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ethyl 4-hydroxybenzoate
Notes:
Antimicrobial agent, preservative. Present in red wine, white wine and sake
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ECSA Chemicals Human Chemistry ECSA Chemicals has been active since 1913 in the trading and international commerce of raw materials. With an organisation divided into industrial segments managed by specialists, it has become one of the largest distributors worldwide. ECSA Chemicals is the largest Swiss-owned company in terms of warehouses for the distribution of chemical products. We have been distributing chemical products for over 100 years and we have a special interest in protecting the environment and in the safety of our facilities and collaborators. Established in 1913 as a small grocery store, in its over 100 years of activity ECSA Chemicals has become one of the most important Swiss-owned distributors of chemical products. The company, which is active in international distribution and trading, is organised into industrial segments that are managed by teams of specialists and experts. They guarantee professional and customised consultancy and services. With our experience, we can rapidly and safely connect you with the best suppliers on the market, providing you with a complete search, consulting and assistance service. The focus of our approach and operations is you, our customers. We strive every day to find the best products that satisfy your needs as quickly as possible. Your satisfaction is our greatest success. WHY CHOOSE ECSA? EXPERIENCE We have been working for 100 years. QUALITY We have obtained many certifications (ISO, SQAS, GDP, Responsible Care, Bio-Inspecta, RSPO, etc.). We guarantee full compliance with the current laws and continuous training for our staff. SAFETY We constantly carry out risk analyses for each infrastructure, defining safety levels and implementing corrective measures promptly wherever they are needed. WIDESPREAD DISTRIBUTION We have warehouses in strategic locations to supply goods to Switzerland and to the rest of the world. STORAGE CAPACITY The 3 ECSA-owned warehouses guarantee considerable storage area and capacity in each warehouse, with full availability of products (base chemicals and speciality chemicals). SPEED Presence all over the country, staff dedicated to sourcing raw materials and considerable storage capacity guarantee that goods are rapidly obtained and supplied. CONSULTANCY Our specialists - in-depth knowledge of the market and products allows us to provide full consulting services, from the purchase to the supply of raw materials. Email: Info Email: Sales Email: Trading Email: Maintenance Email: Energy Voice: +41 91 695 88 00 Fax: +41 91 695 88 01 Linkedin Youtube RSS Feed ECSA Trade ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY Products List: View Product(s): MP-002985 ETHYL PARABEN
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Glentham Life Sciences Ltd The Chemical, Biochemical & Research Essentials Supplier Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK. With a Glentham Life Sciences account you can view more product details, request quotes and order products online. Email: Info Email: Sales Email: Tech Support Voice: +44 (0) 1225 667798 Fax: +44 (0) 2033 978909 Facebook Twitter Linkedin Google+ News Distribution Products List: View Product(s): GK8938 Ethyl 4-hydroxybenzoate
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Penta International Corporation Chemistry innovation At Penta, our products and services help businesses do business better. For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes. US Email: Technical Services US Email: Sales US Voice: (973) 740-2300 US Fax: (973) 740-1839 Product(s): 05-40400 ETHYL-p-HYDROXYBENZOATE 05-40405 ETHYL-P-HYDROXYBENZOATE NF GRADE
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TCI AMERICA Moving Your Chemistry Forward We continuously strive to advance our technology. With East & West Coast distribution centers, count on TCI to deliver products quickly and reliably. Over 30,000 Reagents available today in benchtop to bulk quantities. We also offer custom synthesis solutions. Sign up for a TCI account today for fast and free shipping! Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 70 years of synthesis experience and multi-purpose plants enable TCI to offer more than 30,000 products as well as custom synthesis. US Email: Sales Email: Technical Support Voice: 1-800-423-8616 Fax: 1- 888-520-1075 Facebook Twitter Instagram Linkedin Product(s): H0211 Ethyl 4-Hydroxybenzoate >99.0%(GC)(T)
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| CAS Number: | 120-47-8 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 204-399-4 | |
| FDA UNII: | 14255EXE39 | |
| Nikkaji Web: | J2.917C | |
| Beilstein Number: | 1101972 | |
| MDL: | MFCD00002353 | |
| XlogP3: | 2.50 (est) | |
| Molecular Weight: | 166.17630000 | |
| Formula: | C9 H10 O3 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: antioxidants and preservatives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| FDA/DG SANTE Petitions, Reviews, Notices: | |
| EU SANCO | Ethyl-p-hydroxybenzoate View - review |
| JECFA Food Additive: | Ethyl p-Hydroxybenzoate |
| GSFA Codex: | Ethyl para-hydroxybenzoate (214) |
| DG SANTE Food Flavourings: | 09.367 ethyl 4-hydroxybenzoate |
| DG SANTE Food Additives: | ethyl 4-hydroxybenzoate |
| DG SANTE Food Contact Materials: | ethyl 4-hydroxybenzoate |
| FDA Mainterm (IAUFC): | 120-47-8 ; ETHYLPARABEN |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 118.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 298.00 °C. @ 760.00 mm Hg |
| Vapor Pressure: | 0.001000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 248.00 °F. TCC ( 120.00 °C. ) |
| logP (o/w): | 2.470 |
| Soluble in: | |
| alcohol | |
| water, 1894 mg/L @ 25 °C (est) | |
| water, 885 mg/L @ 25 °C (exp) | |
Organoleptic Properties:
| Odor Strength: | low |
| Odor Description: at 100.00 %. | mild phenolic |
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| CosIng: | cosmetic data |
| Cosmetic Uses: |
preservatives |
Suppliers:
| Acme-Hardesty |
| Ethyl Paraben
Odor: characteristic Use: Antimicrobial Preservative Used in Cosmetics and Personal Care. |
| Alfa Biotechnology |
| For experimental / research use only. |
| Ethylparaben 98% |
| BOC Sciences |
| For experimental / research use only. |
| Ethylparaben |
| Coompo |
| For experimental / research use only. |
| Ethylparaben from Plants ≥96% |
| ECSA Chemicals |
| ETHYL PARABEN |
| ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY |
| EMD Millipore |
| For experimental / research use only. |
| Ethyl 4-hydroxybenzoate |
| ExtraSynthese |
| For experimental / research use only. |
| Ethyl-4-hydroxybenzoate (HPLC) ≥99% |
| Foodchem International |
| Ethyl Paraben |
| Glentham Life Sciences |
| Ethyl 4-hydroxybenzoate |
| HallStar |
| CoSept(tm) E
Odor: characteristic Use: CoSept E provides the good performance against Gram positive bacteria exhibited by all the parabens and has the same limitations regarding pH range (acidic only), system compatibility (avoid high levels of ethoxylates) and water solubility (limited). Ethylparaben has been used in combination with Propylparaben in oral preparations for controlling fermentative action. It can be used alone, but is generally used at 0.10 to 0.25% levels with other CoSepts as the antifungal portion of the preservative system. |
| Inoue Perfumery |
| ETHYL 4-HYDROXY BENZOATE |
| Kingyoung Bio Technical |
| Ethylparaben |
| Kraft Chemical |
| Ethyl Paraben |
| Nanjing Jiancheng Chemical |
| Ethylparaben(Nipagin A)
Odor: characteristic Use: Ethylparaben is mainly used as antiseptics in cosmetics, food and medicine. It is also can be used as feed preservatives and antiseptic for bacteria. |
| Penta International |
| ETHYL-P-HYDROXYBENZOATE NF GRADE |
| Penta International |
| ETHYL-p-HYDROXYBENZOATE |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Ethyl Paraben |
| Sigma-Aldrich: Aldrich |
| For experimental / research use only. |
| Ethyl 4-hydroxybenzoate ReagentPlus®, 99% |
| Sinofi Food Ingredients |
| Ethylparaben
Odor: characteristic Use: Preservative, Cosmetics, Feed, Pharmaceutical, Soft Drink, Alcohol Beverage, Beverage Powder, Fruit Juice, Puddings, Sauces, Baking Food, Sauage, Flavoring Agent. |
| TCI AMERICA |
| For experimental / research use only. |
| Ethyl 4-Hydroxybenzoate >99.0%(GC)(T) |
Safety Information:
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| Xi - Irritant | |
|
R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 - Wear suitable protective clothing. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
oral-rabbit LD50 5000 mg/kg (Sabalitschka & Neufeld-Crzellitzer,1954) oral-rat LD > 200 mg/kg Acta Obstetrica et Gynaecologica Japonica, English Edition. Vol. 22, Pg. 94, 1975. gavage-rat LD50 [sex: F] 4300 mg/kg (CTFA, 1980b) oral-mouse LD50 8000 mg/kg (Sokol, 1952) oral-mouse LD50 6008 mg/kg (Sado, 1973) oral-dog LD50 5000 mg/kg (Sabalitschka & Neufeld-Crzellitzer, 1954) oral-dog LD50 5000 mg/kg FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 81, 1974. oral-guinea pig LD50 2000 mg/kg FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 81, 1974. intraperitoneal-mouse LD50 520 mg/kg Drug Standards. Vol. 20, Pg. 89, 1952. oral-mouse LD50 3000 mg/kg Bromatologia i Chemia Toksykologiczna. Vol. 14, Pg. 301, 1981. oral-rabbit LD50 5000 mg/kg FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 81, 1974. | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | antioxidants and preservatives | ||
| Recommendation for ethyl paraben usage levels up to: | |||
| not for fragrance use. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 10.00 (μg/capita/day) | ||
| Modified Theoretical Added Maximum Daily Intake (mTAMDI): | 3900 (μg/person/day) | ||
| Threshold of Concern: | 1800 (μg/person/day) | ||
| Structure Class: | I | ||
| Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i). | |||
| Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm. | |||
| average usage mg/kg | maximum usage mg/kg | ||
| Dairy products, excluding products of category 02.0 (01.0): | 7.00000 | 35.00000 | |
| Fats and oils, and fat emulsions (type water-in-oil) (02.0): | 5.00000 | 25.00000 | |
| Edible ices, including sherbet and sorbet (03.0): | 10.00000 | 50.00000 | |
| Processed fruit (04.1): | 7.00000 | 35.00000 | |
| Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): | - | - | |
| Confectionery (05.0): | 10.00000 | 50.00000 | |
| Chewing gum (05.0): | - | - | |
| Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): | 5.00000 | 25.00000 | |
| Bakery wares (07.0): | 10.00000 | 50.00000 | |
| Meat and meat products, including poultry and game (08.0): | 2.00000 | 10.00000 | |
| Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): | 2.00000 | 10.00000 | |
| Eggs and egg products (10.0): | - | - | |
| Sweeteners, including honey (11.0): | - | - | |
| Salts, spices, soups, sauces, salads, protein products, etc. (12.0): | 5.00000 | 25.00000 | |
| Foodstuffs intended for particular nutritional uses (13.0): | 10.00000 | 50.00000 | |
| Non-alcoholic ("soft") beverages, excl. dairy products (14.1): | 5.00000 | 25.00000 | |
| Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): | 10.00000 | 50.00000 | |
| Ready-to-eat savouries (15.0): | 20.00000 | 100.00000 | |
| Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): | 5.00000 | 25.00000 | |
Safety References:
| European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): | |
| Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23 View page or View pdf | |
| Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy-substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf | |
| Flavouring Group Evaluation 54 (FGE.54)[1] - Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20 (2005) - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf | |
| Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23 View page or View pdf | |
| Flavouring Group Evaluation 54, Revision 1 (FGE.54Rev1): Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20Rev1 (2009) View page or View pdf | |
| Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf | |
| Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf | |
| Scientific Opinion on Flavouring Group Evaluation 20, Revision 4 (FGE.20Rev4): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf | |
| EPI System: | View |
| Daily Med: | search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 120-47-8 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 8434 |
| National Institute of Allergy and Infectious Diseases: | Data |
| SCCNFP: | opinion |
| WGK Germany: | 1 |
| ethyl 4-hydroxybenzoate | |
| Chemidplus: | 0000120478 |
| RTECS: | DH2190000 for cas# 120-47-8 |
References:
| ethyl 4-hydroxybenzoate | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 120-47-8 |
| Pubchem (cid): | 8434 |
| Pubchem (sid): | 134975046 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| Metabolomics Database: | Search |
| KEGG (GenomeNet): | D01647 |
| HMDB (The Human Metabolome Database): | HMDB32573 |
| FooDB: | FDB010510 |
| YMDB (Yeast Metabolome Database): | YMDB01688 |
| Export Tariff Code: | 2918.29.7500 |
| FDA Listing of Food Additive Status: | View |
| ChemSpider: | View |
| Wikipedia: | View |
| Formulations/Preparations: •trade names: aseptoform e, bobomold oe, easeptol, ethyl butex, ethyl parasept, mycoten, napagin a, nipagina a, nipazin a, sobrol a, solbrol a, and tegosept e. •esters are usually sold in form which contains free phenolic groupparaben esters | |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| preservatives |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| benzoic acid, 4-hydroxy-, ethyl ester | |
| 4- | carbethoxyphenol |
| p- | carbethoxyphenol |
| para- | carbethoxyphenol |
| ethyl 4-hydroxybenzoate | |
| ethyl p-hydroxybenzoate | |
| ethyl para-hydroxybenzoate | |
| ethyl-4-hydroxybenzoate | |
| ethyl-p-hydroxybenzoate | |
| ethyl-para-hydroxybenzoate | |
| ethylparaben | |
| 4- | hydroxy-benzoic acid ethyl ester |
| 4- | hydroxybenzoic acid ethyl ester |
| p- | hydroxybenzoic acid ethyl ester |
| para- | hydroxybenzoic acid ethyl ester |
| 4- | hydroxybenzoic acid ethylester |