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1,4:3,6-dianhydro-D-glucitol
Notes:
1,4:3,6-dianhydro d-glucitol. chemically inert osmotic diuretic used mainly to treat hydrocephalus; also used in glaucoma.
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| CAS Number: | 652-67-5 |  3D/inchi
|
| Other(deleted CASRN): | 151380-60-8 | |
| ECHA EINECS - REACH Pre-Reg: | 211-492-3 | |
| FDA UNII: | WXR179L51S | |
| Nikkaji Web: | J7.077G | |
| Beilstein Number: | 0080510 | |
| MDL: | MFCD00064827 | |
| XlogP3: | -1.40 (est) | |
| Molecular Weight: | 146.14250000 | |
| Formula: | C6 H10 O4 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: indirect food additives: adhesives and components of coatings
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| DG SANTE Food Contact Materials: | 1,4:3,6-dianhydro-D-glucitol |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 62.50 °C. @ 760.00 mm Hg |
| Boiling Point: | 372.05 °C. @ 760.00 mm Hg (est) |
| Flash Point: | 354.00 °F. TCC ( 178.80 °C. ) (est) |
| logP (o/w): | -1.194 (est) |
| Soluble in: | |
| water, 4.714e+005 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Isosorbide |
| Carbosynth |
| For experimental / research use only. |
| 1,4:3,6-Dianhydro-D-glucitol |
| Sigma-Aldrich: Aldrich |
| For experimental / research use only. |
| Dianhydro-D-glucitol 98% |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intraperitoneal-mouse LD50 13600 mg/kg Drugs in Japan Vol. 6, Pg. 71, 1982. intravenous-mouse LD50 6870 mg/kg BRAIN AND COVERINGS: CHANGES IN CEREBRAL SPINAL FLUID Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 15, 1969. oral-mouse LD50 289 mg/kg Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 187, 1969. intravenous-rat LD50 11000 mg/kg Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 64(4), Pg. 158S, 1968. oral-rat LD50 24150 mg/kg Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 15, 1969. | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | indirect food additives: adhesives and components of coatings | ||
| Recommendation for isosorbide usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for isosorbide flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| European Food Safety Authority (EFSA) reference(s): | |
| Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to a 15th list of substances for food contact materials View page or View pdf | |
| Scientific Opinion on the safety evaluation of the substance, 1,4:3,6-dianhydrosorbitol, CAS No 652-67-5, for use in food contact materials View page or View pdf | |
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 652-67-5 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 12597 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 2 |
| (3S,3aR,6R,6aR)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3,6-diol | |
| Chemidplus: | 0000652675 |
| RTECS: | LZ4380000 for cas# 652-67-5 |
References:
| (3S,3aR,6R,6aR)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3,6-diol | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 652-67-5 |
| Pubchem (cid): | 12597 |
| Pubchem (sid): | 134977138 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEMBL: | View |
| Golm Metabolome Database: | Search |
| KEGG (GenomeNet): | D00347 |
| HMDB (The Human Metabolome Database): | Search |
| Export Tariff Code: | 2932.90.5000 |
| MedlinePlusSupp: | View |
| ChemSpider: | View |
| Wikipedia: | View |
| EFSA Update of results on the monitoring of furan levels in food: | Read Report |
| EFSA Previous report: Results on the monitoring of furan levels in food: | Read Report |
| EFSA Report of the CONTAM Panel on provisional findings on furan in food: | Read Report |
| Formulations/Preparations: ismotic (alcon), oral as 45% solution. | |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| devicoran | |
| 1,4:3,6- | dianhydro-D-glucitol |
| 1,4:3,6- | dianhydro-dextro-glucitol |
| D-1,4:3,6- | dianhydroglucitol |
| 1,4- | dianhydrosorbitol |
| D- | glucitol, 1,4:3,6-dianhydro- |
| glucitol, 1,4:3,6-dianhydro-, D- | |
| (3S,3aR,6R,6aR)- | hexahydro-furo[3,2-b]furan-3,6-diol |
| (3R,3aR,6S,6aR)- | hexahydrofuro[3,2-b]furan-3,6-diol |
| (3S,3aR,6R,6aR)-2,3,3a,5,6,6a- | hexahydrofuro[3,2-b]furan-3,6-diol |
| (3R,3aR,6S,6aR)- | hexahydrofuro[3,2-b]furane-3,6-diol |
| hydronol | |
| ismotic | |
| (+)-D-iso | sorbide |
| iso | sorbidum |