hematin
hydroxy(dihydrogen protoporphyrin IX-ato(2-))iron
 
Notes:
None found
Synonyms   Articles   Notes   Search
CAS Number: 15489-90-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 239-518-9
FDA UNII: 0WP180G15G
MDL: MFCD00011615
Molecular Weight: 634.51398000
Formula: C34 H34 Fe N4 O5
NMR Predictor: Predict (works with chrome or firefox)
Category: cosmetic ingredient for hair conditioning
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 1128.50 °C. @ 760.00 mm Hg (est)
Flash Point: 1177.00 °F. TCC ( 636.30 °C. ) (est)
logP (o/w): 7.193 (est)
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: hair conditioning
Synonyms   Articles   Notes   Search   Top
Suppliers:
Santa Cruz Biotechnology
For experimental / research use only.
Hematin ≥95%
Sigma-Aldrich: Sigma
For experimental / research use only.
Hematin porcine
Synonyms   Articles   Notes   Search   Top
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-rat LD50  43 mg/kg
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION BLOOD: HEMORRHAGE
Toxicology Letters. Vol. 2, Pg. 329, 1978.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Synonyms   Articles   Notes   Search   Top
Safety in Use Information:
Category: cosmetic ingredient for hair conditioning
Recommendation for hematin usage levels up to:
 not for fragrance use.
 
Recommendation for hematin flavor usage levels up to:
 not for flavor use.
Synonyms   Articles   Notes   Search   Top
Safety References:
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 27337
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;iron(2+);hydrate
Chemidplus: 0015489904
RTECS: NO6725000 for cas# 15489-90-4
Synonyms   Articles   Notes   Search   Top
References:
 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;iron(2+);hydrate
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 27337
Pubchem (sid): 134992696
Synonyms   Articles   Notes   Search   Top
Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
HMDB (The Human Metabolome Database): Search
FooDB: FDB004145
Export Tariff Code: 2933.90.9500
FDA Color Additive Status ListView
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
 
None Found
 
Synonyms   Articles   Notes   Search   Top
Potential Uses:
 biological additives 
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 cacao bean
Search Trop  Picture
 horseradish root
Search Trop  Picture
Synonyms   Articles   Notes   Search   Top
Synonyms:
 dihydrogen hydroxy(3,8,13,17-tetramethyl-7,12-divinyl-21H,23H-porphine-2,18-dipropionato(4-)-n21,n22,n23,n24)ferrate(2-)
 hematin from bovine blood
3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;iron(2+);hydrate
 ferrihemate
 ferriheme
 haematin
 hydroxo(protoporphyrinato)iron(III)
 hydroxo[3,7,12,17-tetramethyl-8,13-divinylporphyrin-2,18-dipropanoato(2-)]iron(III)
 hydroxy(dihydrogen protoporphyrin IX-ato(2-))iron
 hydroxyhemin
 iron, (dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-))-hydroxy-
 phenodin
 protohematin
Synonyms   Articles   Notes   Search   Top
Articles:
PubMed: Blood meal-based compound. Good choice as iron fertilizer for organic farming.
PubMed: Hemozoin accumulation in Garnham bodies of Plasmodium falciparum gametocytes.
PubMed: Erythrocyte membranes convert monomeric ferriprotoporphyrin IX to β-hematin in acidic environment at malarial fever temperature.
PubMed: Dietary iron-initiated lipid oxidation and its inhibition by polyphenols in gastric conditions.
PubMed: Interactions of the antimalarial drug methylene blue with methemoglobin and heme targets in Plasmodium falciparum: a physico-biochemical study.
PubMed: Toward understanding the chloroquine action at the molecular level in antimalarial therapy--X-ray absorption studies in acetic acid solution.
PubMed: Factors in various fractions of meat homogenates that affect the oxidative stability of raw chicken breast and beef loin.
PubMed: Physicochemical properties, pharmacokinetics, and pharmacodynamics of intravenous hematin: a literature review.
PubMed: Interactions between antiplasmodial 3,6-diamino-1'-dimethyl-9-anilinoacridine and hematin and concanamycin A.
PubMed: The mechanism of antimalarial action of the ruthenium(II)-chloroquine complex [RuCl(2)(CQ)] (2).
PubMed: Alcohols induce beta-hematin formation via the dissociation of aggregated heme and reduction in interfacial tension of the solution.
PubMed: Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9.
PubMed: Structural analysis of the anti-malaria active agent chloroquine under physiological conditions.
PubMed: Antimalarial drugs inhibiting hemozoin (beta-hematin) formation: a mechanistic update.
PubMed: Resonance Raman spectroscopy in malaria research.
PubMed: Insights into the mechanism of action of ferroquine. Relationship between physicochemical properties and antiplasmodial activity.
PubMed: Synthesis of some cryptolepine analogues, assessment of their antimalarial and cytotoxic activities, and consideration of their antimalarial mode of action.
PubMed: A colorimetric high-throughput beta-hematin inhibition screening assay for use in the search for antimalarial compounds.
PubMed: 1,4-bis(3-aminopropyl)piperazine libraries: from the discovery of classical chloroquine-like antimalarials to the identification of new targets.
PubMed: Inhibition of glutathione S-transferases by thonningianin A, isolated from the African medicinal herb, Thonningia sanguinea, in vitro.
PubMed: Raman imaging of hemozoin within the food vacuole of Plasmodium falciparum trophozoites.
PubMed: Structure-activity relationships in 4-aminoquinoline antiplasmodials. The role of the group at the 7-position.
PubMed: Concentration effects in myoglobin-catalyzed peroxidation of linoleate.
PubMed: On the mechanism of hemozoin production in malaria parasites: activated erythrocyte membranes promote beta-hematin synthesis.
PubMed: Generation of lipid peroxyl radicals from edible oils and their biological activities: a need for consideration for anti-radical components and purification processing.
PubMed: Characterization of chloroquine-hematin mu-oxo dimer binding by isothermal titration calorimetry.
PubMed: Phagocytosis of hemozoin (native and synthetic malaria pigment), and Plasmodium falciparum intraerythrocyte-stage parasites by human and mouse phagocytes.
PubMed: Structure-function relationships in aminoquinolines: effect of amino and chloro groups on quinoline-hematin complex formation, inhibition of beta-hematin formation, and antiplasmodial activity.
PubMed: Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth.
PubMed: Deferoxamine: stimulation of hematin polymerization and antagonism of its inhibition by chloroquine.
PubMed: Role of glutathione in the detoxification of ferriprotoporphyrin IX in chloroquine resistant Plasmodium berghei.
PubMed: The ultrastructure of the gastrodermis and the nutrition of the gill parasitic Atriaster heterodus Lebedev and Paruchin, 1969 (Platyhelminthes: Monogenea).
PubMed: Access to hematin: the basis of chloroquine resistance.
PubMed: The iron environment in heme and heme-antimalarial complexes of pharmacological interest.
PubMed: High-performance liquid chromatographic analysis of biological and chemical heme polymerization.
PubMed: Influence of pH, salt and nitrite on the heme-dependent catalase activity of lactic acid bacteria.
PubMed: Heme-dependent catalase activity of lactobacilli.
PubMed: Biochemical characterization of Plasmodium falciparum hemozoin.
PubMed: Generation of reactive intermediates from the tumor promoter butylated hydroxytoluene hydroperoxide in isolated murine keratinocytes or by hematin.
PubMed: Isolation and enumeration of Campylobacter jejuni from poultry products by a selective enrichment method.
PubMed: Protein changes in frozen fish.
PubMed: Phagotrophy and two new structures in the malaria parasite Plasmodium berghei.
Synonyms   Articles   Notes   Search   Top
Please share your Comments.
Email Address:
 
 
 
 
Top of Page Home
Copyright © 1980-2021 Perflavory ™ Disclaimer Privacy Policy