indole-2-carboxylic acid, 1477-50-5

Articles:

PubMed:	Energetic Effect of the Carboxylic Acid Functional Group in Indole Derivatives.
PubMed:	Small molecule Hedgehog pathway antagonists.
PubMed:	In Vitro DNA-Binding, Anti-Oxidant and Anticancer Activity of Indole-2-Carboxylic Acid Dinuclear Copper(II) Complexes.
PubMed:	Energetics of Radical Formation in Eumelanin Building Blocks: Implications for Understanding Photoprotection Mechanisms in Eumelanin.
PubMed:	Fragment-Based Design, Synthesis, and Biological Evaluation of 1-Substituted-indole-2-carboxylic Acids as Selective Mcl-1 Inhibitors.
PubMed:	Discovery of 3-Substituted 1H-Indole-2-carboxylic Acid Derivatives as a Novel Class of CysLT1 Selective Antagonists.
PubMed:	Indole-2-carboxylic acid derived mono and bis 1,4-disubstituted 1,2,3-triazoles: Synthesis, characterization and evaluation of anticancer, antibacterial, and DNA-cleavage activities.
PubMed:	Helicobacter pylori cell binding factor 2: Insights into domain motion.
PubMed:	Biased Agonism and Biased Allosteric Modulation at the CB1 Cannabinoid Receptor.
PubMed:	Phenolic Compounds from the Leaves of Stewartia pseudocamellia Maxim. and their Whitening Activities.
PubMed:	Self-assembly of indole-2-carboxylic acid at graphite and gold surfaces.
PubMed:	Pilot dietary intervention with heat-stabilized rice bran modulates stool microbiota and metabolites in healthy adults.
PubMed:	Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax).
PubMed:	Synthesis of the new ring system bispyrido[4',3':4,5]pyrrolo [1,2-a:1',2'-d]pyrazine and its deaza analogue.
PubMed:	Effects of the melanin precursor 5,6-dihydroxy-indole-2-carboxylic acid (DHICA) on DNA damage and repair in the presence of reactive oxygen species.
PubMed:	Design, synthesis and biological evaluation of 7-nitro-1H-indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase.
PubMed:	Exploratory studies towards various anion recognition chemistry by two different sized cleft shaped organic ligands.
PubMed:	Allosteric modulation of a cannabinoid G protein-coupled receptor: binding site elucidation and relationship to G protein signaling.
PubMed:	Photophysics of indole-2-carboxylic acid (I2C) and indole-5-carboxylic acid (I5C): heavy atom effect.
PubMed:	Inhibitory effects of Korean indigenous plants on tyrosinase and melanogenesis.
PubMed:	Light emission from tryptophan oxidation by hypobromous acid.
PubMed:	Superoxide reaction with tyrosyl radicals generates para-hydroperoxy and para-hydroxy derivatives of tyrosine.
PubMed:	Palladium-catalyzed annulation of allenes with indole-2-carboxylic acid derivatives: synthesis of indolo[2,3-c]pyrane-1-ones via Ar-I reactivity or C-H functionalization.
PubMed:	Protonated carbonic acid and reactive intermediates in the acidic decarboxylation of indolecarboxylic acids.
PubMed:	Allosteric modulator ORG27569 induces CB1 cannabinoid receptor high affinity agonist binding state, receptor internalization, and Gi protein-independent ERK1/2 kinase activation.
PubMed:	Novel hexahydropyridoindole derivative as prospective agent against oxidative damage in pancreatic β cells.
PubMed:	Design and synthesis of novel inhibitors of human kynurenine aminotransferase-I.
PubMed:	Photophysics of indole-2-carboxylic acid in an aqueous environment studied by fluorescence spectroscopy in combination with ab initio calculations.
PubMed:	Inhibition of glycogen phosphorylation induces changes in cellular proteome and signaling pathways in MIA pancreatic cancer cells.
PubMed:	Characterization of N-acetyltryptophan degradation products in concentrated human serum albumin solutions and development of an automated high performance liquid chromatography-mass spectrometry method for their quantitation.
PubMed:	I. Novel HCV NS5B polymerase inhibitors: discovery of indole 2-carboxylic acids with C3-heterocycles.
PubMed:	Gold(III) chloride catalyzed regioselective synthesis of pyrano[3,4-b]indol-1(9H)-ones and evaluation of anticancer potential towards human cervix adenocarcinoma.
PubMed:	Structural influence of indole C5-N-substitutents on the cytotoxicity of seco-duocarmycin analogs.
PubMed:	Parameterization of Org27569: an allosteric modulator of the cannabinoid CB1 G protein-coupled receptor.
PubMed:	The discovery and structure-activity relationships of indole-based inhibitors of glutamate carboxypeptidase II.
PubMed:	Structural necessity of indole C5-O-substitution of seco-duocarmycin analogs for their cytotoxic activity.
PubMed:	Tunable Pd-catalyzed cyclization of indole-2-carboxylic acid allenamides: carboamination vs microwave-assisted hydroamination.
PubMed:	Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors.
PubMed:	The tetrahydroisoquinoline derivative SB269,652 is an allosteric antagonist at dopamine D3 and D2 receptors.
PubMed:	NW-G01, a novel cyclic hexapeptide antibiotic, produced by Streptomyces alboflavus 313: II. Structural elucidation.
PubMed:	Regioselective oxidation of indole- and quinolinecarboxylic acids by cytochrome P450 CYP199A2.
PubMed:	Assembly of indole-2-carboxylic acid esters through a ligand-free copper-catalysed cascade process.
PubMed:	Structure-guided design of alpha-amino acid-derived Pin1 inhibitors.
PubMed:	Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide].
PubMed:	Conformationally constrained peptidomimetic inhibitors of signal transducer and activator of transcription. 3: Evaluation and molecular modeling.
PubMed:	Functional expression of Francisella tularensis FabH and FabI, potential antibacterial targets.
PubMed:	Vibrational spectroscopic studies of indolecarboxylic acids and their metal complexes part VIII. 5-methoxyindole-2-carboxylic acid and its Zn(II) complex.
PubMed:	Synthesis and biological activity of functionalized indole-2-carboxylates, triazino- and pyridazino-indoles.
PubMed:	Effect of dimerization on vibrational spectra of eumelanin precursors.
PubMed:	In vitro scavenging activity for reactive oxygen species by N-substituted indole-2-carboxylic acid esters.
PubMed:	In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity.
PubMed:	Low-abundance kutznerides from Kutzneria sp. 744.
PubMed:	Design, syntheses, biological evaluation, and docking studies of 2-substituted 5-methylsulfonyl-1-phenyl-1H-indoles: potent and selective in vitro cyclooxygenase-2 inhibitors.
PubMed:	A chemical genetics approach for the discovery of apoptosis inducers: from phenotypic cell based HTS assay and structure-activity relationship studies, to identification of potential anticancer agents and molecular targets.
PubMed:	Spectral and thermal studies of divalent transition metal with indole-2-carboxylic acid and 4-substituted hydrazinethiocarbamide.
PubMed:	Tricyclic quinoxalinediones, aza-kynurenic acids, and indole-2-carboxylic acids as in vivo active NMDA-glycine antagonists.
PubMed:	Kutznerides 1-4, depsipeptides from the actinomycete Kutzneria sp. 744 inhabiting mycorrhizal roots of Picea abies seedlings.
PubMed:	Synthesis of 6-[2-(benzoxazol-2-ylmethylamino)ethoxy]-1-alkyl-1H-indole-2-carboxylic acid and inhibitory activity on beta-amyloid aggregation.
PubMed:	Alkaloids from Portulaca oleracea L.
PubMed:	Synthesis and biological activities of novel aryl indole-2-carboxylic acid analogs as PPARgamma partial agonists.
PubMed:	Allosteric modulation of the cannabinoid CB1 receptor.
PubMed:	Isolation of three new naturally occurring compounds from the culture of Micromonospora sp. P1068.
PubMed:	A-770041, a novel and selective small-molecule inhibitor of Lck, prevents heart allograft rejection.
PubMed:	Synthesis and SAR of 2-carboxylic acid indoles as inhibitors of plasminogen activator inhibitor-1.
PubMed:	Spectral and thermal studies of divalent transition metal complexes with indole-2-carboxylic acid and 4-substituted hydrazinethiocarbamide.
PubMed:	CoMFA, synthesis, and pharmacological evaluation of (E)-3-(2-carboxy-2-arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acids: 3-[2-(3-aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic acid, a potent selective glycine-site NMDA receptor antagonist.
PubMed:	Pacemaker activity in hydra is modulated by glycine receptor ligands.
PubMed:	The systemic exposure of an N-methyl-D-aspartate receptor antagonist is limited in mice by the P-glycoprotein and breast cancer resistance protein efflux transporters.
PubMed:	Discovery and SAR of indole-2-carboxylic acid benzylidene-hydrazides as a new series of potent apoptosis inducers using a cell-based HTS assay.
PubMed:	Model structures of the N-methyl-D-aspartate receptor subunit NR1 explain the molecular recognition of agonist and antagonist ligands.
PubMed:	Variations of acidic functions at position 2 and substituents at positions 4, 5 and 6 of the indole moiety and their effect on NMDA-glycine site affinity.
PubMed:	A study on the stereochemical purity of trandolapril and octahydro-1H-indole-2-carboxylic acid by HPLC method.
PubMed:	Key substrate recognition residues in the active site of a plant cytochrome P450, CYP73A1. Homology guided site-directed mutagenesis.
PubMed:	New versatile route to the synthesis of tetrahydro-beta-carbolines and tetrahydro-pyrano[3,4-b]indoles via an intramolecular Michael addition catalyzed by InBr3.
PubMed:	KR-31466, a benzopyranylindol analog, attenuates hypoxic injury through mitochondrial K(ATP) channel and protein kinase C activation in heart-derived H9c2 cells.
PubMed:	3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site.
PubMed:	Inhibition by theanine of binding of [3H]AMPA, [3H]kainate, and [3H]MDL 105,519 to glutamate receptors.
PubMed:	Tricyclic indole-2-carboxylic acids: highly in vivo active and selective antagonists for the glycine binding site of the NMDA receptor.
PubMed:	SM-31900, a novel NMDA receptor glycine-binding site antagonist, reduces infarct volume induced by permanent middle cerebral artery occlusion in spontaneously hypertensive rats.
PubMed:	In vitro and in vivo assessment of the antioxidant activity of melatonin and related indole derivatives.
PubMed:	Singlet oxygen-mediated protein oxidation: evidence for the formation of reactive side chain peroxides on tyrosine residues.
PubMed:	In vitro and in vivo antagonistic activities of SM-31900 for the NMDA receptor glycine-binding site.
PubMed:	The effect of glucose on the potency of two distinct glycogen phosphorylase inhibitors.
PubMed:	Identification of nonpeptidic urotensin II receptor antagonists by virtual screening based on a pharmacophore model derived from structure-activity relationships and nuclear magnetic resonance studies on urotensin II.
PubMed:	Cooperative binding interactions of glycopeptide antibiotics.
PubMed:	Cysteine and indole derivatives as markers for malignant melanoma.
PubMed:	GV196771A, an NMDA receptor/glycine site antagonist, attenuates mechanical allodynia in neuropathic rats and reduces tolerance induced by morphine in mice.
PubMed:	Synthesis and receptor docking studies of N-substituted indole-2-carboxylic acid esters as a search for COX-2 selective enzyme inhibitors.
PubMed:	Synthesis of tricyclic indole-2-carboxylic [correction of caboxylic] acids as potent NMDA-glycine antagonists.
PubMed:	Allosteric modulation of [3H]-CGP39653 binding through the glycine site of the NMDA receptor: further studies in rat and human brain.
PubMed:	Oxidation of Free Tryptophan and Tryptophan Residues in Peptides and Proteins.
PubMed:	Heterocyclic substituted anthralin derivatives as inhibitors of keratinocyte growth and inducers of differentiation.
PubMed:	Molecular co-crystals of 2-aminothiazole derivatives.
PubMed:	A new allosteric site in glycogen phosphorylase b as a target for drug interactions.
PubMed:	Chloptosin, an apoptosis-inducing dimeric cyclohexapeptide produced by Streptomyces.
PubMed:	Biodegradation of carbazole by Ralstonia sp. RJGII.123 isolated from a hydrocarbon contaminated soil.
PubMed:	Receptor binding characteristics of the novel NMDA receptor glycine site antagonist [3H]GV150526A in rat cerebral cortical membranes.
PubMed:	Modulation of nociceptive transmission by NMDA/glycine site receptor in the ventroposterolateral nucleus of the thalamus.
PubMed:	Substituted analogues of GV150526 as potent glycine binding site antagonists in animal models of cerebral ischemia.
PubMed:	The soluble eumelanin precursor 5,6-dihydroxyindole-2-carboxylic acid enhances oxidative damage in human keratinocyte DNA after UVA irradiation.
PubMed:	Expression and characterization of a glycine-binding fragment of the N-methyl-D-aspartate receptor subunit NR1.
PubMed:	Cooperation of dopachrome conversion factor with phenoloxidase in the eumelanin pathway in haemolymph of Locusta migratoria (Insecta).
PubMed:	Infrared, surface-assisted laser desorption ionization mass spectrometry on frozen aqueous solutions of proteins and peptides using suspensions of organic solids.
PubMed:	Enhanced sensitivity of medullary depressor neurons to N-methyl-D-aspartate-glycine site antagonists in the spontaneously hypertensive rat.
PubMed:	Possible involvement of ATP-dependent K-channel related mechanisms in the antihypertensive and cough suppressant effects of the novel ACE inhibitor (2S, 3aS, 7aS)-1-(N2-nicotinoyl-L-lysyl-gamma-D-glutamyl)octahydro-1H- indole-2-carboxylic acid.
PubMed:	Applications of High-Temperature Aqueous Media for Synthetic Organic Reactions.
PubMed:	Novel indole-2-carboxamide and cycloalkeno[1,2-b]indole derivatives. Structure-activity relationships for high inhibition of human LDL peroxidation.
PubMed:	Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist.
PubMed:	Picolinic acid and indole-2-carboxylic acid: two types of glycinergic compounds modulate motor function differentially.
PubMed:	Substituted indole-2-carboxylates as in vivo potent antagonists acting as the strychnine-insensitive glycine binding site.
PubMed:	Binding of the radiolabeled glycine site antagonist [3H]MDL 105,519 to homomeric NMDA-NR1a receptors.
PubMed:	[3H]MDL 105,519, a high-affinity radioligand for the N-methyl-D-aspartate receptor-associated glycine recognition site.
PubMed:	3-(Octadecanoylaminomethyl)indole-2-carboxylic acid derivatives and 1-methyl-3-octadecanoylindole-2-carboxylic acid as inhibitors of cytosolic phospholipase A2.
PubMed:	[Chemistry of the cyclic tautomer of tryptophans].
PubMed:	Altered responsiveness of medullary depressor neurones to L-glutamate and D-serine in SHR rats.
PubMed:	Benzimidazole-type glycine antagonists: the role of the ring nitrogen atoms.
PubMed:	Himastatin, a new antitumor antibiotic from Streptomyces hygroscopicus. III. Structural elucidation.
PubMed:	Formation of indigo and related compounds from indolecarboxylic acids by aromatic acid-degrading bacteria: chromogenic reactions for cloning genes encoding dioxygenases that act on aromatic acids.
PubMed:	MDL 100,458 and MDL 102,288: two potent and selective glycine receptor antagonists with different functional profiles.
PubMed:	Antihypertensive properties of a new long-acting angiotensin converting enzyme inhibitor in renin-dependent and independent hypertensive models.
PubMed:	Effects of the excitatory amino acid receptor antagonists kynurenate and indole-2-carboxylic acid on behavioral and neurochemical outcome following experimental brain injury.
PubMed:	Regulatory factors for polymerization of melanin monomers within coated vesicles and premelanosomes in melanoma cells.
PubMed:	Serum 5-S-cysteinyldopa (5-S-CD) as a marker of melanoma progression.
PubMed:	Characterization of indole-2-carboxylate derivatives as antagonists of N-methyl-D-aspartate receptor activity at the associated glycine recognition site.
PubMed:	Mechanism of glycine protection in hypoxic injury: analogies with glycine receptor.
PubMed:	Competitive antagonism of glutamate receptor channels by substituted benzazepines in cultured cortical neurons.
PubMed:	Effects of glycine antagonists on Mg(2+)- and glycine-induced [3H]N-(1-[2-thienyl]cyclohexyl)-3,4-piperidine binding.
PubMed:	Spinal pharmacology of thermal hyperesthesia induced by constriction injury of sciatic nerve. Excitatory amino acid antagonists.
PubMed:	Specificity of dopachrome tautomerase and inhibition by carboxylated indoles. Considerations on the enzyme active site.
PubMed:	Potentiation of ethanol via interference with calcium channels.
PubMed:	Induction of estradiol metabolism by dietary indole-3-carbinol in humans.
PubMed:	Concentration-jump experiments with NMDA antagonists in mouse cultured hippocampal neurons.
PubMed:	Synthesis and angiotensin converting enzyme inhibitory activity of N-carboxymethyldipeptides with omega-(4-piperidyl)alkyl group.
PubMed:	Blockade of the glycine modulatory site of NMDA receptors modifies dynorphin-induced behavioral effects.
PubMed:	Indole-2-carboxylic acid: a competitive antagonist of potentiation by glycine at the NMDA receptor.
PubMed:	Some indolic compounds as markers of the melanocyte activity.
PubMed:	Photogeneration of free radicals from eumelanogenic intermediates and metabolites.
PubMed:	Effects of thionaphthene 2-carboxylic acid and related compounds on bone resorption in organ culture.
PubMed:	CI-906 and CI-907: new orally active nonsulfhydryl angiotensin-converting enzyme inhibitors.
PubMed:	Auxin action on proton influx in corn roots and its correlation with growth.
PubMed:	A novel synthesis of 2-thioether derivatives of tryptophan. Covalent binding of tryptophan to cysteine sulfhydryl groups in peptides and proteins.
PubMed:	Syntheses of monocyclic and bicyclic peptides of tryptathionine and glycine.
PubMed:	[Studies on indole derivatives. XII. Reaction of indole-2-carboxylic acid derivatives with carbon disulfide].
PubMed:	Mode of action of hypoglycemic agents. 3. Studies on 5-methoxy indole-2-carboxylic acid and quinaldic acid.
PubMed:	[STUDIES ON ANTITUMOUR DRUGS. 18. EXPERIMENTAL THERAPY AND TOXICITY OF 5-(BIS-(2-CHLOROETHYL)-AMINO)-INDOLE-2-CARBOXYLIC ACID (AT-346)].