+ News Distribution Products List: View Product(s): GM9724 3,4-Dihydroxy-L-phenylalanine
-
-
Jiangyin Healthway International Trade Co., Ltd Independent Ingredients Supplier We provide custom synthesis and contract manufacturing from milligrams to metric tonnes. Jiangyin Healthway International Trade Co., Ltd is a professional company, main engaged in manufacturing and exporting aroma chemicals ,food additives , cosmetic ingredient ,pharmaceutical intermediates & other fine chemicals; especially on aroma chemicals , as the major manufacturer of heterocyclic and sulphur aroma compounds , we are the leading independent ingredients supplier to the flavour and fragrance industries in China, can offer hundreds of different high quality aroma chemicals. Email: Info Email: Sales Voice: 86-510-86023169 Fax: 86-510-86023170 Mobile 0086-13093133011 Services Biochemical Natural Food Colour New functional food ingredients Product(s): HLG0320 Levodopa
-
| CAS Number: | 59-92-7 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 200-445-2 | |
| FDA UNII: | 46627O600J | |
| Nikkaji Web: | J9.225H | |
| Beilstein Number: | 2215169 | |
| MDL: | MFCD00002598 | |
| XlogP3: | -2.70 (est) | |
| Molecular Weight: | 197.19047000 | |
| Formula: | C9 H11 N O4 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: information only not used for fragrances or flavors
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Appearance: | white powder (est) |
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 281.00 to 285.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 447.00 to 449.00 °C. @ 760.00 mm Hg |
| Flash Point: | 437.00 °F. TCC ( 225.00 °C. ) |
| logP (o/w): | -1.154 (est) |
| Soluble in: | |
| water, 5000 mg/L @ 20 °C (exp) | |
Organoleptic Properties:
| Odor Type: odorless | |
| Odor Strength: | none |
| Odor Description: at 100.00 %. | odorless |
| Flavor Type: sweet | |
| sweet | |
| Taste Description: | sweet |
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| Ajinomoto USA |
| L-Dopa
Flavor: characteristic L-dopa is not a core amino acid in terms of a building block for proteins. L-dopa is a synthetic protein for medical use. |
| Alfa Biotechnology |
| For experimental / research use only. |
| Levodopa 98% |
| BOC Sciences |
| For experimental / research use only. |
| Levodopa >98%
Odor: characteristic Use: Levodopa (Sinemet) is an amino acid precursor of dopamine with antiparkinsonian properties. |
| Glentham Life Sciences |
| 3,4-Dihydroxy-L-phenylalanine |
| Jiangyin Healthway |
| Levodopa |
| New functional food ingredients |
| Qingdao Dacon Trading |
| Levodopa |
| Shaanxi Y-Herb Biotechnology |
| Levodopa Weight Loss Supplement Powder 10%-98% L- Dopa Seed Mucuna Pruriens Extract |
| Shiva Chemicals and Pharmaceuticals |
| Levodopa |
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| 3,4-Dihydroxy-L-phenylalanine ≥98% (TLC) |
Safety Information:
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| Xn - Harmful. | |
|
R 22 - Harmful if swallowed. R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 02 - Keep out of the reach of children. S 20/21 - When using do not eat, drink or smoke. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intravenous-mouse LD50 450 mg/kg Toxicology and Applied Pharmacology. Vol. 28, Pg. 1, 1974. oral-mouse LD50 2363 mg/kg BEHAVIORAL: EXCITEMENT Toxicology and Applied Pharmacology. Vol. 28, Pg. 1, 1974. oral-rabbit LD50 609 mg/kg Toxicology and Applied Pharmacology. Vol. 28, Pg. 1, 1974. intraperitoneal-rat LD50 624 mg/kg SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: EXCITEMENT SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE Toxicology and Applied Pharmacology. Vol. 28, Pg. 1, 1974. intravenous-rat LD50 > 100 mg/kg Drugs in Japan Vol. 6, Pg. 905, 1982. oral-bird - wild LD50 100 mg/kg Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983. oral-human TDLo 13000 mg/kg/1Y BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Journal of Neurology, Neurosurgery and Psychiatry. Vol. 34, Pg. 668, 1971. oral-human TDLo 156000 mg/kg/10Y BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TOXIC PSYCHOSIS BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" Journal of Neurology, Neurosurgery and Psychiatry. Vol. 34, Pg. 502, 1971. intraperitoneal-mouse LD50 588 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE Toxicology and Applied Pharmacology. Vol. 28, Pg. 1, 1974. unreported-mouse LDLo 3500 mg/kg AUTONOMIC NERVOUS SYSTEM: SYMPATHOMIMETIC Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 153, Pg. 161, 1930. oral-rat LD50 1780 mg/kg BEHAVIORAL: AGGRESSION BEHAVIORAL: ATAXIA BEHAVIORAL: EXCITEMENT Toxicology and Applied Pharmacology. Vol. 28, Pg. 1, 1974. | |
| Dermal Toxicity: | |
|
subcutaneous-mouse LD50 4449 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 3, Pg. 186, 1972. subcutaneous-rat LD50 2000 mg/kg GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 3, Pg. 186, 1972. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | information only not used for fragrances or flavors | ||
| Recommendation for levodopa usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for levodopa flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 59-92-7 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 6047 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid | |
| Chemidplus: | 0000059927 |
| RTECS: | AY5600000 for cas# 59-92-7 |
References:
| (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 6047 |
| Pubchem (sid): | 134972617 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| Golm Metabolome Database: | Search |
| Metabolomics Database: | Search |
| KEGG (GenomeNet): | C00355 |
| HMDB (The Human Metabolome Database): | HMDB00181 |
| FooDB: | FDB000567 |
| Export Tariff Code: | 2922.50.4000 |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
| Formulations/Preparations: •capsules usp: 100, 250, & 500 mg; tablets usp: 100, 250, & 500 mg. •levodopa is one of the main ingredients along with carbidopa in the drug sinemet (tablets) •levodopa is one of the main ingredients along with carbidopa in the drug atamet (tablets) | |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| banana fruit Search Trop Picture | |
| bean fava bean Search Trop Picture | |
| bean fava bean flower Search Trop Picture | |
| bean fava bean fruit Search Trop Picture | |
| bean fava bean leaf Search Trop Picture | |
| bean fava bean seed Search Trop Picture | |
| bean fava bean sprout Search Trop Picture | |
| bean fava bean stem Search Trop Picture | |
| lupinus spp. Search Trop Picture | |
| purslane plant Search Trop Picture |
Synonyms:
| (2S)-2- | amino-3-(3,4-dihydroxyphenyl)propanoic acid |
| (S)-2- | amino-3-(3,4-dihydroxyphenyl)propanoic acid |
| 2- | amino-3-(3,4-dihydroxyphenyl)propanoic acid |
| 3,4- | dihydroxy-L-phenylalanine |
| 3,4- | dihydroxy-laevo-phenyl alanine |
| L-3,4- | dihydroxyphenyl alanine |
| laevo-3,4- | dihydroxyphenyl alanine |
| 3,4- | dihydroxyphenyl-laevo-alanine |
| L-3-(3,4- | dihydroxyphenyl) alanine |
| laevo-3-(3,4- | dihydroxyphenyl) alanine |
| L-beta-(3,4- | dihydroxyphenyl)-alpha-alanine |
| laevo-beta-(3,4- | dihydroxyphenyl)-alpha-alanine |
| 3-(3,4- | dihydroxyphenyl)-L-alanine |
| beta-(3,4- | dihydroxyphenyl)-laevo-alanine |
| 3,4-L- | dihydroxyphenylalanine |
| L-3,4- | dihydroxyphenylalanine |
| L- | dopa |
| laevo- | dopa |
| 3- | hydroxy-L-tyrosine |
| 3- | hydroxy-laevo-tyrosine |
| L- | tyrosine, 3-hydroxy- |