fisetin
flavone, 3,3',4',7-tetrahydroxy-
 
Notes:
None found
  • BOC Sciences
    • BOC Sciences
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      Product(s):
      528-48-3 Fisetin >98%
      Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins.
       
       
  • Jiangyin Healthway
    • Jiangyin Healthway International Trade Co., Ltd
      Independent Ingredients Supplier
      We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.
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      Product(s):
      HL0324 Fisetin 98.0%
       
  • O'Laughlin Industries
    • O'Laughlin Industries Inc.
      Manufacturer of chemicals and ingredients used in flavors, fragrances, food, beverages and cosmetics
      Leading the Flavor and Fragrance Industry since 1980.
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      Product(s):
      774-7110 Fisetin 50
      774-7111 Fisetin 80
       
  • TCI AMERICA
    • TCI AMERICA
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      Product(s):
      T0121 Fisetin >96.0%(HPLC)
       
Synonyms   Articles   Notes   Search
CAS Number: 528-48-3Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 208-434-4
FDA UNII: OO2ABO9578
Nikkaji Web: J1.584I
Beilstein Number: 0292829
MDL: MFCD00006829
XlogP3-AA: 2.00 (est)
Molecular Weight: 286.23990000
Formula: C15 H10 O6
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: cosmetic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 330.00 °C. @ 760.00 mm Hg
Boiling Point: 599.41 °C. @ 760.00 mm Hg (est)
Flash Point: 451.00 °F. TCC ( 233.00 °C. ) (est)
logP (o/w): 1.970 (est)
Soluble in:
 water, 5489 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: cosmetic colorants
skin conditioning
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Suppliers:
Alfa Biotechnology
For experimental / research use only.
Fisetin 95%
BOC Sciences
For experimental / research use only.
Fisetin >98%
Odor: characteristic
Use: Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins.
Changsha Organic Herb
fisetin Folium Cotini Extract
ExtraSynthese
For experimental / research use only.
Fisetin (HPLC) ≥99%
Jiangyin Healthway
Fisetin 98.0%
New functional food ingredients
Maypro Industries
Fisetin
O'Laughlin Industries
Fisetin 50
O'Laughlin Industries
Fisetin 80
Qingdao Dacon Trading
Fisetin
Santa Cruz Biotechnology
For experimental / research use only.
Fisetin ≥98%
Shaanxi Y-Herb Biotechnology
Smoketree Fisetin Powder Natural Rhus Succedanea L Natural boxwood Extract
TCI AMERICA
For experimental / research use only.
Fisetin >96.0%(HPLC)
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LD50  180 mg/kg
U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#01998

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic agents
Recommendation for fisetin usage levels up to:
 not for fragrance use.
 
Recommendation for fisetin flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 528-48-3
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 5281614
National Institute of Allergy and Infectious Diseases: Data
 2-(3,4-dihydroxyphenyl)-3,7-dihydroxychromen-4-one
Chemidplus: 0000528483
RTECS: LK9250000 for cas# 528-48-3
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References:
 2-(3,4-dihydroxyphenyl)-3,7-dihydroxychromen-4-one
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 5281614
Pubchem (sid): 134978800
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C10041
HMDB (The Human Metabolome Database): Search
FooDB: FDB000624
Export Tariff Code: 2932.99.7000
FDA Color Additive Status ListView
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 cotinus coggygria
Search Trop  Picture
 soybean leaf
Search Trop  Picture
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Synonyms:
4H-1-benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-
 C.I. natural brown 1
 cotinin
5-deoxyquercetin
5-desoxy-quercetin
5-desoxyquercetin
3,7-dihydroxy-2-(3,4-dihydroxyphenyl)-4H-1-benzopyran-4-one
2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one
2-(3,4-dihydroxyphenyl)-3,7-dihydroxychromen-4-one
 fiestin
 fisidenolon 1521
 flavone, 3,3',4',7-tetrahydroxy-
 fustel
 fustet
 superfustel K
3,3',4',7-tetrahydroxy-flavone
3,3',4',7-tetrahydroxyflavone
3,7,3',4'-tetrahydroxyflavone
7,3',4'-trihydroxyflavonol
Synonyms   Articles   Notes   Search   Top
Articles:
PubMed: Fisetin improves glucose homeostasis through the inhibition of gluconeogenic enzymes in hepatic tissues of streptozotocin induced diabetic rats.
PubMed: Effects of antioxidants of bamboo leaves and flavonoids on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) formation in chemical model systems.
PubMed: Differences in the hydroxylation pattern of flavonoids alter their chemoprotective effect against direct- and indirect-acting mutagens.
PubMed: The flavonoid fisetin promotes osteoblasts differentiation through Runx2 transcriptional activity.
PubMed: Immunosuppressive effects of fisetin against dinitrofluorobenzene-induced atopic dermatitis-like symptoms in NC/Nga mice.
PubMed: Fisetin antagonizes cell fusion, cytoskeletal organization and bone resorption in RANKL-differentiated murine macrophages.
PubMed: Simultaneous determination of bioactive phenolic compounds in the stem extract of Rhus verniciflua stokes by high performance liquid chromatography.
PubMed: Protective effect of detoxified Rhus verniciflua stokes on human keratinocytes and dermal fibroblasts against oxidative stress and identification of the bioactive phenolics.
PubMed: Dietary flavonoids fisetin, luteolin and their derived compounds inhibit arginase, a central enzyme in Leishmania (Leishmania) amazonensis infection.
PubMed: The polyphenol fisetin protects bone by repressing NF-κB and MKP-1-dependent signaling pathways in osteoclasts.
PubMed: Fisetin protects against hepatosteatosis in mice by inhibiting miR-378.
PubMed: Fisetin, a tetra hydroxy flavone recuperates antioxidant status and protects hepatocellular ultrastructure from hyperglycemia mediated oxidative stress in streptozotocin induced experimental diabetes in rats.
PubMed: Extract of Rhus verniciflua Bark Suppresses 2,4-Dinitrofluorobenzene-Induced Allergic Contact Dermatitis.
PubMed: Cognitive-enhancing effects of Rhus verniciflua bark extract and its active flavonoids with neuroprotective and anti-inflammatory activities.
PubMed: Effects of fisetin supplementation on hepatic lipogenesis and glucose metabolism in Sprague-Dawley rats fed on a high fat diet.
PubMed: Hypocholesterolemic effect of daily fisetin supplementation in high fat fed Sprague-Dawley rats.
PubMed: Fisetin regulates obesity by targeting mTORC1 signaling.
PubMed: A diet low in animal fat and rich in N-hexacosanol and fisetin is effective in reducing symptoms of Parkinson's disease.
PubMed: Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management.
PubMed: Preparative isolation and purification of neuroprotective compounds from Rhus verniciflua by high speed counter-current chromatography.
PubMed: Neuroprotective and anti-inflammatory effects of flavonoids isolated from Rhus verniciflua in neuronal HT22 and microglial BV2 cell lines.
PubMed: Fisetin prevents fluoride- and dexamethasone-induced oxidative damage in osteoblast and hippocampal cells.
PubMed: Immunosuppressive effects of fisetin in ovalbumin-induced asthma through inhibition of NF-κB activity.
PubMed: Dietary chromones as antioxidant agents--the structural variable.
PubMed: Epigallocatechin-3-gallate does not affect the activity of enzymes involved in metabolic activation and cellular excretion of benzo[a]pyrene in human colon carcinoma cells.
PubMed: Fisetin, a novel flavonol attenuates benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice.
PubMed: Directly suspended droplet microextraction with in injection-port derivatization coupled to gas chromatography-mass spectrometry for the analysis of polyphenols in herbal infusions, fruits and functional foods.
PubMed: Fisetin inhibits lipopolysaccharide-induced macrophage activation and dendritic cell maturation.
PubMed: Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals.
PubMed: Fisetin induces apoptosis in Huh-7 cells via downregulation of BIRC8 and Bcl2L2.
PubMed: Involvement of the ERK signaling pathway in fisetin reduces invasion and migration in the human lung cancer cell line A549.
PubMed: The hydroxyflavone, fisetin, suppresses mast cell activation induced by interaction with activated T cell membranes.
PubMed: Induction of p53 contributes to apoptosis of HCT-116 human colon cancer cells induced by the dietary compound fisetin.
PubMed: Metabolism and pharmacokinetics of 3,3',4',7-tetrahydroxyflavone (fisetin), 5-hydroxyflavone, and 7-hydroxyflavone and antihemolysis effects of fisetin and its serum metabolites.
PubMed: Cupric ion reducing antioxidant capacity assay for food antioxidants: vitamins, polyphenolics, and flavonoids in food extracts.
PubMed: Analysis of flavonoids in propolis and Ginkgo biloba by micellar electrokinetic capillary chromatography.
PubMed: [Effects of flavonoids with different structures on proliferation of leukemia cell line HL-60].
PubMed: Dietary flavones and flavonoles are inhibitors of poly(ADP-ribose)polymerase-1 in pulmonary epithelial cells.
PubMed: Determination of flavonoid aglycones in several food samples by mixed micellar electrokinetic chromatography.
PubMed: Effects of various plant polyphenols on bladder carcinogen benzidine-induced mutagenicity.
PubMed: Distinctive antioxidant and antiinflammatory effects of flavonols.
PubMed: Inhibition of the intestinal glucose transporter GLUT2 by flavonoids.
PubMed: Flavonoids modulate monocarboxylate transporter-1-mediated transport of gamma-hydroxybutyrate in vitro and in vivo.
PubMed: Nutraceutical inhibitors of urokinase: potential applications in prostate cancer prevention and treatment.
PubMed: Fisetin inhibits the activities of cyclin-dependent kinases leading to cell cycle arrest in HT-29 human colon cancer cells.
PubMed: Effects of naturally occurring compounds on fibril formation and oxidative stress of beta-amyloid.
PubMed: Oral flavonoids delay recovery from experimental autoimmune encephalomyelitis in SJL mice.
PubMed: Genotoxicity of phytoestrogens.
PubMed: Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC method.
PubMed: Extract from Rhus verniciflua Stokes is capable of inhibiting the growth of human lymphoma cells.
PubMed: Degradation of ethyl docosahexaenoate by gamma-ray irradiation and suppression of this degradation by antioxidants.
PubMed: Antimutagenic activity of flavonoids from the heartwood of Rhus verniciflua.
PubMed: Inhibitory effects of several flavonoids on E-selectin expression on human umbilical vein endothelial cells stimulated by tumor necrosis factor-alpha.
PubMed: Inhibitory effects of plant-derived flavonoids and phenolic acids on malonaldehyde formation from ethyl arachidonate.
PubMed: Kinetic and stoichiometric assessment of the antioxidant activity of flavonoids by electron spin resonance spectroscopy.
PubMed: Inhibition of thyroid type 1 deiodinase activity by flavonoids.
PubMed: High-performance liquid chromatographic analysis of polyhydroxyflavones using solid-phase borate-complex extraction.
PubMed: Food constituents attenuate monoamine oxidase activity and peroxide levels in C6 astrocyte cells.
PubMed: Japanese intake of flavonoids and isoflavonoids from foods.
PubMed: In vitro attenuation of nitric oxide production in C6 astrocyte cell culture by various dietary compounds.
PubMed: Column-switching high-performance liquid chromatographic assay for the determination of quercetin in human urine with ultraviolet absorbance detection.
PubMed: In vitro biotransformation of flavonoids by rat liver microsomes.
PubMed: The inhibition by flavonoids of 2-amino-3-methylimidazo[4,5-f]quinoline metabolic activation to a mutagen: a structure-activity relationship study.
PubMed: In vivo effect of dietary factors on the molecular action of aflatoxin B1: role of non-nutrient phenolic compounds on the catalytic activity of liver fractions.
PubMed: Lignans and flavonoids inhibit aromatase enzyme in human preadipocytes.
PubMed: Antimutagenic effect of plant flavonoids in the Salmonella assay system.
PubMed: Antimutagenic effects of flavonoids, chalcones and structurally related compounds on the activity of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and other heterocyclic amine mutagens from cooked food.
PubMed: Protection by albumin against the pro-oxidant actions of phenolic dietary components.
PubMed: Modifying role of dietary factors on the mutagenicity of aflatoxin B1: in vitro effect of plant flavonoids.
PubMed: An overview of aflatoxicosis of poultry: its characteristics, prevention and reduction.
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