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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 457.50 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 472.00 °F. TCC ( 244.60 °C. ) (est)
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| logP (o/w): | 5.050 (est) |
| Soluble in: |
| | water, 1.494 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for hexadecane dioic acid usage levels up to: | | | not for fragrance use.
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| Recommendation for hexadecane dioic acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | hexadecane-1,16-dioic acid | | | hexadecanedioic acid | | 1,14- | tetradecane dicarboxylic acid | | | tetradecane-omega,omega'-dicarboxylic acid | | | thapsic acid |
Articles:
| PubMed: | A permeability transition in liver mitochondria and liposomes induced by α,ω-dioic acids and Ca(2+) |
| PubMed: | Induction of Ca2+-Dependent Cyclosporin A-Insensitive Nonspecific Permeability of the Inner Membrane of Liver Mitochondria and Cytochrome c Release by α,ω-Hexadecanedioic Acid in Media of Varying Ionic Strength. |
| PubMed: | Long-chain α,ω-dioic acids as inducers of cyclosporin A-insensitive nonspecific permeability of the inner membrane of liver mitochondria loaded with calcium or strontium ions. |
| PubMed: | Lipid profiling for early diagnosis and progression of colorectal cancer using direct-infusion electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry. |
| PubMed: | Suppression of adipose lipolysis by long-chain fatty acid analogs. |
| PubMed: | Stable vesicles composed of monocarboxylic or dicarboxylic fatty acids and trimethylammonium amphiphiles. |
| PubMed: | Analysis of the hibernation cycle using LC-MS-based metabolomics in ground squirrel liver. |
| PubMed: | Synthesis and bio-evaluation of a new fatty acid derivative for myocardial imaging. |
| PubMed: | Amino-modified diamond as a durable stationary phase for solid-phase extraction. |
| PubMed: | Hexadecanedionic acid-sepharose 4B: A new tool for preparation of albumin-depleted plasma. |
| PubMed: | Modulation of insulin secretion by fatty acyl analogs. |
| PubMed: | Transcriptional regulation of human microsomal triglyceride transfer protein by hepatocyte nuclear factor-4alpha. |
| PubMed: | Condensation reactions and formation of amides, esters, and nitriles under hydrothermal conditions. |
| PubMed: | Alkyl and carboxylalkyl esters of 4'-demethyl-4-deoxypodophyllotoxin: synthesis, cytotoxic, and antitumor activity. |
| PubMed: | Cutin and suberin monomers are membrane perturbants. |
| PubMed: | Structural study on polymorphism of long-chain dicarboxylic acids using oblique transmission method for micro FT-IR spectrometers. |
| PubMed: | A new enzyme immunoassay for aconitine and its application to quantitative determination of aconitine levels in plasma. |
| PubMed: | Oxygenation cascade in conversion of n-alkanes to alpha,omega-dioic acids catalyzed by cytochrome P450 52A3. |
| PubMed: | Sensitization to insulin induced by beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) in obese Zucker rats in vivo. |
| PubMed: | Mode of action of peroxisome proliferators as hypolipidemic drugs. Suppression of apolipoprotein C-III. |
| PubMed: | Dicarboxylic acids affect the growth of dermatophytes in vitro. |
| PubMed: | Coordinate induction of hepatic fatty acyl-CoA oxidase and P4504A1 in rat after activation of the peroxisome proliferator-activated receptor (PPAR) by sulphur-substituted fatty acid analogues. |
| PubMed: | Cytochrome P450BM-3 (CYP102): regiospecificity of oxidation of omega-unsaturated fatty acids and mechanism-based inactivation. |
| PubMed: | On the mechanism of the hypolipidemic effect of sulfur-substituted hexadecanedioic acid (3-thiadicarboxylic acid) in normolipidemic rats. |
| PubMed: | Induction of peroxisomal fatty acid beta-oxidation and liver fatty acid-binding protein by peroxisome proliferators. Mediation via the cytochrome P-450IVA1 omega-hydroxylase pathway. |
| PubMed: | Hypocholesterolaemic effect of beta beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) in the male hamster. |
| PubMed: | Tissue selective modulation of redox and phosphate potentials by beta,beta'-methyl-substituted hexadecanedioic acid. |
| PubMed: | Effect of beta, beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16) on laying hen performance and egg yolk lipid composition. |
| PubMed: | Biogenesis of dicarboxylic acids in rat liver homogenate studied by 13C labeling. |
| PubMed: | Characterization of the binding sites for dicarboxylic acids on bovine serum albumin. |
| PubMed: | Hypolipidemic effect of beta, beta'-tetramethyl hexadecanedioic acid (MEDICA 16) in hyperlipidemic JCR:LA-corpulent rats. |
| PubMed: | Inhibition of rat liver acetyl-CoA carboxylase by beta, beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16). |
| PubMed: | Alkylthio acetic acids (3-thia fatty acids)--a new group of non-beta-oxidizable peroxisome-inducing fatty acid analogues--II. Dose-response studies on hepatic peroxisomal- and mitochondrial changes and long-chain fatty acid metabolizing enzymes in rats. |
| PubMed: | Alkylthioacetic acids (3-thia fatty acids) as non-beta-oxidizable fatty acid analogues: a new group of hypolipidemic drugs. III. Dissociation of cholesterol- and triglyceride-lowering effects and the induction of peroxisomal beta-oxidation. |
| PubMed: | Alkylthioacetic acid (3-thia fatty acids)--a new group of non-beta-oxidizable, peroxisome-inducing fatty acid analogues. I. A study on the structural requirements for proliferation of peroxisomes and mitochondria in rat liver. |
| PubMed: | Adipose reduction by beta,beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16). |
| PubMed: | Hypolipidemic, antiobesity, and hypoglycemic-hypoinsulinemic effects of beta,beta'-methyl-substituted hexadecanedioic acid in sand rats. |
| PubMed: | The induction of liver peroxisomal proliferation by beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16). |
| PubMed: | The hypochylomicronemic effect of beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) is mediated by a decrease in apolipoprotein C-III. |
| PubMed: | Hypolipidemic effect of beta, beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) in normal and nephrotic rats. |
| PubMed: | The biological origin of ketotic dicarboxylic aciduria. II. In vivo and in vitro investigations of the beta-oxidation of C8-C16-dicarboxylic acids in unstarved, starved and diabetic rats. |
| PubMed: | The biological origin of ketotic dicarboxylic aciduria. In vivo and in vitro investigations of the omega-oxidation of C6-C16-monocarboxylic acids in unstarved, starved and diabetic rats. |
| PubMed: | Synthesis and biologic distribution of mercapto derivatives of palmitic acid. |
| PubMed: | [Acyl-CoA synthetase activity of long-chain mono and dicarboxylic acid in beef liver preparations (author's transl)]. |
| PubMed: | Subcellular localization of hexadecanedioic acid activation in human liver. |
| PubMed: | In vitro studies on the metabolism of hexadecanedioic acid and its mono-L-carnitine ester. |
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