helium
atomic helium
 
Notes:
helium. a noble gas with the atomic symbol he, atomic number 2, and atomic weight 4.003. it is a colorless, odorless, tasteless gas that is not combustible and does not support combustion. it was first detected in the sun and is now obtained from natural gas. medically it is used as a diluent for other gases, being especially useful with oxygen in the treatment of certain cases of respiratory obstruction, and as a vehicle for general anesthetics. (dorland, 27th ed) Food processing aid
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CAS Number: 7440-59-7Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 231-168-5
FDA UNII: 206GF3GB41
Nikkaji Web: J3.101A
MDL: MFCD00011031
Molecular Weight: 4.00260200
Formula: He
NMR Predictor: Predict (works with chrome or firefox)
Category: processing aids
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
 FDA/DG SANTE Petitions, Reviews, Notices:
184.1355 Helium gas View - review
JECFA Food Additive: Helium
DG SANTE Food Additives: helium
FDA Mainterm (SATF):7440-59-7 ; HELIUM
FDA Regulation:
FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1355 Helium.
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
logP (o/w): 0.280
Soluble in:
 water, 2.5 mg/L @ 21C (exp)
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Organoleptic Properties:
Odor Description:
at 100.00 %. 
odorless
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
Sigma-Aldrich: Aldrich
For experimental / research use only.
Helium ≥99.995%
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: processing aids
Recommendation for helium usage levels up to:
 not for fragrance use.
 
Recommendation for helium flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
ClinicalTrials.gov: search
NIOSH International Chemical Safety Cards: search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 7440-59-7
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 23987
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 helium
Chemidplus: 0007440597
EPA/NOAA CAMEO: hazardous materials
RTECS: 7440-59-7
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References:
 helium
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 7440-59-7
Pubchem (cid): 23987
Pubchem (sid): 134988671
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS): View
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): D04420
HMDB (The Human Metabolome Database): HMDB37238
FooDB: FDB016248
Export Tariff Code: 2804.29.0010
FDA Listing of Food Additive Status: View
VCF-Online: VCF Volatile Compounds in Food
Wikipedia: View
FAO: HELIUM
Formulations/Preparations:
•helium is marketed in compressed form in usual type of steel cylinder. helium, various mixt with oxygen are also available. •grades: usp; technical, 99.995% pure. •commercial specifications: bureau of mines, 99.997%; bb-h-1168a, 99.995%; msfc-364, 99.995%; mil-p-27407, 99.995%; compressed gas association grades - d, 99.995%; e, 99.997; f, 99.999%; g, 99.9999% •crude (approximately 70% helium and 30% nitrogen); grade a (99.995% or better)
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 found in nature
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Synonyms:
 atomic helium
 helium, compressed
 helium, compressed [UN1046] [Nonflammable gas]
 helium, refrigerated liquid (cryogenic liquid)
 helium, refrigerated liquid (cryogenic liquid) [UN1963] [Nonflammable gas]
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Articles:
PubMed: Hydroxyl radical formation in batch and continuous flow ultrasonic systems.
PubMed: Accurate mass fragment library for rapid analysis of pesticides on produce using ambient pressure desorption ionization with high-resolution mass spectrometry.
PubMed: Microbial decontamination of red pepper powder by cold plasma.
PubMed: The post-thaw irradiation of avian spermatozoa with He-Ne laser differently affects chicken, pheasant and turkey sperm quality.
PubMed: Authenticity of carbon dioxide bubbles in French ciders through multiflow-isotope ratio mass spectrometry measurements.
PubMed: Effect of lung inflation level on hyperpolarized 3He apparent diffusion coefficient measurements in never-smokers.
PubMed: Simultaneous testing of multiclass organic contaminants in food and environment by liquid chromatography/dielectric barrier discharge ionization-mass spectrometry.
PubMed: ID-CUBE direct analysis in real time high-resolution mass spectrometry and its capabilities in the identification of phenolic components from the green leaves of Bergenia crassifolia L.
PubMed: Experimental study on pulmonary cryoablation in a porcine model of normal lungs.
PubMed: Cold plasma decontamination of foods.
PubMed: Gas discharge plasmas are effective in inactivating Bacillus and Clostridium spores.
PubMed: Effect of temperature on gas composition and char structural features of pyrolyzed agricultural residues.
PubMed: Asthma in adults (acute).
PubMed: Permeability of cork to gases.
PubMed: Surface swabbing technique for the rapid screening for pesticides using ambient pressure desorption ionization with high-resolution mass spectrometry.
PubMed: Effect of atmospheric pressure plasma on inactivation of pathogens inoculated onto bacon using two different gas compositions.
PubMed: Profile of Thure E. Cerling.
PubMed: Formation of volatile chemicals from thermal degradation of less volatile coffee components: quinic acid, caffeic acid, and chlorogenic acid.
PubMed: Asthma in adults.
PubMed: Assessing direct analysis in real-time-mass spectrometry (DART-MS) for the rapid identification of additives in food packaging.
PubMed: [High pressure processing of spices in atmosphere of helium for decrease of microbiological contamination].
PubMed: Changes in regional airflow obstruction over time in the lungs of patients with asthma: evaluation with 3He MR imaging.
PubMed: Hurdles to helium gas laparoscopy and a readily available alternative.
PubMed: [Characterization of aroma active compounds in blood orange juice by solid phase microextraction and gas chromatography-mass spectrometry-olfactometry].
PubMed: Evidence for an extraterrestrial impact 12,900 years ago that contributed to the megafaunal extinctions and the Younger Dryas cooling.
PubMed: Enhanced selective extraction of hexane from hexane/soybean oil mixture using binary gas mixtures of carbon dioxide.
PubMed: Interactions of water with roasted and ground coffee in the wetting process investigated by a combination of physical determinations.
PubMed: Formation of polycyclic aromatic hydrocarbons from tobacco: the link between low temperature residual solid (char) and PAH formation.
PubMed: Asthma in adults.
PubMed: Heliox therapy and devices cleared by the FDA: after the engineers produce effective designs, why do clinicians still feel the need to jury-rig?
PubMed: Decomposition of biological macromolecules by plasma generated with helium and oxygen.
PubMed: Opportunities and risks of using heliox in your clinical practice.
PubMed: Gas-chromatographic separation of stereoisomers of dipeptides.
PubMed: [Simultaneous determination of 25 persistent organic pollutants in rice by gas chromatography-mass spectrometry with selected ion monitoring mode].
PubMed: Oxidative pyrolysis and postpyrolytic derivatization techniques for the total analysis of maillard model systems: investigation of control parameters of maillard reaction pathways.
PubMed: Low-level laser therapy for wound healing: mechanism and efficacy.
PubMed: Compression of controlled-release pellets produced by a hot-melt extrusion and spheronization process.
PubMed: Pulsed discharge detector: theory and applications.
PubMed: Selected ion flow tube mass spectrometry (SIFT-MS) for on-line trace gas analysis.
PubMed: Effect of trans-resveratrol on the thrombogenicity and atherogenicity in apolipoprotein E-deficient and low-density lipoprotein receptor-deficient mice.
PubMed: Automated dynamic headspace/GC-MS analyses affect the repeatability of volatiles in irradiated Turkey.
PubMed: Automated headspace solid-phase dynamic extraction to analyse the volatile fraction of food matrices.
PubMed: Effect of feed gas composition of gas discharge plasmas on Bacillus pumilus spore mortality.
PubMed: Detection of organotin, organomercury, and organolead compounds with a pulsed discharge detector (PDD).
PubMed: Potential migration release of volatile compounds from plastic containers destined for food use in microwave ovens.
PubMed: Evidence for [1,5] sigmatropic rearrangements of CLA in heated oils.
PubMed: Observation of the swallowing process by application of videofluoroscopy and real-time magnetic resonance imaging-consequences for retronasal aroma stimulation.
PubMed: Identification of hydrolyzed inulin syrup and high-fructose corn syrup in apple juice by capillary gas chromatography: PVM 4:1999.
PubMed: Sample preparation for the analysis of flavors and off-flavors in foods.
PubMed: A sensitive procedure for the study of beta-carotene-d8 metabolism in humans using high performance liquid chromatography-mass spectrometry.
PubMed: Headspace oxygen in sample vials affects volatiles production of meat during the automated purge-and-Trap/GC analyses.
PubMed: Volatiles obtained from whole and ground grain samples by supercritical carbon dioxide and direct helium purge methods: observations on 2,3-butanediols and halogenated anisoles.
PubMed: Use of an autosampler for dynamic headspace extraction of volatile compounds from grains and effect of added water on the extraction.
PubMed: Isotope ratio monitoring gas chromatography/Mass spectrometry of D/H by high temperature conversion isotope ratio mass spectrometry.
PubMed: Determination of extractable organic chlorine and bromine by probe injection dual-microplasma atomic emission spectrometry.
PubMed: Minimizing the residual oxygen in modified atmosphere packaging of bakery products.
PubMed: Repeated normoxic hyperbaric exposures induce haemodynamic and myocardial changes in rats.
PubMed: Determination of benzene in polypropylene food-packaging materials and food-contact paraffin waxes.
PubMed: Effect of exposure to high pressure on subsequent spatial learning and memory in rats.
PubMed: Excimer laser corneal ablation: absence of a significant "incubation" effect.
PubMed: Pesticide analysis by gas chromatography with a novel atomic emission detector.
PubMed: Safety considerations in MR imaging.
PubMed: [Effect of replacement of air nitrogen by inert gases on oxygen consumption by the liver tissues in albino rats on various fatty diets].
PubMed: Dynamic headspace gas chromatography of volatile compounds in milk.
PubMed: [Organization of nutrition for persons subjected to long-term hyperbaria (review of the literature)].
PubMed: Capillary fused-silica on-column injection of chlorinated pesticides with an ultra-low volume rotary valve.
PubMed: Comparison of helium leak test and vacuum leak test using canned foods: collaborative study.
PubMed: The conduct of metabolic balances during simulated deep dives.
PubMed: Postpneumonectomy oesophagopleural fistula.
PubMed: Behavioral effects of morphine on free-operant avoidance under hyperbaric pressure.
PubMed: Headspace sampling and gas-solid chromatographic determination and confirmation of greater than or equal to 1 ppb vinyl chloride residues in polyvinyl chloride food packaging.
PubMed: Dietary requirements of subjects exposed to hyperbaric He-O2 conditions: effects of supplementation with major nutrient groups.
PubMed: Pituitary-thyroid function of rats in hypobaric oxygen-inert gas environments.
PubMed: [Food intake and blood morphological indices in albino mice in sealed chambers with nitrogen in the air substituted by inert gases].
PubMed: The mechanism of microbiological leaker spoilage of canned foods: a review.
PubMed: Biochemical and metabolic effects of a six-month exposure of small animals to a helium-oxygen atmosphere. NASA CR-1372.
PubMed: Irradiation of fish fillets: relation of vapor phase reactions to storage quality.
PubMed: An improved microwave emission gas chromatography detector for pesticide residue analysis.
PubMed: Study of man during a 56-day exposure to an oxygen-helium atmosphere at 258 mm. Hg total pressure. IX. Nutritional evaluation of feeding bite-size foods.
PubMed: Some biological and physical factors in dry heat sterilization: a general review.
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